5/1/2025
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Advanced 40+ Acidophilus 1.5 billion CFUproviding:Lactobacillus. acidophilus, (LA-5®)300 million CFULactobacillus rhamnosus GG (LGG®)300 million CFULactobacillus paracasei (L. CASEI 431®)300 million CFU Bifidobacterium lactis (BB-12®)300 million CFUStreptococcus thermophilus, (TH-4®)300 million CFU
2.4 mg
**
The product is found useful for the following medical conditions
Autoimmune Disorder details
SCIENTIFIC SCORE
Moderately Effective
Based on 48 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.7
9.5
We investigated the potential of Lactococcus lactis, a safe bacterial strain, to deliver protective proteins for preventing type 1 diabetes (T1DM) in NOD mice. Our study used two specially engineered strains that expressed a specific protein.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
We found that oral administration of these Lactococcus lactis strains helped stop high blood sugar, enhanced glucose tolerance, and reduced inflammation in the pancreas. This occurred by suppressing certain auto-reactive T cells and encouraging healthy immune responses. Our results suggest that this method could effectively help prevent T1DM in these mice.
10
Daily relief
Most Useful Review
4 people found this helpful
I ordered this probiotic due to stool issues. To my surprise, it worked wonders! My bathroom habits became regular, and I would recommend it to anyone facing a similar problem.
Bloating details
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.7
USERS' SCORE
Good
Based on 10 Reviews
8.6
9
Bifidobacterium lactis alleviates bloating
We conducted a study to see if a fermented dairy product with Bifidobacterium lactis DN-173 010 could help reduce bloating in patients with irritable bowel syndrome (IBS) and constipation. In a controlled trial with 34 participants over four weeks, we found that this probiotic significantly decreased abdominal girth and improved gastrointestinal transit times.
Patients reported feeling less bloated, and symptom severity also decreased. These findings suggest that fostering faster transit times may be an effective method to combat abdominal distension.
Patients reported feeling less bloated, and symptom severity also decreased. These findings suggest that fostering faster transit times may be an effective method to combat abdominal distension.
9
Bloating alleviated
Most Useful Review
7 people found this helpful
Liked trying different prebiotics from our pharmacies—no effect. Thanks to these "animals," the bloated abdomen, heaviness inside, and unpleasant intestinal sensations disappeared, and my weight began to decrease. This isn't some form of advertising hype! I read about similar bacteria and took a pill each morning on an empty stomach, followed by breakfast with cereal or muesli.
Candidiasis details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 6 Reviews
8.5
9
We set out to explore how lactobacillus acidophilus, specifically strain B-2178, impacts vulvovaginal candidiasis (VVC) in female rats. By dividing our study subjects into five groups, we included controls and examined the effects of different treatments.
In particular, we analyzed the immune response of the vaginal tissue after intravaginal inoculation to establish VVC. The rats treated with strain B-2178 showed a promising ability to maintain an immune-tolerant state in the vaginal epithelium. Through this action, it seemed capable of reducing uncontrolled inflammation, which is often a challenge during candidiasis.
Although our findings suggest that B-2178 may be beneficial in treating VVC, it's important to note that the overall focus was broader and did not isolate lactobacillus acidophilus alone. This makes it difficult to pinpoint the specific advantages of this particular strain compared to others.
Ultimately, it appears that while B-2178 exhibits potential, more targeted research is required to evaluate its effectiveness in isolating and addressing candidiasis comprehensively.
In particular, we analyzed the immune response of the vaginal tissue after intravaginal inoculation to establish VVC. The rats treated with strain B-2178 showed a promising ability to maintain an immune-tolerant state in the vaginal epithelium. Through this action, it seemed capable of reducing uncontrolled inflammation, which is often a challenge during candidiasis.
Although our findings suggest that B-2178 may be beneficial in treating VVC, it's important to note that the overall focus was broader and did not isolate lactobacillus acidophilus alone. This makes it difficult to pinpoint the specific advantages of this particular strain compared to others.
Ultimately, it appears that while B-2178 exhibits potential, more targeted research is required to evaluate its effectiveness in isolating and addressing candidiasis comprehensively.
9
Effective probiotic treatment
Most Useful Review
4 people found this helpful
Great working probiotic! I ordered this in a new form and packaging. A year ago, I took a variant in a glass package which helped me significantly after illnesses and antibiotics; I suffered from prolonged thrush and cystitis attacks. I noticed improvement within the second week, and after completing a three-month course, I generally forgot about this issue. I observed positive changes in digestion, and I did not alter my nutrition or lifestyle. I plan to repeat the course this autumn and found two jars in an advantageous package. I trust the Solgar brand; for me, it’s the best option. Following last year’s distress, I am very pleased this supplement worked well for me. I recommend it highly.
Eczema details
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
We explored the potential of Lactobacillus acidophilus KBL409 in addressing atopic dermatitis, a common form of eczema. By using a mouse model induced by house dust mites, we found that administering this probiotic led to significantly lower dermatitis scores and less immune cell infiltration in the skin.
Additionally, L. acidophilus KBL409 reduced serum immunoglobulin E and influenced various cytokines linked to inflammation. It also positively affected gut microbiota and concentrations of beneficial compounds, hinting at a broader impact on our immune responses. Overall, our findings suggest that L. acidophilus KBL409 may be a promising probiotic for eczema management.
Additionally, L. acidophilus KBL409 reduced serum immunoglobulin E and influenced various cytokines linked to inflammation. It also positively affected gut microbiota and concentrations of beneficial compounds, hinting at a broader impact on our immune responses. Overall, our findings suggest that L. acidophilus KBL409 may be a promising probiotic for eczema management.
9
Happy with results
Most Useful Review
Currently, this product appears to assist my eczema owing to the bacterial strain L.casei. I am very pleased with it!
Pelvic Pain details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
USERS' SCORE
Good
Based on 6 Reviews
8.5
7
We examined the urinary microbiome of women with interstitial cystitis and found it less diverse and containing fewer Lactobacillus acidophilus compared to a control group.
This lack of Lactobacillus was linked to more severe symptoms and poor quality of life. While we noted some associations between higher inflammatory markers and the severity of symptoms, we didn’t see a clear causal relationship.
Essentially, we’re still unsure if the presence of Lactobacillus can effectively reduce pelvic pain in this context.
This lack of Lactobacillus was linked to more severe symptoms and poor quality of life. While we noted some associations between higher inflammatory markers and the severity of symptoms, we didn’t see a clear causal relationship.
Essentially, we’re still unsure if the presence of Lactobacillus can effectively reduce pelvic pain in this context.
9
Post-meal comfort
Most Useful Review
Excellent product! I can't be without it now. I no longer experience pain after eating. I continue to repurchase this regularly.
Bacterial Infection details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
Lactobacillus aids pigs' health
We explored the effects of Lactobacillus acidophilus fermentation products on weanling pigs that were challenged with a harmful strain of bacteria known as enterotoxigenic F4 Escherichia coli (F4-ETEC). To better understand this, we conducted a detailed study involving eighty pigs, which were divided into five groups based on different diets. This included a control diet, as well as diets supplemented with various fermentation products and zinc oxide.
After inoculating the pigs with F4-ETEC to simulate infection, we observed significant changes in the pigs’ fecal microbiome when they were given a combination of Lactobacillus and Saccharomyces products. These changes in the microbiome were previously linked to better growth performance and overall health in young pigs.
Interestingly, the pigs receiving both Lactobacillus acidophilus and Saccharomyces cerevisiae products showed an increase in final live weight. This suggests that using these postbiotics could help manage performance issues associated with ETEC without needing to eliminate the bacteria entirely from the pigs' environment. Therefore, while Lactobacillus acidophilus was not the sole hero in this study, its combined use proved beneficial in combatting the negative effects of this bacterial challenge.
After inoculating the pigs with F4-ETEC to simulate infection, we observed significant changes in the pigs’ fecal microbiome when they were given a combination of Lactobacillus and Saccharomyces products. These changes in the microbiome were previously linked to better growth performance and overall health in young pigs.
Interestingly, the pigs receiving both Lactobacillus acidophilus and Saccharomyces cerevisiae products showed an increase in final live weight. This suggests that using these postbiotics could help manage performance issues associated with ETEC without needing to eliminate the bacteria entirely from the pigs' environment. Therefore, while Lactobacillus acidophilus was not the sole hero in this study, its combined use proved beneficial in combatting the negative effects of this bacterial challenge.
9
Restores intestinal microflora
Most Useful Review
The complex is fantastic! After having Covid, I experienced digestive issues that were difficult to resolve. A doctor recommended an acidophilus complex, and within just one week, I noticed a significant improvement. After completing a full course, my stool returned to normal. I am deeply grateful to iHerb and recommend it to anyone who has had an infection, undergone antibiotic treatment, or those with skin issues. It is truly beneficial for restoring intestinal microflora.
Diarrhea details
SCIENTIFIC SCORE
Possibly Effective
Based on 67 Researches
7.8
USERS' SCORE
Good
Based on 7 Reviews
8.3
9.5
Bifidobacterium lactis reduced diarrhea duration
We explored the impact of Bifidobacterium animalis subsp. lactis BLa80 on diarrhea in young children through a well-structured, randomized, double-blinded, placebo-controlled study.
Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.
Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.
This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.
Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.
This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
9
No adverse effects
Most Useful Review
11 people found this helpful
Very pleased. This is a wonderful product as I have lactose intolerance. I can enjoy a large soft serve "sweet frog" frozen yogurt without experiencing diarrhoea or stomach upset. No adverse side effects to report as of this review.
Food Poisoning details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.5
USERS' SCORE
Good
Based on 5 Reviews
8.2
9
Lacticaseibacillus rhamnosus shows promise
We explored the potential of Lacticaseibacillus rhamnosus GG as a probiotic treatment against avian pathogenic E. coli (APEC) in chickens. Our study showed that this probiotic significantly reduced APEC colonization in the chickens' cecum and improved the balance of gut microbiota over a 24-hour period.
Through laboratory evaluations, we detected novel bioactive peptides in the probiotic's culture supernatants, which may contribute to its antibacterial properties. While the results are promising for poultry health, more research is needed to optimize its use in real farming conditions.
Through laboratory evaluations, we detected novel bioactive peptides in the probiotic's culture supernatants, which may contribute to its antibacterial properties. While the results are promising for poultry health, more research is needed to optimize its use in real farming conditions.
9
Convenient probiotic
Most Useful Review
8 people found this helpful
Working probiotic! A convenient product with positive results after two months. It has helped my whole family cope during these challenging times when food quality is often poor. I am ordering more and recommend it to friends!
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 68 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.1
8
We investigated the impact of a probiotic ice cream containing engineered bacteria on pollen allergies in mice. After sensitizing the mice, we treated them with this unique ice cream for four weeks. The results were promising! The ice cream significantly lowered serum IgE levels, which are linked to allergic reactions. Additionally, beneficial cytokines increased while the levels of a harmful cytokine decreased. Overall, our findings suggest that this probiotic ice cream could improve allergy responses, particularly with Th1 and Treg involvement.
9
Good allergy improvement
Most Useful Review
Recommended purchase. I have observed a good improvement in my allergies.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 47 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8
9
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
9
Convenient effectiveness
Most Useful Review
4 people found this helpful
This is the finest quality product I have tried among all probiotics, even better than those from pharmacies! It's highly convenient for travel, as it doesn't require refrigeration. It significantly assists me with my irritable bowel syndrome.
Constipation details
SCIENTIFIC SCORE
Possibly Effective
Based on 56 Researches
7.7
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.9
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
10
Significant improvement
Most Useful Review
14 people found this helpful
I used to struggle with constipation and irregularity, but this product has resolved that issue. My husband and I take one daily before breakfast, and it has greatly improved our digestive health.
Yeast Infection details
SCIENTIFIC SCORE
Moderately Effective
Based on 24 Researches
8.3
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.8
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
7.5
Highly effective
Most Useful Review
1 people found this helpful
There’s no need to refrigerate this excellent product—it's my favourite probiotic and the most effective for me. A must when on any prescription antibiotics to mitigate typical side effects like gastrointestinal issues and yeast infections. The small capsule is very easy to swallow.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.6
8
Clearer skin
Most Useful Review
6 people found this helpful
I have been taking it for three weeks, and I first noticed a decrease in the number of rashes on my face, with my skin appearing clearer. There were no adverse effects on my gastrointestinal tract; my intestines are functioning well. I took a course after finishing antibiotics and will continue as it seems to boost my immunity.
