NOW Supplements Hyaluronic Acid

Hyaluronic acid peptide shows promise

Possibly Effective

Based on 18 Researches

Su Z, Zhang Y, Cao J, Sun Y, Cai Y, et al. Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist. J Nanobiotechnology. 2023;21:55. doi:10.1186/s12951-023-01812-7

We looked into how a new treatment combining hyaluronic acid with a peptide from fibroblast growth factor 2 could help combat acne. This method targets specific receptors involved in acne development, showing promise by reducing both acne lesions and excess oil production in lab tests. Importantly, our study revealed that this treatment does not encourage certain reactions that would typically hinder acne management. While the results are positive, we acknowledge that ongoing research is necessary for further confirmation of these findings.

Acne gone forever

Most Useful Review

23 people found this helpful

I have experienced a remarkable improvement in my skin condition, and I can happily say that my acne has vanished after years of struggle. At 33, not only has my skin improved, but the hyaluron has also helped alleviate pain in my knee, which feels much better now.

Updated: Apr 2026

Knee Pain details

Hyaluronic acid effectiveness evaluated

Possibly Effective

Based on 15 Researches

Safali S, Ertaş ES, Özdemir A, Cataklı D. Evaluation of single and multiple hyaluronic acid injections at different concentrations with high molecular weight in the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 2024;25:164. doi:10.1186/s12891-024-07200-y

We explored how hyaluronic acid (HA) injections affect knee osteoarthritis (OA) pain and function. This study involved 128 patients, comparing the impact of a single high-dose injection to triple low-dose injections over 12 months.

Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.

So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.

Knees no longer hurt

Most Useful Review

160 people found this helpful

This product is a wonderful source of vitality for the joints. After my treatment course, my knee pain has stopped, and the crunching in the joints has vanished.

Updated: Mar 2026

We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.

Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.

Improved mobility noted

Most Useful Review

173 people found this helpful

This supplement has given me tremendous relief for my back pain! After being recommended for degenerative disc disease, it made me much more mobile within just a week. It is easy to take, and since it’s a long chain of disaccharides, it aids in moisture retention in connective tissues. I highly recommend it as I've experienced remarkable improvements in my chronic back pain.

Updated: Mar 2026

Chronic Cough details

Very good quality. I used it alongside UC-II to address chronic pain in my overworked shoulder, which reduced inflammation and stiffness. After a month, I regained about 35-40% of my movement range. I used to struggle putting on and off a jacket; now, movement is completely free and painless, allowing me to resume weight training. It's a fantastic result that many other supplements failed to provide.

3 people found this helpful

Cold Sores details

Excellent! I bought it for my skin, but it has become an indispensable product for my joints. A wrist that has been sore for years has improved significantly!

Rheumatoid Arthritis details

Hyaluronic acid's role in RA pain

Based on 14 Researches

Liu L, Ma X, Jia X, Hui JH, Hui M. Application of 35 kDa Hyaluronic Acid Fragment in Managing Persistent Localized Pain in Rheumatoid Arthritis : A Case Report. Clin Case Rep. 2025;13:e70361. doi:10.1002/ccr3.70361

We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments.

Prescription-Free Relief

Most Useful Review

14 people found this helpful

A few years ago, I was diagnosed with Rheumatoid Arthritis and prescribed medications. However, after a friend's recommendation, I started taking Hyaluronic Acid. Since then, I’ve stopped taking my prescription drugs! I can hardly believe the difference it has made to how I feel. I absolutely love it and can't thank you enough!

Updated: Apr 2025

Tendonitis details

9 people found this helpful

Despite needing to take double the dosage, it worked remarkably well for me. One tablet alone wasn't enough to tackle the remnants of my tendonitis, but after taking two pills both in the morning and evening, I felt completely relieved. I'm grateful for this high-quality product, which is free from unnecessary ingredients. If you’re under 50, one tablet morning and evening should suffice to notice its effects on your skin.

I purchased double-strength hyaluronic acid to alleviate my ankle pain, and it appears to be effective. This vegan supplement contains L-Proline, Alpha Lipoic Acid, and Grape Seed Extract, along with Sodium (from Sodium Hyaluronate). The 10 mg dosage has made a noticeable difference.

Cardiovascular Disease details

1 people found this helpful

Food Poisoning details

Inflammation buster! After reading the excellent reviews for H.A., I had to try it. Initially, I doubled the dosage for ten days to quickly achieve an optimum level in my system. Within just 48 hours, my gouty arthritis flare-up in my right knee ceased entirely. I will continue using 'Now Foods, Hyaluronic Acid, Double Strength, 100 mg' to combat my age-related arthritis effectively. Now, I can enjoy many previously restricted foods related to gout flare-ups. Yippee!

This supplement helps support joint and skin health. Within a week of taking it, a stubborn morning cough I had dealt with for months disappeared. I researched and found that hyaluronic acid supplements can help heal irritated throat tissue. I can only assume this is a high-quality product. The ingredient list is quite clean too, so I will happily repurchase.

Adenoiditis details

Arthritis details

Hyaluronic acid eases shoulder arthritis

Possibly Effective

Based on 24 Researches

Monti L, Franchi E, Verde F, Sgherzi S, Anghilieri FM. Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid-based injections (Hyalubrix) in patients with glenohumeral osteoarthritis. Reumatismo. 2025;77. doi:10.4081/reumatismo.2024.1699

We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.

By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.

Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.

Quick knee pain relief

Most Useful Review

73 people found this helpful

I discovered that a combination of hyaluronic acid and turmeric could relieve the unbearable arthritis pain in my knee. Remarkably, within two days, my knee pain had decreased by 90%, and it has remained manageable for two weeks now. I'm unsure which supplement works best on its own, but together, they have truly been a miraculous help for me.

Updated: Mar 2026

Bone Pain details

Polynucleotide sodium reduces knee pain

Kim JY, Kim YN, Lee YJ, Sim SE, Ko YR, et al. Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. J Clin Med. 2021;10. doi:10.3390/jcm10051138

We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.

Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.

Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.

Maintaining joint health

Most Useful Review

37 people found this helpful

Great for LMTs with osteoarthritis. As a massage therapist, I faced joint pain in my right thumb due to improper technique, and feared for my career. In my search, I found hyaluronic acid, though opinions on whether articular cartilage can heal itself vary. I've been taking this for a few weeks, and my thumb now feels normal with no pain. While I continue massaging, I'm also undertaking efforts for a low-inflammation diet and additional treatments. I can't find fault with this product, as it's aiding me during this challenging period.

Updated: Mar 2026

Ear Infection details

Almost arthritis-free

This stuff is miraculous! In my early thirties with mild arthritis, since I began taking these, my symptoms have nearly vanished. I feel fantastic!

I've experienced significantly less joint pain and reduced dry skin since starting hyaluronic acid. It remarkably alleviates hip pain while sleeping.

Sleep Apnea details

Hair Loss details

Marked difference noted

4 people found this helpful

Great product! I take one in the morning and initially bought this for my joints based on my daughter's recommendation. While I'm unsure of its effects on my joints, I've noticed a marked difference in hair loss; it has significantly reduced, and my skin is soft now!

Allergies details

No health issues noted

I've been using this supplement intermittently for six years, typically taking a can followed by a break of 3-6 months. I've maintained good health without joint issues, crediting its reliable ingredients. It does not cause allergies for me, and I always ensure adequate hydration and vitamin C intake.

Cold details

Health improved overall

1 people found this helpful

These vitamins have been my lifesaver during the cold season. I have noticed a decrease in illness and an improvement in my overall health. The vitamin composition is very good, and the packaging is convenient for transport. The hyaluronic acid definitely works!

Frozen Shoulder details

No additional benefits from HA injections

Questionable

Based on 16 Researches

Hsieh LF, Hsu WC, Lin YJ, Chang HL, Chen CC, et al. Addition of intra-articular hyaluronate injection to physical therapy program produces no extra benefits in patients with adhesive capsulitis of the shoulder: a randomized controlled trial. Arch Phys Med Rehabil. 2012;93:957. doi:10.1016/j.apmr.2012.01.021

We examined whether adding hyaluronic acid (HA) injections to physical therapy (PT) could improve outcomes for patients with frozen shoulder. In a well-structured study, 70 participants were divided into two groups—with one receiving HA injections alongside PT, while the other focused solely on PT.

After assessing their shoulder movement, pain, and quality of life, we found no significant extra benefits from the HA injections. This suggests that continuing with just PT could be a more cost-effective approach for managing this condition.

No more problems

Most Useful Review

Awesome! I've worked in a physically demanding job and previously had issues with both shoulder and elbow joints. Since I started taking hyaluronic acid, all my problems have vanished. I highly recommend this product.

Updated: Mar 2026

Rash details

Hyaluronic acid gel shows promise

Based on 5 Researches

Morali G, Polatti F, Metelitsa EN, Mascarucci P, Magnani P, et al. Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. Arzneimittelforschung. 2006;56:230.

We examined the effects of a gel containing hyaluronic acid on women experiencing vaginal atrophy symptoms after menopause. The pilot and multicenter studies involved 110 postmenopausal participants using the gel both externally and vaginally. Results showed significant improvements in vaginal dryness, burning, itching, and rash from the first week of treatment, without any reported adverse effects. Overall, the gel was well-accepted and demonstrated promise as a safe alternative to traditional hormone replacement therapies.

Effective for skin

Most Useful Review

18 people found this helpful

This product is brilliant! My facial skin improved significantly during usage, with rashes vanishing and joint pain resolving. I alternate between two months of intake and two months of rest. If you found this review helpful, please like it :)

Updated: Mar 2026

Autoimmune Disorder details

Hyaluronic acid shows promise

Based on 16 Researches

Zeng Y, Wu L, Jiang X, Hu Y, Jin Y, et al. Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis. Int J Pharm. 2025;669:125073. doi:10.1016/j.ijpharm.2024.125073

We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.

8.5

Joint mobility improved

Most Useful Review

74 people found this helpful

I have taken Hyaluronic acid 100 mg from Now for 1.5 years, a tablet daily after meals. I take it after other supplements to improve cartilage quality, joint mobility, and skin hydration while reducing wrinkles. I exercise regularly and maintain an active lifestyle. Hyaluronic acid helps alleviate stress on my joints, and I recommend it for daily use thanks to its quality and performance, especially after the age of 35.

Updated: Mar 2026

Blurred Vision details

Enhances skin and vision

After taking this supplement, my joint pain ceased, and the crunching stopped. I've noticed my vision benefits, and my facial skin looks rejuvenated and youthful. This product has exceeded my expectations in multiple aspects.

1 people found this helpful

Leg Cramps details

An effective drug! This product has shown great results. After a month of intake, my knees no longer crunched during squats, and my legs feel revitalised. Walking has become effortless, and I no longer experience fatigue in my joints. I intend to continue taking it regularly.

48 people found this helpful

Swollen Lymph Nodes details

Excellent! I have varicose veins with nodes that were already discoloured. After a month of taking Gialurinki, collagen, coenzyme, and omega-3, my veins are no longer blue, and the nodes have completely disappeared. I am overall very happy!

Flu details