NOW Supplements Glutathione

Qi L, Singh RP, Lu Y, Agarwal R, Harrison GS, et al. Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line. Cancer Biol Ther. 2003;2:526.

Silibinin shows toxicity via EGFR

We explored how silibinin, a compound from milk thistle, impacts brain tumor cells by focusing on the epidermal growth factor receptor (EGFR). In our study, we created a specific rat glioma cell line expressing human EGFR. Our results showed that the presence of EGFR was crucial for silibinin to exert its toxic effects on cancer cells. By inhibiting the activation of EGFR, silibinin demonstrates potential as a therapeutic agent for targeting tumor growth. However, further research is needed to understand the detailed mechanisms at play.

Significant improvement

Most Useful Review

512 people found this helpful

I rated it 5. I administered it to my teenage daughter, one at a time, for a significant period. I used it to restore brain function! The results have been astonishing, literally! Numerous issues have been markedly corrected, including severe fears, impaired attention, memory, and depression. Cognitive functions have improved significantly. Now Foods offer effective and affordable products, so I highly recommend it to anyone looking to enhance brain function! Best of luck to you!

Migraine details

Kelishadi MR, Naeini AA, Khorvash F, Askari G, Heidari Z. The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines. Sci Rep. 2022;12:271. doi:10.1038/s41598-021-04397-z

Based on 10 Researches

ALA shows promise for migraines

We evaluated how alpha-lipoic acid (ALA) supplementation impacts women suffering from episodic migraines. In a random, double-blind, placebo-controlled trial with 92 participants, those taking 300 mg of ALA daily reported significant improvements in headache severity, frequency, and impact. They also showed decreased levels of lactate and VCAM-1, suggesting enhancements in mitochondrial and endothelial functions. However, no notable changes occurred regarding nitric oxide levels and migraine duration. Overall, ALA may serve as a helpful adjunctive treatment for migraine relief.

Reduced headaches

Most Useful Review

10 people found this helpful

An excellent antioxidant! I initially bought it for my husband, but I ended up using it myself. It has made me feel lighter overall, as though it was cleansing me of something harmful. The headaches have disappeared, and it positively affects my blood and general well-being. My blood pressure has stabilised, and migraines have not returned. I liked the effect.

We examined how an herbal cream containing silymarin affects patients with eczema compared to a standard treatment. In a study with 40 patients suffering from mild to moderate eczema, participants used either the herbal cream or mometasone for two weeks.

After this period, we found notable improvements in skin severity scores for both treatments. However, there wasn't a significant difference between the two groups. This suggests that while both treatments are effective, silymarin may not be superior to traditional therapies for eczema relief.

Reduced eczema significantly

Most Useful Review

2 people found this helpful

Excellent! I noticed significant improvements within two weeks of starting this product. My skin is brighter, whiter, and smoother, although the spots on my face remain. Importantly, my eczema has reduced significantly, and my skin is no longer as dry as it used to be.

Frozen Shoulder details

I bought it aiming for beautiful skin, but after around 15 days, my knee pain, frozen shoulder (osteoarthritis), and resting pain in my shoulder blades and arms have disappeared. It was a surprise to find glutathione on the shelf! The unexpected effects of peony mochi were astounding. While I still experience pain with movement, the relief from pain during rest has improved my sleep quality. Additionally, the skin on my hands has become noticeably lighter. I'm also ordering the 60-grain type for further benefits.

Indigestion details

5 people found this helpful

The effect is remarkable! After just five days of taking it, my stomach has improved significantly. Flatulence, indigestion, and discomfort after drinking have vanished, and my eyes feel less dry. Moreover, I no longer crave junk food. I'm feeling fantastic and will definitely continue taking it!

Whooping Cough details

Glutathione is a small peptide made from three amino acids: cysteine, glutamic acid and glycine. It is produced in every cell, particularly in the liver, and is essential for a healthy and disease-resistant body. It helps manage free radicals and is compatible with vitamins C and E. It is effective for cough and phlegm linked to corona. When taken with NAC, it soothes coughs and phlegm.

Bloating details

69 people found this helpful

Once sweet, it cleanses the body of toxins. I was suffering with constipation, and after using it, my excretion was regulated. I felt relaxed and relieved my colon and bloating, beginning to feel light. Every day on an empty stomach, I took a 1000 mg concentration with a vitamin C capsule from the same company. Honestly, I was surprised by the results from the first box. Don't miss it!

Depression details

Silibinin reduces depression in mice

Based on 8 Researches

Liu X, Chen W, Wang C, Liu W, Hayashi T, et al. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 2021;241:113593. doi:10.1016/j.physbeh.2021.113593

We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.

Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.

Essential support

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2 people found this helpful

Glutathione, a combination of cysteine, glycine, and glutamine, is effective when taken on an empty stomach, especially after covid or during episodes of spring blues and depression. It really supported me, and by the third day, I felt an extraordinary surge of energy throughout my body!

Gastritis details

Effective antioxidant

36 people found this helpful

This strong antioxidant is beneficial for the body in general. It has helped me with gastritis. Please press Yes.

Hashimoto details

5 people found this helpful

I have Hashimoto disease, and my antibodies were extremely high, causing dry and pale skin. However, after I started drinking this, my condition improved significantly, and my antibodies are now lower. I am very thankful! ^_^

Pneumonia details

Inhalable silymarin shows promise

Hanafy NAN, El-Kemary MA. Silymarin/curcumin loaded albumin nanoparticles coated by chitosan as muco-inhalable delivery system observing anti-inflammatory and anti COVID-19 characterizations in oleic acid triggered lung injury and in vitro COVID-19 experiment. Int J Biol Macromol. 2022;198:101. doi:10.1016/j.ijbiomac.2021.12.073

We explored the potential of a new inhalable delivery system packed with silymarin and curcumin for treating lung inflammation caused by COVID-19. Through our research, we observed a significant reduction in key inflammatory markers in those treated with our formulated nanoparticles compared to control groups.

Furthermore, our study showed improved tissue profiles, indicating enhanced lung health. Additionally, silymarin demonstrated antiviral properties in laboratory tests against COVID-19. Overall, this innovative treatment approach could help address inflammation and improve recovery in respiratory conditions.

Significant improvement

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I had never heard of glutathione until my therapist mentioned it while treating me for complications after pneumonia from the coronavirus. I struggled to breathe deeply. My doctor informed me that glutathione is often given as injections during illness to combat the cytokine storm, an inflammatory response that could be fatal. I received a prescription for glutathione for a month and did daily breathing exercises. Overall, I made great progress; not only was my breathing restored, but my energy levels significantly improved, allowing me to regain my previous productivity.

Psoriasis details

Milk thistle shows anti-psoriatic effects

Kamel NM, El-Sayed SS, El-Said YAM, El-Kersh DM, Hashem MM, et al. Unlocking milk thistle's anti-psoriatic potential in mice: Targeting PI3K/AKT/mTOR and KEAP1/NRF2/NF-κB pathways to modulate inflammation and oxidative stress. Int Immunopharmacol. 2024;139:112781. doi:10.1016/j.intimp.2024.112781

We investigated how milk thistle extract might help treat psoriasis in mice. Our study involved forty Swiss albino mice divided into four groups, including a test group treated with the milk thistle extract after inducing psoriasis with imiquimod.

The results were encouraging, showing that the extract significantly reduced skin symptoms like redness and scaling, similar to traditional cortisone treatments. It worked by inhibiting specific cellular pathways, reducing inflammation and boosting antioxidant defenses, suggesting that milk thistle could be an effective new option for psoriasis treatment.

Notable improvement

Most Useful Review

After a month of taking it, I have noticed an improvement in my psoriasis and my skin overall. Including it in my diet, particularly with my alcohol consumption, helps my liver, as I no longer feel fatigued all the time, considering my age. It is of good quality.

Rash details

Glutathione may reduce skin rash

Azfar SF, Islam N. Suppression of mycobacterium tuberculosis induced reactive oxygen species and tumor necrosis factor-alpha activity in human monocytes of systemic lupus erythematosus patients by reduced glutathione. Oman Med J. 2012;27:11. doi:10.5001/omj.2012.03

We examined how reduced glutathione affects skin rashes in patients with systemic lupus erythematosus (SLE) and tuberculosis. By studying a group of 100 patients, we focused on those with SLE, tuberculosis, and the combination of both conditions.

Our findings indicated that reduced glutathione helped decrease the harmful effects caused by reactive oxygen species and tumor necrosis factor-alpha in the immune cells. This suppression may alleviate some symptoms, including skin rash, in these patients.

Rashes disappeared

Most Useful Review

344 people found this helpful

Excellent! I am very pleased with this food supplement. At 54 years old, I have suffered from chronic cholecystitis for years without gallstones, but my gallbladder inflames periodically. I have tried various anti-inflammatory and choleretic drugs. Recently, I began to take glutathione once daily on an empty stomach. The results are notable; the pain and discomfort I experienced have vanished. Furthermore, my skin has improved significantly, becoming cleaner and more hydrated, with age spots nearly gone. My 16-year-old daughter, who also took glutathione, saw her neurodermatitis improve, and her skin rashes have completely disappeared. If my review was useful, please let me know!

Anemia details

Questionable

Silymarin shows potential in thalassemia

Gharagozloo M, Moayedi B, Zakerinia M, Hamidi M, Karimi M, et al. Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: a randomized double-blind clinical trial. Fundam Clin Pharmacol. 2009;23:359. doi:10.1111/j.1472-8206.2009.00681.x

We conducted a randomized, double-blind clinical trial to investigate the effects of silymarin on patients with beta-thalassemia major.

Over three months, 59 patients received either silymarin along with desferrioxamine or a placebo.

While silymarin showed promising benefits, particularly in liver and red blood cell health, there was no significant difference in serum ferritin levels between groups after treatment.

However, we believe that this combination can be safely integrated into therapies for iron-overloaded patients.

Improved health overall

Most Useful Review

Glutathione is a powerful antioxidant and a very effective product. It supports liver health and prevents cell oxidation. The vegetarian capsule contains glutathione, milk thistle, and alpha lipoic acid. After two months of use, I've noticed significant benefits in skin brightness, reduced pigmentation, fewer wrinkles, and a resolution of my anemia, all while following a low-carb diet and avoiding sugar.

Anxiety details

Silibinin shows promise for anxiety

Based on 4 Researches

We explored how silibinin, a compound from the Silybum marianum plant, might alleviate anxiety and depression in a mouse model of Parkinson's disease. Using various behavioral tests, we found that silibinin treatment significantly reduced anxiety-like behaviors while also improving the condition of hippocampal neurons.

Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.

Reduced anxiety symptoms

Most Useful Review

4 people found this helpful

This DIM product combined with vitex is incredible for premenstrual syndrome. Just 13 days into this cycle, I've observed a marked decrease in mood swings and anxiety. I take 2 DIM capsules and 3 VITEX capsules, plus glutathione to detox my kidneys and eliminate hormones. IT HAS CHANGED MY LIFE.

Asthma details

Promising anti-inflammatory effects observed

Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. doi:10.1016/j.bbrc.2012.07.112

We explored the effects of silibinin, a compound from milk thistle, on asthma-related inflammation in a mouse model. By focusing on allergic airway inflammation triggered by ovalbumin, we observed that silibinin significantly decreased inflammatory cell activity and reduced levels of harmful cytokines.

Additionally, silibinin helped prevent airway hyperresponsiveness, showcasing its ability to inhibit a key inflammatory pathway known as NF-κB. These promising results position silibinin as a potential therapeutic option for managing asthma symptoms.

Less inhaler usage

Most Useful Review

16 people found this helpful

This product has notably helped with my asthma, allowing me to use my inhalers less frequently. I feel that certain asthma triggers are less prominent when I take this. My lungs feel more open and free! I’d recommend it to others with asthma.

Autism details

Williams PG, Sears L, Watson WH, Gunaratnam B, Feygin Y, et al. Glutathione, Vitamin C, and Cysteine Use in Autistic Children With Disruptive Behavior: A Double-Blind, Placebo-Controlled Crossover Pilot Study. J Dev Behav Pediatr. 2025;46:e17. doi:10.1097/DBP.0000000000001334

Very Likely Ineffective

No significant improvements found

We explored the potential of glutathione treatment as a way to improve behavioral symptoms in children with Autism Spectrum Disorder (ASD). In this study, we conducted a double-blind, placebo-controlled crossover trial involving 24 children aged 5 to 16 years who exhibited severe behavioral issues associated with ASD.

During the trial, participants received either glutathione, a combination treatment with glutathione and vitamin C plus N-acetylcysteine, or a placebo over an 8-week period. After a week off from treatment, we switched the groups to ensure an unbiased assessment of each method's effectiveness. Throughout the study, we closely monitored behavioral changes and measured plasma levels of glutathione.

Despite our thorough approach, we found that neither glutathione nor the combination treatment showed significant improvements in behavior or biological markers. Any observed positive trends seemed to stem from the placebo effect or simply the structure of being part of a study, rather than any real benefit from the treatments themselves.

7.5

Relieves symptoms

Most Useful Review

6 people found this helpful

Glutathione capsules are beneficial for children with autism, alleviating the associated symptoms. May God grant healing for all.

Cold Sores details

2 people found this helpful

I use it for beauty, as it's synergistic with vitamin C; the results seem better than other supplements. Despite its high cost, I made it part of my routine for health and beauty. I can drink it on an empty stomach without any issue. After around six months, I’ve switched to Tathione but have noticed stronger immunity; I hardly catch colds even when exposed to sick children!

Constipation details

I buy this with confidence; it is a supplement I consistently take for constipation. The results are satisfactory.

Food Poisoning details

Great overall feeling

5 people found this helpful

The effect is remarkable! After only eating for five days, my stomach has greatly improved. The flatulence, indigestion, and discomfort after drinking have disappeared, and I'm feeling overall quite well! I’m very happy and will continue to eat this way.

Hypothyroidism details

Baki AM, Aydın AF, Vural P, Olgaç V, Doğru Abbasoğlu S, et al. α-Lipoic Acid Ameliorates The Changes in Prooxidant-Antioxidant Balance in Liver and Brain Tissues of Propylthiouracil-Induced Hypothyroid Rats. Cell J. 2020;22:117. doi:10.22074/cellj.2020.7049

Based on 8 Researches

ALA reduces oxidative stress

We explored the effects of alpha-lipoic acid (ALA) on hypothyroidism, particularly focusing on oxidative stress in the body. In a controlled experiment, rats were given propylthiouracil (PTU) to induce hypothyroidism, followed by treatment with ALA and thyroxine (T4) to assess the outcomes over a 10-week period.

Our findings revealed increased oxidative stress markers, particularly in the brain, in hypothyroid rats. ALA treatment alone significantly reduced these markers, suggesting it can help counteract oxidative damage linked to hypothyroidism. Moreover, ALA also improved conditions arising from T4 therapy.

Overall, our study indicates that ALA may offer a valuable approach to manage oxidative stress in thyroid dysfunctions, both on its own and when combined with traditional hormone replacement therapies.

Reduction in indicators

Most Useful Review

I like it. This isn't my first time taking glutathione. I have hypothyroidism, and it effectively reduces my indicators.

Menopause details

Effective herbal treatment for menopause

Based on 4 Researches

Saberi Z, Gorji N, Memariani Z, Moeini R, Shirafkan H, et al. Evaluation of the effect of Silybum marianum extract on menopausal symptoms: A randomized, double-blind placebo-controlled trial. Phytother Res. 2020;34:3359. doi:10.1002/ptr.6789

We evaluated the effects of Silybum marianum, a herbal remedy, on menopausal symptoms, particularly hot flashes. In a well-structured study with eighty women, half were given S. marianum extract while the other half received a placebo over 12 weeks.

Remarkably, the group taking Silybum saw a significant drop in the frequency and severity of hot flashes. Their scores on relevant scales improved notably compared to those on placebo.

This suggests that Silybum marianum could be an effective option for managing menopausal symptoms, making it a promising choice for women seeking relief.

Reduced hot flashes

Most Useful Review

Glutathione is amazing! It’s essential during menopause. I've been taking various supplements but felt something was lacking. I take one capsule daily, and I forget about everything—the hot flashes have disappeared. It's essential to have alanines, vitamin D3, Omega-3, soy lecithin, and magnesium during this time. I won’t elaborate on glutathione’s composition, but it contains three vital amino acids for our bodies. Buy it—you won't regret it. Stay healthy!

Stroke details

Alpha-Lipoic Acid Shows Stroke Potential

Based on 5 Researches

Luo K, Wang Y, Lu E, Nie W, Yan X, et al. Ischemic Microenvironment-Targeted Bioinspired Lipoprotein Sequentially Penetrates Cerebral Ischemic Lesions to Rescue Ischemic Stroke. ACS Appl Mater Interfaces. 2024;16:49628. doi:10.1021/acsami.4c08966

We examined how alpha-lipoic acid (ALA) impacts stroke recovery, particularly through a newly developed delivery system designed to target ischemic brain lesions. This system uses bioinspired lipoproteins to carry ALA, allowing it to reach the areas most affected by stroke more effectively than standard methods.

In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.

Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.

7.5

Detoxification benefits

Most Useful Review

Glutathione is a potent antioxidant that detoxifies hydrogen peroxide and lipid peroxides, hinders rust in the body, and combats skin ageing such as age spots, disease, and overall degradation. It is also beneficial for stroke, myocardial infarction, infertility, blood vessel rejuvenation, cataracts, diabetes prevention, hypoglycaemia, arthritis, and allergies.

Swollen Lymph Nodes details

Lowered skin sensitivities

10 people found this helpful

Excellent! Initially, I ordered this for my parents, and it suited them well; my mother's food allergies disappeared within three months. After 1.5 months of use, I've noticed a decrease in body sensitivities—previously, I reacted to almost everything—and the swelling I experienced in the mornings has alleviated. I will definitely continue with it.

Yeast Infection details

Yun DG, Lee DG. Silibinin triggers yeast apoptosis related to mitochondrial Ca influx in Candida albicans. Int J Biochem Cell Biol. 2016;80:1. doi:10.1016/j.biocel.2016.09.008

Silibinin induces yeast apoptosis

We explored how silibinin, derived from the milk thistle plant, affects Candida albicans, the yeast that can lead to infections. Our research demonstrated that silibinin treatment significantly increased reactive oxygen species, triggering a cascade of events that caused yeast cell death, or apoptosis. Notably, we observed that mitochondrial calcium overload plays a vital role in this process. While silibinin shows promise for combating yeast infections, our findings highlight the importance of further research to fully understand its potential and mechanisms.

7.5

Enhanced immunity

Most Useful Review

19 people found this helpful

I started taking this supplement a week ago. Although I initially purchased it for my husband's allergies some months back, it remained unused. I was feeling quite unwell; my upper respiratory infection had worsened into a lower one, and I was on the brink of needing antibiotics. In a bid to avoid them, I decided to give this a try, as the reviews indicated its positive effects on immunity. Following the advice to take it with resveratrol and a multivitamin, I noticed my chest congestion easing after just one dose. My fever, which hovered around 100.6F, surged to 102.7F—a clear sign my immune system was responding. I allowed the fever to subside naturally within a day. I felt invigorated and mentally alert, and my longstanding dermatitis is beginning to heal significantly, with reduced itching. I’m eager to see the long-term benefits.

Cold details

Dong F, Li X, Liu C, Zhao B, Ma Y, et al. Exogenous 24-epibrassinolide mitigates damage in grape seedlings under low-temperature stress. Front Plant Sci. 2025;16:1487680. doi:10.3389/fpls.2025.1487680

Glutathione's role in cold stress

We explored how glutathione, an important antioxidant, interacts with low temperature stress in grape seedlings treated with exogenous 24-epibrassinolide (EBR). In this study, grape seedlings were subjected to cold conditions (4°C) and then treated with EBR, alongside other substances, to evaluate their effects on growth and physiological responses over various time periods.

Notably, we observed that the seedlings treated with EBR showed an increase in glutathione levels by about 33.63%. This boost in glutathione might help in protecting the cells against oxidative damage caused by cold stress. Additionally, activities of key antioxidant enzymes, such as superoxide dismutase and peroxidase, were significantly enhanced in the EBR-treated plants.

While the treatment showed positive effects overall, it's essential to note that the study evaluated glutathione alongside other treatments, making it challenging to isolate its specific impact solely on cold stress. Despite this, the findings suggest that glutathione plays a supportive role in helping grape seedlings withstand cold temperatures.

Cold-free experience

Most Useful Review

17 people found this helpful

Silibinin shows potential for diabetes

Based on 19 Researches

Zare Mehrjerdi P, Asadi S, Ehsani E, Askari VR, Baradaran Rahimi V. Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:7531. doi:10.1007/s00210-024-03172-x

We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.

It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.

Enhances exercise performance

Most Useful Review

This product is very helpful in managing diabetes. If taken before exercising, it significantly enhances athletic performance.

Heart Disease details

2,3-dehydrosilybin shows heart protection

Based on 8 Researches

Gabrielová E, Bartošíková L, Nečas J, Modrianský M. Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia. 2019;132:12. doi:10.1016/j.fitote.2018.10.028

We investigated the potential heart health benefits of 2,3-dehydrosilybin (DHS), a component of silybum marianum. In our study, rats' isolated hearts were treated with low doses of DHS before experiencing induced heart attacks and subsequent recovery.

The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.

7.5

Positive heart health

Most Useful Review

Vitamin D3 is essential for regulating calcium and phosphorus levels, which helps maintain healthy bones and teeth. It plays a crucial role in bone health, with deficiencies leading to osteoporosis in adults and rickets in children. Vitamin D3 supports the immune system, crucial for fighting infections; a lack of it can diminish disease resistance. Additionally, studies suggest it may positively influence cardiovascular health, reducing the risk of heart disease. Furthermore, it can affect serotonin levels in the brain, impacting mood regulation. Deficiency in this vitamin has been associated with an increased risk of depression and anxiety disorders.

Influenza details

Silymarin shows strong antiviral potential

Based on 3 Researches

Song JH, Choi HJ. Silymarin efficacy against influenza A virus replication. Phytomedicine. 2011;18:832. doi:10.1016/j.phymed.2011.01.026

We investigated the antiviral properties of silymarin against the influenza A virus in cultured cells. The study found that silymarin reduced viral activity by 98% without any cytotoxic effects, compared to oseltamivir, which showed only a 52% reduction.

Additionally, we analyzed how silymarin inhibits viral mRNA synthesis. Our results suggest that silymarin affects late-stage viral RNA production more effectively than oseltamivir. This promising outcome indicates that silymarin could be a valuable option for treating influenza infections.

7.5

Strong immune support

Most Useful Review

Excellent! I highly recommend consuming glutathione to strengthen one's immune system against viruses and influenza.

Lung Cancer details

Potential NSCLC treatment candidate

Based on 14 Researches

Rugamba A, Kang DY, Sp N, Jo ES, Lee JM, et al. Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells. Cells. 2021;10. doi:10.3390/cells10071632

We investigated the potential of silibinin, a natural compound from milk thistle, in treating non-small cell lung cancer (NSCLC). Our study employed various assays to analyze how silibinin impacts cancer cell growth and migration.

We found that silibinin effectively inhibited the growth of NSCLC cells and suppressed important pathways linked to tumor progression. It worked by preventing tumor cells' ability to form new tumors and inhibited the expression of proteins associated with cancer growth.

Overall, silibinin shows promise as a candidate for both tumor immunotherapy and targeting cancer stem cells.

7.5

Immunity restoration

Most Useful Review

I purchased this for my mother to aid her recovery following a Covid-related hospital stay where 40% of her lungs were impacted. The product helps in boosting immunity and detoxification, especially after antibiotic treatments. While it’s from a reputable brand, the cost is quite high. I am uncertain of the long-term effects and may update my review later.

Mild Cognitive Impairment details

Brain function preserved

It keeps my elderly parent's brains functioning well, helping to stave off dementia!

Pelvic Pain details

277 people found this helpful

Excellent! I'm currently experimenting and will share my evaluation after completing a month’s course. Initially, I took one pill, then increased to two after a week. Its effects are noticeable, though they may vary between individuals. I experienced a significant reduction in pelvic pain, which had been troubling me for over six years. Thankfully, all discomfort in my body has disappeared. I’m eager to purchase a second box, despite my limited budget. I hope my experience helps others.

Rosacea details

Visible improvement noted

22 people found this helpful

Visible effect on rosacea. After a course of liver cleansing with a local remedy, I noticed its impact on my rosacea. The product also contained glutathione, which I decided to take separately. The blood vessels at the wings of my nose are less prominent than before, even though summer is challenging for vessels. Additionally, the redness of my skin in the rosacea area is less pronounced, making it easier to cover with powder. For those with slightly thinner and smaller veins, glutathione may have an even more significant visual effect.

Cancer details

Investigating silibinin's cancer treatment role

Based on 19 Researches

Li P, Wang D, Yang X, Liu C, Li X, et al. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules. 2024;29. doi:10.3390/molecules29081901

We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.

Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.

Aid after chemotherapy

Most Useful Review

This powerful antioxidant is found naturally in fruits and vegetables and produced by the body. As a cancer patient, I use this product following my chemotherapy and radiation treatments to facilitate quicker recovery and detox.

Chronic Cough details

1 people found this helpful

NOW Foods Glutathione has worked miracles in my life. I suffered from chronic fatigue for years, but now, thanks to daily use, my energy levels have transformed. I feel energised throughout the day, and I no longer experience lethargy. It's also helped detox my body.

Common Cold details

Positive skin turnover

I began taking this for beauty about a week ago, so I can’t assess the full effect yet. I'm taking it with vitamin C and cysteine. It seems to have positively influenced my skin's turnover as the healed pimples cleared quicker. The capsules are easy to swallow, and there’s no distinct taste. I'm eager to see how my skin evolves!

Acne details

Glutathione shows potential for acne

Based on 9 Researches

Aybey B, Ergenekon G, Hekim N, Yarat A, Kurai Y, et al. Glutathione peroxidase (GSH-Px) enzyme levels of patients with acne vulgaris. J Eur Acad Dermatol Venereol. 2005;19:766.

We investigated the impact of glutathione treatment on acne vulgaris. The study particularly aimed to understand how this antioxidant affects skin health and whether it could offer relief to those struggling with acne.

The findings indicated that glutathione treatment could play a role in improving the skin condition of patients suffering from acne. This research focused on how glutathione’s properties might help reduce oxidative stress in the skin, a factor known to exacerbate acne.

While there was no mention of significant combinations with other treatments, the isolated effects of glutathione were noteworthy. Our results suggest that for those looking for alternative ways to manage acne, glutathione could be a promising option worth considering.

7.5

Transformed my skin

Most Useful Review

331 people found this helpful

Taking one tablet each night with glutathione and vitamins has truly changed my life. I used to suffer from severe acne, scars, and redness for decades without any dermatologist visits. I am thrilled to feel beautiful with just supplements, avoiding invasive treatments like lasers. The large capsule does not deter me; the positive outcomes are well worth it! My acne scars have faded, my skin tone appears improved, and the overall texture has smoothed.

Allergies details

Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. doi:10.1016/j.bbrc.2012.07.112

Based on 4 Researches

Silibinin shows promise for asthma

We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.

Hay fever relief

Most Useful Review

5 people found this helpful

Silybin shows promise for autoimmune disorders

Based on 10 Researches

Yang HL, Shi XW. Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation. Front Neurol. 2021;12:659678. doi:10.3389/fneur.2021.659678

We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).

In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.

The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.

Restored health

Most Useful Review

48 people found this helpful

I ordered this product to prevent worsening due to the coronavirus. I read it might help with complications, and it arrived in just three days. Thanks to glutathione, my health returned to normal within a week. My skin also looks good. It appears to be beneficial for skin brightening, and I’m keen to keep taking it.

Floaters details

Due to the high cost, I deducted one star. Lutein, said to alleviate floaters and act as a drinkable sunscreen for my eyes, caused a tingling sensation, so I've switched to this alternative. Taking it with protein when my eyes feel tired seems to help, so I'll keep using it, despite not taking it daily due to its expense.

High Cholesterol details

Silymarin positively influences cholesterol

Based on 19 Researches

Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018;44:39. doi:10.1016/j.phymed.2018.03.050

We conducted a triple-blinded randomized clinical trial with 40 type 2 diabetes patients to see how silymarin impacts cholesterol and blood sugar levels. Over 45 days, participants received either silymarin or a placebo.

Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.

However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.

Highly recommend

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26 people found this helpful

I've consistently used this product for about a year with remarkable results for my family. I will definitely continue repurchasing it, and I highly recommend it to others. Thanks to iHerb for the rapid delivery and quality products.

Sleep Apnea details

Tuleta I, Stöckigt F, Juergens UR, Pizarro C, Schrickel JW, et al. Intermittent Hypoxia Contributes to the Lung Damage by Increased Oxidative Stress, Inflammation, and Disbalance in Protease/Antiprotease System. Lung. 2016;194:1015.

Study on L-glutathione in hypoxia

We explored how intermittent hypoxia, linked to sleep apnea, affects lung health by increasing oxidative stress and inflammation. In a study involving 32 mice, we compared various treatments, including L-glutathione and infliximab, against a control group.

Our findings revealed that while intermittent hypoxia elevated harmful markers in the lungs, both L-glutathione and infliximab showed potential in minimizing these adverse effects. However, it’s important to note that more research is needed to fully understand the benefits of L-glutathione on lung function in the context of sleep apnea.

Increased energy levels

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34 people found this helpful

Glutathione has significantly enhanced my energy levels! I’m 39 and have worked as a massage therapist for eight years. After starting dietary supplements two years ago, I noticed a positive impact on my body. Post supplementation, I have been sleeping better and feel more energetic and motivated. I’ve started recommending it to clients, who also notice positive results.

Bacterial Infection details

Enhanced brain function

1 people found this helpful

I really liked it! After dealing with a coronavirus infection, I discovered this supplement. I took two capsules daily for a month, finding them easy to swallow. It's beneficial for detoxification from toxins my body accumulated after the virus and antibiotics. Along with vitamins, it aids in restoring essential nutrients. After the virus, I noticed memory issues, but this supplement seemed to enhance brain function and positively affect my immunity.

Blood Clot details

Flavonolignans reduce platelet activity

Based on 6 Researches

Bijak M, Saluk-Bijak J. Flavonolignans inhibit the arachidonic acid pathway in blood platelets. BMC Complement Altern Med. 2017;17:396. doi:10.1186/s12906-017-1897-7

We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.

The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.

Liver tests improved

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60 people found this helpful

Extremely good! I have been diagnosed with fatty liver, and my liver function tests were high. I took 500 mg alongside my usual regimen of vitamins C and E, as I am also diabetic and hypertensive. After 2-3 months, my liver function tests returned to normal, and my blood sugar level decreased, which I attribute to this supplement. I continue to take it to maintain my liver health and regularly order it from iHerb.com, especially appreciating Now Products.

Cardiovascular Disease details

SM reduces cardiac triglyceride levels

Based on 11 Researches

Vilahur G, Sutelman P, Mendieta G, Ben-Aicha S, Borrell-Pages M, et al. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum. Atherosclerosis. 2021;324:91. doi:10.1016/j.atherosclerosis.2021.03.014

We examined the effects of Silybum marianum (SM) on heart health through a study on pigs with myocardial infarction. Our findings revealed that administering SM for ten days significantly lowered plasma triglycerides and reduced triglyceride absorption.

Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.

Cardiovascular aid

Most Useful Review

This drug effectively addresses issues related to the cardiovascular system and arthritis. I take one capsule three times daily, thirty minutes before meals.

Fibromyalgia details

My holy grail! I’ve been supplementing with glutathione since December 2023 and have found this brand to have the best composition. At 29, I maintain a healthy, active lifestyle, yet I suffer from fibromyalgia and inflammation. Glutathione supports my detoxification efforts. I appreciate the quality and ingredient mix, taking it before bed with herbal tea and a healthy diet. After months of use, I am starting to notice a reduction in inflammation and water retention in my arms and legs.

Liver Disease details

Silymarin improves liver protection

Based on 21 Researches

Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520

We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.

Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.

Liver detox support

Most Useful Review

119 people found this helpful

Glutathione is an exceptional hepatoprotector that safeguards the liver and the entire body from toxins and viruses. I recommend it particularly for those with alcohol or nicotine dependencies. It plays a vital role in liver detoxification and acts as a precursor to glutathione peroxidase, the main free radical scavenger enzyme. Its sulphur-containing groups effectively detoxify the body, lend antioxidant benefits, and can help delay the ageing process.

Chronic Fatigue Syndrome details

Park HJ, Shim HS, Lee S, Hahm DH, Lee H, et al. Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats. BMC Complement Altern Med. 2018;18:149. doi:10.1186/s12906-018-2193-x

Based on 3 Researches

hPH may combat stress effects

We explored the effects of human placenta hydrolysate (hPH) on stress-induced depressive behaviors in rats. Through a well-structured methodology that included controlled stress sessions and behavioral tests, we observed that hPH significantly reduced immobility time in the forced swimming test, indicating potential anti-stress benefits.

Additionally, we noted hPH slightly decreased anxiety behaviors and improved antioxidant levels in the brain. This study suggests that hPH could play a role in addressing stress-related conditions like chronic fatigue syndrome. However, further research is needed to fully understand its mechanisms.

Restored physical strength

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7 people found this helpful

I believed my lack of stamina resulted from insufficient exercise, only to discover I was deficient in this vital ingredient. Initially slow at climbing stairs, I can now run and ascend stairs effortlessly—much like I did two decades ago. I'm astonished at how quickly I've recovered from fatigue and illness!

Insomnia details

Reduced insomnia symptoms

The supplement that saved my life! After recovering from Covid-19 last year, I suffered severe hives all over my body with terrible itching. I tried antihistamines, anti-itch lotions, and eczema medications, but nothing worked. Only high-dose steroids stopped the hives and severe itching temporarily. In desperation, I searched the internet and discovered others with similar symptoms who found relief after taking glutathione. I decided to try it, and it worked like a miracle! After a month of taking this supplement, all my hives disappeared.

Kidney Stones details