NOW Supplements L-Carnitine

My pain has improved very well.

Cardiovascular Disease details

Supports heart health

To support my heart, my endocrinologist prescribed L-carnitine alongside other medications due to my AIT condition. This ingredient is effective in enhancing metabolism and comes in a convenient packaging that lasts long. Many also use it for better performance in training and weight management.

Chronic Cough details

Consistent energy levels

6 people found this helpful

I have been battling chronic fatigue for some time. Although I take many supplements, this particular one seems to distribute energy evenly throughout the day. Previously, I would experience energy spikes for a few hours, but now I enjoy a steady level of energy until about 6-7pm, which is fantastic! Before, I would feel bedridden and barely able to move, which was quite depressing. I am very pleased with the effects of this supplement. However, it would be wonderful if they could make it smaller as it sometimes gets stuck in my throat. I take a lot of supplements, and this doesn’t usually happen with other large pills. I hope this helps someone else. Good luck with your health.

Cold Sores details

7 people found this helpful

I take this to prevent muscle breakdown and assist with fat burning, having it in the morning before breakfast. After a stable weight, it has begun to shift again, thank goodness. On the day I take it, I notice a chill in my extremities, yet I feel warmer throughout the day (I often feel cold even in August due to a sluggish gland). I recommend trying it, and if it helps, please leave a like.

Depression details

4 people found this helpful

I find great value in this higher dose. It has significantly enhanced my mental clarity and helped manage my depression and brain fog.

Food Poisoning details

Significant weight loss

I was very pleased with Now Foods L-Carnitine! I took five capsules 40 minutes before training, weighing 96 kg originally. After a month, I lost 14 kg without strict dieting, mainly running, as L-Carnitine is effective with aerobic exercise. My endurance improved, fatigue disappeared, and recovery was faster. I trust this product entirely.

Leg Cramps details

Tanizaki R, Miyamatsu Y. Nocturnal Leg Cramping Caused by Carnitine Deficiency Due to Long-Term Pivalate Antibiotics Administration in a Patient With Chronic Kidney Disease. Cureus. 2023;15:e48927. doi:10.7759/cureus.48927

Based on 3 Researches

L-Carnitine alleviates leg cramps

We observed the impact of L-carnitine on leg cramps in a 69-year-old Japanese woman who experienced painful nocturnal leg cramps. This occurred after she had been on cefcapene-pivoxil, a pivalate-containing antibiotic, for six months.

Investigations revealed decreased levels of serum-free carnitine and acylcarnitine in her body, leading to a diagnosis of carnitine deficiency. We learned that this deficiency was likely caused by her long-term use of the antibiotic, which can interfere with carnitine absorption.

After starting oral L-carnitine treatment, we noted marked improvement in her symptoms, suggesting that L-carnitine could play a beneficial role in alleviating leg cramps associated with carnitine deficiency. This case serves as a reminder to consider carnitine levels in patients experiencing leg cramps, particularly those on pivalate-containing antibiotics.

Muscle recovery improvement

Most Useful Review

This is magical. I always take it before my workouts, and my consistency has never been better. It aids significantly in muscle recovery, and I hardly ever find myself in bed with those painful leg cramps as I did before. I won't be leaving it behind.

Liver Disease details

Liver condition improved

I've been using it for over a year, and my liver condition has notably improved. I highly recommend it.

Neuropathy details

Zinc-Acetyl Carnitine Complex Benefits

Caro-Ramírez JY, Bazán LO, Piro OE, Echeverría GA, Jori K, et al. Exploring Zn(II)-Acetyl l-carnitine complex for simultaneous management of depression, chronic pain, and neuroprotection. J Inorg Biochem. 2025;267:112857. doi:10.1016/j.jinorgbio.2025.112857

Our research delved into the potential of a new zinc complex combined with acetyl-l-carnitine (ALC) in addressing neuropathy, alongside its antidepressant effects. We found that this novel compound, Zn(ALC)Cl(HO), not only demonstrated significant antidepressant properties but also effective antinociceptive action, which means it helps reduce pain sensitivity.

Specifically, we observed that the Zn(ALC)Cl(HO) complex improved outcomes in models of diabetic neuropathy by preventing the drop in important protective molecules in cells. When we examined how this complex interacts with the nervous system, it was noted that it can cross the blood-brain barrier, offering neuroprotection against harmful conditions like excitotoxicity.

Additionally, the results indicated that under certain inflammatory conditions, the zinc complex counteracts toxic effects from activated astrocytes. These findings suggest that the combined properties of zinc and ALC may make this complex a promising candidate for treating both neuropathy and mood disorders, presenting an exciting avenue for future therapies.

7.5

Helps during treatment

Most Useful Review

43 people found this helpful

While hospitalised due to chemotherapy complications, I inquired about alleviating the neuropathy caused by the treatment. Two doctors recommended this supplement to prevent the chemotherapy-induced neuropathy from worsening. While it hasn't completely resolved, it certainly helps.

Acne details

Georgala S, Schulpis KH, Georgala C, Michas T. L-carnitine supplementation in patients with cystic acne on isotretinoin therapy. J Eur Acad Dermatol Venereol. 1999;13:205.

Based on 10 Researches

L-carnitine shows promise

We explored the effects of L-carnitine on patients suffering from cystic acne who were undergoing isotretinoin therapy. This study involved 230 patients, all treated with a standard isotretinoin dosage. When they began to experience muscular symptoms, we examined the role of L-carnitine supplementation. Half of the patients received L-carnitine, while the other half received a placebo.

The results were encouraging for those on L-carnitine. Patients who received the supplement reported a notable improvement in muscle pain and discomfort within just a week. Additionally, their liver enzyme levels returned to normal, along with an increase in carnitine levels. In contrast, the placebo group continued to struggle with muscle symptoms, highlighting the potential benefits of L-carnitine for these patients. For those who did not experience muscle issues initially, we observed decreases in carnitine blood levels and elevation in liver enzymes, indicating an overall systemic effect from isotretinoin.

While these findings are promising, they call for further investigation to confirm the benefits of L-carnitine supplementation for patients undergoing isotretinoin therapy.

7.5

Supports acne treatment

Most Useful Review

2nd time buying. L-carnitine is an important amino acid that supports fat metabolism. Among its many benefits, it assists with my facial acne. It’s essential for me.

Autoimmune Disorder details

Hu W, Hu Y, Li J, Men Y, Xia J, et al. Effect of L-Carnitine Level on the Risk of Neuromyelitis Optica Spectrum Disorders: A Two-Sample Mendelian Randomization Study. Mol Neurobiol. 2025;62:5133. doi:10.1007/s12035-024-04607-5

Based on 9 Researches

L-Carnitine linked to NMOSD risk

We explored the relationship between circulating L-carnitine levels and the risk of neuromyelitis optica spectrum disorders (NMOSD) using data from genetic studies.

Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.

This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.

Enhanced energy

Most Useful Review

20 people found this helpful

This L-Carnitine is superb! After finishing my first jar, I take one tablet before training, which gives me a significant surge of energy. I can run twice as far with it, and my figure has tightened, reducing excess fat. The tablets are large and can be tough to swallow, so I plan to try a liquid version next time, but from the same brand.

Brain Tumor details

Enhanced training performance

4 people found this helpful

Endurance and lightness are guaranteed! My trainer recommended L-carnitine. I work out six times a week, with varied intensity. I take it daily in the morning before training, which boosts my energy, enhances exercise effectiveness, and helps my brain stay clear post-training—essential for good performance. This supplement has improved my endurance during workouts, making my day easier.

High Cholesterol details

L-carnitine lowers lipoprotein(a) levels

Based on 12 Researches

Derosa G, Cicero AF, Gaddi A, Mugellini A, Ciccarelli L, et al. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Clin Ther. 2003;25:1429.

We investigated the impact of L-carnitine on cholesterol levels in individuals with type 2 diabetes and high cholesterol. In a well-structured 6-month study, patients were assigned either L-carnitine or a placebo.

Over this period, we observed that L-carnitine significantly reduced plasma lipoprotein(a) levels compared to the placebo. This exciting finding suggests that L-carnitine might be a useful dietary supplement for managing cholesterol in patients with diabetes.

7.5

Converts fat to energy

Most Useful Review

6 people found this helpful

Carnitine is beneficial as it transports fat to the body's energy factories and converts it into energy while reducing harmful cholesterol and triglycerides. This overview highlights the many benefits of carnitine, and I hope it helps you. ❤️

Menopause details

3 people found this helpful

I recommend! After just a week of taking it, I felt a qualitative effect; I stopped feeling sleepy during the day. Overall, I have more energy, and it seems my brain function has improved. For women entering menopause, this is a useful supplement; I started taking it on my gynecologist's advice. It has a convenient size and dosage, as I do fitness and take it right before training without discomfort. Plus, the weight control aspect is a nice bonus.

Obesity details

Optimises energy production

The Carnitine Capsules supplement is an excellent aid for exercise and fitness. Carnitine converts fat into energy, enhancing workouts and optimising energy production, which helps manage obesity effectively. However, results can vary based on individual constitution and lifestyle. Consulting a medical professional before beginning carnitine supplementation is advisable.

Adenoiditis details

6 people found this helpful

I have been battling chronic fatigue and take many supplements. However, this supplement evenly disperses energy throughout the day, allowing me to have consistent energy until about 6-7pm. Previously, after a couple of hours with other supplements, I would feel bedridden and unable to move, which was quite disheartening. I am very pleased with the effects of this supplement. The only downside is that it's quite large and has gotten stuck in my throat; I take many supplements, and this doesn’t happen with others. Please consider making a smaller version. I hope this helps someone in their health journey.

Chronic Fatigue Syndrome details

Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008;46:181.

Possibly Effective

Based on 8 Researches

ALC reduces fatigue in elderly

We investigated the effects of acetyl L-carnitine (ALC) on elderly patients experiencing chronic fatigue. In our study of 96 participants aged 70 and above, we found that ALC significantly reduced both physical and mental fatigue.

After treatment, improvements were noted in functional abilities and cognitive performance, with patients experiencing less muscle pain and fewer sleep disorders. Overall, our findings indicate that ALC can be an effective option for alleviating fatigue and enhancing quality of life in older individuals.

Reduced exercise fatigue

Most Useful Review

21 people found this helpful

I'm impressed with the results! From the first dose, I noticed a difference. At over 55 years old, previous supplements caused heart palpitations. This product brought no discomfort to my heart, and after 45 minutes of cardio, my pulse didn't race, and I experienced no fatigue. The effect is astonishing, especially for evening workouts after a long day at work. The large tablets are easy to swallow with ample water. I believe the value for money is evident, and I will continue taking this product.

Irritable Bowel Syndrome details

The pills are quite large and difficult to swallow, but I quickly accustomed myself to them. They are somewhat salty. I have noticed that I seem to sweat more easily, and my bowel movements have improved.

Pelvic Pain details

8 people found this helpful

GREAT PRODUCT! I suffered from sciatic nerve pain for about six months. After starting physical therapy three times a week, the pain became more manageable. I researched L-Carnitine and ALA, which had shown success for other neuropathies in studies. I began taking L-Carnitine, and within days, my sciatic nerve pain had almost disappeared. After two weeks on the recommended dosage, I was pain-free for over a year. Occasionally, if pain returns, I resume taking this product, and it always provides relief. Totally Amazing!

Bloating details

Effective for insulin

This is my second purchase, and I find it very useful for insulin resistance. The quality is high and the ingredients help compensate for the lack of the substance that aids insulin transport to cells, also effectively getting rid of excess naturally. The package is sizeable, but it must be taken alongside exercise and a balanced diet. While the pill is large and not the best-tasting, it significantly reduces bloating and water retention.

Heart Disease details

El Feky W, El-Afify D, Abdelhai D, Elkashlan M, Fakhreldin A, et al. L-carnitine decreases myocardial injury in children undergoing open-heart surgery: A randomized controlled trial. Eur J Pediatr. 2024;183:2783. doi:10.1007/s00431-024-05534-2

Based on 4 Researches

L-carnitine reduces heart injury

We looked into how L-carnitine might help children facing myocardial injury during open-heart surgery. In our study involving 60 children with congenital heart disease, we split participants into two groups: one received L-carnitine before surgery, while the other got a placebo.

The findings were promising; the L-carnitine group showed lower levels of harmful markers indicating heart damage after surgery and better heart function compared to the placebo group. Overall, we found that L-carnitine may protect the heart and improve recovery in these young patients.

7.5

Effective weight loss

Most Useful Review

3 people found this helpful

This L-carnitine tartrate product works well, and I confirmed this after I'd searched for it. It breaks down faster in the stomach compared to regular L-carnitine, allowing for better absorption. After taking it, I noticed increased sweating during exercise, indicating its effectiveness. I recommend consistent cardio workouts to enhance weight loss—I've noticed a reduction of 2-2.5 kg without changing my diet much.

Polycystic Ovary Syndrome details

20 people found this helpful

Excellent! It gives me energy, and I have polycystic ovary syndrome. It greatly improved my health and my husband’s condition; he also felt more energetic with the diet or intermittent fasting that I follow. I experienced no nausea or stomach discomfort, and it kept me active during exercise. The quality of the grains is good and they hold together well. I recommend eating it in the morning, as its ingredients provide energy like coffee.

Nausea details

20 people found this helpful

Excellent! It provides me with energy, and has significantly helped my health condition, as well as my husband's. He feels more energetic with the diet or intermittent fasting I've adopted. It did not cause me any nausea or stomach discomfort, enhancing my activity levels during exercise. The grains are of good quality and do not fall apart. I recommend consuming it in the morning, as its ingredients offer energy similar to coffee.

Blood Clot details

Effective for weight loss

I wanted to thoroughly test L-Carnitine before writing my review for weight loss. This tartrate form absorbs quickly and maintains high blood levels, promoting fat burning from the start. I noted rapid weight loss initially, followed by continuing success. Research backs the benefits of this form. However, regular aerobic exercise and a proper diet are essential for noticeable results; otherwise, it won’t be effective.

Insomnia details

Carnitine's potential for insomnia relief

Zhou H, Luo Y, Zhang W, Xie F, Deng C, et al. Causal effect of gut-microbiota-derived metabolite trimethylamine N-oxide on Parkinson's disease: A Mendelian randomization study. Eur J Neurol. 2023;30:3451. doi:10.1111/ene.15702

We explored the effects of l-carnitine on insomnia in the context of Parkinson's disease. The study analyzed whether higher levels of l-carnitine could help alleviate sleep disturbances experienced by individuals with this condition.

Interestingly, our findings indicated a suggestive inverse causal effect of l-carnitine on insomnia. Specifically, we observed that increased levels of l-carnitine were associated with a lower likelihood of insomnia, which was demonstrated with a statistically significant odds ratio of 0.817.

While this is promising, it's important to note that these results should be viewed with caution. The link between l-carnitine and insomnia is still being investigated, and further research is needed to confirm these findings and to understand the mechanisms involved. Therefore, we should remain open to a deeper exploration of how l-carnitine might play a role in sleep quality, especially for those suffering from Parkinson's disease.

Weight loss aid

Most Useful Review

An excellent dietary supplement that aids in weight loss and boosts endurance. I genuinely like L-carnitine; the results are quite noticeable with regular use. There is one downside, which is insomnia, but if you listen to your body and time your intake properly, you’ll be fine! Consulting a specialist is recommended, though I prefer to trust my own instincts, but I wouldn't advise others to do the same!

Diarrhea details

Lighter strength needed

2 people found this helpful

I experienced diarrhoea and realised that taking a lighter strength could be beneficial in managing it.

Headache details

IEM diagnosis reveals headache treatment

Onuki T, Hiroshima S, Sawano K, Shibata N, Ogawa Y, et al. A Study of Maternal Patients Diagnosed with Inborn Errors of Metabolism Due to Positive Newborn Mass Screening in Their Newborns. Children (Basel). 2023;10. doi:10.3390/children10081341

We took a closer look at the effects of l-carnitine on headaches in new mothers diagnosed with inborn errors of metabolism (IEM), identified through newborn screening. Our study included mothers of newborns who had false-positive results from screenings, revealing noteworthy insights into their health conditions.

Out of several examined cases, three mothers were newly diagnosed with IEM. Among these cases, two mothers experienced significant relief from headaches and fatigue after starting oral l-carnitine treatment. This suggests that l-carnitine might play a beneficial role in managing these symptoms.

While it’s important to remember that these findings are preliminary and based on a small sample size, the marked improvement in headaches in two of the mothers indicates that l-carnitine may have a positive effect worth considering in treatment plans for individuals with IEM.

Headache issue

Most Useful Review

Appointed by a gastroenterologist for improved fat metabolism, as I’ve struggled to gain weight. However, I developed a headache after taking it.

Common Cold details

Cold alleviation effective