NOW Supplements UC-II Type II Collagen

1 people found this helpful

Cold Sores details

A beneficial supplement for older individuals with sore joints. I recommended it to my mother, who took it alongside chondroitin and glucosamine. It effectively reduced joint stiffness and the frequency of pain.

6 people found this helpful

Leg Cramps details

Great product! After two months, my hip joints no longer ache, and my elderly parents have experienced a significant decrease in back, leg, and arm pain. I genuinely believe this will help maintain their joint health effectively.

This product is excellent; it significantly improves mood, sleep, and relieves stress. As a serotonin precursor, it effectively alleviates anxiety. The size is adequate for me, and the quality remains consistently high with premium ingredients. I felt the benefits quickly, and it comes with no taste, which is a plus.

Anxiety details

Arthritis details

Collagen may alleviate knee OA symptoms

Possibly Effective

Based on 16 Researches

Simental-Mendía M, Ortega-Mata D, Acosta-Olivo CA, Simental-Mendía LE, Peña-Martínez VM, et al. Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials. Clin Exp Rheumatol. 2025;43:126. doi:10.55563/clinexprheumatol/kflfr5

We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.

The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.

Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.

Life-changing supplement

Most Useful Review

164 people found this helpful

After enduring a debilitating neck injury for five years, I found only temporary relief through doctors prescribing NSAIDs. Learning about Type II collagen, I decided to try it. Just one week later, my pain ceased, and I experienced better sleep than I have in years. This has been a complete turnaround for me! If you are suffering from arthritis, I highly recommend trying this product.

Updated: Mar 2026

Athlete’s Foot details

My sister and I have taken it for two months, and now our feet no longer hurt. We will continue to take it.

Autoimmune Disorder details

GSZD reduces RA symptoms effectively

Based on 7 Researches

Wei SJ, Zhang Q, Xiang YJ, Peng LY, Peng W, et al. decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis. Pharm Biol. 2021;59:262. doi:10.1080/13880209.2021.1876100

We explored the effects of decoction (GSZD) on bone erosion linked to rheumatoid arthritis (RA) in a rat model. Our study involved various groups receiving either GSZD or standard treatments, monitoring changes in paw volume and arthritic severity.

The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.

Therapeutic effect

Most Useful Review

27 people found this helpful

While marketed for cartilage strengthening, I utilise it for "relapsed polychondritis," an autoimmune disorder I've suffered from for six years. This disorder is caused by collagen type 2 producing autoantibodies. I've proven that UC-II acts therapeutically with my body, and I am nearly fully recovered but take it daily for prevention.

Updated: Mar 2026

Chronic Cough details

Completely healthy now

1 people found this helpful

I like collagen and take it in courses with breaks. It's effective for my knee osteoarthritis. I’ve combined it with Boswellia, B vitamins, and Omega-3. After six years of chronic illness, I was restored in two years and now feel completely healthy. Supplements have become crucial for me. If my story helps you, I’m glad!

It really works! My knees no longer fear the cold. It has become an essential item for me—I've come to rely on it completely!

Cold details

2 people found this helpful

Diabetes details

An excellent form of collagen for joints. I have multiple spinal fractures and associated issues - protrusions, coxarthrosis, etc. I've tried numerous chondroprotectors in various forms for extended periods. Currently, these capsules are the best in my experience. Considering my type 2 diabetes mellitus, collagen is optimal, as glucosamine and chondroitin-based chondroprotectors worsen diabetes. A large package lasts for a lengthy course of four months. Overall, it turns out to be cost-effective. My order was well packaged and arrived safely in four weeks to Yekaterinburg. I would appreciate a like if this review was helpful to you. Thank you for your attention.

Flu details

Pain returned quickly

2 people found this helpful

A year ago, my husband developed knee arthrosis. After two unsuccessful treatments, I purchased collagen from iHerb, and after three months, he was pain-free. Sadly, once we stopped, the pain returned. This made me realise that collagen works best when combined with types I and III along with vitamin C, chondroitin, glucosamine, and hyaluronic acid. It took time to recover from deficiencies, but with proper hydration and care of our bodies, I hope my review assists others.

Updated: Jul 2026

Multiple Sclerosis details

Painkiller elimination

I took this supplement for two months based on my rheumatologist's advice, alongside medicinal treatments and vitamin D (I have unspecified reactive arthropathy). The results have been remarkable; I've managed to completely stop using painkillers. However, it’s important to note that collagen might be detrimental if you have rheumatic conditions such as systemic scleroderma or systemic sclerosis. Therefore, consulting a doctor before use is essential.

266 people found this helpful

Pelvic Pain details

Amazing effect and results. For a long time, I struggled to find the right balance of collagen to support my joint tissues. This product has been a lifesaver. Within a month, my knees stopped hurting, and after two months, I forgot about the clicks in my knees and the internal "dryness." A friend with a knee injury also stopped experiencing pain after a month. Initially, I felt unusual in my stomach, but that went away after a few weeks.

Swollen Lymph Nodes details

Cumulative improvement

9 people found this helpful

Wonderful! I take the UC-II supplement alongside other dietary supplements for joint health. The effects accumulate, but I noticed the first positive results within 1.5 weeks. The pain in my bones decreased, and the swelling disappeared, which was delightful. I also observed improvements in my skin; it has become smoother and more elastic. I will continue to order this supplement.

Updated: Apr 2026

Cardiovascular Disease details

Collagen source shows varying effectiveness

Based on 5 Researches

Liu H, Yang Y, Liu Y, Cui L, Fu L, et al. Various bioactive peptides in collagen hydrolysate from salmo salar skin and the combined inhibitory effects on atherosclerosis in vitro and in vivo. Food Res Int. 2022;157:111281. doi:10.1016/j.foodres.2022.111281

We explored the beneficial effects of collagen hydrolysate derived from salmon skin on atherosclerosis, a key contributor to cardiovascular diseases. The study showed that this collagen extract exhibits promising anti-inflammatory and antioxidant properties.

In tests with mice, it effectively reduced arterial thickening and plaque formation without side effects, comparable to the effects of aspirin. However, the results indicate that while collagen from salmon skin has potential, more research is needed before making definitive claims.

Joint restoration

Most Useful Review

8 people found this helpful

Type II collagen is crucial for joint health, involved in the structure of cartilage and intervertebral discs. With age, collagen decreases. This supplement aids in breaking down and regenerating collagen effectively, thus helping counter joint diseases. I take it on an empty stomach and have faced no side effects, with my knee pain now resolved.

Updated: Mar 2026

Headache details

It’s effective. Taking it alongside glucosamine can enhance relief from knee headaches.

Convenient to use. I take it twice a year, following a course of collagen types I and III. It contains hyaluronic acid, MSM, and vitamin C, alongside which I ensure to utilise chondroprotectors. Since then, Chondromalacia Patella has ceased to trouble me.

Chondromalacia Patella details

Frozen Shoulder details

Our father mentioned that not only did his knee joints feel less painful after use, but his shoulders also improved significantly. The product supplements the ingredients our joints lack, and the effect is commendable. It is suitable for all ages, does not affect eating habits, and the packaging is excellent.

Menopause details

Immediate improvement

Wonderful! Very high quality with good ingredients. I plan to order again for menopause as I have experienced an improvement in joint feelings, with an immediate effect.

I truly appreciate these probiotics. Consuming nuts like cashews and peanuts typically leads to constipation for me, but since taking these probiotics alongside those nuts, I've not experienced any constipation issues.

Constipation details

2 people found this helpful

High Cholesterol details

The best product of its kind! I’ve tried many collagen brands, but NOW's is the most effective for me. Just 40 mg daily makes my knees flexible again, like oiling the joints. I also absorb Calcium and Magnesium from Aquamin’s seaweed better. No stomach irritation at all. I highly recommend this product for joint health.

No discomfort experienced

Allergies details

I bought this for my husband, who often suffered from knee pain, and since he’s been taking it, everything has normalised. He takes it in the morning on an empty stomach, and it hasn't caused him any allergies or discomfort. I recommend it for its reasonable price.

Kidney Stones details

Improved joint movement

It was effective. Due to overuse in marathons and triathlons, my meniscus was damaged, leading to joint discomfort. However, after continuing to take this, my joints have moved more smoothly for a year, and the excess fluid on my knees has decreased. Although not entirely cured, movement has gradually become easier. I particularly appreciate the improvement as it feels like a twofold benefit since my skin condition has also improved.

Rheumatoid Arthritis details

GSZD shows anti-RA potential

Based on 10 Researches

We investigated the effects of GSZD, a traditional decoction, on bone erosion in a rat model of rheumatoid arthritis. Fifty rats were divided into control and treatment groups. Over 21 days, those receiving GSZD showed improved signs of inflammation and reduced joint damage compared to controls.

Specifically, GSZD lowered osteoclast numbers and enhanced protective factors, indicating its potential as a treatment option for rheumatoid arthritis. This study suggests GSZD could serve as a valuable supplement in managing RA symptoms.

7.5

Knees stopped hurting

Most Useful Review

122 people found this helpful

I began taking collagen on my rheumatologist's advice due to my rheumatoid arthritis. After 10 days, my knees stopped hurting and my hands felt easier. While miracles don’t happen and damaged joints can't be restored, at least my mobility has improved. If you have joint pain, don’t delay treatment! I highly recommend it!

Updated: Apr 2025

Sleep Apnea details

Sleep significantly improved

The quality of my sleep has greatly improved since starting this product, and I find the price very reasonable.

Tendonitis details

Notable tendon benefit

27 people found this helpful

I have tried nearly every supplement for healing tendonitis. However, this specific collagen type has been the only one providing significant benefits to the damaged tendon in my knee.

Excessive fatigue diminished

Chronic Fatigue Syndrome details

1 people found this helpful

After just a week, I already feel a difference; no longer do I experience excessive fatigue in my knee. I will continue taking it, hoping for further benefits, and I thank God I'm much better now!

Significant progress observed

Food Poisoning details

Now Foods UC-II Joint Health capsules have become my mother's favourite. This product provides undenatured type II collagen that supports healthy joints. After two months, my mother, who suffers from hip joint issues, has experienced significant improvement. I find the quality excellent and have started purchasing it regularly because of its effectiveness.

Osteoporosis details

Beneficial for elderly

This product does wonders for my mum’s osteoporosis. She has experienced positive effects since taking it.

Initially, I experienced discomfort, but after some time eating, it improved significantly, and I felt no nausea! I have repurchased it a second time, and the effect is remarkable!

Nausea details

Acne details

Microneedling depth impacts scars

Based on 6 Researches

El-Domyati M, Moftah NH, Ahmed AM, Ibrahim MR. Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study. Int J Dermatol. 2024;63:632. doi:10.1111/ijd.17006

In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.

On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.

The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.

7.5

Helps with acne

Most Useful Review

2 people found this helpful

This product is fantastic for my knee and shoulder pain at a great price for a 60-day supply. I believe it has also helped with my acne, as I've noticed a significant reduction since starting this supplement.

Updated: Oct 2025

Knee Pain details