Selenium's antifungal potential explored(MeOPhSe)2, a synthetic organic selenium compound, inhibits virulence factors of Candida krusei: Adherence to cervical epithelial cells and biofilm formation.
We delved into the potential of a synthetic organic selenium compound, known as p,p'-methoxyl-diphenyl diselenide, or (MeOPhSe), to combat candidiasis, particularly focusing on its effects on Candida krusei. This research is important because Candida species can lead to both mild and serious infections, and finding effective treatments is crucial.
Our study demonstrated that (MeOPhSe) is non-toxic to human cells, such as cervical epithelial and fibroblastic cells, and has a notable antifungal effect. We observed that it inhibited the growth of C. krusei in a dose-dependent manner, altering its growth pattern and extending the length of its lag phase. Most significantly, we found that this compound reduced the ability of both C. krusei and C. albicans to adhere to human cells, a critical step in the infection process.
The reductions we measured were substantial: C. krusei adherence dropped by 37.24%, while C. albicans showed a 32.84% reduction, both being statistically significant. Interestingly, both species responded similarly to (MeOPhSe), highlighting its potential as a broad-spectrum antifungal agent against various Candida infections.
Overall, our findings suggest that (MeOPhSe) holds promise as an antifungal treatment targeting the virulence factors of different Candida species, paving the way for new treatment options in battling candidiasis.
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I purchased this as an immune booster, but I discovered it offers much more! It reduces cancer risks, enhances brain health, supports thyroid function, acts as a potent antioxidant, and combats heart disease, to name a few benefits. Additionally, it helps address Candidiasis. When I feel under the weather, I take two pills twice daily, but normally, I only need one pill once a day with food. I highly recommend this product at this dosage (100mcg).