Nature's Bounty Fish Oil

We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.

For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.

9.5

Improves cardiovascular health

Most Useful Review

Wonderful! A great fish oil. Omega 3 can lower the risk of cardiovascular disease and improve blood circulation. It enhances cognitive functions and memory, reduces blood pressure, and aids in diabetes prevention. My family takes omega regularly and finds it offers an ideal price-quality ratio. The capsules are large but easy to swallow.

Back Pain details

SCIENTIFIC SCORE

Possibly Effective

Based on 12 Researches

Eicosapentaenoic acid alleviates back pain

Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.

Most Relevant Research

We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.

Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.

In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.

No leg pain

Most Useful Review

These softgels are fantastic and do the job well. I used to suffer from pain in my legs, but since taking this fish oil, I no longer experience any pain. I can now bend down to clean the cat litter with ease. I wouldn't go back to the 1200mg fish oil as it caused my legs to hurt again.

Autoimmune Disorder details

SCIENTIFIC SCORE

Possibly Effective

Based on 31 Researches

Resolvin D1 impacts lupus progression

Resolvin D1 inhibits T follicular helper cell expansion in systemic lupus erythematosus.

Most Relevant Research

We focused on how Resolvin D1 (RvD1), a pro-resolving lipid, impacts systemic lupus erythematosus (SLE). Our study measured RvD1 levels and T follicular helper (Tfh) cell counts in SLE patients versus healthy individuals.

We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.

Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.

8.8

Improved mood swings

Most Useful Review

Fish Oil is excellent! I believe it is genuinely helping me manage my mood swings, particularly before my menstruation. I purchased this for my daughter, but we've been sharing. I feel less irritable and have noticed a significant effect on my autoimmune disorder. The softgels are easy to swallow, and the dosage of EPA and DHA is beneficial for my heart, joints, and vision. The entire family takes it regularly, and I've observed better concentration and overall well-being. I recommend this product for its quality and value.

Bone Pain details

SCIENTIFIC SCORE

Likely Very Effective

Resolvin D1 alleviates bone cancer pain

Systemic administration of Resolvin D1 reduces cancer-induced bone pain in mice: Lack of sex dependency in pain development and analgesia.

Most Relevant Research

We explored the potential of Resolvin D1 (RvD1) as a non-opioid treatment for bone cancer pain in a mouse model. RvD1 was administered intravenously, showing a remarkable ability to lessen pain effects similarly in both male and female mice.

We found that a single dose effectively reduced pain, while daily treatments eliminated it entirely. Notably, sex didn't influence the pain or treatment efficacy, opening doors for RvD1 as a viable alternative to opioids in managing bone cancer pain.

9.5

Pain relief

Most Useful Review

My mother found relief from her bone pain using this excellent product.

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE

Possibly Effective

Based on 8 Researches

Eicosapentaenoic acid benefits CFS

Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes.

Most Relevant Research

We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.

After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.

This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.

8.8

Improved concentration

Most Useful Review

Fish oil has significantly improved my mood swings, especially around my menstrual cycle. I have noticed I am less irritable and more focused, which I believe aids in managing my chronic fatigue syndrome. I appreciate the softgel size for easy swallowing. The omega-3s benefit my heart, joints, and vision, and it also contains vitamin D3. My family and I take it regularly and have felt great overall. I highly recommend it for its quality and value!

Heart Disease details

SCIENTIFIC SCORE

Possibly Effective

Based on 32 Researches

Omega-3 reduces heart disease risk

Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.

Most Relevant Research

We examined the relationship between plasma omega-3 levels and heart failure (HF), focusing on how this affects mortality in patients with existing HF. Our analysis of the UK Biobank, which included nearly 272,000 participants without HF, showed that higher omega-3 levels were linked to a 21% lower risk of developing HF over nearly 14 years.

For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.

9.5

Mood and heart benefits

Most Useful Review

Fish Oil is remarkable! I believe it's assisting with my mood swings. Initially bought for my daughter, we now share it. I've noticed I'm less irritable, and it appears beneficial for heart disease and my autoimmune issues. The softgels are easy to swallow. I recommend purchasing, and I’ll continue using it!

Knee Pain details

SCIENTIFIC SCORE

Possibly Effective

Based on 18 Researches

DHA reduces knee pain and swelling

Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritis.

Most Relevant Research

We explored whether purified docosahexaenoic acid (DHA), an omega-3 fatty acid, can ease knee pain and swelling in a mouse model of arthritis. Mice with arthritis were treated with either oral or injected DHA, and we observed notable improvements in pain behavior and knee swelling.

This study highlights that DHA may reduce pain and inflammation in knee arthritis, suggesting it could be a helpful option for those suffering from rheumatoid arthritis. However, it’s essential to keep in mind that these results come from an animal model, and human studies are necessary.

9.5

Relieved knee pain

Most Useful Review

My mother found relief from her knee pain with this excellent product.

Blurred Vision details

Improved concentration

Most Useful Review

Fish Oil is excellent! I think this is really helping me with my mood swings. I tend to get easily upset, especially before my menstruation. I bought this for my daughter, but we’ve been sharing it. I have noticed I’m less irritable. Although I haven't done much research yet, as long as I feel good, I'll continue using it. I’m so grateful to have found iHerb during this pandemic, especially with the increasing prices of vitamins in my country. I’ve been using this brand for a while, and it has significantly benefited my body, particularly for my autoimmune syndromes. The softgels are easy to swallow, and they’re a great value for the benefits. I take it for my heart, joints, and especially vision. After a couple of weeks, I felt a noticeable boost in my concentration and control.