Nature's Bounty Melatonin

Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.

Most Relevant Research

We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.

The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.

Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.

9.5

Sleep improvement

Most Useful Review

Excellent drug. I have always had trouble sleeping, often waking up several times. However, after taking it two hours before bedtime, I sleep like a baby. I highly recommend it!

Dizziness details

Melatonin's impact on dizziness

Addressing Sleep Disorders in Psychiatry: Comparing the Use of Melatonin, Trazodone, and Doxepin.

Most Relevant Research

We assessed how melatonin affects dizziness in patients dealing with sleep disturbances tied to psychiatric conditions. In a study with 175 participants, we found that melatonin was slightly less effective than trazodone and doxepin in improving overall sleep quality. However, it stood out for having a low incidence of adverse effects. Specifically, the rates of dizziness associated with melatonin use were measured, showing a relatively low occurrence.

While it did not provide the most substantial improvement in sleep quality, melatonin showed promise in enhancing tolerability among users. Only 10% of participants reported dizziness, which indicates that melatonin might be a safer option for those worried about side effects from more potent medications. By choosing melatonin, patients can potentially find a balance between managing sleep disturbances while minimizing unwanted symptoms like dizziness.

Overall, we observed that for individuals focused on avoiding adverse effects, melatonin serves as a viable alternative within this treatment landscape. Its effectiveness in curbing dizziness contributes to discussions on how best to treat sleep disorders in psychiatric patients without compromising their comfort.

9.5

No dizziness reported

Most Useful Review

Great. I'm purchasing this for the third time for my elderly father. He had no dizzy head the second day and slept well at night.

Insomnia details

SCIENTIFIC SCORE

Possibly Effective

Based on 23 Researches

Melatonin delivery enhances sleep

Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.

Most Relevant Research

We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.

Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.

Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.

We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.

9.5

Most effective OTC

Most Useful Review

This product works exceedingly well for my chronic pain, which causes persistent insomnia. I’ve trialed many sleep aids and other melatonin brands, including dissolvable forms, but this is the most effective over-the-counter option I’ve found after years of effort.

Headache details

SCIENTIFIC SCORE

Possibly Effective

Based on 15 Researches

Agomelatine relieves hypnic headaches

Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option.

Most Relevant Research

We explored how melatonin-based treatments, particularly agomelatine, can affect headaches, focusing on hypnic headaches (HH). This form of headache typically occurs during sleep, disrupting the rest of those affected. A fascinating case of a 58-year-old woman who experienced these nocturnal headaches for three years demonstrated the potential benefits of agomelatine.

After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.

This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.

No headaches after use

Most Useful Review

It works like a charm. I have no headaches afterwards. However, I don't use it for insomnia; I only take it when I need to fall asleep earlier than usual.

Autoimmune Disorder details

SCIENTIFIC SCORE

Possibly Effective

Based on 16 Researches

Melatonin improves MS-related symptoms

12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial.

Most Relevant Research

We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.

We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.

This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.

9.5

Highly effective alternative

Most Useful Review

I absolutely loved this melatonin! It is unfortunate that it is banned from shipping to my country. It outperforms the offerings at my local pharmacy significantly.