NOW Supplements Glucosamine Sulfate

We aimed to understand how N-acetyl glucosamine (GlcNAc), a compound known for its anti-inflammatory properties, affects the development and severity of collagen-induced arthritis (CIA). Our investigation involved applying a special multivalent GlcNAc-terminated glycoconjugate and assessing its influence through various methodologies.

The results were promising. We observed that GlcNAc treatment significantly reduced inflammation at the site of arthritis, notably decreasing the presence of immune cells that contribute to the disease. Furthermore, it appeared to hinder the activation of other immune cells, which are often involved in the production of harmful pro-inflammatory molecules.

Additionally, GlcNAc treatment not only delayed the onset of arthritis symptoms but also eased the severity of these symptoms in many cases. We found that about 18% to 31% of participants treated with GlcNAc completely avoided any arthritis symptoms. Overall, our findings support a new approach to managing arthritis by focusing on the glycobiological aspects of treatment, presenting GlcNAc as a potential therapeutic option for those suffering from this debilitating condition.

7.5

Slowed progression

Most Useful Review

9 people found this helpful

Works for my osteoarthritis. I've used this for several years for the osteoarthritis in my hands, and it seems to have significantly slowed the progression of the bumps on my knuckles. I use it alongside SAM-e.

We explored the experiences of 56 breast cancer patients taking aromatase inhibitors (AIs) outside of clinical trials. Surprisingly, 61% reported worsening joint and bone pain after starting their treatments. Pain was often severe and persistent, impacting their treatment plans significantly.

We observed that while some managed pain through acetaminophen, anti-inflammatory drugs, and glucosamine, a significant 20% of patients still chose to discontinue their medication due to pain. This highlights the need for better patient education and effective strategies for managing pain in these patients.

Significant improvement

Most Useful Review

45 people found this helpful

Everything is real; I am writing this two months after starting the treatment. I’m 55 and have meniscus issues in both legs from old sports injuries, and I refused surgery. After a month and a half of taking glucosamine, I felt a noticeable difference. I can run up to the fourth floor without pain and can manage stairs without difficulty. Previously, getting out of bed was a struggle due to severe bone pain, but now I can extend my legs comfortably. Glucosamine really works, and I hope my review helps others. Wishing everyone good health!

Chronic Cough details

Effective pain management

Most Useful Review

I've experienced excellent relief from arthritis, significantly alleviating much of my hand and knee discomfort. My spouse discovered that it also helped with chronic toe pain. When we didn't take it on a trip, they realised that the arthritic toe pain returned, leading to a commitment to always bring glucosamine on our travels. The quality of this product is exceptional, and I have complete trust in Now Foods.

Knee Pain details

5 people found this helpful

This supplement is perfect for my joints. I used to have a crunching sound in my knees, but that disappeared after a month of taking these capsules, which I also combine with vitamin D3 for better effect. The capsules are easy to swallow, and I take them every morning after breakfast. I plan to buy them again.

Pelvic Pain details

Pain alleviation noted

Most Useful Review

Sweet, the quality is good. I bought it for my mother, and it suits her. Praise be to God. The packaging is nice, and the benefit is adequate. The pain from her knee joints has diminished. The pain has lessened, though the taste is bland.

Back Pain details

SCIENTIFIC SCORE

Questionable

Based on 3 Researches

USERS' SCORE

Good

Based on 24 Reviews

Chondroprotectors show limited efficacy

Danilov AB, Grigorenko NV. [An antinociceptive effect of chondroprotectors: a myth or a reality?]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115:84. doi:10.17116/jnevro20151159184-89

We reviewed various studies to see how effective glucosamine and similar chondroprotectors are for treating chronic back pain.

Our findings indicated that these drugs may provide pain relief comparable to traditional anti-inflammatory medications, showing potential benefits in reducing inflammation and improving function.

However, the overall evidence suggests that while they can help with osteoarthritis, the support for back pain relief specifically remains limited. This means glucosamine might not be the go-to treatment for everyone suffering from back issues.

7.5

Significant pain relief

Most Useful Review

45 people found this helpful

Everything is real; I am writing two months after starting the treatment. I am 55 and have meniscus issues in both legs due to old sports injuries, and I refused surgery. After researching, I began taking glucosamine. After one and a half months, I felt results—I can now run up four flights of stairs without pain and descend without discomfort or crunching in my knees. Previously, getting out of bed was excruciating, taking ages just to straighten my knees. Glucosamine truly works, and I hope my review helps others. Wishing good health to everyone!