Polygonum Cuspidatum Complex
9.5
Memory protection
Most Useful Review
Resveratrol positively affects the nervous system and protects brain cells, potentially preventing memory issues and Alzheimer's disease. It also improves blood circulation in the brain, alleviating dizziness and weakness. If this review helps you, please like it!
9.5
Neuroprotection
Most Useful Review
Resveratrol is a potent antioxidant fighting free radicals and has anti-inflammatory properties. It may help slow the progression of Alzheimer's disease and increase cerebral blood flow. Generally safe, it does require caution when taken with certain medications.
Ginkgo
9.5
Family use
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My family regularly uses ginkgo biloba extract due to its impressive benefits. It helps slow down the ageing process and has a positive impact on conditions like Alzheimer’s, improving memory and clarity of thought. I highly recommend it for anyone looking to support their health.
9.5
Effective for elderly
Most Useful Review
I've been buying this ginkgo supplement for my aunt, who began to forget things. After taking it, we noticed a remarkable difference—she no longer forgets or repeats herself, which is crucial for those showing signs of Alzheimer’s. A daily pill has made significant improvements.
Coconut Oil
9.5
Alzheimer’s relief
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Excellent! It is ideal for the elderly, particularly in easing Alzheimer’s symptoms. I plan to reorder as the packaging matches the price well.
8.3
Clear difference
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I purchased this for my grandmother, who has Alzheimer’s, as recommended by her doctor. I noticed a clear difference when she stopped taking it; it genuinely helps, even if just a little.
Nattokinase
9.5
Alzheimer's assistance
Most Useful Review
This top cardiovascular supplement aids in blood flow and supports Alzheimer’s management effectively, avoiding the adverse effects of traditional medications like aspirin.
8.8
Supports Alzheimer's treatment
Most Useful Review
Nattokinase, derived from natto, greatly aids blood circulation. Its properties are multifaceted, beneficial for preventing osteoporosis, Alzheimer's, and heart conditions. As a food supplement, it normalises blood pressure and reduces cholesterol, offering a natural alternative to aspirin.
Vitamins
7
Vitamin E's potential in Alzheimer's
The role of α-tocopherol in the prevention and treatment of Alzheimer's disease.
Most Relevant Research
We sought to understand the potential role of α-tocopherol, a form of vitamin E, in preventing and treating Alzheimer's disease. Various research studies have indicated that this antioxidant might slow down the disease's progression or even reduce the risk of developing dementia. Our review delved into the biochemical mechanisms of α-tocopherol, highlighting its anti-inflammatory properties and ability to combat oxidative stress, which are vital in Alzheimer's pathology.
Interestingly, higher intake of α-tocopherol is linked to a lower incidence of mild cognitive impairment, suggesting its protective effects. However, we also noted that many people do not consume sufficient amounts of this vital nutrient. While there's a promising outlook for α-tocopherol supplementation as part of Alzheimer's management, we acknowledge that further research is necessary to draw definitive conclusions regarding its effectiveness and the mechanism behind its action.
Overall, our exploration into the relationship between vitamin E and Alzheimer's sheds light on a possible avenue for intervention, though clarity in treatment specifics and comprehensive studies are still required.
Interestingly, higher intake of α-tocopherol is linked to a lower incidence of mild cognitive impairment, suggesting its protective effects. However, we also noted that many people do not consume sufficient amounts of this vital nutrient. While there's a promising outlook for α-tocopherol supplementation as part of Alzheimer's management, we acknowledge that further research is necessary to draw definitive conclusions regarding its effectiveness and the mechanism behind its action.
Overall, our exploration into the relationship between vitamin E and Alzheimer's sheds light on a possible avenue for intervention, though clarity in treatment specifics and comprehensive studies are still required.
9.5
Alzheimer's treatment support
Most Useful Review
Vitamin E is an essential antioxidant vitamin that safeguards cranial nerves and possibly averts cataracts. It is fat-soluble and well-absorbed. I've found that it has a proven track record in aiding Alzheimer’s treatment, and I take it three times daily for its benefits.
Tumeric
9
Turmeric aids Alzheimer’s treatment
Curcuma wenyujin extract alleviates cognitive deficits and restrains pyroptosis through PINK1/Parkin mediated autophagy in Alzheimer's disease.
Most Relevant Research
We explored the effects of Curcuma wenyujin extract, commonly known as turmeric, on Alzheimer's disease (AD) using a methodical approach. The research centered on how this traditional medicine could potentially improve cognitive function and combat the negative processes associated with AD.
To investigate these effects, mice that were induced with amyloid-beta (Aβ) to mimic AD received daily treatments with turmeric extracts for three weeks. We assessed their cognitive abilities through various behavioral tests and employed proteomics analysis to identify the therapeutic targets impacted by the extract.
Our findings revealed that the ethyl acetate fraction of turmeric showed the most promise in treating Alzheimer's. The treatment not only enhanced memory and cognition in the mice but also contributed to better neuronal health and reduced amyloid accumulation in the brain. Importantly, we observed that turmeric helped lower inflammation and promoted processes like mitophagy, key for cell health, through the activation of the PINK1/Parkin pathway.
To investigate these effects, mice that were induced with amyloid-beta (Aβ) to mimic AD received daily treatments with turmeric extracts for three weeks. We assessed their cognitive abilities through various behavioral tests and employed proteomics analysis to identify the therapeutic targets impacted by the extract.
Our findings revealed that the ethyl acetate fraction of turmeric showed the most promise in treating Alzheimer's. The treatment not only enhanced memory and cognition in the mice but also contributed to better neuronal health and reduced amyloid accumulation in the brain. Importantly, we observed that turmeric helped lower inflammation and promoted processes like mitophagy, key for cell health, through the activation of the PINK1/Parkin pathway.
9.5
Alzheimer prevention
Most Useful Review
A highly recommended product! This well-known brand provides quality ingredients, offering a capsule a day that potentially helps prevent Alzheimer's and cancer.
L Carnosine
8
l-Carnosine shows promise for Alzheimer's
Carnosine Mitigates Cognitive Impairment and Dopamine Release in an Okadaic Acid-Induced Zebrafish Model with Alzheimer's Disease-like Symptoms.
Most Relevant Research
We focused on understanding the impact of l-carnosine (CAR) in an innovative zebrafish model that mimics Alzheimer’s disease (AD). This model replicates key characteristics of the disease, including cognitive decline and abnormal tau protein behavior. By observing the effect of CAR on these symptoms, we aimed to explore its potential as a therapeutic agent.
Our results highlighted that l-carnosine can significantly improve learning abilities and reduce anxiety-like behaviors in these zebrafish. Notably, we discovered that CAR helps protect against dopamine release impairments, which are often associated with AD. Furthermore, the treatment indicated varying outcomes based on the sex of the zebrafish, suggesting that responses to CAR might differ across genders.
In essence, our findings provide strong evidence for l-carnosine as a promising candidate for future research into preventive therapies for Alzheimer’s disease. We are excited about the potential implications for delaying or mitigating the onset of this challenging condition.
Our results highlighted that l-carnosine can significantly improve learning abilities and reduce anxiety-like behaviors in these zebrafish. Notably, we discovered that CAR helps protect against dopamine release impairments, which are often associated with AD. Furthermore, the treatment indicated varying outcomes based on the sex of the zebrafish, suggesting that responses to CAR might differ across genders.
In essence, our findings provide strong evidence for l-carnosine as a promising candidate for future research into preventive therapies for Alzheimer’s disease. We are excited about the potential implications for delaying or mitigating the onset of this challenging condition.
9.5
Neuroprotective effects
Most Useful Review
This is a remarkable aid for brain dysfunction and optimising neurons. My nephew with autism has shown improvement alongside lipoic acid and DHA. My wife and I take it as well to help prevent Alzheimer's disease.
Fish Oil
9
DHA's role in Alzheimer's management
Cosupplementation with DHA and medium-chain triglycerides ameliorates NAFLD and reduces amyloid-β accumulation by modulating hepatic lipid metabolism in APP/PS1 mice.
Most Relevant Research
We aimed to uncover how docosahexaenoic acid (DHA) might affect Alzheimer's disease, particularly in relation to nonalcoholic fatty liver disease (NAFLD). Our study involved 40 three-month-old male APP/PS1 mice, which are commonly used in Alzheimer's research, divided into four groups. These groups ate different diets—one with DHA, one with medium-chain triglycerides (MCTs), one with both, and one control—as we observed their impacts on liver health and amyloid-β (Aβ) accumulations over eight months.
Our findings showed that mice with Alzheimer's displayed both NAFLD and increased levels of Aβ in their brains. Interestingly, the combination of DHA and MCTs led to lower blood and liver lipids. It also alleviated fat buildup in the liver and reduced Aβ levels in both the brain and serum. Moreover, it effectively raised the levels of proteins linked to Aβ clearance while altering the expression of key enzymes related to liver lipid metabolism.
In essence, our research suggests that DHA, particularly when paired with MCTs, may offer protective benefits against the progression of NAFLD and simultaneously reduce Aβ accumulation. This could indicate a more significant response to metabolic changes in APP/PS1 mice compared to normal mice. Our study adds to the understanding of DHA's potential role in managing Alzheimer's disease through its effects on liver metabolism and Aβ processing.
Our findings showed that mice with Alzheimer's displayed both NAFLD and increased levels of Aβ in their brains. Interestingly, the combination of DHA and MCTs led to lower blood and liver lipids. It also alleviated fat buildup in the liver and reduced Aβ levels in both the brain and serum. Moreover, it effectively raised the levels of proteins linked to Aβ clearance while altering the expression of key enzymes related to liver lipid metabolism.
In essence, our research suggests that DHA, particularly when paired with MCTs, may offer protective benefits against the progression of NAFLD and simultaneously reduce Aβ accumulation. This could indicate a more significant response to metabolic changes in APP/PS1 mice compared to normal mice. Our study adds to the understanding of DHA's potential role in managing Alzheimer's disease through its effects on liver metabolism and Aβ processing.
9.5
Supports brain health
Most Useful Review
Excellent! DHA is vital for brain health, particularly for those with a family history of Alzheimer's. I appreciate this NOW product as it contains 500mg of DHA per capsule.
Omega 3
4
Eicosapentaenoic acid affects brain levels
Providing lysophosphatidylcholine-bound omega-3 fatty acids increased eicosapentaenoic acid, but not docosahexaenoic acid, in the cortex of mice with the apolipoprotein E3 or E4 allele.
Most Relevant Research
We explored the effects of eicosapentaenoic acid (EPA) on Alzheimer’s disease-related conditions through a study involving the administration of lysophosphatidylcholine-bound omega-3 fatty acids to mice with different genetic backgrounds. Specifically, we looked at how these supplements affected levels of EPA and docosahexaenoic acid (DHA) in the brains of mice that carry the apolipoprotein E ε3 (APOE3) or ε4 (APOE4) allele.
Over two and four months, the mice were given oral doses of LPC n-3, containing both EPA and DHA, and compared to a control group that received sunflower oil. After two months, we observed that the EPA levels increased in the brains of APOE3 mice, while there was no significant change in EPA or DHA levels for the APOE4 mice. After four months, both groups had elevated EPA levels, but DHA showed no significant improvement.
These findings suggest that while EPA supplementation can increase EPA levels in the brain, especially in those with the APOE3 allele, the same cannot be said for DHA or for APOE4 carriers. This highlights important differences in how genetic factors can influence the effectiveness of omega-3 fatty acid treatments.
Over two and four months, the mice were given oral doses of LPC n-3, containing both EPA and DHA, and compared to a control group that received sunflower oil. After two months, we observed that the EPA levels increased in the brains of APOE3 mice, while there was no significant change in EPA or DHA levels for the APOE4 mice. After four months, both groups had elevated EPA levels, but DHA showed no significant improvement.
These findings suggest that while EPA supplementation can increase EPA levels in the brain, especially in those with the APOE3 allele, the same cannot be said for DHA or for APOE4 carriers. This highlights important differences in how genetic factors can influence the effectiveness of omega-3 fatty acid treatments.
9.5
Memory support
Most Useful Review
Omega-3 is crucial for preventing Alzheimer's and supporting heart health. I take 2 capsules daily and have also tried a higher dosage. This product is effective, with no fishy aftertaste and a pleasant lemon flavour.
Vitamin B12
7
Vitamin B12 aids Alzheimer therapy
Synergistic Effect of Donepezil and Neurotropic B Vitamins on Dysregulated Antioxidant, Inflammation and Neurotransmitter Status in Aluminium Chloride-Induced Neurotoxicity in Rats.
Most Relevant Research
We investigated the effects of vitamin B12 in combination with donepezil on rats suffering from aluminium chloride-induced neurotoxicity, a model mimicking aspects of Alzheimer’s disease. Our study involved several groups of rats, some receiving only aluminium chloride, while others were treated with donepezil and/or vitamin B12, along with vitamin B6 and vitamin B1. Over 40 days, we closely examined the biochemical changes in their brains and their behavior in cognitive tests.
Our observations revealed that vitamin B12, when combined with donepezil, contributed positively by reducing levels of harmful markers typically associated with neurotoxicity. The combination therapy showed enhanced protection compared to donepezil alone, boosting measures of neurotransmitter levels and antioxidant activity while lowering inflammation and oxidative stress indicators.
While vitamin B12 played a significant role in this combination therapy, we noted that the best results came from the combination of donepezil and vitamin B1. However, our findings illustrate that even though vitamin B12 showed effectiveness, it works best alongside donepezil and other B vitamins, rather than in isolation. This underscores the potential of combination therapies in tackling the complexities of neurodegenerative conditions like Alzheimer’s.
Our observations revealed that vitamin B12, when combined with donepezil, contributed positively by reducing levels of harmful markers typically associated with neurotoxicity. The combination therapy showed enhanced protection compared to donepezil alone, boosting measures of neurotransmitter levels and antioxidant activity while lowering inflammation and oxidative stress indicators.
While vitamin B12 played a significant role in this combination therapy, we noted that the best results came from the combination of donepezil and vitamin B1. However, our findings illustrate that even though vitamin B12 showed effectiveness, it works best alongside donepezil and other B vitamins, rather than in isolation. This underscores the potential of combination therapies in tackling the complexities of neurodegenerative conditions like Alzheimer’s.
7.8
Quality recommendation
Most Useful Review
This is a very high-quality product. I recommend it for my patients who exhibit mild Alzheimer’s and neurological issues.