NOW Foods Selenium

Selenium compounds may fight breast cancer

Based on 18 Researches

Radomska D, Czarnomysy R, Szymanowska A, Radomski D, Chalecka M, et al. Di- and Triselenoesters-Promising Drug Candidates for the Future Therapy of Triple-Negative Breast Cancer. Int J Mol Sci. 2024;25. doi:10.3390/ijms25147764

We set out to explore the effects of selenium-containing compounds on breast cancer cells, particularly focusing on their potential as treatments. Our research involved testing several novel selenoesters on two breast cancer cell lines, MCF-7 and MDA-MB-231, to understand how these compounds can impact cell growth and survival.

What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.

The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.

In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.

Cancer cell disappearance

Most Useful Review

2 people found this helpful

During my breast cancer treatment, I started taking one tablet of selenium daily after reading Mitsuishi Iwao's book. I continued with this dosage and a high-protein, vitamin-rich, low-carbohydrate diet throughout pre-operative chemotherapy. Remarkably, the lump shrank significantly, and post-surgery pathology indicated that cancer cells had vanished. Although navigating the chemotherapy's side effects was challenging, I believe the supplements aided my resilience while working. I intend to keep taking it diligently and would recommend it to anyone facing similar challenges during breast cancer treatment.

We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.

The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.

Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.

Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.

Significant allergy relief

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3 people found this helpful

Can help with allergy relief. Take only if you have had blood tests taken! It's easy to overdose on this. I owe this (not solely) huge relief for my mite allergy symptoms. Currently, I follow a specific diet and supplement plan to support my thyroid functions. I added an optimal dose of vitamin D3, vitamin C, selenium, magnesium, and vitamin B complex in a well-absorbing form. To my surprise, this combination of healthy foods and these supplements made a substantial impact on reducing the swelling and clearing my nose (my allergy pill did not alleviate all the symptoms). I'm considering pausing my allergy medicine to assess improvements in my immune system's efficiency.

Anxiety details

6 people found this helpful

After taking the capsule at noon, I experienced a sedative effect. My mind feels clear but inclined towards sleep. Anxiety has dissipated and my pupils appear normal. This medication is not compatible with other drugs. I plan to take it tonight to aid my sleep, using half a dosage every two days.

Arthritis details

Helpful for arthritis

My mother finds it very helpful with arthritis.

Brain Tumor details

136 people found this helpful

Selenium is an indispensable supplement for cancer prevention. If you wish to maintain your health and reduce the risk of tumours, then this supplement is essential.

Chronic Fatigue Syndrome details

Selenium effects on chronic fatigue

Shao C, Song J, Zhao S, Jiang H, Wang B, et al. Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Green Tea on Chronic Fatigue Syndrome. Polymers (Basel). 2018;10. doi:10.3390/polym10111269

We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.

Elevated mood

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111 people found this helpful

The product arrived promptly, and the capsules are easy to take. After a month of use, I feel energetic, especially during this typically fatigue-heavy autumn. With Selenium, I am enjoying elevated spirits and less hair loss, which is exceptional for this time of year. I highly recommend it!

Depression details

Selenium's potential in depression treatment

Garcia CS, Besckow EM, da Silva Espíndola CN, D'Avila Nunes G, Zuge NP, et al. Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT Receptors. ACS Chem Neurosci. 2022;13:1746. doi:10.1021/acschemneuro.2c00129

This study explored how a selenium-containing compound, SeI, impacts depression-like behavior in mice. During behavioral tests, this compound reduced immobility, signaling an antidepressant-like effect without affecting movement.

Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).

However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed.

Depression alleviated

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6 people found this helpful

This selenium from IHerb is remarkable. As someone with a goitre, I take it alongside iodine. Since I started, my depression has vanished, and I feel fantastic. It assists with iodine absorption, and I've noticed fewer colds. I take 200 mcg daily for myself and 100 mcg for my daughter each morning with breakfast. Overall, I feel a boost in my health.

High Cholesterol details

Selenium supports cholesterol management

Dhingra S, Bansal MP. Modulation of hypercholesterolemia-induced alterations in apolipoprotein B and HMG-CoA reductase expression by selenium supplementation. Chem Biol Interact. 2006;161:49.

We investigated how selenium supplementation affects cholesterol levels and the associated molecular changes. Using Sprague-Dawley male rats, we fed them diets supplemented with selenium alongside high cholesterol for three months.

The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.

Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.

Excellent thyroid support

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1 people found this helpful

The best supplement for thyroid health! The quality is exceptional, and I’ve overcome hormone deficiency. I’ll continue using it to support my body.

Hyperthyroidism details

I have been using selenium for two years following a disruption in my body post-Covid, which caused thyroid problems. Taking it with Euthyrox, I value the all-natural ingredients and small size for easy swallowing. It aids in addressing deficiencies and has no significant symptoms of hyperthyroidism. I recommend this supplement!

Irritable Bowel Syndrome details

Improved menstrual cycle

During menopause, I experienced symptoms of congenital hypothyroidism, including lethargy and forgetfulness, which made me irritable. After being advised by an endocrinologist to take Selenium, I feel significantly better. My menstrual cycle has normalised, my memory is restored, and I’ve become much calmer and balanced. The benefits of dietary supplements for thyroid health are quite evident.

Leg Cramps details

10 people found this helpful

Works wonders for my leg cramps that strike in the middle of the night. I take one before bed and I'm good for the night.

Urinary Tract Infection details

Cleanses urinary tract

D-Mannose is a natural sugar that helps cleanse the urinary tract and promotes bladder health. It is only minimally digested, and any excess is rapidly excreted in urine, meaning it won’t disrupt normal blood sugar levels. Clinical studies indicate that regular intake of D-Mannose aids in maintaining normal urinary tract function by supporting bladder lining health.

Adrenal Gland Disorder details

Improved sleep quality

The product fully meets its purpose, and the quality is of the highest standard. The ingredients help to effectively address the primary function of this dietary supplement. It has proven beneficial after my prolonged use of stimulants that affected my adrenal glands; I began to experience improved sleep and my cortisol levels normalised. The taste is neutral and the dosages are appropriately sized. I highly recommend it!

Cold Sores details

Effective immune booster

7 people found this helpful

The drug was prescribed for my thyroid function, and it has significantly improved my well-being. Selenium is an excellent antioxidant and a great remedy for immunity. With consistent use, I see remarkable improvement in my skin and overall health and a notable reduction in the risk of colds. I recommend it 100%.

Common Cold details

Micronutrient treatment reduces cold symptoms

Based on 2 Researches

Schmidt K, Zirkler S. [Dietary efficacy of a micronutrient combination in patients with recurrent upper respiratory tract infections. Results of a placebo-controlled double-blind study]. MMW Fortschr Med. 2011;153 Suppl 3:83.

We evaluated how a specific mix of vitamins and minerals, including selenium, influences recurrent colds in a group of 192 patients over 16 weeks. This randomized, placebo-controlled study showed that those receiving the micronutrient combination experienced a greater improvement in cold symptoms compared to the placebo group.

Notably, individuals below 45 reported fewer job absences due to colds. Overall, vitamin and mineral levels increased significantly for those on the treatment, suggesting that micronutrients may enhance immune defense and reduce the severity of common colds. However, the specific role of selenium in these improvements needs more exploration.

Effective cold prevention

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1 people found this helpful

After purchasing this product, I heard it works well with NAC to combat cold germs and prevent catching a cold. I take it every two days, and perhaps that's why I don't catch a cold even when others around me are affected!

Menopause details

da Rocha JT, Pinton S, Mazzanti A, Mazzanti CM, Beckemann DV, et al. Diphenyl diselenide ameliorates cognitive deficits induced by a model of menopause in rats. Behav Pharmacol. 2012;23:98. doi:10.1097/FBP.0b013e32834ed849

Based on 5 Researches

Cognition enhancement in menopause

We investigated how diphenyl diselenide, a synthetic selenium compound, affects cognitive performance in a rat model of menopause. Female rats underwent ovariectomy, mimicking hormone loss in postmenopausal women, and were treated with diphenyl diselenide daily for 30 days.

The results showed that this treatment improved cognitive abilities, as evidenced by better performance in behavioral tests and prevented the increase of acetylcholinesterase activity.

Overall, diphenyl diselenide appears to hold promise in mitigating cognitive decline linked to menopause.

Thyroid support

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1 people found this helpful

Great thyroid support. This product really helps support my thyroid as I go through menopause.

Prostate Cancer details

Selenium nanoparticles show promise

Bissardon C, Proux O, Gazze SA, Filhol O, Toubhans B, et al. Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells. Nanomaterials (Basel). 2023;13. doi:10.3390/nano13232999

We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.

By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.

This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.

Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.

Cancer prevention

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136 people found this helpful

Selenium is an essential supplement for preventing cancer. To maintain my health and reduce tumour risks, I believe this supplement is crucial.

Alzheimer details

Supports mental abilities

3 people found this helpful

Selenium is essential for bolstering the immune system, fighting inflammation, and protecting cells from damage. Its antioxidant properties benefit the heart by reducing cardiovascular disease risks. Selenium supports the thyroid gland's function, shielding it from environmental harm and stimulating hormone synthesis. It also optimises gastrointestinal activities, enhances intestinal flora, and accelerates mucosal regeneration. Importantly, selenium aids in supporting mental abilities and preventing Alzheimer's disease, with studies showing that it enhances memory and concentration.

Atrial Flutter details

Atrial flutter resolved

The quality of this product is excellent. After dealing with various arrhythmias, I began taking selenium two years ago. Since then, my atrial flutter has disappeared, and I've been pleased with the results.

Autoimmune Disorder details

Selenium aids Graves' orbitopathy treatment

Questionable

Based on 17 Researches

Sharabati I, Qafesha RM, Hindawi MD, Amro S, Ayesh BM. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials. Clin Endocrinol (Oxf). 2024;101:669. doi:10.1111/cen.15128

We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.

The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.

We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.

Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.

Lowered antibodies

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210 people found this helpful

Selenium plays a crucial role in thyroid function, acting as a catalyst for converting inactive hormone T4 to active T3 while protecting thyroid cells from oxidative damage. I suffer from an autoimmune disorder, hypothyroidism, and my doctor recommended selenium. After taking it for over two years, my antibody levels have significantly decreased, as evidenced by my tests.

Candidiasis details

Selenium's antifungal potential explored

Based on 9 Researches

de Siqueira VM, da Silva BGM, Passos JCDS, Pinto AP, da Rocha JBT, et al. (MeOPhSe)2, a synthetic organic selenium compound, inhibits virulence factors of Candida krusei: Adherence to cervical epithelial cells and biofilm formation. J Trace Elem Med Biol. 2022;73:127019. doi:10.1016/j.jtemb.2022.127019

We delved into the potential of a synthetic organic selenium compound, known as p,p'-methoxyl-diphenyl diselenide, or (MeOPhSe), to combat candidiasis, particularly focusing on its effects on Candida krusei. This research is important because Candida species can lead to both mild and serious infections, and finding effective treatments is crucial.

Our study demonstrated that (MeOPhSe) is non-toxic to human cells, such as cervical epithelial and fibroblastic cells, and has a notable antifungal effect. We observed that it inhibited the growth of C. krusei in a dose-dependent manner, altering its growth pattern and extending the length of its lag phase. Most significantly, we found that this compound reduced the ability of both C. krusei and C. albicans to adhere to human cells, a critical step in the infection process.

The reductions we measured were substantial: C. krusei adherence dropped by 37.24%, while C. albicans showed a 32.84% reduction, both being statistically significant. Interestingly, both species responded similarly to (MeOPhSe), highlighting its potential as a broad-spectrum antifungal agent against various Candida infections.

Overall, our findings suggest that (MeOPhSe) holds promise as an antifungal treatment targeting the virulence factors of different Candida species, paving the way for new treatment options in battling candidiasis.

Effective support

Most Useful Review

This product certainly does the job! I have been taking Now Selenium for some time, and I genuinely believe it works. I combine it with milk thistle and other supplements to assist with Candida-related liver concerns.

Constipation details

The quality is superb, and the ingredients are top-notch. My health has improved with this supplement, which comes in a decent-sized package. Digestion has enhanced, and my intestines function well; constipation has resolved. The dosage is excellent, and the taste is good.

Hashimoto details

Selenium effective in Hashimoto's treatment

Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878

We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.

In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.

However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.

This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.

Significant improvement

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2 people found this helpful

Selenium makes a substantial difference for those suffering from Hashimoto. I highly recommend it.

Indigestion details

52 people found this helpful

I write my opinion honestly so that everyone may benefit. It has many advantages, the most significant of which are: 1/ Antioxidant, 2/ Useful for indigestion, 3/ Beneficial for heart health, 4/ Reduces complications of diabetes, 5/ Aids in glutathione production, 6/ Very beneficial for vitiligo and skin pigmentation, 7/ Helpful for the thyroid gland, 8/ Assists in removing mercury from the body, and 9/ Reduces the risk of male infertility. Personally, I use it daily after meals to expel toxins, and with prolonged use, I feel strong and active.

Migraine details

Selenium showed no significant effects

Based on 2 Researches

Balali A, Sadeghi O, Anjom-Shoae J, Rouhani MH, Khorvash F, et al. The effect of selenium supplementation on oxidative stress, clinical symptoms and mental health status in patients with migraine: a study protocol for a double-blinded randomized clinical trial. Trials. 2024;25:209. doi:10.1186/s13063-024-08018-8

We examined a clinical trial that investigates whether selenium supplementation can help alleviate migraine symptoms. In this randomized, double-blinded study, 72 patients were divided into two groups: one received a daily selenium supplement while the other got a placebo, all over 12 weeks.

We tracked headache severity, frequency, and mental health markers like anxiety and depression, alongside measuring oxidative stress biomarkers. Despite the hopes for selenium’s antioxidant benefits, the trial did not find significant improvements in migraine symptoms or related health measures.

7.5

Migraine reduction noted

Most Useful Review

1 people found this helpful

It has a strong smell. Used in combination with vitamin E, my migraines have reduced considerably, which I find satisfying. However, the scent resembles that of a rotten egg. This is attributed to the nature of selenium, which is consistent across various products. Yet, when the odour is overwhelming, it can be hard to manage. Additionally, there's a slight concern that the capsule might stick upon swallowing, although it is smaller compared to others available in Japan. This has led to some dissatisfaction with tablet types from different brands.

Psoriasis details

Protects from diseases

Taking selenium reliably guards against influenza viruses, normalises the functioning of the gastrointestinal tract, and alleviates the symptoms of several common conditions, including psoriasis, dermatosis, and bronchial asthma. Each capsule contains 200 mg of selenium, and it is recommended to take one per day with meals.

Arteriosclerosis details

Prevents arteriosclerosis

1 people found this helpful

Selenium is a trace element and essential nutrient for the human body. Once converted into selenoproteins, it helps counteract free radicals and enhance metabolic circulation, benefiting overall health. Additionally, it protects the cardiovascular system, prevents arteriosclerosis, reduces inflammatory responses, and lowers the risk of cardiovascular diseases.

Asthma details

Selenium intake boosts lung function

Based on 8 Researches

Jiang H, Yang G, Chen J, Yuan S, Wu J, et al. The correlation between selenium intake and lung function in asthmatic people: a cross-sectional study. Front Nutr. 2024;11:1362119. doi:10.3389/fnut.2024.1362119

This study explored how selenium intake relates to lung function in people with asthma. We analyzed data from 4,541 participants in a national survey using various statistical methods. Our findings showed a positive connection between higher selenium intake and better lung function, particularly in forced vital capacity and forced expiratory volume. We noted that to potentially enhance respiratory health, asthma patients could benefit from consuming between 137.65 mcg and 200 mcg of selenium daily, while also being cautious of any adverse effects.

7.5

Reduces wheezing

Most Useful Review

1 people found this helpful

taken daily to boost my immune system, I was pleasantly surprised to find that it significantly reduced the wheezing associated with my asthma.

Cancer details

Selenium drug shows selective toxicity

Based on 27 Researches

Qin X, Guo J, Li H, He H, Cai F, et al. Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy. Adv Sci (Weinh). 2025. doi:10.1002/advs.202412062

We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.

The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.

Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.

Boosts cancer defence

Most Useful Review

191 people found this helpful

This mineral supplement is vital for immunity and thyroid health. Selenium acts as a powerful antioxidant, combating atherosclerosis, cancer, infertility risk, and chronic fatigue. I recommend it for improving brain function and reducing cardiovascular disease risks.

Chemotherapy details

Effective during treatment

2 people found this helpful

After reading Mitsuishi Iwao's book, I began taking one 200μg tablet of selenium daily during my breast cancer treatment. To avoid toxicity, I maintained this dosage along with a high-protein, high-vitamin, low-carbohydrate diet until the end of pre-operative chemotherapy. Throughout treatment, the lump reduced significantly, becoming unnoticeable, and a pathology test after surgery confirmed that the cancer cells had vanished. Although the chemotherapy's side effects were challenging, I believe the supplements helped me persevere while working. I intend to continue taking selenium and would recommend it to anyone striving during cancer treatment.

Eczema details

Selenium's combined benefits for sheep

Questionable

Based on 4 Researches

Grace ND, Munday R, Thompson AM, Towers NR, O'Donnell K, et al. Evaluation of intraruminal devices for combined facial eczema control and trace element supplementation in sheep. N Z Vet J. 1997;45:236.

We explored the use of intraruminal devices containing zinc oxide, designed to prevent facial eczema in sheep while also addressing trace element deficiencies. Specifically, we looked at how adding selenium and cobalt to these devices might improve the health of pregnant ewes by monitoring changes in blood selenium and serum Vitamin B12 levels.

The devices we tested included 16.4 mg of selenium, in the form of sodium selenate, and 20.4 mg of cobalt, provided as cobalt sulfate. Our findings revealed that these devices were effective in raising and sustaining higher blood selenium levels for at least 84 days, with notable increases in serum Vitamin B12 for up to 42 days.

This dual action means that the devices not only offer protection against facial eczema but also help prevent trace element deficiencies in sheep, demonstrating a valuable approach for improving overall animal health.

Significant improvement

Most Useful Review

6 people found this helpful

Quickly improves my hand eczema. My family has been on vitamin therapy for about a year. I take protein and vitamin C 1000mg twice daily, vitamin E 400IU twice, vitamin B complex 50 once, niacinamide 500mg twice, and mega benfotiamine 250mg once in the morning, along with vitamin D3K2, zinc, and iron 36mg twice at night. My hand eczema worsens with seasonal changes, leaving both my hands bandaged. After starting selenium three days ago, I noticed improvement—the cracks have vanished and I no longer require bandages. Vitamins E, zinc, and selenium seem effective together. Being deficient in selenium may have been the issue, and my metal allergy might have contributed to my recovery. Nevertheless, I intend to moderate my intake.

Influenza details

I call selenium a miracle. Research confirms it boosts immunity, making it crucial during SARS and influenza seasons. It improves metabolic functions and is vital for expectant mothers. After two months of taking this supplement, I remain healthy while others around me have fallen ill with the flu. The capsules are easy on my stomach.

Liver Disease details

Selenium nanoparticles reduce liver toxicity

Based on 15 Researches

Mrwad AA, El-Shafey SE, Said NM. Chitosan-encapsulated selenium nanoparticles alleviate CCl induced hepatotoxicity through synergistically modulating NF-κB and Nrf2 signaling pathways and regulating Bcl-2 and Caspase-3 expression: A comprehensive study with multiple regression analysis. J Trace Elem Med Biol. 2024;86:127563. doi:10.1016/j.jtemb.2024.127563

We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.

The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.

Cleanses the body

Most Useful Review

The ingredients and quantity are adequate, suitable for all ages. This product has wonderful benefits, facilitating radical cleansing in the body. The formula acts as a strong oxidizer for the liver. The taste is neutral and I plan to reorder due to its effectiveness.

Acne details

Questionable

Razavi M, Jamilian M, Kashan ZF, Heidar Z, Mohseni M, et al. Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome. Horm Metab Res. 2016;48:185. doi:10.1055/s-0035-1559604

Selenium reduces acne in PCOS

We examined how selenium supplementation impacts acne among women with polycystic ovary syndrome (PCOS) through a rigorous 8-week trial. In a randomized double-blind and placebo-controlled setup, we compared 32 women taking 200 μg of selenium daily against 32 taking a placebo.

Notably, those receiving selenium showed a significant drop in acne rates, from 12.5% in the placebo group to 46.9% in the selenium group. This indicates that selenium might indeed help reduce acne, alongside other reproductive and health improvements. However, some hormonal factors didn't show notable changes.

Quick healing effects

Most Useful Review

4 people found this helpful

This supplement has yielded good results for my skin issues, including acne and post-acne scars. It cleans the skin and heals wounds swiftly while benefiting the body overall. I encourage positive feedback on my review.

Anemia details

Prevents anemia effectively

Excellent! Selenium is crucial for human health and plays a role in various physiological processes. It is particularly beneficial as it helps to increase compromised immunity, stimulates metabolism, and prevents the onset of anemia by participating in hematopoiesis. Selenium also protects cells from free radical damage, aids in iodine absorption by the thyroid, and is necessary for producing various enzymes. Additionally, it helps slow down aging, positively influences male fertility, and lowers the risk of miscarriage.

Chronic Cough details

Relieves symptoms effectively

3 people found this helpful

Selenium is a fantastic nutrient that often lacks in our diets, especially during periods of chronic stress. It plays a vital role in thyroid function, heart health, and immune system support. Notably, it alleviates symptoms associated with chronic cough and headaches linked to thyroid issues. I have benefited significantly from taking high-dosage selenium, and it’s affordable and of excellent quality. I recommend determining the right dosage according to personal needs, often beyond the standard levels, to experience the full benefits.

Dizziness details

This supplement contains selenium in an active form, with no yeast in its composition. The tablets have a peculiar smell, which I appreciate. Prior to purchasing, I found several reviews where women noted increased heartbeat and dizziness after consuming a whole pill; I encountered this as well. I felt a wave of cheerfulness and energy but experienced dizziness a little later, which eventually subsided. I chose to take half the dosage, as each tablet has 182%, and I give the same dosage to my children.

Ear Infection details

Prevents infections effectively

Selenium is an essential mineral and powerful antioxidant. It plays a vital role in cellular health by neutralising free radicals and reducing oxidative stress, while also being crucial for thyroid hormone production. Personally, I take it for immune support as it enhances my defense against infections. This product effectively boosts my immune system, and though I have no thyroid issues, I see it as preventative for potential problems. The vegetarian capsules are a boon for those avoiding animal products.

Food Poisoning details

Qiao L, Chang J, Yang G, Deng T, Liu P, et al. Prophylactic supplementation with selenium nanoparticles protects against foodborne toxin zearalenone-induced intestinal barrier dysfunction. Ecotoxicol Environ Saf. 2024;284:116914. doi:10.1016/j.ecoenv.2024.116914

Based on 4 Researches

Effect of SeNPs on ZEA toxicity

We explored the protective effects of selenium nanoparticles (SeNPs) against the harmful impacts of zearalenone (ZEA), a toxin from grains that can disrupt gut health. In a controlled setting, we observed that ZEA damages intestinal cells, leading to inflammation and increased permeability.

Our findings showed that SeNPs can counteract this damage by enhancing antioxidant activity and improving gut microbiota balance. Despite these promising results, it’s crucial to note that the effectiveness of SeNPs in humans still requires further investigation.

7.5

Reduced antibody levels

Most Useful Review

50 people found this helpful

An excellent dosage of 200mcg for thyroid issues, while a lower dosage of 100mcg is advisable for prevention. My endocrinologist recommended I maintain selenium intake due to an increase in antibodies. After several months of taking selenium, these antibodies decreased. I alternate my intake every month and find this approach highly beneficial compared to the more expensive Cefasel. I buy from Now Foods and am very pleased with the quality and price.

Hypothyroidism details

Selenium benefits Hashimoto's patients

Based on 17 Researches

Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34:295. doi:10.1089/thy.2023.0556

We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.

Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.

Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.

However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.

Restored balance

Most Useful Review

198 people found this helpful

I have congenital hypothyroidism, which only manifested severe symptoms during menopause—lethargy, drowsiness, forgetfulness, and irritability. Upon my endocrinologist's advice, I started taking selenium. My well-being has dramatically improved; my menstrual cycle is back to normal, memory has returned, and I feel calm and balanced. It's evident that bioadditives are vital for thyroid function, and completing a full course of them was crucial.

Lung Cancer details

Selenium compound inhibits lung tumors

Zhang Y, Chen Y, Wang B, Cai Y, Zhang M, et al. A novel selenium nanocomposite modified by AANL inhibits tumor growth by upregulating CLK2 in lung cancer. Bioorg Chem. 2024;148:107459. doi:10.1016/j.bioorg.2024.107459

We explored the effectiveness of a novel selenium nanocomposite, AANL-SeNPs, in treating lung cancer. This innovative compound, created from a natural ingredient, demonstrated significant inhibition of lung cancer cell growth in various cell lines, showing up to a 67% reduction in viability.

Furthermore, AANL-SeNPs slowed tumor growth in live models and appeared safe for normal cells. While promising, our findings indicate that although AANL-SeNPs upregulate the protein CLK2 and can enhance therapeutic response, further studies are needed to fully understand its potential.

7.5

Cancer prevention focus

Most Useful Review

12 people found this helpful

The antioxidant properties of selenium, especially in combination with amino acids, are significant for cancer patients. I decided to purchase it after reading Professor Tokumi Fujikawa's work, highlighting selenium's role beyond vitamin C and E. Its small, easy-to-swallow veggie capsule is advantageous. The higher ingredient content compared to Japanese supplements makes it effective. Though my cancer is nearly in remission, I will continue its use to prevent recurrence.

Rash details

6 people found this helpful

This was my first experience with selenium due to facial skin issues. I committed to one tablet daily for six months, with fantastic results—the rash disappeared. Now, I’ve ordered another jar for my sister, who the doctor advised to take for a year for thyroid regulation. Her first analysis confirmed selenium’s effectiveness, so I recommend following a doctor’s prescription when using this product.

Adenoiditis details

Improved throat condition

Excellent selenium! I've been taking it with Kelp for two months, and the lump in my throat has diminished. After reading reviews, I realised iodine is essential with selenium. I previously took Kelp alone. With my subclinical hypothyroidism, I hope my TSH and T3 levels normalise after this regimen. I plan to have blood tests in two weeks.

Cardiovascular Disease details

Selenium aids heart recovery post-MI

Based on 8 Researches

USERS' SCORE

Good

Based on 10 Reviews

Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. doi:10.1016/j.freeradbiomed.2025.03.004

This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.

We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.

Thyroid support

Most Useful Review

1 people found this helpful

Help your thyroid gland! I take selenium regularly as it aids the thyroid in producing hormones, converting T4 to T3, and potentially reducing antibodies to thyroid peroxidase. Selenium deficiency is linked with worsening eye conditions and increases the risk of postpartum thyroid issues. Experts recommend checking selenium levels in thyroid disease patients. It’s hard to obtain selenium from food, especially from selenium-rich Brazil nuts. If levels are low, consult your doctor about supplementation.

Diabetes details

Selenium aids gestational diabetes management

Based on 21 Researches

Yigit E, Sayar I. Selenium Supplementation and Gestational Diabetes: A Randomised Controlled Trial. J Coll Physicians Surg Pak. 2024;34:561. doi:10.29271/jcpsp.2024.05.561

We explored whether selenium supplementation could improve blood glucose levels in pregnant women with gestational diabetes. In this randomized controlled trial conducted at an Istanbul university, women diagnosed with gestational diabetes received either diet alone or diet plus 200 µg of selenium daily for four weeks.

Findings showed that pregnant women had lower selenium levels compared to healthy counterparts. Those taking selenium experienced a more significant decrease in blood sugar levels than those on diet alone, indicating a beneficial effect of selenium on managing gestational diabetes.

Boosts immune system

Most Useful Review

3 people found this helpful

Selenium is vital for cancer protection and immunity against viruses. It aids pancreatic cell growth and improves glucose absorption, essential for managing diabetes by reducing insulin resistance. This mineral is best absorbed with fat-soluble vitamins A, D, and E, and it’s crucial for synthesising thyroid hormones.

Sleep Apnea details

Examined antioxidants in sleep apnea

Saruhan E, Sertoglu E, Unal Y, Bek S, Kutlu G. The role of antioxidant vitamins and selenium in patients with obstructive sleep apnea. Sleep Breath. 2021;25:923. doi:10.1007/s11325-020-02207-w

We examined the levels of selenium and key vitamins in patients suffering from obstructive sleep apnea (OSA) without additional health issues. Our study, involving 146 subjects split into different OSA severity levels, aimed to understand how these antioxidants might play a role in OSA's impact on health.

Interestingly, we found that higher concentrations of selenium and vitamin A appeared to bolster the body’s defense against OSA. Although our findings suggest potential benefits, it's important to note that antioxidants alone should not replace conventional treatments for OSA.

7.5

Relaxation and sleep improvement

Most Useful Review

20 people found this helpful

I consumed one litre of the tablets at night, which helped relax me and improve my sleep quality. It also positively affected the growth of my nails and hair.

Blood Clot details

Ebselen delays blood clot formation

Based on 9 Researches

Lindenblatt N, Schareck W, Belusa L, Nickels RM, Menger MD, et al. Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression. Thromb Haemost. 2003;90:882.

We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.

In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.

This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.

Essential for wellness

Most Useful Review

I prefer natural vitamins, but I make an exception for selenium due to its undeniable benefits. Within days, I noticed its antioxidant effects, which are crucial for cardiovascular health. Selenium is vital for the formation and function of red blood cells, and it supports overall immunity. It's remarkable how selenium fulfills numerous biological roles, protecting my body from harmful radicals and bolstering nutrient absorption. It's a necessary addition to my health regimen.

Blurred Vision details

Selenium shows short-term benefits only

Wang C, Qiao J, Liu S, Piao S, Zhou Y, et al. Selenium in the treatment of mild-to-moderate Graves' orbitopathy: a 5-year prospective controlled cohort study. Endocrine. 2024;84:1072. doi:10.1007/s12020-023-03672-5

Our study examined the effects of selenium in treating mild-to-moderate Graves' orbitopathy (GO) over five years. We followed 74 patients who took selenium or a placebo for six months, tracking their symptoms and quality of life.

Initially, selenium showed promise by reducing symptoms like blurred vision, with significant improvements over six months. However, when we looked at long-term outcomes after five years, both groups had similar results, indicating that while selenium may help in the short term, it doesn't contribute to lasting changes.

7.5

Vision improvement

Most Useful Review

I take selenium twice a year to improve my vision. There are no side effects. I take one a day.

Heart Attack details

Selenium nanoparticles for heart health

Based on 18 Researches

Sun Q, Ma H, Zhang J, You B, Gong X, et al. A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction. Adv Sci (Weinh). 2023;10:e2204999. doi:10.1002/advs.202204999

We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.

Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.

Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.

7.5

Boosted immunity

Most Useful Review

8 people found this helpful

Selenium is essential for health! I've been taking it for autoimmune thyroiditis as prescribed by my doctor. It strengthens my immunity and overall well-being. One capsule daily prepares me for any challenge. I trust NOW products, and this specific selenium supplement has been effective. It serves various functions including antioxidant action, support for the immune system, and heart health, which is vital given the risk of heart attack.

Heart Disease details

Selenium nanoparticles support heart health

Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. doi:10.1016/j.biomaterials.2025.123119

We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.

SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.

Heart health improvement

Most Useful Review

7 people found this helpful

I started taking selenium for my relatives, initially loading for two weeks before adding iodine. My mother-in-law has experienced better heart function and improved mental clarity, prompting her to ask when she can start taking selenium again.

Hypertension details

Supports cardiovascular health

Selenium is essential for conditions such as arrhythmia, ischemic heart disease, hypertension, and atherosclerosis, particularly in recovery from a myocardial infarction. It helps to normalise fat metabolism and cholesterol levels, protects the cardiovascular system, and lowers the likelihood of hypertension.

Pelvic Pain details

Shevchenko S Y, Kulchavenya E V, Baranchukova A A. [The possibility of correcting oxidative stress in patients with inflammatory type of chronic abacterial prostatitis (chronic pelvic pain syndrome category IIIa)]. Urologiia. 2023.

Based on 4 Researches

Selenium boosts antioxidant status

We sought to understand how a mineral-vitamin complex, specifically Selzinc-plus, may help treat chronic abacterial prostatitis, a condition often linked with pelvic pain. In a study involving 47 men, we divided them into two groups: one received standard therapy, and the other received additional Selzinc-plus for two months.

While standard therapy showed effects, the antioxidant treatment significantly enhanced these benefits on symptoms. Notably, though the overall antioxidant system improved, no significant changes were observed in leukocyte counts. Our findings suggest that this antioxidant approach may offer added relief for those suffering from pelvic pain.

7.5

Increased energy

Most Useful Review

4 people found this helpful

I purchased this as an add-on for megavitamin therapy, feeling overwhelmed by chronic fatigue, insomnia, and pelvic pain. Since beginning the supplement a week ago, I've noticed significant energy increases. Even though I still face atopic dermatitis, my skin has improved, giving me hope.

Stroke details

Health improvement post-stroke

My dad drinks this after having a stroke. The results are good; there has been no deterioration in his health.

Yeast Infection details

Essential for yeast issues

1 people found this helpful

I like NOW Foods’ Selenium mainly because it's yeast-free. I experienced severe yeast overgrowth, so the absence of yeast is crucial for me.

Headache details

Selenium shows promise for migraines

Balali A, Sadeghi O, Khorvash F, Rouhani MH, Askari G. The effect of selenium supplementation on oxidative stress, clinical and physiological symptoms in patients with migraine: a double-blinded randomized clinical trial. Front Nutr. 2024;11:1369373. doi:10.3389/fnut.2024.1369373

We explored the effects of selenium supplementation in a double-blinded trial involving 72 patients with migraines. Over 12 weeks, participants received either selenium or a placebo. We observed that those taking selenium experienced reduced headache frequency and severity.

Additionally, selenium improved antioxidant levels and lowered oxidative stress markers. However, it appears that many other factors related to migraine symptoms did not see significant changes. While this research shows promise, further studies are necessary to confirm these findings.

Headaches ceased

Most Useful Review

After starting selenium, I noticed some headaches. I am unsure if it was directly related; regardless, I ceased taking selenium and switched to vitamins that contain selenium. Now, I am headache-free.

Nausea details