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Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (100% as Beta-Carotene)(from Blakeslea trispora and Sunflower Oil)
7,500 mcg
833%
The product is found useful for the following medical conditions
Acne
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 20 Reviews
8.7
9.5
Vitamin A's effectiveness in acne
The role of vitamins and nutrients in rosacea.
Most Relevant Research
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
9.5
Natural and effective
Most Useful Review
GREAT alternative to synthetic Vitamin A. I’ve dealt with acne for years, and this has helped considerably without the negative side effects associated with synthetic options. It’s pure, natural, and I don’t want to be without it. A great brand too!
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.7
9.5
Effective against colds
Most Useful Review
This has been effective for preventing colds in the throat and nose. During the summer air-conditioning season and in the cold winter, I frequently suffered from pharyngitis and acute sinusitis. I learned this ingredient is great for strengthening mucous membranes, so I started taking it daily, and now I hardly ever catch a cold in my throat or nose!
Eczema
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.4
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Alitretinoin improves eczema treatment
The Endogenous Dual Retinoid Receptor Agonist Alitretinoin Exhibits Immunoregulatory Functions on Antigen-Presenting Cells.
Most Relevant Research
We explored the effects of alitretinoin, a form of vitamin A, on chronic hand eczema (CHE). This powerful drug is known to target specific receptors in the skin, offering insights into its method of action. Through our detailed study, we examined skin samples from patients who responded well to alitretinoin treatment.
Our analysis revealed a total of 231 genes that were markedly regulated. We found that alitretinoin primarily impacts keratinocytes, the skin's primary cells, by addressing inflammation and enhancing skin barrier function. This treatment improved the expression of certain protective proteins while fostering the production of hyaluronic acid, a substance that helps hydrate and soothe the skin.
Furthermore, we observed that alitretinoin also affects immune cells, particularly dendritic cells, which play a vital role in our immune response. These cells, when treated with alitretinoin, displayed unique alterations in their appearance and function. They had lower levels of specific markers that typically spur an immune response and stimulated the production of IL-10, a cytokine that promotes immune tolerance. Most impressively, these treated cells were less effective at activating T cells, which are crucial for initiating inflammation.
Our findings indicate that alitretinoin not only treats the visible symptoms of eczema but also helps regulate the immune response, providing a dual approach in the management of chronic hand eczema. Ultimately, these insights show that vitamin A treatment holds significant promise for improving outcomes in eczema patients.
Our analysis revealed a total of 231 genes that were markedly regulated. We found that alitretinoin primarily impacts keratinocytes, the skin's primary cells, by addressing inflammation and enhancing skin barrier function. This treatment improved the expression of certain protective proteins while fostering the production of hyaluronic acid, a substance that helps hydrate and soothe the skin.
Furthermore, we observed that alitretinoin also affects immune cells, particularly dendritic cells, which play a vital role in our immune response. These cells, when treated with alitretinoin, displayed unique alterations in their appearance and function. They had lower levels of specific markers that typically spur an immune response and stimulated the production of IL-10, a cytokine that promotes immune tolerance. Most impressively, these treated cells were less effective at activating T cells, which are crucial for initiating inflammation.
Our findings indicate that alitretinoin not only treats the visible symptoms of eczema but also helps regulate the immune response, providing a dual approach in the management of chronic hand eczema. Ultimately, these insights show that vitamin A treatment holds significant promise for improving outcomes in eczema patients.
10
Fast eczema relief
Most Useful Review
This pill cleared my eczema in just days! I have both eczema and seborrheic dermatitis and did my research that indicated vitamin A could help. Although I’ve only been taking it for a few days, my eczema is 90% cleared, my scalp is less itchy, and even the rosacea on my cheeks is much calmer. It's remarkable how much my skin has improved in less than a week!
Ear Infection
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Lung infection remedy
Most Useful Review
A safe way to clear a green lung infection. Years ago, I didn't want antibiotics, so I took six NOW Beta-Carotene pills multiple times a day, and my lung infection cleared up without medication. Now my husband and I use these regularly for prevention and increase the dosage when necessary, staying healthy since.
Skin Cancer
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Good
Based on 1 Review
8.5
8
Vitamin A derivatives fight skin cancer
The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review.
Most Relevant Research
We delved into the effects of retinoids, which are natural and synthetic derivatives of vitamin A, on skin cancer prevention and treatment. Non-melanoma skin cancers (NMSCs), a diverse group encompassing basal cell carcinoma and cutaneous squamous cell carcinoma, create significant challenges for patients and healthcare systems alike.
Through a comprehensive review, we observed how retinoids operate within the skin by influencing critical biological processes such as cell growth, differentiation, blood vessel formation, and immune responses. This modulation contributes to the suppression of skin cancer development.
Both topical and systemic forms of retinoids have been rigorously tested in clinical trials, showing promising efficacy and tolerability. As a result, regulatory authorities have sanctioned their use in managing NMSCs. Additionally, we noted acceptable off-label applications, expanding our understanding of these compounds in oncology.
Overall, our review highlighted the biochemistry of retinoids, their beneficial effects on skin physiology, and their therapeutic potential in clinical settings. This paints a hopeful picture for those at risk of or battling skin cancers.
Through a comprehensive review, we observed how retinoids operate within the skin by influencing critical biological processes such as cell growth, differentiation, blood vessel formation, and immune responses. This modulation contributes to the suppression of skin cancer development.
Both topical and systemic forms of retinoids have been rigorously tested in clinical trials, showing promising efficacy and tolerability. As a result, regulatory authorities have sanctioned their use in managing NMSCs. Additionally, we noted acceptable off-label applications, expanding our understanding of these compounds in oncology.
Overall, our review highlighted the biochemistry of retinoids, their beneficial effects on skin physiology, and their therapeutic potential in clinical settings. This paints a hopeful picture for those at risk of or battling skin cancers.
8
Cat's ear healed
Most Useful Review
Worked for the cat. These capsules served their intended purpose, earning a 5-star rating. A cat was abandoned on our property, and after a vet visit, he started living in our breezeway to avoid bullies. This cat has one white ear, which unfortunately gets sunburned, leading to skin cancer. Thankfully, the vet caught the ear's sun damage early, advising a daily dose of beta-carotene or vitamin A. I opted for beta-carotene due to the distance to the vet for blood tests. I applied two capsules to the cat's food every morning and evening, with strict outdoor time restrictions to prevent sunbathing. Within two months, the ear healed, and he's now allowed out for limited time only, with no sun exposure.
Cataract
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.9
USERS' SCORE
Good
Based on 1 Review
8.4
9.5
Vitamin A improves post-surgery vision
Case of persistent corneal epithelial damage after cataract surgery leading to diagnosis of vitamin A deficiency.
Most Relevant Research
We analyzed a case involving a 74-year-old man who experienced ongoing blurred vision after cataract surgery. His condition included persistent damage to the corneal epithelium, which raised concerns over the underlying reasons for his visual impairment.
To investigate, we recorded his full-field electroretinograms (ff-ERGs) to assess both scotopic and photopic responses of the retina. We also performed optical coherence tomography (OCT) to visualize changes in his retinal structure. Laboratory tests revealed a critically low level of vitamin A in his blood.
Given these findings, we diagnosed him with vitamin A deficiency (VAD) and initiated treatment with oral vitamin A supplements. Remarkably, after three months, we noted significant improvements: his visual acuity, ff-ERGs, and OCT results returned to normal. This highlighted the potential of vitamin A in managing visual issues related to cataract surgery.
Our findings suggest that vitamin A plays an important role in recovery from eye surgeries, especially for patients like him who experience corneal damage and impaired vision. We believe this case underscores the importance of monitoring vitamin A levels in patients presenting with similar complications.
To investigate, we recorded his full-field electroretinograms (ff-ERGs) to assess both scotopic and photopic responses of the retina. We also performed optical coherence tomography (OCT) to visualize changes in his retinal structure. Laboratory tests revealed a critically low level of vitamin A in his blood.
Given these findings, we diagnosed him with vitamin A deficiency (VAD) and initiated treatment with oral vitamin A supplements. Remarkably, after three months, we noted significant improvements: his visual acuity, ff-ERGs, and OCT results returned to normal. This highlighted the potential of vitamin A in managing visual issues related to cataract surgery.
Our findings suggest that vitamin A plays an important role in recovery from eye surgeries, especially for patients like him who experience corneal damage and impaired vision. We believe this case underscores the importance of monitoring vitamin A levels in patients presenting with similar complications.
7.5
Vision improvement
Most Useful Review
This product works wonders for sharpening vision. I have a cataract, and it has significantly slowed its progression and enhanced the vision in my good eye.
Nausea
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 1 Review
8.2
8
Vitamin A reduces pregnancy nausea
Vitamin A or beta-carotene supplementation reduces symptoms of illness in pregnant and lactating Nepali women.
Most Relevant Research
We conducted a double-masked, placebo-controlled trial involving 15,832 Nepali women to explore how vitamin A and beta-carotene supplementation affects pregnancy-related nausea and overall illness symptoms. Our observations showed that while there was no noticeable impact during the early stages of pregnancy, vitamin A supplementation made a significant difference in late pregnancy.
Specifically, we found that women who received vitamin A experienced a reduction in nausea. Additionally, symptoms such as faintness and night blindness were also less prevalent in those women. Beta-carotene supplementation did not yield the same benefits for nausea, highlighting the unique role of vitamin A in managing these symptoms.
Moreover, supplementation with vitamin A contributed to a shorter labor duration, which is promising for expectant mothers. It also helped reduce the postpartum risks of conditions like night blindness and loose stools. Overall, our findings indicate that ensuring adequate vitamin A intake can be important for improving reproductive health in women, particularly in areas with limited healthcare access.
Specifically, we found that women who received vitamin A experienced a reduction in nausea. Additionally, symptoms such as faintness and night blindness were also less prevalent in those women. Beta-carotene supplementation did not yield the same benefits for nausea, highlighting the unique role of vitamin A in managing these symptoms.
Moreover, supplementation with vitamin A contributed to a shorter labor duration, which is promising for expectant mothers. It also helped reduce the postpartum risks of conditions like night blindness and loose stools. Overall, our findings indicate that ensuring adequate vitamin A intake can be important for improving reproductive health in women, particularly in areas with limited healthcare access.
4.8
Helps skin
Most Useful Review
The supplement doesn't assist with tanning, but it does have dietary benefits. I've taken it daily for almost a month with no change in my skin tone, although my skin feels rejuvenated. It may have caused a bit of nausea as I have a sensitive stomach.
Headache
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
8
Vitamin A toxicity's impact on headaches
A Rare Case Report of Benign Intracranial Hypertension Caused by Hypervitaminosis A.
Most Relevant Research
We examined a rare case involving a 13-year-old girl who experienced symptoms of headache and visual disturbances due to benign intracranial hypertension (BIH) related to vitamin A toxicity. This condition was characterized by elevated pressure inside her skull, which led to her experiencing severe headaches, photophobia, and vomiting.
After conducting various tests, including magnetic resonance imaging and a lumbar puncture, we confirmed the diagnosis of BIH. Treatment was initiated with acetazolamide, a medication commonly used to reduce intracranial pressure. Although the study primarily focuses on the condition resulting from vitamin A excess, the use of acetazolamide makes it challenging to isolate the effect of vitamin A on headache relief specifically.
What's particularly noteworthy in this case is the significant elevation of serum vitamin A levels, which aligned with her symptoms. Following treatment, this patient showed a remarkable clinical improvement, including a reduction in papilledema during regular eye check-ups. Within just two weeks after starting treatment, she was discharged symptom-free, highlighting how important it is to consider vitamin A levels in children presenting with similar symptoms.
This case serves as a reminder for clinicians regarding the potential consequences of vitamin A toxicity, especially when evaluating children with headaches correlated to papilledema.
After conducting various tests, including magnetic resonance imaging and a lumbar puncture, we confirmed the diagnosis of BIH. Treatment was initiated with acetazolamide, a medication commonly used to reduce intracranial pressure. Although the study primarily focuses on the condition resulting from vitamin A excess, the use of acetazolamide makes it challenging to isolate the effect of vitamin A on headache relief specifically.
What's particularly noteworthy in this case is the significant elevation of serum vitamin A levels, which aligned with her symptoms. Following treatment, this patient showed a remarkable clinical improvement, including a reduction in papilledema during regular eye check-ups. Within just two weeks after starting treatment, she was discharged symptom-free, highlighting how important it is to consider vitamin A levels in children presenting with similar symptoms.
This case serves as a reminder for clinicians regarding the potential consequences of vitamin A toxicity, especially when evaluating children with headaches correlated to papilledema.
0
Causes headaches
Most Useful Review
Terrible product causes headaches; the dose is far too high and can lead to very bad toxicity.
Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.2
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.4
8
Retinoic acid enhances glioma treatment
Retinoic acid-induced alterations enhance eATP-mediated anti-cancer effects in glioma cells: Implications for P2X7 receptor variants as key players.
Most Relevant Research
We investigated how retinoic acid (RA), a derivative of vitamin A, could influence cancer treatment, particularly in glioma, a type of brain tumor. Previous attempts to use RA as a therapeutic option were inconclusive, so we aimed to explore its effects alongside extracellular ATP (eATP) to harness their combined potential.
Our experiments examined two human glioma cell lines, M059K and M059J, to see how they responded to RA-based differentiation. Notably, this process led to changes in the expression of a receptor called P2X7 and reduced the activity of enzymes that break down nucleotides. These modifications contributed to a significant decrease in cell proliferation and migration abilities, as well as an increased sensitivity to the effects of eATP.
Specifically, we found that in the presence of eATP, cell viability decreased by up to 40% in RA-treated M059K cells and 20% in M059J cells. Migration capabilities of the cells were reduced by as much as 60% when exposed to a specific concentration of ATP, showing that the P2X7 receptor plays a major role in mediating these effects.
Our observations suggest that combining retinoic acid with eATP can have anti-cancer benefits by influencing purinergic signaling pathways in glioma cells. This points to the need for further exploration of P2X7 receptor variants as potential therapeutic targets for treating glioma.
Our experiments examined two human glioma cell lines, M059K and M059J, to see how they responded to RA-based differentiation. Notably, this process led to changes in the expression of a receptor called P2X7 and reduced the activity of enzymes that break down nucleotides. These modifications contributed to a significant decrease in cell proliferation and migration abilities, as well as an increased sensitivity to the effects of eATP.
Specifically, we found that in the presence of eATP, cell viability decreased by up to 40% in RA-treated M059K cells and 20% in M059J cells. Migration capabilities of the cells were reduced by as much as 60% when exposed to a specific concentration of ATP, showing that the P2X7 receptor plays a major role in mediating these effects.
Our observations suggest that combining retinoic acid with eATP can have anti-cancer benefits by influencing purinergic signaling pathways in glioma cells. This points to the need for further exploration of P2X7 receptor variants as potential therapeutic targets for treating glioma.
2.5
Cancer risk increase
Most Useful Review
Be warned. A large study concluded that supplementation with this nutrient increases the risk of lung cancer. Google for more details.
