Solgar Choline/Inositol

Myo-inositol enhances vitamin D effects

Questionable

Based on 5 Researches

Krysiak R, Kowalcze K, Okopień B. The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study. J Clin Pharm Ther. 2022;47:1759. doi:10.1111/jcpt.13730

Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.

We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.

Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.

Reduced stress levels

Most Useful Review

4 people found this helpful

Under immense stress and nearing a nervous breakdown, I discovered this supplement, which remarkably calmed me. I am absolutely ordering it again, and I appreciate its vegan formulation.

Chronic Cough details

Boosts energy effectively

2 people found this helpful

Excellent! An amazing supplement that provides significant energy while supporting the liver. I wholeheartedly recommend it for detoxing and enhancing energy, especially for active individuals or those under stress. I’m pleased with the quality and believe the ingredients are top-notch. It helps alleviate symptoms of chronic fatigue. I endorse this product for all its benefits.

Chronic Fatigue Syndrome details

Detox and energy boost

2 people found this helpful

This is an amazing supplement that provides significant energy while also supporting liver health. I highly recommend it for detoxification and boosting energy, especially for those engaged in sports or under stress. The quality meets my expectations, and I believe the ingredients are top notch. It effectively alleviates symptoms of chronic fatigue, making it a great addition to anyone's routine.

Leg Cramps details

Improved menstrual cramps

Great! I take this product as it's reputed to aid with menstrual irregularities and menstrual cramps. I trust Solgar products. My menstrual cramps have significantly improved since using it. The ingredients, quality, packaging, and delivery are all satisfactory. I will continue to use it regularly in the future. Thank you.

Menopause details

Cho KA, Kim YH, Woo SY, Ryu KH. Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle. Tissue Eng Regen Med. 2025. doi:10.1007/s13770-025-00709-w

Based on 9 Researches

Myo-Inositol Support in Menopause

We investigated whether small extracellular vesicles (sEVs) derived from human palatine tonsil mesenchymal stem cells could boost myo-inositol levels in the context of menopause. This was particularly interesting given that menopausal women are prone to chronic inflammation due to physiological changes and related issues like metabolic syndrome.

To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.

Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.

7.5

Effective weight loss

Most Useful Review

4 people found this helpful

Wonderful inositol combats excess weight, reduces cholesterol, and addresses premature menopause. I recommend it to everyone; after taking it, I lost 10 kg. I took 2 tablets twice a day for 3 months. Very effective!

Premenstrual Syndrome details

Significant PMS relief

4 people found this helpful

A fantastic product! I'm delighted to have discovered it, as my gynecologist recommended it. I'm on my second can and it's working wonders. I take 2 medium-sized capsules in the morning. They have no taste or smell. My mental clarity has improved, and my symptoms related to premenstrual syndrome have changed significantly—almost completely gone. Hurray!

High Cholesterol details

Okazaki Y, Katayama T. Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane. Nutr Res. 2008;28:714. doi:10.1016/j.nutres.2008.07.003

Based on 10 Researches

IP6 improves cholesterol levels

We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.

Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.

Normalised cholesterol

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10 people found this helpful

Super! After only a month of taking this, my tests confirmed that my cholesterol had returned to normal. Strangely, I feel calmer, and my craving for sweets has decreased. I've even lost 1.5 kg!

Migraine details

Migraine-free experience

9 people found this helpful

I absolutely love this product! I suffer from frequent migraines, often weekly, which can last for days despite medication. Remarkably, after taking this for over six months, I haven't experienced any headaches! I started noticing benefits after a few days of consistent use, adhering to the recommended two capsules daily. The capsules are a manageable size without any unpleasant aftertaste. The product arrived well-packaged and in excellent condition. Thank you for creating such a quality product, and I look forward to reordering soon!

Sleep Apnea details

2 people found this helpful

This supplement has greatly improved my sleep. I take it with 650 mg magnesium dimalate before bed, and I wake up feeling refreshed and free from mental fatigue. The quality of the ingredients is top-notch, which adds to its effectiveness in treating my sleep apnea.

Anxiety details

Herwig E, Classen HL, Walk CL, Bedford M, Schwean-Lardner K. Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens. Animals (Basel). 2019;9. doi:10.3390/ani9110938

Questionable

Based on 7 Researches

Inositol reduces anxiety in hens

We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.

Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.

Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.

Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.

7.5

Reduced anxiety

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119 people found this helpful

Good product; I noticed results after a month. I read that Choline/Inositol helps reduce panic attacks. I take two capsules daily. It has been effective for my depressive disorder, and I've experienced fewer migraines. The anxiety that troubled me at night has vanished, and I feel more clarity in my mind.

Cardiovascular Disease details

Inositol protects against cardiac damage

L'Abbate S, Nicolini G, Forini F, Lepore E, Marchetti S, et al. Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice. Biomed Pharmacother. 2024;178:117287. doi:10.1016/j.biopha.2024.117287

We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.

The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.

Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.

Fatty liver improvement

Most Useful Review

I feel good after buying it for fatty liver disease, and it seems to be helping well. My weight is slowly decreasing.

Cholecystitis details

This choline with inositol from a well-known manufacturer is excellent. The medium-sized capsules are easy to swallow. I take one twice daily for my cholecystitis and to support women's health over a month. I've noticed a decrease in pain in my right hypochondrium and my pressure has stabilised. I plan to order more.

Heart Attack details

ITPP enhances heart attack recovery

Likely Very Effective

Oknińska M, El-Hafny-Rahbi B, Paterek A, Mackiewicz U, Crola-Da Silva C, et al. Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells. J Cell Mol Med. 2020;24:2272. doi:10.1111/jcmm.14909

We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.

Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.

In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.

Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.

7.5

Significant improvement noted

Most Useful Review

29 people found this helpful

Wonderful! Verified it helps! I took 2 capsules a day. After 2 weeks, I noticed that anxiety and panic attacks had lessened. After a month, symptoms of depression and apathy diminished significantly. The drug works gently without sudden spikes. I combined it with ginkgo biloba, resulting in improved clarity of thought. Moreover, the choline in this product aids in liver restoration. I trust Solgar, and this product did not disappoint!

Heart Disease details

Inositol boosts heart protective adiponectin

Based on 3 Researches

Fu L, Du J, Furkert D, Shipton ML, Liu X, et al. Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin. Cardiovasc Res. 2024;120:954. doi:10.1093/cvr/cvae017

Our research focused on understanding how inositol, specifically a molecule called 5-InsP7, plays a role in heart health by influencing levels of a substance called adiponectin. Adiponectin is important because it helps protect against cardiovascular issues and metabolic disorders.

We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.

When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.

The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.

Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.

Lower cholesterol

Most Useful Review

6 people found this helpful

Choline is essential for liver cell restoration and its protection, as well as preventing cardiovascular disease by lowering cholesterol levels. It maintains healthy blood vessels, strengthens the heart muscle, and normalises heart rate. Choline promotes regeneration of damaged liver cells and decreases gallstone formation. Insufficient choline intake leads to fat accumulation in the liver, resulting in fatty liver degeneration or hepatosis.

Pelvic Pain details

I purchased this for menstrual pain, and it appears that my menstrual pain and premenstrual syndrome have both diminished.

Irritable Bowel Syndrome details

Spagnuolo R, Cosco C, Mancina RM, Ruggiero G, Garieri P, et al. Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome. Eur Rev Med Pharmacol Sci. 2017;21:102.

Supplement improves IBS symptoms

We explored how a mixture of beta-glucan, inositol, and digestive enzymes could alleviate gastrointestinal symptoms in patients with inflammatory bowel disease (IBD) and concurrent irritable bowel syndrome (IBS).

The study involved 43 patients who were already in clinical remission and treated only with mesalamine. They were divided into two groups: one received the usual treatment plus the supplement, while the other only received the standard care.

After four weeks, we observed notable improvements in symptoms such as bloating, flatulence, and abdominal pain in the group taking the supplement. Our findings suggest that this combination may significantly enhance the overall well-being of IBD-IBS patients, making their daily lives a bit easier.

7.5

Improves symptoms

Most Useful Review

1 people found this helpful

An excellent quality dietary supplement that promotes energy production and supports nervous system health and metabolism. It improves the symptoms associated with polycystic ovary syndrome, regulates blood sugar levels, and enhances brain, liver, heart, and fetal health.

Weight Loss details

Questionable

Myo-inositol aids insulin sensitivity

USERS' SCORE

Good

Based on 9 Reviews

Genazzani AD, Prati A, Santagni S, Ricchieri F, Chierchia E, et al. Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients. Gynecol Endocrinol. 2012;28:969. doi:10.3109/09513590.2012.685205

We investigated how myo-inositol affects insulin sensitivity and weight in obese women with polycystic ovary syndrome (PCOS). After 8 weeks of treatment with 2 grams daily, we observed a decrease in body mass index, insulin resistance, and several hormonal levels. Interestingly, women with higher initial insulin levels experienced the most significant improvements, particularly in their fasting insulin levels. This suggests that myo-inositol may be especially beneficial for those struggling with elevated insulin in conjunction with PCOS.

7.5

Effective weight loss

Most Useful Review

38 people found this helpful

Good for weight loss; it reduces fat in the liver and helps convert dietary fat into energy rather than store it. It also lowers blood cholesterol levels. Vitamin B8 cannot be easily sourced from pharmacies and is rarely included in vitamin complexes. I took this inositol to achieve weight loss, and I've noticed a definite effect. If you find this useful, please like it. Best of luck to everyone, and here's to a slender body!

Liver Disease details

Myo-inositol improves insulin resistance

Aghajani T, Arefhosseini S, Ebrahimi-Mameghani M, Safaralizadeh R. The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD. Food Sci Nutr. 2024;12:7177. doi:10.1002/fsn3.4267

We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.

Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.

The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.

Improved liver markers

Most Useful Review

102 people found this helpful

Excellent for liver support and alleviating anxiety. I researched choline as a supplement for NASH liver disease, finding that deficiencies in our diets may lead to fatty liver. Alongside my usual liver support (like milk thistle), my ALT liver enzyme normalised within months, and I found significant reductions in anxiety. This product is an excellent choice for liver health.

Acne details

Myo-inositol improves acne symptoms

Based on 8 Researches

Zacchè MM, Caputo L, Filippis S, Zacchè G, Dindelli M, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25:508. doi:10.1080/09513590903015544

We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.

At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.

Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.

This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.

Effective for PCOS

Most Useful Review

1 people found this helpful

I initially purchased only inositol for my acne related to polycystic ovaries, and I achieved very good results. Now, I am keen to try choline, which supports brain and nervous system health.

Dizziness details

Great excellent quality and composition. It combines a double component in large packaging, offering undeniable benefits. I have noticed that the symptom of dizziness has lessened.

Brain Tumor details