NOW Supplements Hyaluronic Acid

Effective, safe pelvic pain treatment

Based on 16 Researches

Sherif H, Sebay A, Kandeel W, Othman T, Fathi A, et al. Safety and efficacy of Intravesical hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome. Turk J Urol. 2019;45:296. doi:10.5152/tud.2018.63600

We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.

Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.

Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.

Effective combo treatment

Most Useful Review

153 people found this helpful

This combination works wonders! I bought hyaluronic acid double strength and collagen type II for my mother, and within two weeks, her back and knee pain vanished. She now finds it easier to stand and move about comfortably.

We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.

By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.

Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.

Effective for arthritis

Most Useful Review

102 people found this helpful

A worthy competitor to medicinal chondroprotectors! The order arrived in 4 days, well packed, with the product matching the description and expiry date. The capsules are medium-sized, easy to take, and have a yeasty smell. I find this medication beneficial for my arthritis; the crunch in my knee joint disappears, and any discomfort subsides during exertion. My skin feels more hydrated, and fine wrinkles are less apparent. The convenient dosage of 100mg, when combined with adequate hydration and vitamin C, proves effective.

Athlete’s Foot details

Five stars from me! Initially, I didn't have high hopes for this hyaluronic acid, thinking it might help slightly with skin hydration, but it has far exceeded my expectations. My entire body feels significantly more hydrated, with no dry feet or parched facial skin anymore! The ingredients appear to be high quality. I intend to keep using this.

Back Pain details

Hyaluronic acid effective for back pain

Questionable

Based on 14 Researches

Fuchs S, Erbe T, Fischer HL, Tibesku CO. Intraarticular hyaluronic acid versus glucocorticoid injections for nonradicular pain in the lumbar spine. J Vasc Interv Radiol. 2005;16:1493.

We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.

Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.

Improved mobility noted

Most Useful Review

173 people found this helpful

This supplement has given me tremendous relief for my back pain! After being recommended for degenerative disc disease, it made me much more mobile within just a week. It is easy to take, and since it’s a long chain of disaccharides, it aids in moisture retention in connective tissues. I highly recommend it as I've experienced remarkable improvements in my chronic back pain.

Rheumatoid Arthritis details

Liu L, Ma X, Jia X, Hui JH, Hui M. Application of 35 kDa Hyaluronic Acid Fragment in Managing Persistent Localized Pain in Rheumatoid Arthritis : A Case Report. Clin Case Rep. 2025;13:e70361. doi:10.1002/ccr3.70361

Based on 14 Researches

Hyaluronic acid's role in RA pain

We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments.

Prescription-Free Relief

Most Useful Review

14 people found this helpful

A few years ago, I was diagnosed with Rheumatoid Arthritis and prescribed medications. However, after a friend's recommendation, I started taking Hyaluronic Acid. Since then, I’ve stopped taking my prescription drugs! I can hardly believe the difference it has made to how I feel. I absolutely love it and can't thank you enough!

Tendonitis details

9 people found this helpful

Despite needing to take double the dosage, it worked remarkably well for me. One tablet alone wasn't enough to tackle the remnants of my tendonitis, but after taking two pills both in the morning and evening, I felt completely relieved. I'm grateful for this high-quality product, which is free from unnecessary ingredients. If you’re under 50, one tablet morning and evening should suffice to notice its effects on your skin.

Cardiovascular Disease details

Joint lubrication support

The primary benefits of hyaluronic acid include regulating skin's water balance, boosting its protective functions, and normalising intraocular pressure while lubricating joints. It can be a true saviour for damaged joints, particularly in cases of osteoarthritis, arthritis, or osteochondrosis, where synovial fluid production is insufficient. This leads to cartilage degradation as well as increased pain and inflammation due to friction. Hyaluronic acid supplements mimic synovial fluid, acting as a protective shock absorber for joints. With age, it also safeguards against wrinkles. However, there are some contraindications to consider.

Food Poisoning details

1 people found this helpful

Inflammation buster! After reading the excellent reviews for H.A., I had to try it. Initially, I doubled the dosage for ten days to quickly achieve an optimum level in my system. Within just 48 hours, my gouty arthritis flare-up in my right knee ceased entirely. I will continue using 'Now Foods, Hyaluronic Acid, Double Strength, 100 mg' to combat my age-related arthritis effectively. Now, I can enjoy many previously restricted foods related to gout flare-ups. Yippee!

Adenoiditis details

This supplement helps support joint and skin health. Within a week of taking it, a stubborn morning cough I had dealt with for months disappeared. I researched and found that hyaluronic acid supplements can help heal irritated throat tissue. I can only assume this is a high-quality product. The ingredient list is quite clean too, so I will happily repurchase.

Bone Pain details

Polynucleotide sodium reduces knee pain

Kim JY, Kim YN, Lee YJ, Sim SE, Ko YR, et al. Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. J Clin Med. 2021;10. doi:10.3390/jcm10051138

We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.

Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.

Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.

Maintaining joint health

Most Useful Review

37 people found this helpful

Great for LMTs with osteoarthritis. As a massage therapist, I faced joint pain in my right thumb due to improper technique, and feared for my career. In my search, I found hyaluronic acid, though opinions on whether articular cartilage can heal itself vary. I've been taking this for a few weeks, and my thumb now feels normal with no pain. While I continue massaging, I'm also undertaking efforts for a low-inflammation diet and additional treatments. I can't find fault with this product, as it's aiding me during this challenging period.

Cold Sores details

3 people found this helpful

Excellent! I bought it for my skin, but it has become an indispensable product for my joints. A wrist that has been sore for years has improved significantly!

Ear Infection details

Almost arthritis-free

This stuff is miraculous! In my early thirties with mild arthritis, since I began taking these, my symptoms have nearly vanished. I feel fantastic!

Sleep Apnea details

I've experienced significantly less joint pain and reduced dry skin since starting hyaluronic acid. It remarkably alleviates hip pain while sleeping.

Hair Loss details

Marked difference noted

4 people found this helpful

Great product! I take one in the morning and initially bought this for my joints based on my daughter's recommendation. While I'm unsure of its effects on my joints, I've noticed a marked difference in hair loss; it has significantly reduced, and my skin is soft now!

Acne details

Hyaluronic acid peptide shows promise

Possibly Effective

Based on 13 Researches

Su Z, Zhang Y, Cao J, Sun Y, Cai Y, et al. Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist. J Nanobiotechnology. 2023;21:55. doi:10.1186/s12951-023-01812-7

We looked into how a new treatment combining hyaluronic acid with a peptide from fibroblast growth factor 2 could help combat acne. This method targets specific receptors involved in acne development, showing promise by reducing both acne lesions and excess oil production in lab tests. Importantly, our study revealed that this treatment does not encourage certain reactions that would typically hinder acne management. While the results are positive, we acknowledge that ongoing research is necessary for further confirmation of these findings.

Acne gone forever

Most Useful Review

23 people found this helpful

I have experienced a remarkable improvement in my skin condition, and I can happily say that my acne has vanished after years of struggle. At 33, not only has my skin improved, but the hyaluron has also helped alleviate pain in my knee, which feels much better now.

Allergies details

No health issues noted

I've been using this supplement intermittently for six years, typically taking a can followed by a break of 3-6 months. I've maintained good health without joint issues, crediting its reliable ingredients. It does not cause allergies for me, and I always ensure adequate hydration and vitamin C intake.

Common Cold details

Huang S, Constant S, De Servi B, Meloni M, Culig J, et al. In vitro safety and performance evaluation of a seawater solution enriched with copper, hyaluronic acid, and eucalyptus for nasal lavage. Med Devices (Auckl). 2019;12:399. doi:10.2147/MDER.S209644

Based on 2 Researches

Evaluation of nasal cold relief

We explored the safety and effectiveness of a unique seawater solution enhanced with hyaluronic acid, eucalyptus, and copper for treating common cold symptoms, especially nasal congestion. Using an advanced 3D nasal tissue model, the solution showed no negative effects on nasal cell health and improved mucociliary clearance.

Those treated with this solution had better nasal drainage and overall relief from congestion. Though the study was conducted in vitro, these promising results suggest that this seawater solution could be a helpful option for alleviating cold symptoms.

Energy boost

Most Useful Review

This supplement energises me for the entire day and helps combat a common cold in just a few hours.

Rash details

Morali G, Polatti F, Metelitsa EN, Mascarucci P, Magnani P, et al. Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. Arzneimittelforschung. 2006;56:230.

Based on 5 Researches

Hyaluronic acid gel shows promise

We examined the effects of a gel containing hyaluronic acid on women experiencing vaginal atrophy symptoms after menopause. The pilot and multicenter studies involved 110 postmenopausal participants using the gel both externally and vaginally. Results showed significant improvements in vaginal dryness, burning, itching, and rash from the first week of treatment, without any reported adverse effects. Overall, the gel was well-accepted and demonstrated promise as a safe alternative to traditional hormone replacement therapies.

Effective for skin

Most Useful Review

18 people found this helpful

This product is brilliant! My facial skin improved significantly during usage, with rashes vanishing and joint pain resolving. I alternate between two months of intake and two months of rest. If you found this review helpful, please like it :)

Frozen Shoulder details

No additional benefits from HA injections

Questionable

Based on 16 Researches

Hsieh LF, Hsu WC, Lin YJ, Chang HL, Chen CC, et al. Addition of intra-articular hyaluronate injection to physical therapy program produces no extra benefits in patients with adhesive capsulitis of the shoulder: a randomized controlled trial. Arch Phys Med Rehabil. 2012;93:957. doi:10.1016/j.apmr.2012.01.021

We examined whether adding hyaluronic acid (HA) injections to physical therapy (PT) could improve outcomes for patients with frozen shoulder. In a well-structured study, 70 participants were divided into two groups—with one receiving HA injections alongside PT, while the other focused solely on PT.

After assessing their shoulder movement, pain, and quality of life, we found no significant extra benefits from the HA injections. This suggests that continuing with just PT could be a more cost-effective approach for managing this condition.

Healed shoulder

Most Useful Review

3 people found this helpful

I cannot recommend this product highly enough. I've often hurt my shoulder during workouts, and this product has consistently helped restore it to normal. The addition of L-Proline is beneficial! It's ideal for maintaining healthy joints, particularly shoulders and knees.

Autoimmune Disorder details

Zeng Y, Wu L, Jiang X, Hu Y, Jin Y, et al. Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis. Int J Pharm. 2025;669:125073. doi:10.1016/j.ijpharm.2024.125073

Based on 16 Researches

Hyaluronic acid shows promise

We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.

8.5

Joint mobility improved

Most Useful Review

74 people found this helpful

I have taken Hyaluronic acid 100 mg from Now for 1.5 years, a tablet daily after meals. I take it after other supplements to improve cartilage quality, joint mobility, and skin hydration while reducing wrinkles. I exercise regularly and maintain an active lifestyle. Hyaluronic acid helps alleviate stress on my joints, and I recommend it for daily use thanks to its quality and performance, especially after the age of 35.

Cold details

Joint pain alleviated

1 people found this helpful

The product is of excellent quality and easily absorbed; the 100 mg dosage is perfect for supporting joint and skin health. There are no unnecessary additives, which matters greatly to me. There's hardly any taste, making it easy to consume. After 2-3 weeks of use, I observed significant improvements: minor joint discomfort disappeared, making mobility much easier. My skin is more hydrated, looking smoother and radiant. Notably, dryness has vanished, even in the cold season. This is truly a fantastic product for maintaining both joint and skin health.

Blurred Vision details

Enhances skin and vision

After taking this supplement, my joint pain ceased, and the crunching stopped. I've noticed my vision benefits, and my facial skin looks rejuvenated and youthful. This product has exceeded my expectations in multiple aspects.

Leg Cramps details

1 people found this helpful

An effective drug! This product has shown great results. After a month of intake, my knees no longer crunched during squats, and my legs feel revitalised. Walking has become effortless, and I no longer experience fatigue in my joints. I intend to continue taking it regularly.

Flu details