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Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Selenium (elemental)(from 40 mg L-Selenomethionine)
200 mcg
364%
The product is found useful for the following medical conditions
Autoimmune Disorder
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.9
USERS' SCORE
Excellent
Based on 48 Reviews
9
9
Selenium aids Graves' orbitopathy treatment
The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
Most Relevant Research
We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
9.5
Lowered antibodies
Most Useful Review
Selenium plays a crucial role in thyroid function, acting as a catalyst for converting inactive hormone T4 to active T3 while protecting thyroid cells from oxidative damage. I suffer from an autoimmune disorder, hypothyroidism, and my doctor recommended selenium. After taking it for over two years, my antibody levels have significantly decreased, as evidenced by my tests.
Breast Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 8 Reviews
8.9
9
Selenium compounds may fight breast cancer
Di- and Triselenoesters-Promising Drug Candidates for the Future Therapy of Triple-Negative Breast Cancer.
Most Relevant Research
We set out to explore the effects of selenium-containing compounds on breast cancer cells, particularly focusing on their potential as treatments. Our research involved testing several novel selenoesters on two breast cancer cell lines, MCF-7 and MDA-MB-231, to understand how these compounds can impact cell growth and survival.
What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.
The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.
In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.
What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.
The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.
In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.
9.5
Cancer cell disappearance
Most Useful Review
During my breast cancer treatment, I started taking one tablet of selenium daily after reading Mitsuishi Iwao's book. I continued with this dosage and a high-protein, vitamin-rich, low-carbohydrate diet throughout pre-operative chemotherapy. Remarkably, the lump shrank significantly, and post-surgery pathology indicated that cancer cells had vanished. Although navigating the chemotherapy's side effects was challenging, I believe the supplements aided my resilience while working. I intend to keep taking it diligently and would recommend it to anyone facing similar challenges during breast cancer treatment.
Cancer
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
USERS' SCORE
Good
Based on 62 Reviews
8.9
9.5
Selenium drug shows selective toxicity
Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.
Most Relevant Research
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
9.5
Boosts cancer defence
Most Useful Review
This mineral supplement is vital for immunity and thyroid health. Selenium acts as a powerful antioxidant, combating atherosclerosis, cancer, infertility risk, and chronic fatigue. I recommend it for improving brain function and reducing cardiovascular disease risks.
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 16 Reviews
8.9
9.5
Effective cold prevention
Most Useful Review
After purchasing this product, I heard it works well with NAC to combat cold germs and prevent catching a cold. I take it every two days, and perhaps that's why I don't catch a cold even when others around me are affected!
Prostate Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 14 Reviews
8.9
8
Selenium nanoparticles show promise
Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.
Most Relevant Research
We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.
By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.
This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.
Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.
By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.
This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.
Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.
9.5
Cancer prevention
Most Useful Review
Selenium is an essential supplement for preventing cancer. To maintain my health and reduce tumour risks, I believe this supplement is crucial.
Diabetes
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 13 Reviews
8.7
9
Antidiabetic effects of selenium
Physicochemical properties, structural characterization, and antidiabetic activity of selenylated low molecular weight apple pectin in HFD/STZ-induced type 2 diabetic mice.
Most Relevant Research
We investigated the impact of a novel selenylated low molecular weight apple pectin on diabetes management. The study focused on mice induced with type 2 diabetes through a high-fat diet and streptozotocin treatment.
Our findings revealed that this modified pectin significantly improved several diabetic symptoms. It reduced weight loss, lower blood sugar levels, and oxidative stress, while also protecting organs like the liver and kidneys.
Additionally, we observed enhanced glucose tolerance and improvements in lipid metabolism and insulin sensitivity among the mice receiving the treatment. The selenylated apple pectin not only had a notable effect on glucose metabolism but also appeared to offer protective benefits against inflammation and tissue damage.
Our findings revealed that this modified pectin significantly improved several diabetic symptoms. It reduced weight loss, lower blood sugar levels, and oxidative stress, while also protecting organs like the liver and kidneys.
Additionally, we observed enhanced glucose tolerance and improvements in lipid metabolism and insulin sensitivity among the mice receiving the treatment. The selenylated apple pectin not only had a notable effect on glucose metabolism but also appeared to offer protective benefits against inflammation and tissue damage.
9.5
Boosts immune system
Most Useful Review
Selenium is vital for cancer protection and immunity against viruses. It aids pancreatic cell growth and improves glucose absorption, essential for managing diabetes by reducing insulin resistance. This mineral is best absorbed with fat-soluble vitamins A, D, and E, and it’s crucial for synthesising thyroid hormones.
Heart Attack
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
USERS' SCORE
Good
Based on 15 Reviews
8.7
9.5
Selenium nanoparticles for heart health
A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction.
Most Relevant Research
We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.
Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.
Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.
Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.
Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.
8.8
Boosted immunity
Most Useful Review
Selenium is essential for health! I've been taking it for autoimmune thyroiditis as prescribed by my doctor. It strengthens my immunity and overall well-being. One capsule daily prepares me for any challenge. I trust NOW products, and this specific selenium supplement has been effective. It serves various functions including antioxidant action, support for the immune system, and heart health, which is vital given the risk of heart attack.
Bacterial Infection
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Selenium bandages prevent infections
Selenium Bandages and Cotton Cloth That Kill Microorganisms in Wounds.
Most Relevant Research
We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
9.5
Effective against Lyme disease
Most Useful Review
This is crucial for my immune health. I use it as part of my treatment for Lyme Disease, effectively preventing bacterial biofilm formation. Combined with oregano oil from the same brand, I believe I have successfully tackled this persistent bacterial infection. I maintain this protocol to prevent relapses, and I have faith in its efficacy where conventional medicine has failed.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Works wonders
Most Useful Review
Works wonders for my leg cramps that strike in the middle of the night. I take one before bed and I'm good for the night.
Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
9
Powerful effects
Most Useful Review
Good brand! Worked great; some supplements feel like a placebo, but these were excellent. I felt my body fighting off colds. I took these with vitamin D and C supplements and would definitely buy this brand again.
Eczema
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 1 Review
8.4
8
Selenium's combined benefits for sheep
Evaluation of intraruminal devices for combined facial eczema control and trace element supplementation in sheep.
Most Relevant Research
We explored the use of intraruminal devices containing zinc oxide, designed to prevent facial eczema in sheep while also addressing trace element deficiencies. Specifically, we looked at how adding selenium and cobalt to these devices might improve the health of pregnant ewes by monitoring changes in blood selenium and serum Vitamin B12 levels.
The devices we tested included 16.4 mg of selenium, in the form of sodium selenate, and 20.4 mg of cobalt, provided as cobalt sulfate. Our findings revealed that these devices were effective in raising and sustaining higher blood selenium levels for at least 84 days, with notable increases in serum Vitamin B12 for up to 42 days.
This dual action means that the devices not only offer protection against facial eczema but also help prevent trace element deficiencies in sheep, demonstrating a valuable approach for improving overall animal health.
The devices we tested included 16.4 mg of selenium, in the form of sodium selenate, and 20.4 mg of cobalt, provided as cobalt sulfate. Our findings revealed that these devices were effective in raising and sustaining higher blood selenium levels for at least 84 days, with notable increases in serum Vitamin B12 for up to 42 days.
This dual action means that the devices not only offer protection against facial eczema but also help prevent trace element deficiencies in sheep, demonstrating a valuable approach for improving overall animal health.
7.5
Improved eczema
Most Useful Review
Eczema is more manageable now. I use this remedy for my eczema since my dermatologist offered no assistance. After doing my own research, I found it helpful. I combine it with NOWMSM, and while I am not completely cured, my eczema has improved.
Hypothyroidism
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.3
8
Selenium benefits Hashimoto's patients
Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Most Relevant Research
We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
8.8
Positive changes
Most Useful Review
It is rather unpleasant to swallow. I purchased this because I have hypothyroidism, and I think it helps! Initially, the taste was tough, but after a few days, I no longer noticed it. I've observed some positive changes in how I feel since starting this product.
Nausea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.5
2.5
Smell caused nausea
Most Useful Review
The pills are small and easy to swallow, but the smell is so terrible that it makes me nauseous.
