Supplement Facts
Serving Size: 4 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
1 g
<1%**
Dietary Fiber
1 g
4%**
Vitamin D (as cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as calcium citrate)
1000 mg
77%
Sodium†
20 mg
<1%
The product is found useful for the following medical conditions
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Good
Based on 10 Reviews
8.7
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
9
Nail strength improvement
Most Useful Review
4 people found this helpful
I've been taking this calcium supplement for two months as recommended by my doctor. I've seen excellent results, particularly with my nails; they no longer break as they used to. I'm thoroughly satisfied and will continue to order more.
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 6 Reviews
8.7
9
Our research focused on understanding how Vitamin D (VitD) might influence blood clotting, especially in the context of COVID-19. We found that when human endothelial cells were exposed to IL-6—an inflammatory cytokine associated with severe COVID-19—it led to dysfunction in these cells. This dysfunction was marked by increased levels of Tissue Factor (TF) and cell adhesion molecules (CAMs), which promote blood clotting.
Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.
Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.
Remarkably, when we treated these endothelial cells with VitD, we observed a reversal of these harmful effects. VitD appeared to inhibit the expression of TF and CAMs and even modulated the levels of the ACE2 receptor, which is crucial for the entry of the virus into cells. Our findings suggest that VitD could play a protective role against the blood clotting complications associated with COVID-19 by counteracting IL-6's effects on endothelial cells.
Overall, this study paves the way for further research into VitD as a potential therapeutic option for mitigating thrombotic risks in COVID-19 patients.
10
Calcium levels restored
Most Useful Review
11 people found this helpful
My mother, with her thyroid gland removed, relies on calcium supplementation and has struggled to maintain proper calcium levels until she tried this calcium citrate. Previous alternatives did not yield the desired blood test results. This product has successfully normalised her calcium levels, much to our delight! Despite the large pill size, it's the effectiveness in maintaining calcium that matters most.
Cold Sores details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
We explored how a specific genetic variant associated with vitamin D might influence the occurrence of cold sores, also known as Herpes Simplex Labialis (HSL). Our research involved nearly 1,800 participants from the TwinsUK registry, with a focus on a group of 595 that completed both blood tests and questionnaires regarding their cold sore experiences.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
9
Enamel strengthened
Most Useful Review
This supplement is brilliant! Recommended by my orthodontist, I began taking calcium citrate with vitamin D3 to strengthen my tooth enamel before getting braces. I trust Solgar for their quality and effectiveness. After a month, my test results showed normal calcium levels, and my doctor was pleased! I've always had issues with sensitive teeth, but since starting this supplement, I no longer experience pain from hot, cold, or sweet foods. I feel confident that my teeth can now withstand braces without the risk of damage to the enamel.
Leg Cramps details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
5.9
USERS' SCORE
Good
Based on 14 Reviews
8.6
9
Calcium dobesilate reduces leg cramps
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
7.5
Cramps reduced
Most Useful Review
9 people found this helpful
Initially, my legs had mild cramps at bedtime, which worsened and disrupted my sleep. I noted brittle nails and excessive hair loss, prompting me to analyse my calcium levels. Realising I needed calcium citrate for better absorption, I ordered this product and after half a month, noted a reduction in cramping, alongside stronger nails. Although the tablets are large, that isn’t an issue for me. I would recommend them and plan to order more.
Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
9
Effective calcium supplement
Most Useful Review
I purchased this as recommended by my doctor for my rheumatoid arthritis. I found that calcium citrate is absorbed significantly better than calcium carbonate and should be taken with vitamin D. Finally, I've found an excellent source of calcium! Although the tablets are quite large, I manage to chew them. I take one tablet in the evening, post 6 PM, for optimal absorption. I highly recommend it to everyone!
Kidney Stones details
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.3
USERS' SCORE
Good
Based on 6 Reviews
8.5
8
Urinary factors impact kidney stone risk
We undertook a thorough analysis of 24-hour urine collections from over 6,200 participants to explore how various urinary factors contribute to kidney stone formation.
Our findings revealed that higher levels of urine volume, citrate, potassium, magnesium, and uric acid were linked to a lower risk of developing stones. Conversely, increased levels of calcium, oxalate, phosphorus, and sodium were associated with a higher risk.
Interestingly, urine acidity did not seem to play a role. Our research highlighted the complexity and varying importance of these urinary factors regarding their relationship with stone formation.
Our findings revealed that higher levels of urine volume, citrate, potassium, magnesium, and uric acid were linked to a lower risk of developing stones. Conversely, increased levels of calcium, oxalate, phosphorus, and sodium were associated with a higher risk.
Interestingly, urine acidity did not seem to play a role. Our research highlighted the complexity and varying importance of these urinary factors regarding their relationship with stone formation.
9
Osteoporosis treatment success.
Most Useful Review
4 people found this helpful
The product performs excellently, and one gets accustomed to the large capsules. I have been using it for three years to treat osteoporosis and have seen improvements in my densitometry results, rising from -2.6 to -1.4. Previously, I took Nycomed Forte Calcium D3 for two years, which affected my kidneys and my osteoporosis did not improve. I’m delighted to have found this product.
Knee Pain details
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.7
USERS' SCORE
Good
Based on 6 Reviews
8.5
8
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
9
Knees feel better
Most Useful Review
3 people found this helpful
Perfectly! I take this supplement as per my doctor's advisory. Within a month, I noticed a difference: my knees no longer caused me trouble.
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Vitamin D supports bone health
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
9
Highly recommended
Most Useful Review
Excellent! I have been taking this since 2014 when I entered complete surgical menopause at 41 due to severe endometriosis. I take 2 pills in the morning and evening. This product is fantastic!
Adenoiditis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
Diet supplemented easily
Most Useful Review
Excellent! It was a good and easy addition to my diet, and it didn't stick in my throat.
Bloating details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
We aimed to assess how the supplement OsteoCalVitFort, which includes 500 mg of calcium and 400 I.U. of vitamin D3, affects bloating and overall satisfaction among users. In our study, 186 participants aged between 18 and 65 were invited to take two tablets daily—one after breakfast and one after dinner—over a period defined by the contents of a single pack.
After the supplement use, we discovered that symptoms like bloating and constipation showed a remarkable decline. Specifically, the reported cases of bloating decreased from 12.5% to just 0.6%. Similarly, occurrences of constipation dropped significantly, evidencing that the supplement not only supports bone health but also alleviates some common digestive concerns.
With a fantastic 94% satisfaction rate among users, it seems that OsteoCalVitFort stands out as a favorable option for those looking to enhance their calcium and vitamin D intake without experiencing the side effects often associated with similar supplements. Overall, this study gives us encouraging insights into the positive effects of vitamin D in reducing bloating.
After the supplement use, we discovered that symptoms like bloating and constipation showed a remarkable decline. Specifically, the reported cases of bloating decreased from 12.5% to just 0.6%. Similarly, occurrences of constipation dropped significantly, evidencing that the supplement not only supports bone health but also alleviates some common digestive concerns.
With a fantastic 94% satisfaction rate among users, it seems that OsteoCalVitFort stands out as a favorable option for those looking to enhance their calcium and vitamin D intake without experiencing the side effects often associated with similar supplements. Overall, this study gives us encouraging insights into the positive effects of vitamin D in reducing bloating.
8
No bloating issues
Most Useful Review
5 people found this helpful
Calcium Citrate with Vitamin D3 is incomparable; I ordered it for the second time. I've tried calcium from various companies, but this one doesn’t cause nausea or bloating. I’m very pleased with this supplement.
Cold details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.8
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
9
Pain-free experience
Most Useful Review
The dentist suggested a course of calcium citrate with vitamin D3 to improve my enamel. I noticed a remarkable positive effect: my sensitive tooth enamel used to react vigorously to sweet-hot-cold, but after using this supplement, I've forgotten about my discomfort. My teeth no longer hurt or ache.
Cancer details
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 3 Reviews
8.3
5
We conducted an observational study to examine the levels of vitamin D in female patients with benign and malignant breast diseases. The research aimed to determine if there is a significant difference in vitamin D levels between those with non-cancerous conditions and those diagnosed with breast cancer.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
9
Breast cancer concern
Most Useful Review
4 people found this helpful
Wonderful product! Highly recommend it! The tablets are not as large as others claim. I typically take one or two tablets several times a day, but it's best to take two at night for better sleep. They are significantly smaller than the calcium pills I previously took, which is a huge plus! I will certainly purchase them again! It's also important to mention they are soy-free, which is crucial for me as I have had breast cancer.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.8
USERS' SCORE
Good
Based on 4 Reviews
8.3
0
We conducted a study to see if high-dose vitamin D3 could improve vascular health and reduce fatigue in individuals suffering from chronic fatigue syndrome (CFS). This was a well-structured trial involving 50 participants, all of whom met specific diagnostic criteria for CFS. Participants were divided into two groups: one received 100,000 units of vitamin D3 every two months, while the other received a placebo over a period of six months.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
9
Increased energy
Most Useful Review
Great vitamins combining calcium with vitamin D3 have eliminated my fatigue and drowsiness, giving me a boost of energy.
Reflux details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
9
No reflux experienced
Most Useful Review
Very nice product; I like it because I do not experience any side effects, which is usual for Calcium Carbonate. Additionally, I no longer suffer from stomach acid reflux, a problem I encountered when using Calcium Citrate from other vendors.
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.3
7
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
7.5
Improved sleep quality
Most Useful Review
2 people found this helpful
Good product! I suffer from CFS and take the calcium as the citrate form is easily absorbed. I also take it with Magnesium aspartate, and this combination notably improves my sleep.
Nausea details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Good
Based on 3 Reviews
8.2
8
Vitamin D and nausea in gastroparesis
We delved into an intriguing question: how do low vitamin D levels affect nausea in people experiencing gastroparesis, a condition that slows gastric emptying? By measuring the vitamin D levels of patients from the Gastroparesis Clinical Consortium Registry, we aimed to uncover the relationships between vitamin D, nausea, and gastric function.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
9
Muscle tension relieved
Most Useful Review
Very good. After a period of use, the muscle tension is alleviated, and it does not induce nausea.
Pelvic Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 17 Reviews
8.2
7
We explored the treatments for primary dysmenorrhea by comparing magnesium citrate and combination oral contraceptives. Our study involved 172 women with dysmenorrhea and a matched control group.
While both treatments significantly reduced pelvic pain, those using oral contraceptives experienced greater relief and a decreased need for painkillers. Interestingly, we also found lower levels of calcium and vitamin D in patients with dysmenorrhea. Magnesium citrate did provide some relief, but it wasn’t as effective as oral contraceptives.
While both treatments significantly reduced pelvic pain, those using oral contraceptives experienced greater relief and a decreased need for painkillers. Interestingly, we also found lower levels of calcium and vitamin D in patients with dysmenorrhea. Magnesium citrate did provide some relief, but it wasn’t as effective as oral contraceptives.
9
Pelvic pain relief
Most Useful Review
27 people found this helpful
Salvation while breastfeeding! After giving birth, my pelvic bones ached terribly, and my hair was falling out while my nails were exfoliating. I tried costly vitamins from our pharmacy. There was zero effect. After a month of taking this calcium with D3, I felt revitalised. I can now walk with the stroller for extended periods, my nails are growing rapidly, and my hair no longer falls out. My teeth remain healthy. Solgar is simply the best!
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 27 Reviews
8.1
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
10
Bones don't hurt
Most Useful Review
14 people found this helpful
I ordered this calcium citrate + Vitamin D³ for my pregnancy. As my body needed more calcium, I often experienced bone pain and numbness in my legs at night. However, I am thoroughly convinced that Solgar works wonders. I take one vitamin after breakfast for optimal absorption. The delivery to Moscow was swift, and the jar was securely packed. I appreciate the protective coating under the lid. All the vitamins were intact, and the expiry date is good. I feel fantastic now, my hair is back to normal, and my bones no longer ache!
Yeast Infection details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.1
9
We examined the potential of vitamin D as a treatment for yeast infections, specifically targeting the troublesome Candida species. The study employed both in vitro and in vivo methods to assess the antifungal capabilities of vitamin D, revealing promising results in inhibiting the growth of these fungi.
Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.
Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.
These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.
Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.
These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
6
Prevents infections
Most Useful Review
Calcium is a vital mineral that strengthens the body's bones, including cartilage, joints, and teeth. It provides various nutritional elements that fortify bones and restore proper cartilage and joint structure. Widely used for preventing and treating osteoporosis and osteochondrosis, calcium citrate also supports the genitourinary system. It helps prevent kidney stones and fights infections in the bladder. Directions for use: Take 4 tablets daily with food.
Heartburn details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.9
8
We explored the effectiveness of calcium in alleviating heartburn, especially in pregnant women. Our findings highlighted that many expectant mothers experience heartburn due to hormonal changes and the physical pressure of a growing fetus on the stomach.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
9
Heartburn relief achieved
Most Useful Review
Excellent calcium. It quickly raises calcium levels in the blood, as citrate is its best form. It is well tolerated in cases of gastrointestinal issues, with no heartburn or cramps. I recommend it.
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.4
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.4
7
Calcium citrate improves bone density
We conducted a well-designed trial involving 1,471 healthy postmenopausal women to explore the effects of calcium citrate on bone density and fracture rates over five years.
While we found that calcium significantly improved bone density, with noted benefits in spine and hip areas, the impact on actual fracture prevention was less clear.
Notably, longer-term compliance was an issue, which may have diminished its effectiveness. Ultimately, while calcium citrate appears to help with bone health, its role in preventing fractures remains uncertain.
While we found that calcium significantly improved bone density, with noted benefits in spine and hip areas, the impact on actual fracture prevention was less clear.
Notably, longer-term compliance was an issue, which may have diminished its effectiveness. Ultimately, while calcium citrate appears to help with bone health, its role in preventing fractures remains uncertain.
9
Effective for healing bones
Most Useful Review
19 people found this helpful
At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones.
Constipation details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Medium or Average
Based on 12 Reviews
6.3
7
We explored how calcium intake relates to constipation, particularly focusing on individuals with metabolic syndrome, a condition that significantly impacts health. Using data from the National Health and Nutrition Examination Survey conducted between 2005 and 2010, we assessed the dietary habits of participants and looked at how often they experienced constipation.
Our findings suggest a noteworthy connection: as dietary calcium intake increases, the risk of constipation decreases among those with metabolic syndrome. This suggests that calcium could play a beneficial role in gastrointestinal health.
By analyzing dietary recalls and bowel movement frequency, we provided valuable insights into how making dietary changes can potentially improve symptoms for those affected by metabolic syndrome. This emphasizes the importance of dietary calcium as a simple yet impactful strategy for managing gastrointestinal issues in this specific population.
Our findings suggest a noteworthy connection: as dietary calcium intake increases, the risk of constipation decreases among those with metabolic syndrome. This suggests that calcium could play a beneficial role in gastrointestinal health.
By analyzing dietary recalls and bowel movement frequency, we provided valuable insights into how making dietary changes can potentially improve symptoms for those affected by metabolic syndrome. This emphasizes the importance of dietary calcium as a simple yet impactful strategy for managing gastrointestinal issues in this specific population.
9
No constipation issues
Most Useful Review
2 people found this helpful
The best calcium! This is the first calcium that does not irritate, cause allergies or constipation. I have purchased my second pot; it’s perfect and my favourite! I highly recommend considering this formulation.
