' 
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%**
Sodium
150 mg
7%
Glucosamine Sulfate(from 1,500 mg Glucosamine PotassiumSulfate Complex)
1.1 g (1,100 mg)
†
Chondroitin Sodium Sulfate(from Bovine Cartilage)
1.2 g (1,200 mg)
†
MSM (Methylsulfonylmethane)
300 mg
†
The product is found useful for the following medical conditions
Arthritis
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.5
USERS' SCORE
Good
Based on 59 Reviews
8.6
9.5
N-Acetyl Glucosamine reduces arthritis
Collagen-induced arthritis: severity and immune response attenuation using multivalent N-acetyl glucosamine.
Most Relevant Research
We aimed to understand how N-acetyl glucosamine (GlcNAc), a compound known for its anti-inflammatory properties, affects the development and severity of collagen-induced arthritis (CIA). Our investigation involved applying a special multivalent GlcNAc-terminated glycoconjugate and assessing its influence through various methodologies.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.
Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.
9.5
Immediate results
Most Useful Review
Noticed a difference the very next day! After experiencing severe pain, I was informed I have onset arthritis. I researched natural supplements and found this product. I took three capsules upon arrival and the next day, my pain reduced significantly from an 8 to a 2, with improved mobility. I am optimistic about further improvements.
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
8.8
Knee pain relief
Most Useful Review
Helped to cope with knee pain. I acquired this medication on recommendation. In winter, I experienced knee difficulties, unable to bend or straighten, leading to considerable discomfort while walking. The exacerbation period lasted two weeks, but the pain does return occasionally. After a month’s course, I've noticed significant improvement; now, the knee only aches in the cold. Doctors found no issues and prescribed nothing. When I inquired about taking chondroitin, they unanimously deemed it unnecessary. However, I do not regret taking it. In the autumn, I intend to complete the full course, needing three jars. At its initial, non-neglected stage, it proves very effective.
Back Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
Converted sceptic
Most Useful Review
As a natural sceptic regarding supplements, especially in my 40s and wanting to stay active, I turned to NOW Glucosamine/Chondroitin with MSM when I began experiencing knee pain. I'm astonished by how much of a difference it has made. Initially, results took time, but now I feel so much better! So long as I take it daily, there's no knee pain. If I miss it, the pain returns, often severely.
Flu
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Not applicable
Most Useful Review
Not applicable.
Osteoporosis
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 1 Review
8.5
8
MSM enhances bone cell differentiation
Methylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells.
Most Relevant Research
We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
8.8
Pleased with results
Most Useful Review
My mother, aged 65, has mild osteoporosis symptoms and has been using this product for nearly two years, particularly for her knees and hands. She is quite pleased with the results, especially in winter when joint discomfort rises.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.3
8.8
Effective pain relief
Most Useful Review
Supplement Review. I am typically sceptical about supplements, but these actually work! I have grappled with bone and joint pain for the last eight years, yet these have certainly softened my level of pain.
