' 
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Saturated Fat
0.5 g
3%**
Cholesterol
10 mg
3%
Fish Oilprovides 360 mg of Total Omega-3 Fatty Acids†comprising of:EPA (Eicosapentaenoic Acid)DHA (Docosahexaenoic Acid)Other Fatty Acids
1,200 mg (1.2 g)
***************
The product is found useful for the following medical conditions
Blood Clot
SCIENTIFIC SCORE
Most Likely Effective
Based on 15 Researches
7.6
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
9
Eicosapentaenoic acid influences clotting
Emergence of omega-3 fatty acids in biomedical research.
Most Relevant Research
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
9.5
Blood clot reduction
Most Useful Review
Omega-3 regulates blood pressure and mitigates blood clot formation, thus lowering the risk of heart attack and stroke. It also reduces triglycerides and low-density cholesterol while offering anti-inflammatory and antiarrhythmic benefits. A wonderful product with top-notch quality, and the handy two-pack is a bonus.
Cardiovascular Disease
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.3
USERS' SCORE
Excellent
Based on 5 Reviews
9.5
9
EPA's role in diabetic heart health
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Most Relevant Research
We explored the impact of eicosapentaenoic acid (EPA), a nutrient known for its heart benefits, on diabetic cardiomyopathy (DC), a condition leading to heart failure. Our study focused on diabetic mice and revealed that EPA plays a protective role against DC, particularly by reducing harmful M1-polarized macrophages in the heart.
In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.
We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.
Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.
In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.
We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.
Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.
9.5
Improves cardiovascular health
Most Useful Review
Wonderful! A great fish oil. Omega 3 can lower the risk of cardiovascular disease and improve blood circulation. It enhances cognitive functions and memory, reduces blood pressure, and aids in diabetes prevention. My family takes omega regularly and finds it offers an ideal price-quality ratio. The capsules are large but easy to swallow.
Heartburn
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
9.5
Heartburn relief
Most Useful Review
Omega 3 has been a wonderful solution for us. Since our family began taking it, my husband no longer suffers from heartburn, which was a persistent issue. I’ve also noticed an improvement in my skin and overall well-being. Working at a school is demanding, but since I recalled my childhood memories of taking fish oil regularly with my sister, we feel healthier and more resilient against illness. This product has truly suited our needs. Thank you!
Knee Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
6.8
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
8
Eicosapentaenoic acid alleviates knee pain
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Most Relevant Research
We explored the potential benefits of eicosapentaenoic acid (EPA) combined with l-serine in relieving chronic low-back and knee pain among adults. In a well-structured randomized, double-blind, placebo-controlled trial, we followed 120 participants who suffered from pain for over three months. They were divided into two groups: one received daily doses of 594 mg of l-serine and 149 mg of EPA, while the other group was given a placebo.
After eight weeks of treatment and a four-week follow-up, we observed pain relief improvements reported through various questionnaires. The results indicated that the combination of l-serine and EPA was effective in reducing pain in the lower back and knees, highlighting the significance of these components in managing chronic pain conditions. Though EPA was part of a combination treatment, its anti-inflammatory properties may offer a promising avenue for individuals suffering from knee pain specifically.
Our findings provide an encouraging perspective for those seeking alternatives for pain management. While the study combined l-serine with EPA, it became evident that these ingredients together can lead to meaningful relief for patients with persistent knee pain.
After eight weeks of treatment and a four-week follow-up, we observed pain relief improvements reported through various questionnaires. The results indicated that the combination of l-serine and EPA was effective in reducing pain in the lower back and knees, highlighting the significance of these components in managing chronic pain conditions. Though EPA was part of a combination treatment, its anti-inflammatory properties may offer a promising avenue for individuals suffering from knee pain specifically.
Our findings provide an encouraging perspective for those seeking alternatives for pain management. While the study combined l-serine with EPA, it became evident that these ingredients together can lead to meaningful relief for patients with persistent knee pain.
9.5
Relieved knee pain
Most Useful Review
My mother found relief from her knee pain with this excellent product.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 3 Reviews
9
9.5
Pain relief
Most Useful Review
My mother found relief from her bone pain using this excellent product.
Allergies
SCIENTIFIC SCORE
Most Likely Effective
Based on 11 Researches
7.8
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8
Omega-3s and skin allergies
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
Most Relevant Research
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
8.8
Reduces allergy symptoms
Most Useful Review
Great value packaging. Fish oil can alleviate allergy symptoms and also benefits heart health. The taste is not too fishy, and a sufficient dose of omega makes it a great choice.
Autoimmune Disorder
SCIENTIFIC SCORE
Most Likely Effective
Based on 15 Researches
7.4
USERS' SCORE
Very Good
Based on 2 Reviews
8.8
8
Eicosapentaenoic acid benefits MS
The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
8.8
Improved mood swings
Most Useful Review
Fish Oil is excellent! I believe it is genuinely helping me manage my mood swings, particularly before my menstruation. I purchased this for my daughter, but we've been sharing. I feel less irritable and have noticed a significant effect on my autoimmune disorder. The softgels are easy to swallow, and the dosage of EPA and DHA is beneficial for my heart, joints, and vision. The entire family takes it regularly, and I've observed better concentration and overall well-being. I recommend this product for its quality and value.
Back Pain
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.4
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
9
Eicosapentaenoic acid alleviates back pain
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Most Relevant Research
We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
8.8
Less pain
Most Useful Review
Bought at a significant discount and very pleased with the quality and quantity. I've been taking three tablets daily for four months, and I recommend them. They have noticeably improved my health and reduced my back pain.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Most Likely Effective
Based on 5 Researches
7.9
USERS' SCORE
Very Good
Based on 2 Reviews
8.8
9.5
Eicosapentaenoic acid benefits CFS
Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes.
Most Relevant Research
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
8.8
Improved concentration
Most Useful Review
Fish oil has significantly improved my mood swings, especially around my menstrual cycle. I have noticed I am less irritable and more focused, which I believe aids in managing my chronic fatigue syndrome. I appreciate the softgel size for easy swallowing. The omega-3s benefit my heart, joints, and vision, and it also contains vitamin D3. My family and I take it regularly and have felt great overall. I highly recommend it for its quality and value!
Heart Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
6.8
USERS' SCORE
Very Good
Based on 6 Reviews
8.8
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Most Relevant Research
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
9.5
Mood and heart benefits
Most Useful Review
Fish Oil is remarkable! I believe it's assisting with my mood swings. Initially bought for my daughter, we now share it. I've noticed I'm less irritable, and it appears beneficial for heart disease and my autoimmune issues. The softgels are easy to swallow. I recommend purchasing, and I’ll continue using it!
