' 
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Calories
<5
Total Carbohydrate
<1 g
<1%**
Total Sugars
0 g
†
Includes 0 g Added Sugars
0%**
Xylitol
<1 g
†
Vitamin C (as Ascorbic Acid)
100 mg
111%
Zinc (elemental) (from 15 mg Zinc Bisglycinate) (TRAACS™)
3 mg
27%
Elderberry (10:1 Concentrate)(Sambucus nigra) (Fruit)
150 mg
†
The product is found useful for the following medical conditions
Cold Sores details
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.3
USERS' SCORE
Excellent
Based on 82 Reviews
9.2
9
Zinc cream alleviates cold sores
A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.
Most Relevant Research
We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.
Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.
As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.
As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
10
Miraculous throat improvement
Most Useful Review
My children began to recover remarkably faster! Viruses have stopped affecting their throats! Thanks to elderberry, zinc, and vitamins C and D, I am thrilled with the results. I discarded all other immunity products from local pharmacies. This simple yet effective composition is all my family needed during cold season. When my throat starts to ache, I suck this delightful pill, which is pleasantly tangy. Elderberry is well-known for its medicinal benefits, and zinc with vitamin C is invaluable!
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.6
USERS' SCORE
Good
Based on 29 Reviews
8.9
9
Vitamin C impacts autoimmune response
Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies.
Most Relevant Research
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
9.5
Great for throat
Most Useful Review
These pleasant throat lozenges have a slightly sour berry taste and are highly effective against sore throats and ARVI symptoms. My husband finds them especially beneficial. We take them alongside a throat spray, and the results are fantastic!
Constipation details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.8
8
Vitamin C's impact on constipation
Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms.
Most Relevant Research
We conducted a fully decentralized clinical trial to explore the effects of vitamin C on constipation symptoms. Participants who experienced functional constipation were randomly assigned to receive either Lactobacillus with vitamin C or vitamin C alone over a two-week treatment period. The study allowed us to gather data remotely, which is quite innovative and accessible.
Looking specifically at the results from the group that received vitamin C, we observed that while there was an increase in the frequency of bowel movements compared to the control group, the isolated effect of vitamin C itself wasn't entirely clear. The combination treatment appeared to improve bowel regularity, but it was difficult to determine how much vitamin C contributed independently to these results.
Additionally, we found that about 67% of participants were diligent in tracking their bowel diary entries, which helped ensure the reliability of our findings to an extent. Yet, a significant portion of the records were not kept as scheduled, highlighting potential hurdles in data collection for decentralized trials.
Overall, our observations suggest that while vitamin C, especially when paired with Lactobacillus, may provide some benefits for those struggling with constipation, we should exercise caution before attributing all improvements solely to vitamin C.
Looking specifically at the results from the group that received vitamin C, we observed that while there was an increase in the frequency of bowel movements compared to the control group, the isolated effect of vitamin C itself wasn't entirely clear. The combination treatment appeared to improve bowel regularity, but it was difficult to determine how much vitamin C contributed independently to these results.
Additionally, we found that about 67% of participants were diligent in tracking their bowel diary entries, which helped ensure the reliability of our findings to an extent. Yet, a significant portion of the records were not kept as scheduled, highlighting potential hurdles in data collection for decentralized trials.
Overall, our observations suggest that while vitamin C, especially when paired with Lactobacillus, may provide some benefits for those struggling with constipation, we should exercise caution before attributing all improvements solely to vitamin C.
10
Constipation relief
Most Useful Review
The quality is excellent, and the ingredients are the finest. My health has improved significantly, and the supplement is just what I needed. The packaging is good, and I have noticed benefits in my digestion. My microbiome is better, absorption has increased, and my intestines function well. Constipation is no longer an issue. The dosage is perfect, and the taste is enjoyable.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.8
9
Zinc reduces migraine symptoms
Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
10
Headache relief
Most Useful Review
Good composition, fast delivery, high-quality packaging, with nothing damaged. The dosage is excellent, made from natural herbal ingredients. The capsules are slightly large, but swallowing them is not an issue, and they have a citrus flavour that I enjoy. I take one capsule daily with my meals alongside vitamin D3+K2, magnesium, and vitamin B6. After just 10 days, I've noticed significant benefits; my energy has increased, headaches have ceased, and my mood remains positive during the day. I highly recommend this product, especially for those engaged in sports, fitness, or maintaining a diet, as omega-3 truly energises and replenishes what the body needs.
Laryngitis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.8
9.5
Effective cold remedy
Most Useful Review
An excellent remedy for the first signs of a cold, laryngitis, sore throat, and more. It locally removes the inflammatory process and is suitable for both children and adults. With a pleasant sweet taste, anyone who has experienced elderberry knows its benefits. I always keep it in my first aid kit as a superb alternative to pharmacy "pacifiers" that only alleviate symptoms without providing a cure. I definitely recommend it!
Tonsillitis details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 8 Reviews
8.8
9
Zinc in supplement reduces tonsillitis symptoms
The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.
Most Relevant Research
This study took a closer look at the effects of a dietary supplement, PediaFlù, which includes honey, propolis, and zinc, on children suffering from acute tonsillopharyngitis, a common throat infection. We explored how well this supplement worked alongside standard care compared to standard care alone over six days.
The results were quite encouraging! We found that children who received the supplement alongside standard treatment reported lower throat pain and erythema (redness of the throat) by day six. There were also improvements in swallowing and overall throat severity scores by days four and six. Interestingly, only one child in the standard care group needed additional treatment with ibuprofen, suggesting that the supplement may help alleviate symptoms effectively.
However, it's important to note that while zinc was part of this combination treatment, the study focused on the overall effect of all components together. We couldn't isolate zinc's individual impact on tonsillitis specifically. That said, the findings point to the possibility of using this dietary supplement as a helpful adjunct in treating upper respiratory tract infections, which may reduce unnecessary antibiotic use in pediatric care.
The results were quite encouraging! We found that children who received the supplement alongside standard treatment reported lower throat pain and erythema (redness of the throat) by day six. There were also improvements in swallowing and overall throat severity scores by days four and six. Interestingly, only one child in the standard care group needed additional treatment with ibuprofen, suggesting that the supplement may help alleviate symptoms effectively.
However, it's important to note that while zinc was part of this combination treatment, the study focused on the overall effect of all components together. We couldn't isolate zinc's individual impact on tonsillitis specifically. That said, the findings point to the possibility of using this dietary supplement as a helpful adjunct in treating upper respiratory tract infections, which may reduce unnecessary antibiotic use in pediatric care.
10
Effective treatment
Most Useful Review
Tasty and effective for a sore throat! I’ve used this elderberry product on multiple occasions, and it’s proven to be highly effective for early tonsillitis symptoms. Almost immediately after dissolving, my sore throat is alleviated, and the cold itself subsides quickly. A high-quality remedy; I highly recommend it!
Athlete’s Foot details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
USERS' SCORE
Good
Based on 4 Reviews
8.7
9.5
Zinc aids athlete's foot treatment
Efficacy of undecylenic acid-zinc undecylenate powder in culture positive tinea pedis.
Most Relevant Research
We explored the effectiveness of a powder containing 2% undecylenic acid and 20% zinc undecylenate for treating athlete's foot, also known as tinea pedis. In a double-blind study, 151 participants were assigned to apply either the active powder or a placebo twice daily for four weeks. The results were telling.
From the 85 patients with confirmed fungal infections, a remarkable 88% of those using the active powder had negative cultures after the treatment, compared to only 17% in the placebo group. Additionally, 80% of those on the active treatment were found to be free of fungus in KOH skin scrapings after four weeks, while only 49% of placebo users achieved this. Furthermore, we observed significant improvement in symptoms like itching, burning, erythema, and scaling, with no side effects reported.
Overall, our findings indicate that the combination of undecylenic acid and zinc may offer a robust solution for individuals suffering from athlete's foot, effectively reducing fungal presence and alleviating uncomfortable symptoms. However, it is important to note that while zinc played a role in this combination treatment, we cannot fully assess its isolated effect on its own without further studies.
From the 85 patients with confirmed fungal infections, a remarkable 88% of those using the active powder had negative cultures after the treatment, compared to only 17% in the placebo group. Additionally, 80% of those on the active treatment were found to be free of fungus in KOH skin scrapings after four weeks, while only 49% of placebo users achieved this. Furthermore, we observed significant improvement in symptoms like itching, burning, erythema, and scaling, with no side effects reported.
Overall, our findings indicate that the combination of undecylenic acid and zinc may offer a robust solution for individuals suffering from athlete's foot, effectively reducing fungal presence and alleviating uncomfortable symptoms. However, it is important to note that while zinc played a role in this combination treatment, we cannot fully assess its isolated effect on its own without further studies.
9.5
Effective for all
Most Useful Review
I liked the medicine very much; it is suitable for both adults and children, and it quickly helps you recover in case of illness. It tastes good, and I have used it multiple times; it consistently aids my recovery.
Bronchitis details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.3
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Zinc accelerates bronchiolitis recovery
Zinc sulphate for acute bronchiolitis: A double-blind placebo-controlled trial.
Most Relevant Research
We investigated the effectiveness of zinc sulphate in treating acute bronchiolitis in children, aiming to uncover whether this supplement could help speed recovery. In our study, we closely examined 100 young patients diagnosed with the condition. Half of the children received oral zinc sulphate while the other half received a placebo.
Over the course of the treatment, we compared the clinical signs and symptoms between the two groups at several intervals: 24, 48, 72, 96, and 120 hours after starting. Encouragingly, we observed that those in the zinc group showed a more favorable trend in recovery compared to the placebo group across all time points. Notably, significant differences were noted in improvements of coughing and wheezing at the 48 and 72-hour marks.
Remarkably, we found that 98% of the children who received zinc sulphate achieved full recovery within 72 hours of treatment—indicating a rapid response to the therapy. Our findings suggest that zinc sulphate can notably accelerate the improvement of clinical symptoms in acute bronchiolitis. Therefore, we feel confident recommending zinc sulphate as a helpful treatment option for this condition.
Over the course of the treatment, we compared the clinical signs and symptoms between the two groups at several intervals: 24, 48, 72, 96, and 120 hours after starting. Encouragingly, we observed that those in the zinc group showed a more favorable trend in recovery compared to the placebo group across all time points. Notably, significant differences were noted in improvements of coughing and wheezing at the 48 and 72-hour marks.
Remarkably, we found that 98% of the children who received zinc sulphate achieved full recovery within 72 hours of treatment—indicating a rapid response to the therapy. Our findings suggest that zinc sulphate can notably accelerate the improvement of clinical symptoms in acute bronchiolitis. Therefore, we feel confident recommending zinc sulphate as a helpful treatment option for this condition.
9.5
Rapid recovery experienced
Most Useful Review
I want to share my impressions of these pastilles. I was sceptical about immunity pills. Having chronic tonsillitis, I frequently fell ill. After taking these vitamins, my husband and child both fell ill. I gave them the lozenges—my husband recovered in a week, my child bounced back in 2 days, and I remained healthy, which was surprising. Highly recommend!
Diabetes details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
Zinc alleviates diabetic muscle atrophy
Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39.
Most Relevant Research
Our investigation aimed to understand how zinc affects muscle atrophy in diabetes, a serious complication that leads to muscle loss. Using diabetes-induced mice, we treated them with zinc sulfate for six weeks and observed notable improvements in their muscle condition.
We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.
Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.
We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.
Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.
9.5
Cold symptoms relief
Most Useful Review
I bought this for my son, who has a decade of experience managing diabetes. An endocrinologist recommended it. The results were swift; while on holiday, he took one lozenge daily, and by the second evening, his cold symptoms vanished. Typically, it takes longer to recover even with a high dose of vitamin C. I highly recommend this; it will now be a staple in our home first aid kit.
Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.7
8
Elderberry reduces cold duration
Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial.
Most Relevant Research
We explored whether elderberry could help reduce the duration and severity of colds for economy class passengers traveling internationally. In a well-structured randomized, double-blind, placebo-controlled clinical trial involving 312 participants, we looked at how a standardized elderberry extract affected respiratory health during air travel.
Participants tracked their cold episodes, duration, and symptoms in daily diaries, using a scoring method to quantify their experiences. They also completed surveys about their upper respiratory symptoms and quality of life at different points: before traveling and four days post-travel.
While we noted that the group taking the placebo experienced more cold episodes, the difference wasn't statistically significant. However, those taking elderberry had a significantly shorter duration of cold days and a lower average symptom score overall, suggesting that elderberry may significantly lessen the impact of colds during air travel.
Further research is essential to validate our findings and to better understand the broader health benefits of elderberry, both physical and mental.
Participants tracked their cold episodes, duration, and symptoms in daily diaries, using a scoring method to quantify their experiences. They also completed surveys about their upper respiratory symptoms and quality of life at different points: before traveling and four days post-travel.
While we noted that the group taking the placebo experienced more cold episodes, the difference wasn't statistically significant. However, those taking elderberry had a significantly shorter duration of cold days and a lower average symptom score overall, suggesting that elderberry may significantly lessen the impact of colds during air travel.
Further research is essential to validate our findings and to better understand the broader health benefits of elderberry, both physical and mental.
9.5
Prevention of colds
Most Useful Review
Great defence/update. I've been taking this product since 2020 and realised I haven't had a cold. I can't say it's the only reason, but I believe it played a part. I took it faithfully for a while, then slacked off a bit. However, whenever I notice a scratchy throat or a sniffle, I take it for a few days and all is well again. I shall never run out of Sambucus Zinc-C with elderberry. Update: 10/22. I work with young children daily, so it's crucial to keep my immune system functioning at its best. I haven't had a cold since I started this product. I can't credit it entirely, but I double up when I feel symptoms and the next day I'm fine. I've even introduced it to my colleagues.
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.4
USERS' SCORE
Good
Based on 9 Reviews
8.6
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
Most Relevant Research
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
9.5
Stopped nasal allergy
Most Useful Review
I initially bought this product for vitamin C supplementation as I have nasal allergies. After taking 1 pill, I was amazed that I stopped begging from it. I take 1 pill every day when I wake up, and my nose feels much better.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 16 Reviews
8.6
9.5
Immediate relief found
Most Useful Review
How did I live without these lozenges? They are fantastic, providing immediate relief for my throat, and the bone pain subsides instantly. They’re also enjoyable; even my 4-year-old loves them. I definitely recommend purchasing them!
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 15 Reviews
8.6
9
Zinc counters heart cell injury
Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation.
Most Relevant Research
We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
9.5
Effective complex
Most Useful Review
This SUPER COMPLEX has significantly boosted my immunity. The combination of zinc, vitamin C, and elderberry is remarkable. I've found that increasing the dosage at the first sign of a cold leads to noticeable relief often within a day. I consistently take them for both myself and my parents, and I appreciate the convenience of needing only one tablet per day for prevention.
Chest Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.4
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
Vitamin C improves coronary response
Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing.
Most Relevant Research
We explored the effects of vitamin C on chest pain in chronic smokers experiencing endothelial dysfunction. In our study, 31 patients, who were undergoing diagnostic catheterization without significant coronary artery issues, participated in a controlled trial. They were given either an IV infusion of 3 grams of ascorbic acid (vitamin C) or a placebo saline solution before undergoing a cold pressor test to assess their coronary artery response.
The results were telling. Smokers typically showed a decrease in luminal area—an indicator of blood flow—during the cold pressor test. However, after infusing vitamin C, this response shifted positively, demonstrating improved blood flow through a vasodilation effect. On the other hand, those who received the placebo did not experience significant changes.
This means that for chronic smokers, acute administration of vitamin C appears to enhance the function of the endothelium, which is vital for proper blood vessel health and managing chest pain. Ultimately, we observed that vitamin C may help prevent the inactivation of nitric oxide, a compound that supports healthy blood flow, and this effect could be crucial for managing cardiovascular health in smokers.
The results were telling. Smokers typically showed a decrease in luminal area—an indicator of blood flow—during the cold pressor test. However, after infusing vitamin C, this response shifted positively, demonstrating improved blood flow through a vasodilation effect. On the other hand, those who received the placebo did not experience significant changes.
This means that for chronic smokers, acute administration of vitamin C appears to enhance the function of the endothelium, which is vital for proper blood vessel health and managing chest pain. Ultimately, we observed that vitamin C may help prevent the inactivation of nitric oxide, a compound that supports healthy blood flow, and this effect could be crucial for managing cardiovascular health in smokers.
10
Effective find
Most Useful Review
This is just a find! After reading reviews, I tried it and was amazed by the effect! My child had a sore throat, and I gave one lozenge; by morning, the chest pain was gone. My mother felt discomfort after drinking cold milk, but these lozenges saved her from more severe illness. I now keep them in our first aid kit and recommend them to friends!
Common Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.6
9
Zinc shortens cold duration variability
Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration.
Most Relevant Research
We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.
Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.
Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.
Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.
Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.
Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.
Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.
9.5
Prevents common colds
Most Useful Review
Tastes pleasant, prevents colds effectively, and boosts immunity during flu season.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Ascorbic Acid and Dizziness Study
Change of extracellular ascorbic acid in the brain cortex following ice water vestibular stimulation: an on-line electrochemical detection coupled with in vivo microdialysis sampling.
Most Relevant Research
We explored how ice water vestibular stimulation affects ascorbic acid (AA) levels in the brain, particularly in relation to dizziness. Using a method called in vivo microdialysis coupled with electrochemical detection, we monitored changes in extracellular AA in the primary somatosensory area of guinea pigs. Our study included 16 guinea pigs divided into three groups: one group received ice water stimulation, while the other two were exposed to warm water and ice water without vestibular input.
The results revealed that the concentration of extracellular AA increased in the brain following the ice water stimulation. This finding suggests that there may be neurochemical responses associated with AA that play a role in managing conditions like vertigo. However, while the study shows an intriguing relationship between AA levels and vestibular stimulation, it does not establish a direct link between vitamin C's effectiveness in treating dizziness specifically.
Overall, the insights gained from this research could help pave the way for further investigations into the role of vitamin C in vertigo-related treatments, adding a layer of understanding to its neurochemical functions.
The results revealed that the concentration of extracellular AA increased in the brain following the ice water stimulation. This finding suggests that there may be neurochemical responses associated with AA that play a role in managing conditions like vertigo. However, while the study shows an intriguing relationship between AA levels and vestibular stimulation, it does not establish a direct link between vitamin C's effectiveness in treating dizziness specifically.
Overall, the insights gained from this research could help pave the way for further investigations into the role of vitamin C in vertigo-related treatments, adding a layer of understanding to its neurochemical functions.
9.5
Dizziness resolved
Most Useful Review
It's delicious, albeit sour. I give a small amount to my one-year-old, who craves more. Since I began consuming it daily, I've noticed an improvement in my anaemia. Previously, I often felt dizzy, but that sensation has now vanished.
Food Poisoning details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Vitamin C alleviates food poisoning
Vitamin C alleviates acute enterocolitis in Campylobacter jejuni infected mice.
Most Relevant Research
To explore the effects of vitamin C on food poisoning caused by Campylobacter jejuni, we conducted a study using mice specifically bred to develop a condition similar to human campylobacteriosis. Mice were treated with synthetic vitamin C in their drinking water starting four days before they were infected with the bacteria. Our goal was to see if this treatment could lessen the severity of their symptoms.
Over the course of our research, we found that the mice receiving vitamin C had lower levels of the bacteria in their intestines. They also experienced less severe inflammation and other symptoms associated with infections. Interestingly, the benefits of vitamin C extended beyond just the intestines; we noticed reduced inflammatory responses in other organs such as the liver, kidneys, and lungs.
This suggests that vitamin C could be a promising option for both preventing and treating acute campylobacteriosis. Our findings highlight the potential health benefits of this vitamin and its role in managing foodborne illnesses like those triggered by Campylobacter jejuni.
Over the course of our research, we found that the mice receiving vitamin C had lower levels of the bacteria in their intestines. They also experienced less severe inflammation and other symptoms associated with infections. Interestingly, the benefits of vitamin C extended beyond just the intestines; we noticed reduced inflammatory responses in other organs such as the liver, kidneys, and lungs.
This suggests that vitamin C could be a promising option for both preventing and treating acute campylobacteriosis. Our findings highlight the potential health benefits of this vitamin and its role in managing foodborne illnesses like those triggered by Campylobacter jejuni.
8.8
Supports immune function
Most Useful Review
BAA Now Foods Zinc with Vitamin C and Elderberry is my first dietary supplement, featuring the wonderful immune-supporting elderberries. I appreciate its pleasant taste and tablet form. I have proven the effectiveness of dietary supplements for immunity, and I hope they continue to perform well in the future. For prevention, this affordable form is great, but for a rapid therapeutic effect, consider concentrated syrups, which tend to be more effective though pricier. This complex, supplemented with Vitamin C and Zinc, while in small doses, is beneficial for the immune system and suitable for both adults and children over four years old.
Frozen Shoulder details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin C shows promise against frozen shoulder
Vitamin C as a Potential Prophylactic Measure Against Frozen Shoulder in an In Vivo Shoulder Contracture Animal Model.
Most Relevant Research
In our controlled laboratory study, we aimed to investigate whether vitamin C could help prevent frozen shoulder, particularly the secondary type that often occurs after trauma or surgery. We created a shoulder contracture model using Sprague-Dawley rats, which involved immobilizing their right shoulder.
Our experimental group, consisting of eight rats, received vitamin C orally, while a control group of nine rats did not receive vitamin C. We primarily measured the thickness of the joint capsule at the shoulder using magnetic resonance imaging (MRI).
The results were promising, indicating that vitamin C may reduce the thickening of the joint capsule linked to secondary frozen shoulder. Although we also conducted histological examinations, we did not perform statistical analysis on those findings due to variability in our cutting techniques.
This preclinical study suggests that vitamin C could be a valuable, non-invasive way to prevent secondary frozen shoulder, particularly in situations involving surgery or immobilization. However, more research is needed to determine its effects on humans and establish proper dosage guidelines.
Our experimental group, consisting of eight rats, received vitamin C orally, while a control group of nine rats did not receive vitamin C. We primarily measured the thickness of the joint capsule at the shoulder using magnetic resonance imaging (MRI).
The results were promising, indicating that vitamin C may reduce the thickening of the joint capsule linked to secondary frozen shoulder. Although we also conducted histological examinations, we did not perform statistical analysis on those findings due to variability in our cutting techniques.
This preclinical study suggests that vitamin C could be a valuable, non-invasive way to prevent secondary frozen shoulder, particularly in situations involving surgery or immobilization. However, more research is needed to determine its effects on humans and establish proper dosage guidelines.
9.5
Effective for treatment
Most Useful Review
This powerful remedy is fantastic at the first signs of a sore throat or burning in the nose, as it can tackle the virus effectively. My throat tends to be my weak point; I often feel pain if it gets a bit cold. When that happens, I immediately take zinc, as it helps prevent issues during hypothermia. Generally, this approach works well, but if the pain persists, sucking on these lozenges alleviates the sore throat within a day. I also give it to my 6-year-old, and it makes a significant difference! This has become a staple in my home first-aid kit.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin C reduces cholesterol levels
Effect of Using Vitamin C Supplementation on Performance, Blood Parameters, Carcass Characteristics and Meat Quality of Broiler Chickens Under Heat Stress Condition: A Meta-Analysis.
Most Relevant Research
We explored how vitamin C supplementation affects cholesterol levels in broiler chickens, particularly under heat stress conditions. Through a thorough meta-analysis of 35 studies conducted between 1985 and 2023, we assessed various performance metrics, including blood parameters, carcass characteristics, and overall meat quality.
Our findings revealed that vitamin C significantly reduced cholesterol levels in the broiler chickens subjected to heat stress. Specifically, the study reported a notable decrease in cholesterol concentrations, with a standard mean difference of -0.976, indicating a strong beneficial effect of vitamin C in managing high cholesterol.
Additionally, we noticed improvements in body weight and average daily gain among chickens receiving vitamin C when compared to those that did not. While vitamin C did not significantly impact feed intake or breast meat quality, it emerged as a valuable antioxidant that can help lower blood triglycerides and reduce cholesterol, thus promoting better overall health and growth in broilers during stressful conditions.
Ultimately, this meta-analysis supports the use of vitamin C at a recommended dosage of 250 mg/kg as an effective growth promoter and antioxidant in broiler diets under heat stress, directly influencing cholesterol management.
Our findings revealed that vitamin C significantly reduced cholesterol levels in the broiler chickens subjected to heat stress. Specifically, the study reported a notable decrease in cholesterol concentrations, with a standard mean difference of -0.976, indicating a strong beneficial effect of vitamin C in managing high cholesterol.
Additionally, we noticed improvements in body weight and average daily gain among chickens receiving vitamin C when compared to those that did not. While vitamin C did not significantly impact feed intake or breast meat quality, it emerged as a valuable antioxidant that can help lower blood triglycerides and reduce cholesterol, thus promoting better overall health and growth in broilers during stressful conditions.
Ultimately, this meta-analysis supports the use of vitamin C at a recommended dosage of 250 mg/kg as an effective growth promoter and antioxidant in broiler diets under heat stress, directly influencing cholesterol management.
9.5
Cholesterol reduction
Most Useful Review
This vitamin has greatly enhanced my mental and physical health. After a few months of taking this supplement, I’ve observed a significant improvement in my mood and energy levels. The effects are noticeable the following day after taking a dose. Additionally, it has aided me in managing my weight and reducing my cholesterol levels.
Knee Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Vitamin C for knee pain relief
Skeletal manifestations of scurvy: a case report from dubai.
Most Relevant Research
We observed an intriguing case involving a 4.5-year-old boy who developed significant knee pain due to a rare nutritional deficiency, scurvy. This condition stemmed from his exclusive intake of meat over the past two years, resulting in skeletal issues and inflammation in multiple joints, including his knees.
Upon examination, the child exhibited several symptoms, including pain, swelling, and an inability to walk. Standard blood tests primarily indicated anemia, but X-rays revealed alarming conditions related to scurvy, such as delayed bone age and severe osteopenia. This alarming picture led us to the conclusion that vitamin C deficiency was the underlying culprit behind his knee pain and skeletal issues.
After initiating vitamin C therapy, we noted a remarkable reduction in pain and swelling over the next two months. The child’s condition improved significantly, allowing him to walk again, and follow-up X-rays confirmed the positive changes in his bone health. This case clearly illustrates how vitamin C can effectively alleviate knee pain related to scurvy and reinforces the importance of proper nutrition for overall skeletal health.
Upon examination, the child exhibited several symptoms, including pain, swelling, and an inability to walk. Standard blood tests primarily indicated anemia, but X-rays revealed alarming conditions related to scurvy, such as delayed bone age and severe osteopenia. This alarming picture led us to the conclusion that vitamin C deficiency was the underlying culprit behind his knee pain and skeletal issues.
After initiating vitamin C therapy, we noted a remarkable reduction in pain and swelling over the next two months. The child’s condition improved significantly, allowing him to walk again, and follow-up X-rays confirmed the positive changes in his bone health. This case clearly illustrates how vitamin C can effectively alleviate knee pain related to scurvy and reinforces the importance of proper nutrition for overall skeletal health.
9
Improved condition
Most Useful Review
My daughter experienced vaginal pain, and I gave her this along with manuka honey. Thankfully, she feels better today with no pain.
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Vitamin C reduces liver injury
The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study.
Most Relevant Research
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.
This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
9.5
Effective cold prevention
Most Useful Review
They taste great and, importantly, they work! During the autumn and winter months, these saved our family from colds and illnesses.
Nausea details
SCIENTIFIC SCORE
Likely Ineffective
Based on 5 Researches
4.8
USERS' SCORE
Good
Based on 10 Reviews
8.6
7
Zinc treatment reduces nausea risk
Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
Most Relevant Research
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
9.5
Highly effective option
Most Useful Review
Great budget option! Works well and is tasty! I usually experience slight nausea after taking zinc, but not with this product. I appreciate its rich composition: vitamin C, echinacea, zinc! It's an affordable solution for the first signs of illness. I wholeheartedly recommend this drug; it’s worthy of praise. All sick, recover quickly!
Sinusitis details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin C aids chloride transport
Effect of L-ascorbate on chloride transport in freshly excised sinonasal epithelia.
Most Relevant Research
We explored the effects of L-ascorbate, commonly known as Vitamin C, on chloride transport in sinonasal epithelial tissues. This research is particularly significant as it addresses the common condition of chronic rhinosinusitis (CRS) and its potential link to the function of the cystic fibrosis transmembrane conductance regulator (CFTR) — a key chloride ion channel.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
9.5
Effective for colds
Most Useful Review
This is my go-to remedy! At the first sign of a cold, I take one tablet, and it has never let me down. I have chronic sinusitis and tonsillitis, and whenever I feel a runny nose or sore throat, I take the tablet before bed, and by morning, there’s no trace of the illness.
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.6
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
Vitamin C improves sleep apnea endothelial function
Antioxidant vitamin C improves endothelial function in obstructive sleep apnea.
Most Relevant Research
We evaluated how vitamin C might improve endothelial function in patients with obstructive sleep apnea (OSA). In our study, we compared 10 individuals with untreated OSA to 10 matched control subjects without sleep issues. We measured how well blood vessels reacted to increased blood flow, known as flow-mediated dilation (FMD), using ultrasound before and after administering vitamin C.
Our findings revealed a significant difference: baseline FMD was lower in OSA patients compared to the control group. However, after an intravenous injection of vitamin C, the FMD in OSA patients improved dramatically, reaching levels similar to those seen in the healthy controls. Interestingly, vasoreactivity in the control subjects remained unchanged.
These results suggest that oxidative stress might be a key factor contributing to the endothelial dysfunction experienced by individuals with OSA. The positive response to vitamin C opens up exciting possibilities for exploring antioxidant treatments in managing cardiovascular issues related to OSA.
Our findings revealed a significant difference: baseline FMD was lower in OSA patients compared to the control group. However, after an intravenous injection of vitamin C, the FMD in OSA patients improved dramatically, reaching levels similar to those seen in the healthy controls. Interestingly, vasoreactivity in the control subjects remained unchanged.
These results suggest that oxidative stress might be a key factor contributing to the endothelial dysfunction experienced by individuals with OSA. The positive response to vitamin C opens up exciting possibilities for exploring antioxidant treatments in managing cardiovascular issues related to OSA.
9.5
Great benefits for sleep
Most Useful Review
This is a great product. I chose it for various reasons: price, taste, quality, and results. It contains a wealth of beneficial substances in convenient packaging. I recommend it to everyone as it meets all descriptions and expectations without any issues.
Angina details
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.1
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Vitamin C improves heart perfusion
Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers.
Most Relevant Research
We explored the impact of vitamin C on heart blood flow in patients undergoing a procedure called percutaneous coronary intervention (PCI) for stable angina. In our study, we enrolled 56 participants and divided them into two groups: one received a vitamin C infusion and the other a placebo.
Our findings were quite promising. Before the procedure, a significant percentage of patients in both groups had impaired heart blood flow. However, after the intervention, those who received vitamin C showed a notable improvement in microcirculatory perfusion, meaning their heart's small blood vessels were working better.
Specifically, only 4% of the vitamin C group had poor blood flow post-procedure, compared to 32% in the placebo group. Furthermore, most patients treated with vitamin C achieved complete micro-circulatory reperfusion. Additionally, we observed that oxidative stress markers in the vitamin C group significantly decreased, indicating reduced damage to the heart.
This suggests that vitamin C infusion could play a critical role in enhancing heart health by mitigating oxidative stress during such procedures.
Our findings were quite promising. Before the procedure, a significant percentage of patients in both groups had impaired heart blood flow. However, after the intervention, those who received vitamin C showed a notable improvement in microcirculatory perfusion, meaning their heart's small blood vessels were working better.
Specifically, only 4% of the vitamin C group had poor blood flow post-procedure, compared to 32% in the placebo group. Furthermore, most patients treated with vitamin C achieved complete micro-circulatory reperfusion. Additionally, we observed that oxidative stress markers in the vitamin C group significantly decreased, indicating reduced damage to the heart.
This suggests that vitamin C infusion could play a critical role in enhancing heart health by mitigating oxidative stress during such procedures.
8.3
Effective for angina
Most Useful Review
We frequently suffer from angina, so we bought it without much hope for results. After sucking four tablets a day, it improved the sore throat in four days! These pills have a long shelf life and are reasonably priced.
Asthma details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Dietary zinc may reduce asthma
Association between dietary zinc intake and asthma in overweight or obese children and adolescents: A cross-sectional analysis of NHANES.
Most Relevant Research
We explored the relationship between dietary zinc intake and asthma in overweight or obese children and adolescents. This research utilized data from the National Health and Nutrition Examination Survey, focusing on those aged 20 and younger who had both asthma and dietary zinc consumption.
Our findings indicate that there is an inverse association between zinc intake and the occurrence of asthma. In simpler terms, higher dietary zinc appears to be linked with lower asthma rates in these children. This suggests that zinc could play an important role in respiratory health, especially for kids struggling with their weight.
While our study sheds light on this potential protective effect of zinc, we recognize that the results in existing literature have been mixed. Some research indicates benefits, while other studies don’t show significant effects. Therefore, while we have uncovered a correlation worth noting, further research is required to fully understand zinc’s role in asthma management.
Our findings indicate that there is an inverse association between zinc intake and the occurrence of asthma. In simpler terms, higher dietary zinc appears to be linked with lower asthma rates in these children. This suggests that zinc could play an important role in respiratory health, especially for kids struggling with their weight.
While our study sheds light on this potential protective effect of zinc, we recognize that the results in existing literature have been mixed. Some research indicates benefits, while other studies don’t show significant effects. Therefore, while we have uncovered a correlation worth noting, further research is required to fully understand zinc’s role in asthma management.
9.5
Reduced shortness of breath
Most Useful Review
I bought this for my son who has asthma, and it has significantly helped stop the shortness of breath attacks. The quality is good, and it is very convenient to take.
Heartburn details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Zinc's role in heartburn relief
Esophageal ulcer related to zinc deficiency following a total gastrectomy.
Most Relevant Research
We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.
After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.
Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.
After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.
Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.
9.5
No heartburn felt
Most Useful Review
I was pleased that there were no unpleasant sensations in my stomach. Unlike usual vitamin C, which increased acidity and caused heartburn, I don’t experience that here. During the covid period at work, many have fallen ill, but I’ve stayed healthy. I take it before bed and today tried it in the morning.
Influenza details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Elderberry's limited flu efficacy
Echinacea and elderberry-should they be used against upper respiratory tract infections during pregnancy?
Most Relevant Research
We explored the effectiveness of elderberry in treating influenza, drawing from clinical trials that examined its impact. Over the years, three specific trials involving different elderberry preparations were conducted, with a total of only 77 participants receiving treatment. While these trials concluded that elderberry could be effective against influenza, the very limited sample size raises questions about the robustness of these findings.
Additionally, it’s important to note that in the larger context of herbal remedies, there isn’t enough comprehensive evidence to fully endorse elderberry as a reliable treatment. Though the studies indicated some level of efficacy against the flu, the small number of participants means we must approach these results with caution.
Given that substantial evidence of safety and effectiveness is lacking, it wouldn't be prudent to rely solely on elderberry for influenza treatment, especially among vulnerable groups like pregnant women.
Additionally, it’s important to note that in the larger context of herbal remedies, there isn’t enough comprehensive evidence to fully endorse elderberry as a reliable treatment. Though the studies indicated some level of efficacy against the flu, the small number of participants means we must approach these results with caution.
Given that substantial evidence of safety and effectiveness is lacking, it wouldn't be prudent to rely solely on elderberry for influenza treatment, especially among vulnerable groups like pregnant women.
9.5
Effective during influenza
Most Useful Review
This product has been my saviour during the influenza pandemic! With an excellent composition that's easy to ingest, I’ve experienced fantastic results without any side effects. I even noticed improvements in hair health during winter. It's a reliable choice for anyone looking to stay healthy during the influenza season.
Leg Cramps details
SCIENTIFIC SCORE
Questionable
Based on 1 Research
5
USERS' SCORE
Good
Based on 2 Reviews
8.5
5
Leg cramps treatment comparison
Calcium and magnesium status in pregnant women. A comparison between treatment with calcium and vitamin C in pregnant women with leg cramps.
Most Relevant Research
We explored the effects of vitamin C on leg cramps in a group of 60 pregnant women through a double-blind trial. Participants received either calcium or vitamin C (1 g twice daily) as treatment. Our observations revealed that there was no significant difference in clinical improvement between the two treatment groups.
Notably, 14 patients experienced complete relief from symptoms, while 27 reported significant improvement regardless of which treatment they received. Unfortunately, 17 participants found their symptoms unchanged, and only two noticed an increase in leg cramps during the treatment period.
Throughout the study, we measured serum levels of total and ionized calcium, total magnesium, and albumin, but these parameters did not show significant changes in either treatment group. We also didn’t identify any biochemical differences when comparing the effectiveness of vitamin C and calcium for alleviating cramps.
Ultimately, our findings suggest that vitamin C may not be an effective solution for leg cramps in pregnant women, as both treatments yielded similar results with minimal biochemical changes.
Notably, 14 patients experienced complete relief from symptoms, while 27 reported significant improvement regardless of which treatment they received. Unfortunately, 17 participants found their symptoms unchanged, and only two noticed an increase in leg cramps during the treatment period.
Throughout the study, we measured serum levels of total and ionized calcium, total magnesium, and albumin, but these parameters did not show significant changes in either treatment group. We also didn’t identify any biochemical differences when comparing the effectiveness of vitamin C and calcium for alleviating cramps.
Ultimately, our findings suggest that vitamin C may not be an effective solution for leg cramps in pregnant women, as both treatments yielded similar results with minimal biochemical changes.
9.5
Muscle cramps relief
Most Useful Review
The quality is excellent, and the results are noticeable after just a few uses. My sleep has improved, and the muscle cramps in my legs and arms have ceased to trouble me. My joints also don't react as much to changing weather. The benefits are clear, and this is only my first jar; I'll continue to observe. The ingredients are of good quality.
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
8.8
Throat swelling relief
Most Useful Review
We dissolve them for throat and pharynx ailments, particularly when there is a loss of voice, effectively alleviating throat swelling. I highly recommend using this! Thanks for the thumbs up!
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Good
Based on 6 Reviews
8.4
9
Vitamin C enhances immune response
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response.
Most Relevant Research
We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
9.5
Prostate cancer prevention
Most Useful Review
This product is very useful in preventing prostate cancer and provides general benefits to the body.
Lung Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
Vitamin C reduces lung cancer spread
Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway.
Most Relevant Research
We explored the effects of vitamin C on lung cancer, particularly its ability to inhibit pulmonary metastasis—meaning the spread of cancer to the lungs. Using an H22 pulmonary metastasis mouse model, we observed that vitamin C administration, both intraperitoneally and orally, showed promising results.
Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.
Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.
Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.
Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.
Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.
Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.
8
Boosts immunity
Most Useful Review
Very delicious vitamins, the Immune Cocktail, is effective against the initial signs of ARVI. Elderberry acts as a natural immunity enhancer, containing anthocyanin pigments that stimulate immune function and exhibit antiviral properties. The formulation includes vitamin C and zinc. Vitamin C (ascorbic acid) promotes interferon protein production, possesses anti-inflammatory properties, and aids in neutralising free radicals, thereby protecting lung cells from harm. Zinc, according to recent findings, inhibits coronavirus multiplication by blocking the activities of the RNA polymerase and ACE2 enzymes, which facilitate the virus's entry into cells. If you find my review useful, please click "Yes" 👍. Happy shopping on iHerb!
Whooping Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 19 Reviews
8.4
9.5
Effective for symptoms
Most Useful Review
The other day, my husband complained of a sore throat. Just the day prior, I received these vitamins, so I immediately gave him one tablet each day. Believe it or not, his initial cough symptoms disappeared instantly. I think they're fantastic!
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.3
8.8
Improved skin condition
Most Useful Review
Healthy and yummy with a delightful natural sweet and sour taste, my 12-year-old daughter enjoys taking these vitamins. Remarkably, it alleviated her discomfort as she had been constantly ill throughout September. I believe this supplement has significantly contributed to her improved health. Additionally, her face has become much clearer, not merely a seasonal change, as the teenage rashes remained persistent all year. I will definitely re-order given the benefits for her skin.
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.2
9
Vitamin C shows effectiveness for acne
Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial.
Most Relevant Research
In our recent study, we set out to explore the effectiveness of a 5% sodium L-ascorbyl-2-phosphate lotion, a stable form of vitamin C, for treating acne. We conducted a double-blind, controlled trial with 50 participants over 12 weeks, where half used the vitamin C lotion and the other half received a placebo.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.
The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.
Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.
8.8
Softer skin
Most Useful Review
I liked it very much! My skin has become softer, the tone of my face has improved, and the acne has diminished. I recommend it to everyone.
