Peptide hydrogel boosts islet transplantationA novel self-assembling peptide nanofiber hydrogel with glucagon-like peptide-1 functionality enhances islet survival to improve islet transplantation outcome in diabetes treatment.
We explored a cutting-edge peptide hydrogel designed to improve islet transplantation outcomes for diabetes. By integrating glucagon-like peptide-1 (GLP-1) into a self-assembling nanofiber structure, we aimed to address the common issues of islet graft survival and function.
In our tests, this innovative hydrogel notably increased islet function and longevity, reducing inflammation and enhancing metabolic control in a mouse model. The findings show promise for localized delivery methods and suggest a potential breakthrough in diabetes treatment through improved graft efficacy.
Reduces blood sugar
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