Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)
25 mg
6%
The product is found useful for the following medical conditions
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
USERS' SCORE
Good
Based on 39 Reviews
8.9
9
Vitamin B6 treatment alleviates anxiety
Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring.
Most Relevant Research
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
9.5
Improved mental stability
Most Useful Review
Mental stability! This supplement is absolutely essential. Taking it has virtually eliminated my vague anxiety. After discovering my deficiency in vitamin B6, I've been using it regularly. Although I have a panic disorder, I no longer experience anxiety about anticipation or agoraphobia, and my sleep has significantly improved.
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
USERS' SCORE
Good
Based on 13 Reviews
8.9
8
Vitamin B6 shows promise in liver disease
Vitamin B6 Metabolic Pathway is Involved in the Pathogenesis of Liver Diseases via Multi-Omics Analysis.
Most Relevant Research
We explored the effects of vitamin B6 on liver diseases, particularly looking at its potential benefits in patients with liver cirrhosis and hepatocellular carcinoma (HCC). The study involved analyzing tissue and plasma samples from 44 HCC patients and 28 patients with advanced liver cirrhosis. To gain deeper insights, researchers conducted microbiome, metabolome, and proteome analyses.
Our findings indicated significant differences in bacterial communities between cancerous and non-cancerous tissues. Notably, certain metabolites were found to be better diagnostic markers for HCC than traditional tests, showcasing the potential of metabolomics in liver disease detection. Most importantly, when researchers tested vitamin B6 in a mouse model of chronic liver injury induced by carbon tetrachloride, they observed improvements in liver health. Vitamin B6 treatment reduced inflammation and cellular damage in the liver.
Overall, this study highlights the promise of vitamin B6 as part of a therapeutic strategy for managing liver diseases, particularly in improving the condition of inflamed livers.
Our findings indicated significant differences in bacterial communities between cancerous and non-cancerous tissues. Notably, certain metabolites were found to be better diagnostic markers for HCC than traditional tests, showcasing the potential of metabolomics in liver disease detection. Most importantly, when researchers tested vitamin B6 in a mouse model of chronic liver injury induced by carbon tetrachloride, they observed improvements in liver health. Vitamin B6 treatment reduced inflammation and cellular damage in the liver.
Overall, this study highlights the promise of vitamin B6 as part of a therapeutic strategy for managing liver diseases, particularly in improving the condition of inflamed livers.
9.5
Gallstone relief
Most Useful Review
Helps dissolve gallstones. I found this B6 form effective in dissolving cholesterol stones in gallstones, including those with calcifications. Vitamin B6 enhances bile's capability to hold cholesterol. After the first treatment, solid crusts detached, accompanied by sand. A second session led to a small stone (0.5 cm) disappearing, while a 1 cm stone became soft. After the third course, no gallstones remained. Other vitamins and supplements supported my liver and digestion.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 39 Reviews
8.9
9.5
Sleep significantly improved
Most Useful Review
Best shape B6! The optimal form of vitamin B6. I take it with magnesium citrate, as they enhance each other’s effects. Together, they have significantly improved my sleep.
Autoimmune Disorder details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.7
8
Vitamin B6 improves cognitive function
The possible beneficial effects of higher vitamin B6 intake from diet on cognitive function of patients with neuromyelitis optica spectrum disorder.
Most Relevant Research
We conducted an intriguing study that looked into how vitamin B6 affects cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder often brings along cognitive challenges, so understanding potential dietary influences could be beneficial.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
9.5
Supports nervous system
Most Useful Review
P-5-P is an excellent form of vitamin B6 that provides superb support for the nervous system. This formulation offers a superior bioavailability and aids in combating nervous exhaustion. Our attending physician prescribed it for a severe cold alongside other medications. I ordered two packs at once and noticed marked improvements in my well-being, with no signs of depression and a revitalised nervous system.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 11 Reviews
8.7
10
Rapid recovery
Most Useful Review
This product has been very helpful for my tenosynovitis and tendonitis. I suffer from synovitis in multiple areas and wished to avoid surgery. After using it, I couldn’t believe how quickly my pain vanished. I initially ordered two packs and was so impressed that I ordered four more. It may be a little expensive but certainly worth it!
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.7
8
Vitamin B6 as glioblastoma target
Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.
Most Relevant Research
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
9.5
Reduces anxiety levels
Most Useful Review
This medication significantly improves my sleep and alleviates the persistent anxiety that troubled me. Now, I feel calm, and even my friends and family have noticed a dramatic change. This is due to 5-HTP enhancing the brain's serotonin production, leading to noticeable improvements in mood.
Cold Sores details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Effective sore throat relief
Most Useful Review
I purchased this for myself and I've been pleased with it. Previously, I took it as a picolinate, but this time opted for lozenges and I have no regrets. They have a pleasant taste and soothe my throat effectively. I often experience nausea with zinc in pharmaceutical forms, but these lozenges didn't cause that issue. If you do experience it, avoid taking them on an empty stomach. I notice the effect particularly when I take them at the onset of a sore throat every two hours—they significantly ease my discomfort. Highly recommended!
Kidney Stones details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.7
8
Vitamin B6 may lower kidney stones
Intake of vitamins B6 and C and the risk of kidney stones in women.
Most Relevant Research
We examined the relationship between vitamin B6 intake and kidney stone formation in women. This research involved over 85,000 women with no prior history of kidney stones, monitored over 14 years. The study utilized food-frequency questionnaires to track participants' dietary vitamin consumption from both food and supplements.
Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.
On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.
On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
9.5
Effective vitamin B6
Most Useful Review
This active form of vitamin B6 helps me relax and enhances my mood. Additionally, it prevents the formation of kidney stones and bile stones. If oxalates are already present, it's crucial to take R-5-R urgently! You can safely take it long-term, increasing the dosage to 100 mg per day. Vitamin B6, when combined with magnesium citrate and sodium ascorbate, dissolves oxalate stones or sand in the kidneys. By taking 300 mg/day, I can monitor my urine. Furthermore, it lowers histamine levels and aids with seasonal allergies, along with other health benefits.
Menopause details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.7
8
Vitamin B6 may delay menopause
Dietary intake and age at natural menopause: results from the UK Women's Cohort Study.
Most Relevant Research
We investigated how dietary factors, particularly vitamin B6, influence the timing of natural menopause in women. Our study focused on women aged 40 to 65 who completed a food frequency questionnaire and recorded their reproductive history.
Over a 4-year follow-up period, we found that a higher intake of vitamin B6 was associated with a delay in the onset of menopause. Specifically, each additional milligram of vitamin B6 consumed each day was linked with a postponement of menopause by 0.6 years. While this suggests that increasing vitamin B6 intake could be beneficial for delaying menopause, it’s important to note that this effect was not isolated from other dietary influences, which may complicate our understanding of its specific role.
We also observed that certain foods like oily fish and fresh legumes were associated with later menopause, while refined pasta and rice were linked to earlier menopause. Our findings underline the potential influence of diet on menopause timing, though we must approach the effects of vitamin B6 with the understanding that it may not act alone.
Over a 4-year follow-up period, we found that a higher intake of vitamin B6 was associated with a delay in the onset of menopause. Specifically, each additional milligram of vitamin B6 consumed each day was linked with a postponement of menopause by 0.6 years. While this suggests that increasing vitamin B6 intake could be beneficial for delaying menopause, it’s important to note that this effect was not isolated from other dietary influences, which may complicate our understanding of its specific role.
We also observed that certain foods like oily fish and fresh legumes were associated with later menopause, while refined pasta and rice were linked to earlier menopause. Our findings underline the potential influence of diet on menopause timing, though we must approach the effects of vitamin B6 with the understanding that it may not act alone.
9.5
Improved sleep quality
Most Useful Review
Dream recall indicates it's effective! I've taken this B6 form before bed for years, as low dream recall signals a deficiency. Since I am in menopause, this, along with Magnesium and bioidentical Progesterone, has restored rejuvenating sleep. I'm back to remembering my dreams almost nightly.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 2 Reviews
8.6
4
Vitamin B6 and CFS relationship
Vitamin B status in patients with chronic fatigue syndrome.
Most Relevant Research
We observed the functional status of vitamin B6, also known as pyridoxine, in patients suffering from chronic fatigue syndrome (CFS). Our study involved comparing 12 untreated CFS patients with 18 healthy individuals, matched for age and sex.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
8.8
Improved overall tone
Most Useful Review
Vitamin B6 in the form of P-5-P has become essential in my daily diet. This product has significantly eased my fatigue and enhanced my overall tone. Since I began taking vitamin B6, I’ve noticed improvements in memory and concentration. The capsules are easy to swallow and gentle on the stomach. Being vegetarian-friendly, there are no concerns about animal products. I recommend it to anyone aiming to improve their health.
Diabetes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Normalises blood sugar
Most Useful Review
P-5-P is a form of vitamin B6 that must be replenished since it is water-soluble and quickly excreted. This vital nutrient aids metabolic processes and the assimilation of proteins and fats, positively affecting skin condition. Additionally, pyridoxine enhances nervous system health, combats depression, mitigates anxiety, and bolsters the immune system. It also helps regulate blood sugar levels, thus reducing the risk of diabetes.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin B6 reduces cholesterol levels
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Most Relevant Research
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
9.5
Lowered prolactin levels
Most Useful Review
Diagnosed with severe osteoporosis, I began taking 150 mg of vitamin B6 daily upon reading about its effects on lowering prolactin. Remarkably, after 32 years, my prolactin test result normalised for the first time after a few weeks of B6. This vitamin, along with other B vitamins, was also suggested by osteoporosis expert Keith McCormick.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.6
8.8
Improves sleep quality
Most Useful Review
Vitamin B6 comes in a well-digestible formula, at a good dosage and reasonable price. I take it with magnesium to alleviate stress, enhance sleep quality, and manage occasional leg cramps. Noticeable results were evident within a week: my sleep improved, and my legs no longer twisted. I anticipate that after completing the full course, I will feel fine, as I have already experienced results after just a week of taking it!
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
Vitamin B6 shows promise for migraines
Pyridoxine, folate and cobalamin for migraine: A systematic review.
Most Relevant Research
We delved into the potential benefits of vitamin B6 (pyridoxine) in treating migraines, particularly in how it relates to other B vitamins like folate and B12. By examining various studies, we focused on the efficacy of B6 alone and in combination with these other vitamins.
The findings were intriguing! While the management of acute migraine attacks using these vitamins didn’t show promising results in one controlled trial, we noted significant benefits when B6 was used as a preventative measure. In several trials, B6 alone or combined with folate, or with both folate and B12, proved to be effective for adults suffering from migraine with aura—outperforming placebo treatments in most cases.
Interestingly, we also found that while folate as a standalone treatment didn’t yield better outcomes than placebo, the overall safety profile of these vitamins was quite good. Most participants reported only mild gastrointestinal side effects. However, we came across limited data regarding the effects of these vitamins on migraine without aura in both children and adults, making it difficult to draw broader conclusions.
In summary, our exploration of the role of vitamin B6 in migraine protection reveals its potential to aid adults with migraine with aura, though more thorough research is needed for other types, especially in younger populations.
The findings were intriguing! While the management of acute migraine attacks using these vitamins didn’t show promising results in one controlled trial, we noted significant benefits when B6 was used as a preventative measure. In several trials, B6 alone or combined with folate, or with both folate and B12, proved to be effective for adults suffering from migraine with aura—outperforming placebo treatments in most cases.
Interestingly, we also found that while folate as a standalone treatment didn’t yield better outcomes than placebo, the overall safety profile of these vitamins was quite good. Most participants reported only mild gastrointestinal side effects. However, we came across limited data regarding the effects of these vitamins on migraine without aura in both children and adults, making it difficult to draw broader conclusions.
In summary, our exploration of the role of vitamin B6 in migraine protection reveals its potential to aid adults with migraine with aura, though more thorough research is needed for other types, especially in younger populations.
9.5
Very helpful treatment
Most Useful Review
Great for migraines; I find taking two of these each day very beneficial for my migraines. There are no side effects, and I have been using them for years.
Tendonitis details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 2 Reviews
8.6
7
Vitamin B6 may aid tendonitis recovery
Blocking proteinase-activated receptor 2 signaling relieves pain, suppresses nerve sprouting, improves tissue repair, and enhances analgesic effect of B vitamins in rats with Achilles tendon injury.
Most Relevant Research
We explored how vitamin B6, part of the vitamin B complex, affects pain and healing after an Achilles tendon injury. The study focused on the role of proteinase-activated receptor 2 (PAR2) in chronic pain and tendon changes following a tendon injury.
Blocking PAR2 signaling was found to reduce pain, suppress unnecessary nerve growth, and encourage tissue repair. Additionally, vitamin B complex, which includes vitamin B6, helped alleviate pain and supported recovery in the injured tendons by working to suppress PAR2 activation.
By observing these findings, we understand that managing PAR2 could offer a promising route for improving treatment strategies for tendonitis. Overall, this study indicates that incorporating vitamin B6 into treatment regimens may help those suffering from tendon injuries, easing pain and enhancing healing.
Blocking PAR2 signaling was found to reduce pain, suppress unnecessary nerve growth, and encourage tissue repair. Additionally, vitamin B complex, which includes vitamin B6, helped alleviate pain and supported recovery in the injured tendons by working to suppress PAR2 activation.
By observing these findings, we understand that managing PAR2 could offer a promising route for improving treatment strategies for tendonitis. Overall, this study indicates that incorporating vitamin B6 into treatment regimens may help those suffering from tendon injuries, easing pain and enhancing healing.
9.5
Very useful
Most Useful Review
Very useful for treating tendonitis.
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Vitamin B6 aids allergy management
Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation.
Most Relevant Research
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
9.5
Effective treatment
Most Useful Review
Allergies are not an issue anymore. It has worked well.
Bloating details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
Vitamin B6 improves IBS symptoms
Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients.
Most Relevant Research
We conducted a controlled trial involving twenty-five patients diagnosed with Irritable Bowel Syndrome (IBS) to explore the effects of a unique combination of probiotics—Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001—along with vitamin B6 on gastrointestinal symptoms, particularly bloating.
Over a period of two months, we randomly assigned patients to receive either the probiotic combination with vitamin B6 or a placebo, ensuring that the study design was double-blind to eliminate bias. Throughout the study, we assessed symptoms, including abdominal pain and bloating, as well as the overall severity of IBS.
Remarkably, our findings revealed that the probiotic formulation significantly reduced bloating, showing a decrease of 36.35% compared to a slight increase with the placebo. This improvement also corresponded with reduced abdominal pain and improved intestinal health indicators. The probiotics not only alleviated bloating but also favored a healthier balance of gut bacteria, suggesting a positive overall impact on the IBS patients’ digestive wellness.
Although we cannot attribute effects solely to vitamin B6 since it was used in combination with probiotics, the results indicate that this formulation can improve symptoms associated with bloating and overall IBS severity. Thus, our study illuminates a potential approach for better managing IBS symptoms without relying solely on traditional medications.
Over a period of two months, we randomly assigned patients to receive either the probiotic combination with vitamin B6 or a placebo, ensuring that the study design was double-blind to eliminate bias. Throughout the study, we assessed symptoms, including abdominal pain and bloating, as well as the overall severity of IBS.
Remarkably, our findings revealed that the probiotic formulation significantly reduced bloating, showing a decrease of 36.35% compared to a slight increase with the placebo. This improvement also corresponded with reduced abdominal pain and improved intestinal health indicators. The probiotics not only alleviated bloating but also favored a healthier balance of gut bacteria, suggesting a positive overall impact on the IBS patients’ digestive wellness.
Although we cannot attribute effects solely to vitamin B6 since it was used in combination with probiotics, the results indicate that this formulation can improve symptoms associated with bloating and overall IBS severity. Thus, our study illuminates a potential approach for better managing IBS symptoms without relying solely on traditional medications.
8.8
Reduces bloating
Most Useful Review
Vitamin B6 (pyridoxine) is essential for over 100 enzymatic reactions in the body, including protein synthesis and the regulation of blood sugar levels. It is also important for the metabolism of estrogen and the production of key neurotransmitters like dopamine and adrenaline, along with detoxification processes involving glutathione. This vitamin can alleviate bloating and discomfort during the luteal phase (two weeks before menstruation) and help relieve PMS symptoms. Additionally, it may assist with low mood resulting from dietary deficiencies in this vitamin.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Vitamin B6 pathway affects cancer survival
Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.
Most Relevant Research
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
8.8
Energy improvement
Most Useful Review
I have cancer and have noticed a slight boost in my energy levels. The packaging was excellent, and the delivery was swift.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.9
USERS' SCORE
Good
Based on 4 Reviews
8.5
9
Vitamin B6 effectively battles depression
Vitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice.
Most Relevant Research
We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
9.5
Cognition and mood improvement
Most Useful Review
This product comes in an active form, and I take it with methyl folate and methyl cobalamin to improve my cognitive function and alleviate symptoms of depression. The results have been exceptional.
Food Poisoning details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Vitamin B6 mitigates food symptoms
The biochemistry of vitamin B6 is basic to the cause of the Chinese restaurant syndrome.
Most Relevant Research
We explored an intriguing connection between vitamin B6 and something called the Chinese Restaurant Syndrome, often linked to the consumption of monosodium L-glutamate (MSG). This study involved a group of 155 students who had not taken extra vitamin B6. By analyzing an enzyme called aspartate transaminase in their blood cells, we identified 27 individuals with notably low levels, which suggested they might have a vitamin B6 deficiency.
Among these 27 participants, we challenged them with glutamate and a placebo, where 12 recognized symptoms associated with the syndrome while 15 did not. Through a double-blind treatment over twelve weeks, we administered pyridoxine (a form of vitamin B6) and a placebo. After completing the treatment, we re-challenged them with glutamate.
We found that those who received pyridoxine showed a significant decrease in symptoms, proving treatment was effective for most of them. Specifically, only 3 of the 12 who received placebo experienced the symptoms again, while 8 of the 9 who had pyridoxine did not react to glutamate. Our results indicate a strong link between vitamin B6 levels and the management of symptoms tied to this syndrome, suggesting that vitamin B6 may play a critical role in enhancing our resilience against certain forms of food-related discomfort.
Among these 27 participants, we challenged them with glutamate and a placebo, where 12 recognized symptoms associated with the syndrome while 15 did not. Through a double-blind treatment over twelve weeks, we administered pyridoxine (a form of vitamin B6) and a placebo. After completing the treatment, we re-challenged them with glutamate.
We found that those who received pyridoxine showed a significant decrease in symptoms, proving treatment was effective for most of them. Specifically, only 3 of the 12 who received placebo experienced the symptoms again, while 8 of the 9 who had pyridoxine did not react to glutamate. Our results indicate a strong link between vitamin B6 levels and the management of symptoms tied to this syndrome, suggesting that vitamin B6 may play a critical role in enhancing our resilience against certain forms of food-related discomfort.
8
Effective protocol
Most Useful Review
Just what I need to combat trigger finger and carpal tunnel. The magnesium is beneficial as well. The protocol I follow requires 50mg three times a day with food, as advised by the doctor who examined my hands. So far, it seems effective in addressing these issues.
Nausea details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 10 Reviews
8.5
4
Vitamin B6 risks in pregnancy
The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review.
Most Relevant Research
We investigated the use of vitamin B6 as a common treatment for nausea and vomiting during pregnancy. There has been an ongoing discussion about how effective high doses of this vitamin actually are, and we wanted to shed light on this issue.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
10
Helpful for nausea
Most Useful Review
Helpful for nausea I did some research and found that pregnant women use P5P for nausea, so I tried it, because even though I’m not pregnant, I struggle with nausea, and it really works!
Blood Clot details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.4
9.5
High homocysteine management strategy
Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events.
Most Relevant Research
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
9.5
Reliable and effective
Most Useful Review
Excellent product! A neurologist recommended these capsules years ago. I order them every spring, as they significantly enhance blood vessel and nervous system function. The product's efficacy is clear, and I wholeheartedly recommend it for quality and affordability.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.3
7
Vitamin B6 may influence IBS symptoms
Low intake of vitamin B6 is associated with irritable bowel syndrome symptoms.
Most Relevant Research
We explored the relationship between vitamin B6 intake and the severity of symptoms in individuals with irritable bowel syndrome (IBS). Through a study involving 17 participants diagnosed with IBS according to the Rome II criteria, we gathered daily symptom reports and food intake logs over a week.
Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.
This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.
This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
8
Eases irritability
Most Useful Review
Very good! All vitamins have inactive forms that need to be converted in the body for absorption. Pyridoxal five phosphate is the most active form of vitamin B6, which the body absorbs effectively, unlike pyridoxine, and it includes magnesium as a cofactor. If you often feel irritable and anxious, this supplement might help address your problem. Please like, kind person 🙏🏻
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 3 Reviews
8.2
7
Pyridoxine improves skin hydration
Pyridoxine stimulates filaggrin production in human epidermal keratinocytes.
Most Relevant Research
We explored the effects of pyridoxine, a form of vitamin B6, on skin health, focusing particularly on its potential benefits for those struggling with acne. Our research indicates that pyridoxine plays a significant role in maintaining the function of the epidermis, the outermost layer of our skin.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
9.5
Smooth skin
Most Useful Review
I have excessive sebum, so I take it for acne care, and since it reduces sebum production, I can now enjoy smooth skin even in summer. If taken alongside pantothenic acid, the sebum production settles to the point of slight dryness.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.7
9
Vitamin B6 could aid insomnia
A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study.
Most Relevant Research
We set out to investigate how vitamin B6 contributes to improving sleep quality in individuals experiencing mild to moderate insomnia. Our study involved 40 participants who were given a combination treatment containing melatonin, vitamin B6, and extracts from various medicinal plants.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
7.5
Mind stability improvement
Most Useful Review
This has been beneficial for my insomnia and has helped stabilise my mind. Along with other supplements and dietary care, I can now fall asleep swiftly and maintain an optimistic outlook, positively influencing my interactions during the day.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.4
8
Vitamin B6 may aid migraines
Pyridoxine, folate and cobalamin for migraine: A systematic review.
Most Relevant Research
We explored how vitamin B6, along with other B vitamins like folate and B12, might help in preventing migraines. Through a thorough review of existing research, we discovered that while vitamin B6 showed some promise in reducing migraines with aura in adults, the results aren’t as clear-cut for individuals suffering from other forms of headaches. In fact, in the context of treating acute migraine attacks, the benefits of these vitamins have not been supported by strong evidence from studies.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
9.5
Memory improvement
Most Useful Review
I took it, my memory improved, and my headache went away.
