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Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Alpha GPC (L-alpha-glycerylphosphorylcholine)
600 mg
*
The product is found useful for the following medical conditions
Brain Tumor details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Increased focus
Most Useful Review
Wonderful! Productivity has increased by 220%. This supplement for the brain is quite expensive but worthwhile. It has significantly aided me during my programming courses and while learning English. I notice enhanced attentiveness and perseverance, as well as a strong desire to absorb new information. My interests have broadened, and my thinking has improved. I took 2 tablets daily, which helped my sleep; I now fall asleep faster than before.
Alzheimer details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Alpha-GPC reduces Alzheimer's symptoms
Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease.
Most Relevant Research
We investigated the potential benefits of alpha-glyceryl-phosphoryl-choline (α-GPC) in tackling the complex challenges of Alzheimer's disease (AD). Using a triple transgenic mouse model known as 3xTg-AD, mice were treated with α-GPC for eight months starting at four months of age. This approach allowed us to assess its impact on both neuroinflammation and memory over a significant timeframe.
Our findings revealed that chronic treatment with α-GPC led to a notable reduction in amyloid deposits, which are often associated with AD. We observed improvements in the balance of the immune response within the brain, especially among important cells like astrocytes and microglia. These changes reflected not just a decrease in inflammation but also an increase in protective, anti-inflammatory molecules.
Furthermore, the treatment positively influenced synaptic function, crucial for memory and learning. Behaviorally, the α-GPC-treated mice demonstrated enhanced cognitive abilities, as evidenced by longer exploration times of new objects—a key indicator of memory function—compared to their untreated counterparts.
In summary, our research supports α-GPC as a promising candidate for therapeutic intervention in the early stages of Alzheimer's. Its ability to reduce inflammation and support brain health could provide new avenues for aiding memory and cognitive function as we age.
Our findings revealed that chronic treatment with α-GPC led to a notable reduction in amyloid deposits, which are often associated with AD. We observed improvements in the balance of the immune response within the brain, especially among important cells like astrocytes and microglia. These changes reflected not just a decrease in inflammation but also an increase in protective, anti-inflammatory molecules.
Furthermore, the treatment positively influenced synaptic function, crucial for memory and learning. Behaviorally, the α-GPC-treated mice demonstrated enhanced cognitive abilities, as evidenced by longer exploration times of new objects—a key indicator of memory function—compared to their untreated counterparts.
In summary, our research supports α-GPC as a promising candidate for therapeutic intervention in the early stages of Alzheimer's. Its ability to reduce inflammation and support brain health could provide new avenues for aiding memory and cognitive function as we age.
8.8
Enhances memory clarity
Most Useful Review
Alpha GPC greatly enhances my nootropic regimen, particularly in improving short-term memory. I incorporate it with a group of B vitamins, DMAE capsules, and magnesium. Memory issues, even in young individuals, can sometimes stem from forgetfulness due to stress. I encourage anyone facing these challenges, including those concerned about Alzheimer’s, to consider it as it has greatly benefitted me.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Enhanced mental clarity.
Most Useful Review
I found this incredibly helpful for my mental clarity. It was part of a Chronic Inflammatory Response Syndrome (CIRS) protocol that indicated inflammatory responses reduced neurotransmitter production. This product significantly improved my mental state and alleviated various bizarre neurological symptoms that accompany chronic fatigue disorders, such as muscle twitches and GI issues.
Stroke details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 16 Reviews
8.4
9
alpha-GPC enhances stroke recovery
alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial.
Most Relevant Research
We investigated how alpha-glycerophosphocholine (alpha-GPC) can aid in recovery for individuals who have recently suffered strokes or transient ischemic attacks. In this multicenter clinical trial involving 2044 patients, alpha-GPC was given after the event—first through injections for 28 days and then as a daily oral supplement for five months.
Throughout the treatment, we measured cognitive recovery using various scales, including the Mathew Scale, Mini Mental State Test, Crichton Rating Scale, and Global Deterioration Scale. Over the course of just 28 days, patients showed significant improvements in their mental recovery, with the Mathew Scale score increasing by an impressive 15.9 points. By the end of the five-month study, we noticed that many participants achieved near-normal cognitive scores, with 71% experiencing no cognitive decline.
While some patients did report mild adverse effects like heartburn and nausea, the overall tolerability was excellent, with only 2.14% needing to discontinue treatment due to side effects. We learned that alpha-GPC has a promising role in supporting cognitive recovery following strokes and transient ischemic attacks, highlighting its potential benefits in rehabilitation settings.
Throughout the treatment, we measured cognitive recovery using various scales, including the Mathew Scale, Mini Mental State Test, Crichton Rating Scale, and Global Deterioration Scale. Over the course of just 28 days, patients showed significant improvements in their mental recovery, with the Mathew Scale score increasing by an impressive 15.9 points. By the end of the five-month study, we noticed that many participants achieved near-normal cognitive scores, with 71% experiencing no cognitive decline.
While some patients did report mild adverse effects like heartburn and nausea, the overall tolerability was excellent, with only 2.14% needing to discontinue treatment due to side effects. We learned that alpha-GPC has a promising role in supporting cognitive recovery following strokes and transient ischemic attacks, highlighting its potential benefits in rehabilitation settings.
9.5
Restores recovery
Most Useful Review
An excellent remedy for my seriously ill child, helping to restore memory, speech, and mood. We have seen consistent improvement over 1.5 years. It's particularly beneficial for those recovering from stroke or TBI, with no side effects like headaches.
Anxiety details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
8
Mental health improvement
Most Useful Review
Alpha GPC has quickly become an essential part of my regimen. Returning to study in my 40s, I experienced anxiety and fatigue. Using a sample stack with L-Theanine and others helped me feel focused and relaxed. I completed three days worth of assignments in one day. I recommend talking to your doctor before starting any supplements.
Bloating details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
0
Increased bloating issues
Most Useful Review
I felt unwell after taking the choline—my stomach was upset, and I experienced bloating and lethargy. Yuck!
Headache details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 23 Reviews
7.5
9.5
Headache relief
Most Useful Review
Perfect replacement for gliatylin. I bought it instead of the expensive gliatylin after a concussion. The composition is the same and, combined with phosphatidylserine, my headaches have completely disappeared.
