Coenzyme Q10
9
ALDH2 mutation and CoQ10 impacts
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis.
Most Relevant Research
Our investigation centered around the effects of a genetic mutation in the ALDH2 enzyme, known as ALDH2*2, on the risk of developing atrial fibrillation (AF). We discovered that this mutation led to an increased incidence of AF in mice, accompanied by a decrease in the threshold for AF events compared to their non-mutant counterparts.
A key finding in our study was the alteration in signaling pathways related to retinoic acid, which impacted the expression of crucial sodium channels involved in heart rhythm. The reduced levels of these channels, specifically the SCN5A, raised concerns about their role in AF susceptibility.
We also conducted a multi-omics analysis that revealed disruptions in fatty acid metabolism and energy production within the mitochondria, leading to heightened oxidative stress. To counter these issues, we administered Coenzyme Q10, a well-known mitochondrial co-factor, to the mutant mice. Remarkably, this treatment offered protection against AF episodes.
By bridging our findings, we could see how Coenzyme Q10 may pave the way for personalized treatment options for individuals with the ALDH2*2 genotype at risk for AF, making it a potential game-changer in managing heart health.
A key finding in our study was the alteration in signaling pathways related to retinoic acid, which impacted the expression of crucial sodium channels involved in heart rhythm. The reduced levels of these channels, specifically the SCN5A, raised concerns about their role in AF susceptibility.
We also conducted a multi-omics analysis that revealed disruptions in fatty acid metabolism and energy production within the mitochondria, leading to heightened oxidative stress. To counter these issues, we administered Coenzyme Q10, a well-known mitochondrial co-factor, to the mutant mice. Remarkably, this treatment offered protection against AF episodes.
By bridging our findings, we could see how Coenzyme Q10 may pave the way for personalized treatment options for individuals with the ALDH2*2 genotype at risk for AF, making it a potential game-changer in managing heart health.
9.5
Significant improvement
Most Useful Review
My mother suffered from atrial fibrillation for years, enduring frequent hospital visits. After a heart attack, she began taking coenzyme Q10, initially at 60-90 mg daily. Within five months, her arrhythmia attacks ceased, and her overall health improved. Now she takes 100 mg daily without interruption, having bought the supplement abroad at a much lower price. Both my husband and I have also started taking it, and we've noticed increased energy and better health.
Magnesium
7
Magnesium's role in preventing AF
Magnesium sulphate to prevent perioperative atrial fibrillation in cardiac surgery: a randomized clinical trial : A protocol description of the PeriOperative Magnesium Infusion to Prevent Atrial fibrillation Evaluated (POMPAE) trial.
Most Relevant Research
We conducted a clinical trial to explore whether magnesium sulphate can help prevent postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery. This phase 2 study involved 530 participants who were randomly assigned to receive either intravenous magnesium or a placebo, with the goal of keeping their magnesium levels balanced.
Our primary focus was on whether this treatment could reduce the onset of POAF in the week following surgery. Hypomagnesaemia, or low magnesium levels, is common after such procedures, and previous evidence suggested that restoring these levels might help.
By comparing outcomes between the magnesium and placebo groups, we aimed to provide clear insights into the potential benefits of magnesium in cardiac surgery. The hope is that this research could lead to better prevention strategies for POAF, ultimately improving patient outcomes after surgery.
Our primary focus was on whether this treatment could reduce the onset of POAF in the week following surgery. Hypomagnesaemia, or low magnesium levels, is common after such procedures, and previous evidence suggested that restoring these levels might help.
By comparing outcomes between the magnesium and placebo groups, we aimed to provide clear insights into the potential benefits of magnesium in cardiac surgery. The hope is that this research could lead to better prevention strategies for POAF, ultimately improving patient outcomes after surgery.
9.5
Successful magnesium treatment
Most Useful Review
I've suffered from atrial fibrillation for about five years and have tried numerous medications that affected my thyroid. Despite having RFA, I still felt interruptions in my heart. A cardiologist suggested magnesium, leading me to Doctor's Best. After taking it for three weeks, I've enjoyed sinus rhythm for over ten days without seizures, even after stress! I suspect my arrhythmia was due to magnesium deficiency.