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Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
250 mg
278%
Vitamin E (as d-alpha Tocopheryl Succinate)
20 mg
133%
Alpha Lipoic Acid
100 mg

The product is found useful for the following medical conditions

Neuropathy

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 18 Reviews
8.7
8
Alpha-lipoic acid reduces AGEs
Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.
Most Relevant Research
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.

Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.

Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
8.8
Effective treatment
Most Useful Review
I love this product! I deal with very painful nerve pain and cramps that travel through my hips, thighs, and legs. This supplement, recommended by my husband, performed excellently compared to a medication I was prescribed, which left me feeling drugged. I've had a remarkable reduction in painful night cramps, and overall peripheral pain has lessened—a true improvement in my quality of life.

Diabetes

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 17 Reviews
8.6
8
Vitamin C improves diabetes control
Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses.
Most Relevant Research
We examined the effects of vitamin C supplementation on diabetes, focusing specifically on glycemic control and insulin resistance. Our analysis included a comprehensive review of fourteen systematic reviews and meta-analyses that assessed five different water-soluble vitamins: B-1, B-3, biotin, B-9 (folic acid), and C.

The findings revealed that vitamin C can significantly improve glycemic control in individuals with type 2 diabetes. We noticed reductions in fasting blood glucose levels and HbA1c, especially when supplementation lasted longer than 30 days. This is promising news for those managing diabetes, as it suggests that incorporating vitamin C could be beneficial.

Furthermore, we found that folic acid also plays a role in improving insulin resistance. However, there is a clear need for more well-designed randomized controlled trials to solidify these findings and develop a deeper understanding of the relationship between water-soluble vitamins and diabetes management.
9.5
Effective for prediabetes
Most Useful Review
Highly recommend for any diabetic or prediabetic. After being prescribed alpha lipoic acid due to prediabetes, I noticed an improvement in my blood work within three months. My A1c dropped, and my glucose levels normalised, thanks to the supplements and my healthier lifestyle. I feel better overall and intend to continue this regimen as recommended by my doctor.

Arthritis

SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.6
7
Vitamin C's role in arthritis management
The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review.
Most Relevant Research
We explored the role of vitamin C in addressing arthritis symptoms, particularly its effect on joint inflammation. Vitamin C is known for its antioxidant properties, and we found that it plays a crucial role in collagen synthesis. This feature is important as collagen forms the structural basis of our joints.

What excited us was the possibility that vitamin C could help reduce inflammation in patients with rheumatoid arthritis. Given that inflammation is a major factor in the discomfort and damage associated with this condition, any reduction could significantly enhance the quality of life for those affected.

However, while vitamin C shows promise due to its supportive functions, we must remember that the evidence concerning its direct effectiveness on arthritis specifically is still evolving. The correlation between vitamin C intake and reduced joint inflammation points to a beneficial role, but more detailed studies are necessary to solidify these findings and determine optimal dosages.

Overall, our review highlights that while vitamin C may indeed support joint health and aid in managing inflammation, further research is essential to fully understand its impact and to evaluate how it can be integrated into arthritis management strategies effectively.
8.8
Neuropathy alleviation
Most Useful Review
Great stuff! I used to suffer from intense nerve pain and cramps, which were debilitating. After consulting my rheumatologist for osteoarthritis and looking into alternative treatments, I started taking Alpha Lipoic Acid. This supplement has worked wonders; night cramps have vanished and the peripheral pain has significantly decreased. I'm extremely pleased with these results, and so is my rheumatologist.

Leg Cramps

SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 3 Reviews
8.6
7
Vitamin E's potential in leg cramps
Are there alternatives to the use of quinine to treat nocturnal leg cramps?
Most Relevant Research
We explored the potential role of vitamin E in treating leg cramps, particularly in populations such as those undergoing dialysis. The study aimed to understand if vitamin E could provide relief from troublesome nocturnal leg cramps—an issue that many individuals face.

While the effects of quinine, a common treatment, have been closely scrutinized, vitamin E emerges as a noteworthy alternative. Although large-scale randomized controlled trials focusing specifically on vitamin E for leg cramps are limited, some data suggest that it may hold promise for alleviating symptoms. This is especially true for those who might not respond to other treatments.

We observed that incorporating vitamin E could be a safer option, as this supplement generally has a more favorable safety profile compared to quinine. However, it's important to underscore that patients should consider exploring other treatments before turning to quinine, particularly given the latter's potential side effects.
8.8
Pain relief achieved
Most Useful Review
I suffer from intense nerve pain and cramps in my legs, often requiring emergency care. After years of prescription medication that made me feel drugged, I turned to alpha-lipoic acid on my husband's recommendation. This supplement has worked wonderfully. It's been weeks without painful night cramps, and any cramps I do have are no longer the severe ones I used to experience. Very pleased with the results.

Migraine

SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.6
8
Vitamin C potentially reduces migraines
Association between dietary vitamin C intake and migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey.
Most Relevant Research
We explored the connection between dietary vitamin C and migraines using data from the National Health and Nutrition Examination Survey (NHANES) that covered several years from 1999 to 2004. In our analysis, we found that 4101 participants reported their migraine experiences, with over 17% indicating they had faced them recently. Using a detailed dietary recall system to assess vitamin C intake, we conducted various statistical analyses to understand the potential effects of vitamin C on migraine occurrence.

What we discovered was quite intriguing: higher dietary vitamin C intake seemed to be associated with a lower likelihood of experiencing migraines. Specifically, our results showed that those in the highest intake category had a significantly reduced risk of migraines compared to those with the lowest intake. The odds ratio indicated that for every increase in vitamin C intake, the likelihood of migraines decreased.

This linear relationship suggests that incorporating more vitamin C-rich foods into our diets could be beneficial for individuals prone to migraines. Our findings indicate that vitamin C may serve as a useful dietary consideration for managing migraine severity and frequency. Overall, these insights could pave the way for further research and highlight the importance of nutrition in migraine management.
9.5
Reduces frequency
Most Useful Review
My neurologist, who directs the University of Pittsburgh's headache centre, recommended taking this daily. It has definitely reduced the frequency and severity of my migraines.

Nausea

SCIENTIFIC SCORE
Very Likely Ineffective
Based on 1 Research
2
USERS' SCORE
Good
Based on 1 Review
8.6
2
Vitamin C ineffective against nausea
The Role of hCG and Histamine in Emesis Gravidarum and Use of a Chewing Gum Containing Vitamin C as a Treatment Option: A Double-Blinded, Randomized, Controlled Trial.
Most Relevant Research
We explored the effects of vitamin C as a treatment for nausea and vomiting in pregnancy, also known as emesis gravidarum. Our study involved 111 participants, who were given either vitamin C-containing chewing gum, a placebo, or no treatment at all. We monitored them over two follow-up visits in early pregnancy to assess their symptoms.

While we measured various factors that could influence nausea—including hormone levels like hCG and DAO—our findings showed that the chewing gum did not effectively reduce nausea symptoms compared to the placebo or no treatment. Specifically, the vitamin C gum was not associated with any significant alleviation of nausea or vomiting.

Interestingly, we found that elevated levels of hCG were linked to increased nausea severity. In contrast, higher levels of DAO appeared to have a protective effect against symptoms. Additionally, elevated thyroxine and pyridoxine levels correlated with worsened nausea.

Overall, while vitamin C is often highlighted for its health benefits, our results suggest it does not play a significant role in treating nausea during pregnancy. This study highlights the complexities behind nausea in pregnancy, indicating that further research is necessary to uncover effective treatment options.
9.5
No nausea relief
Most Useful Review
Solid brand! This NOW ALA product has surpassed my expectations. Previously, I used GNC's synthetic ALA, which caused my urine to appear bright green and nauseated me. Now, I rely on NOW for most of my supplements, and I've not experienced any nausea with this product. It has contributed to keeping my immune system in check while still allowing for occasional dietary indulgences. 5 stars for price, quantity, and effectiveness!

Psoriasis

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.2
USERS' SCORE
Good
Based on 1 Review
8.6
8
DDH-1 shows psoriasis improvement
Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression.
Most Relevant Research
We explored the potential of DDH-1, a unique derivative of ascorbic acid, in treating psoriasis, a chronic inflammatory skin condition driven by certain cytokines. In our research, mice with psoriasis-like skin lesions induced by imiquimod were treated with DDH-1 to examine its effects on inflammatory markers.

During our study, we found that treatment with DDH-1 significantly reduced the expression of inflammatory cytokines IL-1β and TNF-α in the affected skin. This finding is crucial, as these cytokines are key players in the development and persistence of psoriasis.

Additionally, we observed noticeable improvement in the skin lesions of the mice following the application of DDH-1. These promising results indicate that DDH-1 may be beneficial for those looking to manage psoriasis and could serve as a supplement in treatment strategies.
10
Psoriasis cleared
Most Useful Review
After my husband stopped his dermatologist-prescribed medications that weren't helping his moderate to severe psoriasis, he tried this. Four months later, his skin is 99% clear, and his joint pain has vanished!

Autoimmune Disorder

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin C impacts autoimmune response
Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies.
Most Relevant Research
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.

Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.

Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.

Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
8.8
Increased energy levels
Most Useful Review
I feel more "whole" since taking this supplement, with improved energy levels, despite my ongoing struggle with multiple autoimmune disorders which can leave me bedbound. This product helps to enhance my mental clarity and energy, and I've noticed a distinct difference on the days I forget to take it. It's definitely worth purchasing again, though I’ll opt for a stronger dosage next time.

Back Pain

SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.3
USERS' SCORE
Good
Based on 1 Review
8.5
4
Vitamin C's limited impact on pain
The Efficacy of Vitamin C on Postoperative Outcomes after Posterior Lumbar Interbody Fusion: A Randomized, Placebo-Controlled Trial.
Most Relevant Research
We conducted a year-long study to investigate the effects of vitamin C on postoperative pain and recovery after a specific type of spine surgery known as posterior lumbar interbody fusion (PLIF). In this randomized, placebo-controlled trial, we worked with 123 patients, dividing them into two groups: one receiving vitamin C and the other a placebo.

Our main focus was to see how vitamin C influenced lower back pain measured by a visual analogue scale. While we found that there was no significant difference in pain levels at the one-year mark between the two groups, there was a silver lining. We observed that vitamin C appeared to enhance functional improvement, especially within the first three months after surgery.

So, while vitamin C didn’t seem to directly reduce pain intensity after surgery, it could play a role in supporting early recovery and everyday function. This finding may encourage further exploration into vitamin C's potential benefits in postoperative care for patients undergoing spine surgeries.
8.8
Irritation lessened
Most Useful Review
I’ve been taking this for true nerve pain from a pinched nerve in my back. This supplement has significantly lessened the irritation, effectively alleviating my pain. It's been a valuable addition to my daily routine.

Liver Disease

SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin C reduces liver injury
The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study.
Most Relevant Research
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.

Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.

This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
8.8
Detoxifies liver effectively
Most Useful Review
I use Alpha Lipoic Acid for mitochondrial disease, as it helps absorb Coenzyme Q10, boosting my energy. It also supports peripheral nerve health and blood sugar control, crucial for diabetics. Additionally, it detoxifies the liver of metal pollutants and lowers cholesterol. I believe everyone should include this in their diet.

Headache

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.4
8
Vitamin C intake reduces migraines
Association between dietary vitamin C intake and migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey.
Most Relevant Research
We aimed to understand how dietary vitamin C affects migraines by analyzing data from the National Health and Nutrition Examination Survey, conducted from 1999 to 2004. In this survey, we identified adults who reported experiencing severe headaches or migraines over the past three months.

Our findings were quite revealing. Out of 4,101 participants, 702 individuals reported having a migraine, which represents about 17% of the group. We discovered an interesting trend: higher dietary vitamin C intake seemed to correlate with a lower likelihood of experiencing migraines. Specifically, participants with the highest vitamin C intake had a 36% reduced odds of suffering from migraines compared to those with the lowest intake.

We employed various statistical methods to confirm our results, including logistic regression and restricted cubic spline regression, which showed a clear linear relationship between vitamin C intake and the frequency of migraines.

Overall, this study suggests that increasing our dietary vitamin C might help minimize migraines, which is promising news for those who suffer from these intense headaches. However, as with all studies, further research is necessary to solidify these findings and fully understand the relationship between vitamin C and headache relief.
9.5
Reduced migraine frequency
Most Useful Review
My neurologist, the director of the headache center at University of Pittsburgh Medical Center, recommended taking this daily. It has significantly reduced both the frequency and severity of my migraines.

Shingles

SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.3
7
Vitamin C prevents chronic shingles pain
A Study of Intravenous Administration of Vitamin C in the Treatment of Acute Herpetic Pain and Postherpetic Neuralgia.
Most Relevant Research
We conducted a study to understand how intravenous Vitamin C might help with shingles, specifically focusing on both the immediate pain and the longer-term risk of postherpetic neuralgia (PHN). To do this, we enrolled 87 patients diagnosed with herpes zoster (shingles) and divided them into two groups—one received an infusion of Vitamin C along with normal saline, while the other received only normal saline.

After treatment, we assessed the patients on pain severity and side effects using questionnaires throughout the first five days and then followed up later at intervals of two, four, eight, and sixteen weeks post-discharge. The results showed that while Vitamin C did not significantly reduce the acute pain associated with shingles, it notably lowered the incidence of PHN after the eighth week compared to the control group.

So, although patients didn’t find immediate relief from their acute pain, those receiving Vitamin C seemed less likely to suffer from long-lasting pain issues related to shingles. Our findings suggest that Vitamin C may have a more specific role in preventing chronic pain conditions rather than addressing acute symptoms.
6.8
Neuropathy relief
Most Useful Review
This product has provided some relief from the neuropathy I developed after a shingles infection almost 19 months ago. After a couple of weeks, I have noticed improvements, albeit gradual. I welcome any benefit to this chronically sore area in my body.
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