NOW Supplements BioCell CollagenÂ® Hydrolyzed Type II

We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.

Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.

Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.

Significant joint relief

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698 people found this helpful

I took collagen with Eicherb, and after the course, I noted significant improvements. My previous issues with joint pain, particularly knee discomfort, lessened considerably. After a month of taking this collagen, the pain in my knees decreased drastically, with some days completely pain-free. Should the pain return, it is not as severe as it was before.

Bone Pain details

Polynucleotide sodium reduces knee pain

Kim JY, Kim YN, Lee YJ, Sim SE, Ko YR, et al. Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. J Clin Med. 2021;10. doi:10.3390/jcm10051138

We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.

Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.

Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.

Significant improvement

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698 people found this helpful

After completing a course of collagen, I've noticed a marked improvement in my joints. Previously, I struggled with discomfort and bone pain, especially in my knees. However, after a month of taking this product, the pain has significantly decreased, often disappearing entirely. On days when the pain returns, it's far less intense than before, which is a relief.

We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.

By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.

Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.

Pain reduction observed

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68 people found this helpful

This really works! I was informed that I had severe arthritis in my left hip and needed a replacement. After researching, I discovered that this collagen greatly aids in rebuilding cartilage between joints. After one month of taking it, I experienced significant improvement in pain and mobility. Hopefully, I will avoid a hip replacement!

Autoimmune Disorder details

SCIENTIFIC SCORE

Moderately Effective

Based on 23 Researches

Hyaluronic acid shows promise

Zeng Y, Wu L, Jiang X, Hu Y, Jin Y, et al. Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis. Int J Pharm. 2025;669:125073. doi:10.1016/j.ijpharm.2024.125073

We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.

Consistent results achieved

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70 people found this helpful

I ordered this collagen on my doctor's advice. At 38, with a diagnosis of coxarthrosis, I took 2 capsules each morning for three months. I saw results after a month and a half, with discomfort fading away. I now take it once a year for prophylaxis and will continue ordering.

Cardiovascular Disease details

SCIENTIFIC SCORE

Moderately Effective

Based on 5 Researches

Collagen source shows varying effectiveness

Liu H, Yang Y, Liu Y, Cui L, Fu L, et al. Various bioactive peptides in collagen hydrolysate from salmo salar skin and the combined inhibitory effects on atherosclerosis in vitro and in vivo. Food Res Int. 2022;157:111281. doi:10.1016/j.foodres.2022.111281

We explored the beneficial effects of collagen hydrolysate derived from salmon skin on atherosclerosis, a key contributor to cardiovascular diseases. The study showed that this collagen extract exhibits promising anti-inflammatory and antioxidant properties.

In tests with mice, it effectively reduced arterial thickening and plaque formation without side effects, comparable to the effects of aspirin. However, the results indicate that while collagen from salmon skin has potential, more research is needed before making definitive claims.

Obvious joint improvement

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2 people found this helpful

GREAT FOR JOINTS! Type 2 collagen is particularly beneficial for combating joint and cartilage diseases. The product also contains Chondroitin sulfate and Hyaluronic acid. It's crucial to select either type 2 collagen or types 1 and 3, as they cannot be taken simultaneously. I noticed a significant improvement in my joints' condition within a month of use. My knees have especially benefited from this collagen.

Frozen Shoulder details

SCIENTIFIC SCORE

Questionable

Based on 16 Researches

No additional benefits from HA injections

Hsieh LF, Hsu WC, Lin YJ, Chang HL, Chen CC, et al. Addition of intra-articular hyaluronate injection to physical therapy program produces no extra benefits in patients with adhesive capsulitis of the shoulder: a randomized controlled trial. Arch Phys Med Rehabil. 2012;93:957. doi:10.1016/j.apmr.2012.01.021

We examined whether adding hyaluronic acid (HA) injections to physical therapy (PT) could improve outcomes for patients with frozen shoulder. In a well-structured study, 70 participants were divided into two groups—with one receiving HA injections alongside PT, while the other focused solely on PT.

After assessing their shoulder movement, pain, and quality of life, we found no significant extra benefits from the HA injections. This suggests that continuing with just PT could be a more cost-effective approach for managing this condition.

Effective rehabilitation

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3 people found this helpful

This has been definitely helpful in the rehabilitation of my shoulder injury. I have completely recovered, confirming its effectiveness. Unfortunately, it does not contain vitamin C, which I had to purchase separately.

Leg Cramps details

Life-enhancing results

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28 people found this helpful

My mother was initially sceptical about dietary supplements until severe knee arthrosis made it impossible for her to get out of bed. Doctors prescribed a pharmacy collagen with chondroitin, but I insisted she try iHerb's collagen. Now, five months later, she's on her third can, delighting in life again without leg pain, and enjoys walks with her grandchildren. She also takes chondroitin, calcium, magnesium, and vitamin D. Wishing all our mothers good health!

Rash details

SCIENTIFIC SCORE

Moderately Effective

Based on 5 Researches

Hyaluronic acid gel shows promise

Morali G, Polatti F, Metelitsa EN, Mascarucci P, Magnani P, et al. Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. Arzneimittelforschung. 2006;56:230.

We examined the effects of a gel containing hyaluronic acid on women experiencing vaginal atrophy symptoms after menopause. The pilot and multicenter studies involved 110 postmenopausal participants using the gel both externally and vaginally. Results showed significant improvements in vaginal dryness, burning, itching, and rash from the first week of treatment, without any reported adverse effects. Overall, the gel was well-accepted and demonstrated promise as a safe alternative to traditional hormone replacement therapies.

No rashes

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1 people found this helpful

I took this collagen several times, and it suited me very well. There were no rashes, unlike with beef.

Allergies details

Effective for allergies

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An excellent tool for restoring and maintaining joints and all organs and systems of the body. I've been taking it for the second month and noticed its effectiveness after three weeks. My joints reacted positively, and my skin and hair appear more well-groomed. The packaging is convenient, and there is no aftertaste. I recommend it for individuals with allergies. The carefully selected ingredients will suit the elderly, as my knee has stopped creaking, hair loss has ceased, and my skin condition has improved. A very effective tool, even for those on a diet. I plan to order these products again in the future.

Athlete’s Foot details

Mum loves this collagen. I highly recommend it. Her feet were in pain, but after taking it, along with hyaluronic acid and vitamin C, the discomfort gradually diminishes. It also assists with hair loss.

Food Poisoning details

20 people found this helpful

My mother has arthrosis of the kneecaps. After a long search, we chose this collagen along with chondroitin from Doctor's Best, magnesium citrate from Now Foods, and vitamins C and D3 from California Gold. A month ago, she struggled to move, but now she walks easily. Initially, I was hesitant about iHerb, preferring the pharmacy “Fleksinovo”, but I persisted. Now she is delighted with the results.

Osteoporosis details

Helps with osteoporosis

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I used to take collagen in powder form, but since I'm travelling, I opted for capsules. I consistently take collagen as prescribed due to my osteoporosis, in conjunction with chondroitin and glucosamine. I believe it helps.

Ear Infection details

2 people found this helpful

Super Joint Relief is excellent collagen for maintaining cartilage and connective tissue. It contains hyaluronic acid, glucosamine, and chondroitin, though these may not be necessary. I alternate it with type 1.3 collagen, and my mother uses it from early spring to mid-autumn. Overall, my back and knees hurt significantly less. The ache in my knee during activity has also subsided. It's effective! Remember to take it on an empty stomach, an hour before meals. The jar suggests two capsules twice daily, but the website seems to incorrectly state two per day.

Menopause details

My wife is ageing and experiencing menopause, using NOW Collagen for her hair and skin. It appears to be working particularly well for her skin, which has improved significantly with increased smoothness and elasticity.

Sleep Apnea details

Reduction in joint pain

Most Useful Review

This collagen is fantastic for joints! I took it for knee issues, and after my first experience, I'm definitely planning to use it again. The pain has decreased significantly, and I now sleep through the night. I’m highly satisfied with this product!

Tendonitis details

Restores cartilage structure

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1 people found this helpful

I've been using this collagen to improve my joints and tendons' condition. It restores cartilage structure effectively. I take it separately from collagen types 1 and 3.

Back Pain details

SCIENTIFIC SCORE

Questionable

Based on 14 Researches

Hyaluronic acid effective for back pain

Fuchs S, Erbe T, Fischer HL, Tibesku CO. Intraarticular hyaluronic acid versus glucocorticoid injections for nonradicular pain in the lumbar spine. J Vasc Interv Radiol. 2005;16:1493.

We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.

Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.

Knee pain relief

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9 people found this helpful

After years of knee pain, I took one collagen capsule and noticed a dramatic improvement within 24 hours. My knee pain has almost vanished, and notably, my back pain feels better too. I am genuinely thrilled with these results!

Knee Pain details

SCIENTIFIC SCORE

Possibly Effective

Based on 31 Researches

Collagen supplements improve knee pain

Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study. BMC Musculoskelet Disord. 2025;26:17. doi:10.1186/s12891-024-08244-w

We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.

After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.

Notable improvements

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6 people found this helpful

I recommended this for my mother whose knees pained her excessively, to the point of struggling to walk. Doctors suggested costly knee injections, yet many report them as ineffective. Instead, we opted for collagen, glucosamine, and chondroitin in courses, leading to noticeable improvements. We will continue this regimen.

Acne details

SCIENTIFIC SCORE

Possibly Effective

Based on 19 Researches

Hyaluronic acid peptide shows promise

Su Z, Zhang Y, Cao J, Sun Y, Cai Y, et al. Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist. J Nanobiotechnology. 2023;21:55. doi:10.1186/s12951-023-01812-7

We looked into how a new treatment combining hyaluronic acid with a peptide from fibroblast growth factor 2 could help combat acne. This method targets specific receptors involved in acne development, showing promise by reducing both acne lesions and excess oil production in lab tests. Importantly, our study revealed that this treatment does not encourage certain reactions that would typically hinder acne management. While the results are positive, we acknowledge that ongoing research is necessary for further confirmation of these findings.

7.5

Skin improvement

Most Useful Review

This is the best collagen I’ve ever tried. After taking it for two weeks, I really like it. It’s notable that the acne beneath my skin began to appear as I started using it (two capsules daily), leading to more elastic and nourished skin.