Calcium
9.5
Calcium's role in RA treatment
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.
Most Relevant Research
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
9.5
Strong nails improvement
Most Useful Review
Very high-quality calcium combined with magnesium. I’ve been using NowFoods products for a while, and this calcium to magnesium blend did not disappoint. My nails, which weren't strong naturally, became noticeably stronger and shinier. I also had issues with tooth enamel, but now I don’t feel sensitivity to acids or temperature. Magnesium has helped me manage stress, making me calmer. I confidently recommend this supplement for strengthening nails, teeth, and supporting bone health and the nervous system.
Oregano
9
Oregano extract combats type 1 diabetes
Ethyl Acetate Extract of Origanum vulgare L. ssp. hirtum Prevents Streptozotocin-Induced Diabetes in C57BL/6 Mice.
Most Relevant Research
We explored the potential of Origanum vulgare L. ssp. hirtum, commonly known as Greek oregano, in the realm of autoimmune disorders, particularly type 1 diabetes (T1D). This study specifically looked at how an ethyl acetate extract of oregano (EAO) could influence the development of T1D in mice.
To conduct the research, researchers induced type 1 diabetes in male C57BL/6 mice using multiple low doses of streptozotocin. They then treated these mice with EAO over ten days. Our findings revealed that EAO not only reduced the incidence of diabetes but also helped preserve pancreatic islets—critical for insulin production.
The results were promising as we observed significant immunomodulatory effects from the oregano extract. In vitro tests indicated that EAO suppressed the activation of immune cells, particularly macrophages and T lymphocytes. Furthermore, it appeared to decrease the levels of certain inflammatory T cell populations and their associated transcription factors, which play a role in promoting inflammation.
These discoveries suggest that oregano extract could potentially serve as a therapeutic option for managing type 1 diabetes by targeting the autoimmune responses involved in the disease. Overall, this study highlights an exciting avenue for plant-based treatments in diabetes management.
To conduct the research, researchers induced type 1 diabetes in male C57BL/6 mice using multiple low doses of streptozotocin. They then treated these mice with EAO over ten days. Our findings revealed that EAO not only reduced the incidence of diabetes but also helped preserve pancreatic islets—critical for insulin production.
The results were promising as we observed significant immunomodulatory effects from the oregano extract. In vitro tests indicated that EAO suppressed the activation of immune cells, particularly macrophages and T lymphocytes. Furthermore, it appeared to decrease the levels of certain inflammatory T cell populations and their associated transcription factors, which play a role in promoting inflammation.
These discoveries suggest that oregano extract could potentially serve as a therapeutic option for managing type 1 diabetes by targeting the autoimmune responses involved in the disease. Overall, this study highlights an exciting avenue for plant-based treatments in diabetes management.
9.5
SIBO relief
Most Useful Review
This is a potent "herbal antibiotic"! My SIBO (small intestinal bacterial overgrowth) symptoms have disappeared. I took three capsules three times a day for a month alongside medications to support my liver, as it's crucial for detoxification. After two weeks, I started a delayed-release probiotic to restore the right gut flora.
D Mannose
9
D-mannose shows promise for UC
D-mannose reduces oxidative stress, inhibits inflammation, and increases treg cell proportions in mice with ulcerative colitis.
Most Relevant Research
We examined how D-mannose impacts ulcerative colitis (UC) in a mouse model designed to mimic human inflammatory bowel disease. Our findings reveal that D-mannose significantly lessens UC symptoms by reducing inflammation and oxidative stress. Notably, it increases regulatory T (Treg) cell levels, which are crucial in controlling immune responses. This study is the first to show D-mannose's therapeutic potential for UC, bringing newfound hope for managing this condition.
8.8
Effective treatment
Most Useful Review
After trying LifeSeasons, Urinari-X, I opted for D-mannose and Cranberries due to persistent cystitis linked to my autoimmune disorder. I found these alternatives to be cost-effective and lasted longer. By taking one of each tablet twice daily throughout winter, I avoided severe attacks. This treatment truly deserves a high rating.
9.5
Improved microflora
Most Useful Review
I sought a probiotic for my child, aged 2.6 years, due to digestive issues. After starting this probiotic as recommended by a gastroenterologist, I noticed a significant improvement in just four days; atopic redness vanished. I give my child one tablet in the afternoon and one at bedtime. They're chewable, which my child enjoys.
9.5
Immunity restored
Most Useful Review
A fantastic agent! These drops helped treat my child's longstanding Staphylococcus aureus in the intestine. After enduring ineffective treatments for 1.5 years, I found this Echinacea without harmful substances. Within a week of using it, my child's symptoms improved significantly. We have since kept it on hand for the school period, highly recommending it for children with immune deficiencies.
Vitamin B Complex
9.5
Nervous system support
Most Useful Review
I ordered children's B vitamins to strengthen my nervous system. This complex stabilises my emotional state, improves my mood, and provides extra energy. It’s from a reliable manufacturer. I take it in the morning; the capsules are small and easy to swallow, and while there is a smell, it does not bother me.
9.5
Energy boost
Most Useful Review
These B vitamins are effective! After switching to a vegan, gluten-free diet, my B12 levels dropped significantly. On the advice of my doctor, I tried Solgar, which truly helped me. I felt more energetic from the third day of use, and my sleep improved. While I did experience tachycardia initially, it soon faded. Overall, I recommend these vitamins for managing autoimmune disorder symptoms.
Multivitamins
9.5
Supports immune function
Most Useful Review
An excellent formulation of enzymes that aided me significantly. I initially purchased it for my son on a doctor's recommendation, but I decided to take it myself when I faced issues with my pancreas. It provided immediate relief and plays a crucial role in immune defence as well.
9.5
Symptoms alleviated
Most Useful Review
My salvation from falling fingers! I ordered this for my arms due to an autoimmune disorder linked to a postpartum injury. I noticed an effect within a week, and my symptoms have nearly vanished. I previously avoided using it as per my doctor's prescription, wearing braces was inconvenient with a child. After four months, these vitamins have helped immensely. I'm grateful to NewChapter. The only downside is that symptoms return if I stop, though not as severe. Thankfully, I can breastfeed without issues now. Highly recommended!
L Lysine
9.5
Autism support
Most Useful Review
I’ve started giving L-lysine to my daughter, noticing improvements with her autism-related symptoms. While some herpes lesions initially appeared, as they cleared, her cognitive function seemed to improve. It appears that lysine plays an essential role here.
9.5
Herpes suppression
Most Useful Review
Lysine is essential for those with an autoimmune disorder like herpes. It prevents the virus from multiplying, greatly reducing outbreaks. After three months of 1000 mg daily, my herpes stopped appearing, even after minor colds or stress. It’s been a year now without any symptoms. I recommend this to friends and family suffering from herpes.
Probiotics
9
Probiotics may aid rheumatoid arthritis
The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages.
Most Relevant Research
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
9.5
Improved health
Most Useful Review
Wonderful helpers for pregnant and lactating mothers. I started taking these vitamins when I was seven months pregnant, as I had previously suffered from anaemia. After consultation with my physician, I found the composition approved. My hemoglobin normalised after taking these vitamins. The size of the tablets is similar to Elevit, and I appreciate their herbal smell. My hair is thriving, and fatigue has lessened. I’m definitely repurchasing, as these vitamins are essential for me.
Cranberry
9.5
Effective remedy
Most Useful Review
An excellent remedy for chronic cystitis! This supplement has significantly reduced my excruciating relapses connected to my autoimmune disorder. Despite lengthy struggles and numerous antibiotics, I found relief through cranberries combined with d-mannose and ant tree bark. I highly recommend it for anyone facing similar issues!
9.5
Rapid relief
Most Useful Review
I initially ordered cranberries for my son’s kidney issues but ended up using them during my cystitis attack, which was related to my autoimmune disorder. After taking two at night, I felt much better in the morning. Within three days, I had forgotten about the problem.
Quercetin
9.5
Miracle cure
Most Useful Review
We took Quercetin for immune support, and it unexpectedly alleviated my mother’s leg pain. It also helped with sleep and excessive sweating. I plan to keep ordering more!
9.5
Asthma and rhinitis
Most Useful Review
Now Foods’ Quercetin with Bromelain has remarkably improved my asthma and rhinitis. I recommend it to anyone struggling with respiratory issues!
Garlic
9.5
Effective for BP
Most Useful Review
Just what the doctor ordered. I mentioned to my doctor that I was taking these to lower my blood pressure. Kyolic is in their recommendations, and I can confirm they work, bringing my systolic pressure down from the 160s to the 140s. I will buy again.
9.5
Reduced chest pain
Most Useful Review
I used to experience random chest pains, but despite tests showing my heart was functioning properly, I felt my circulation was lacking. After starting these supplements twice daily, the chest pains have disappeared. I will continue to use these!
Evening Primrose
9.5
Unexpected recovery
Most Useful Review
Surprisingly excellent! I did not expect miracles. I ordered this supplement among others. For two years, I had amenorrhea, and doctors said nothing could be done. After starting evening primrose oil, my cycle normalised. I later discovered this product was aimed at treating amenorrhea. I felt compelled to share my experience after a year.
9.5
Remarkable improvement
Most Useful Review
I initially didn't observe benefits, but after two months, my follow-up showed a normal endometrium instead of endometritis. I am pleasantly surprised and will continue taking evening primrose oil.
Vitamin E
9.5
Rash improvement
Most Useful Review
I'm enthusiastic about these vitamins! I developed a rash on my forehead and brittle nails due to my autoimmune disorder. I ordered these vitamins based on reviews, and after a month, I've seen improvement. The rash has disappeared, my nails are stronger, my skin has improved, and I even have new hair growth. I would definitely order more, and I recommend them!
9.5
Eliminated monthly pain
Most Useful Review
Vitamin E has been a lifesaver for my autoimmune disorder, particularly my endometriosis. After starting treatment with high doses, my debilitating pain during ovulation has significantly subsided and is now barely noticeable. I advise anyone with similar issues to consider this treatment.
Magnesium
9.5
Improved sleep quality
Most Useful Review
I had wanted to order magnesium for a long time and this is the first company I've tried. I started taking it before bed and was pleasantly surprised to find I began to sleep well. I used to wake up feeling tired, but now I wake up before my alarm, full of energy. Additionally, it has helped with my constipation. I recommend it!
9.5
Emotional stability
Most Useful Review
I noticed various forms of magnesium in this product, although the manufacturer did not specify their ratios. After a month, I've felt remarkably calmer, observing that the emotional reactions of others no longer affect me as they did before. However, it's essential to consult with a doctor before using it to ensure it's right for your autoimmune disorder.
Vitamin A
9.5
Skin improvement noted
Most Useful Review
I have taken Aevit for years, prescribed for my autoimmune disorder (hyperkeratosis), but it had no effect. Recently, I ordered this drug without specific intent. After two weeks, my skin improved significantly, cheilitis resolved, and my hair and nails got better. Now, after a break, my skin is returning to its previous state. Remember, this should not be taken during pregnancy due to high vitamin A doses harming the unborn child.
9.5
Significant mucous improvement
Most Useful Review
Despite consuming greens, my mucous membranes remained problematic for years. Once I increased my vitamin A intake, all my issues, including angular cheilitis and nosebleeds, significantly improved. While some studies question the efficacy of supplements, I believe in their power and will continue to use them for my autoimmune disorder.
Potassium
9.5
Heart health improved
Most Useful Review
This potassium citrate is remarkable! I suffer from an autoimmune disorder, and have experienced extreme fatigue. On my doctor's advice, I've been taking potassium for two months, with this citrate being ideal. Though potassium exists in foods like bananas, I cannot tolerate them. This potassium citrate suits me perfectly; I take 3-4 capsules daily, alongside omega 3 and vitamins D3. I've regained my energy, memory is sharper, and importantly, my heart no longer aches. I'm thrilled with the results and plan to order again.
9.5
Seizures alleviated
Most Useful Review
I’ve suffered from seizures, made worse in recent years due to my autoimmune disorder. Despite trying various treatments, nothing worked until I learned about potassium's potential benefits. I started taking this supplement and noticed a significant improvement; my seizures disappeared within three days. I’ve been taking it for six months now and it is remarkably effective.
Nattokinase
9.5
Blood thinner effective
Most Useful Review
Great natural blood thinner. My father struggled with thick blood due to cholesterol and an autoimmune disorder. He developed diabetes after Covid, worsening his condition. After trying various blood thinners, I ordered him this well-rated Nattokinase supplement, and it has worked excellently. Within a month, he noticed thinner blood, improved glucose levels, and normalised blood pressure. He is very happy with the results and highly recommends this product.
9.5
Health markedly improved
Most Useful Review
A colleague recommended Nattokinase for my husband, who struggled with swollen, dark veins due to sitting for long periods. He has been taking Nattokinase for two years, with significant health improvements. We also saw benefits for my own autoimmune disorder, as the dizziness I experienced has nearly disappeared.
Vitamin Bs
8
Vitamin B6's anti-inflammatory benefits
Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner.
Most Relevant Research
We explored the effects of vitamin B6 on inflammation, particularly in relation to autoimmune disorders. The study focused on macrophages, which play a crucial role in our immune response. It found that vitamin B6 can significantly reduce the buildup of a substance called sphingosine-1-phosphate (S1P) in a way that depends on an enzyme known as sphingosine-1-phosphate lyase (SPL).
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
9.5
Improved sleep quality
Most Useful Review
I ordered this medication for my brother, who has heart issues and irritability. The doctor recommended it as part of his treatment protocol. After a while, he began to show noticeable improvements—his sleep quality enhanced, and he became less irritable. I highly recommend this to anyone struggling with energy production, tissue health, sleep, and the nervous system.
Coconut Oil
8.8
Supports autoimmune treatment
Most Useful Review
Protocol PCOS and AIT. Autoimmune disorders, such as autoimmune thyroiditis (AIT), can create significant health challenges. Coconut oil is a simple yet effective remedy for AIT, helping to reduce inflammation and regulate the immune system. With regular use, it has made a noticeable difference in my health, improving skin moisture and hair quality. It has become a staple in my routine, whether at home or on trips.
9.5
Weight loss achieved
Most Useful Review
Now Virgin Coconut Oil genuinely provided me with more energy. I combined these with the Now Thyroid Energy tablets and noticed weight loss after altering my diet and exercising. I lost 12lbs in just a week. I will certainly reorder.
Spirulina
9.5
Pain relief achieved
Most Useful Review
Immunity for free! My family has experienced significant pain due to an autoimmune disorder. After some time, I began using spirulina powder from ayherbe, and remarkably, the pain subsided. I recommended it to family, and now we all feel much better, with improved blood health. I will continue ordering!
8.3
Cold recovery
Most Useful Review
Initially, I tried to consume the spirulina directly, but I found it quite unpleasant. However, I did notice a surge in energy and it accelerated my recovery from a persistent cold. I might opt for tablets next time.
Proprietary Blendmanna Fraxinus Ornus L)
9.5
Significant pain relief
Most Useful Review
My wife suffers from fibromyalgia and has noticed a significant reduction in pain since using this product. This improvement has occurred after just a week to ten days of use. I decided to try Bitters after reading positive feedback from other fibromyalgia sufferers.
8.8
Stomach improvement
Most Useful Review
I purchased this product on the recommendation of family and friends for my stomach issues. I've been taking it twice daily for a week, and my body has responded well. I dilute a teaspoon in around 50 grams of water, and I feel less discomfort than before.
Oleuropein
9.5
Positive trend observed
Most Useful Review
So I absolutely love this! My son was prescribed a nutritionist alongside other treatments. Olive is remarkable. All his infancy ailments began to resurface and this is fantastic ✅ until we finish the course, but I can already see a positive trend. I ordered it for myself and my husband too.
9.5
Reduced inflammation
Most Useful Review
I have an autoimmune disorder and this has significantly helped me with inflammation levels.
Astragalus Root
9.5
Useful for immunity
Most Useful Review
Astragalus is a regular purchase for my family. It helps at the first signs of a cold when taken with vitamin C and other supplements. While its traditional Chinese use is well-known, Western research lacks specific backing for longevity claims. However, it does alleviate illnesses, but caution is advised for those with autoimmune disorders, particularly as it may lower blood pressure.
9.5
Strengthens immunity
Most Useful Review
Astragalus is fantastic for boosting immunity, especially during the COVID-19 pandemic. I ordered it specifically for its beneficial properties and found it to be an excellent dietary supplement.
Ubiquinol
9.5
Improved symptoms
Most Useful Review
I have been using this product for 5 years, and for the last 3 years I have purchased it from iHerb. At 52, I experienced serious health issues related to menopause, including weight gain, swollen legs, and shortness of breath. Along with hypertension medication and acupuncture, I incorporated ubiquinol, which alleviated these symptoms. I now take 2 capsules daily, exercise regularly, and maintain a healthy diet. Proper nutrition and exercise are essential; without them, supplements are a waste.
9.5
Normalised cycles
Most Useful Review
I ordered this product on my reproductive specialist's advice as preparation for IVF. After struggling with scanty periods and pain, I tried this supplement, and miraculously, my periods returned! They have become regular with no discomfort. The capsules are easy to swallow, and I take them with fatty foods. I'm hopeful about my chances in the IVF protocol, as my mood has improved, and I feel invigorated.
Herbal Extracts
5
Echinacea's Effect on Autoimmunity
Review and Assessment of Medicinal Safety Data of Orally Used Echinacea Preparations.
Most Relevant Research
We examined the effects of Echinacea, a plant often turned to for its medicinal properties, specifically regarding its impact on autoimmune disorders. Our analysis highlighted that while there are various preparations of Echinacea, information about their effects on autoimmune conditions can be inconsistent.
Interestingly, some preparations that contain alkamides—certain compounds in Echinacea—showed a potential to suppress certain immune responses, raising questions about the traditional contraindications for their use in autoimmune diseases. Despite some studies indicating that improvements might be observed, the overall evidence does not strongly support significant benefits specifically for treating autoimmune disorders.
We also looked into the safety profile of Echinacea; adverse effects reported were typically mild and without clear evidence of causality. Moreover, long-term studies of up to six months revealed no serious toxicological concerns, suggesting that Echinacea can generally be well-tolerated.
Our journey through the literature led us to conclude that, while Echinacea preparations are popular and generally safe, they may not provide substantial therapeutic benefits specifically for individuals battling autoimmune issues.
Interestingly, some preparations that contain alkamides—certain compounds in Echinacea—showed a potential to suppress certain immune responses, raising questions about the traditional contraindications for their use in autoimmune diseases. Despite some studies indicating that improvements might be observed, the overall evidence does not strongly support significant benefits specifically for treating autoimmune disorders.
We also looked into the safety profile of Echinacea; adverse effects reported were typically mild and without clear evidence of causality. Moreover, long-term studies of up to six months revealed no serious toxicological concerns, suggesting that Echinacea can generally be well-tolerated.
Our journey through the literature led us to conclude that, while Echinacea preparations are popular and generally safe, they may not provide substantial therapeutic benefits specifically for individuals battling autoimmune issues.
9.5
Headaches alleviated
Most Useful Review
I ordered this supplement on my doctor's recommendation. Initially, I had daily headaches from my neck and back, but after a few days of taking it, the headaches nearly disappeared. This is likely due to the drug's effect on blood vessels, leading to improved blood flow. I take one tablet in the morning after breakfast, and it doesn't cause nausea like other supplements. So far, I have experienced no side effects. I highly recommend it and will be ordering more.
Iron
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Most Relevant Research
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
9.5
Raised hemoglobin levels
Most Useful Review
This is the best iron for treating my autoimmune disorder during pregnancy. Despite various prescriptions failing to help, I turned to this product. Within three weeks, my haemoglobin rose from 96 to 123, and ferritin increased from 40 to nearly 90. I also experienced no gastrointestinal issues, unlike previous products. I'm glad to share my experience; it really works!
Vitamin K2
9.5
Increased energy
Most Useful Review
An essential vitamin for an active life! This is my salvation! After taking K-2 for a week on my doctor's advice, I felt revitalised; my fatigue vanished by the end of long workdays. I will definitely order it regularly, especially for those engaged in physical exertion or living an active lifestyle.
9.5
Essential for D3
Most Useful Review
Vitamin K2 is essential when high doses of D3 are prescribed to prevent calcification in blood vessels and soft tissues.
Vitamin B12
8
Vitamin B12 and autoimmune gastritis
Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China.
Most Relevant Research
We investigated the dietary and lifestyle factors associated with autoimmune gastritis (AIG) among Chinese patients. Our study involved 479 individuals across seven centers in China, where we collected detailed clinical and lifestyle data.
From the findings, we noticed that most AIG patients were middle-aged females. Interestingly, our analysis highlighted that a diet rich in vitamin B12 appeared to play a protective role against AIG. This means that the more vitamin B12 included in the diet, the better the potential outcomes regarding autoimmune gastritis.
Furthermore, we established a predictive model that relied on various factors. Alongside vitamin B12, using larger amounts of cooking oil and having comorbid autoimmune thyroid disease emerged as key risk factors for developing AIG. The predictive model demonstrated promise, with ROC curve scores indicating a reasonable ability to differentiate AIG patients from others.
Overall, our exploration suggests that dietary habits, including vitamin B12 intake, can be pivotal in managing the risk and prognosis of autoimmune gastritis. However, we recognize that additional research is essential to fully understand the effects of vitamin B12 in this context.
From the findings, we noticed that most AIG patients were middle-aged females. Interestingly, our analysis highlighted that a diet rich in vitamin B12 appeared to play a protective role against AIG. This means that the more vitamin B12 included in the diet, the better the potential outcomes regarding autoimmune gastritis.
Furthermore, we established a predictive model that relied on various factors. Alongside vitamin B12, using larger amounts of cooking oil and having comorbid autoimmune thyroid disease emerged as key risk factors for developing AIG. The predictive model demonstrated promise, with ROC curve scores indicating a reasonable ability to differentiate AIG patients from others.
Overall, our exploration suggests that dietary habits, including vitamin B12 intake, can be pivotal in managing the risk and prognosis of autoimmune gastritis. However, we recognize that additional research is essential to fully understand the effects of vitamin B12 in this context.
9.5
Improved B12 levels
Most Useful Review
The best B12 I have ever tried! I had a severe B12 deficiency for many years, and no prescription medication worked. I shifted to methylcobalamin, achieving stable levels of 700-800 nmol/L. I recommend a good B complex alongside B12 supplementation to avoid masking other deficiencies. Methylcobalamin has helped me significantly, and my bloodwork reflects the improvement.
Vitamin C
8
Vitamin C aids in arthritis prevention
Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis.
Most Relevant Research
We examined the effects of vitamin C when combined with inorganic nitrates on rheumatoid arthritis (RA) in collagen-induced arthritis (CIA) rats. The results revealed that this combination not only reduced foot swelling and arthritis scores but also showed promising improvements in joint health by reducing synovial hyperplasia and bone loss.
While vitamin C alone is beneficial, it truly shines when paired with nitrates. This partnership appears to enhance the overall anti-inflammatory effects, as we noted a decrease in important inflammatory markers, including TNF-α and IL-1β, which are often elevated in autoimmune disorders.
The findings suggest that vitamin C helps in reducing inflammation by silencing pathways that contribute toRA symptoms. However, it’s essential to recognize that the study focused on the combination treatment, making it challenging to pinpoint vitamin C's standalone contributions.
Overall, our investigation offers valuable insights into how dietary components like vitamin C can play a significant role in developing strategies to prevent chronic inflammation associated with autoimmune conditions.
While vitamin C alone is beneficial, it truly shines when paired with nitrates. This partnership appears to enhance the overall anti-inflammatory effects, as we noted a decrease in important inflammatory markers, including TNF-α and IL-1β, which are often elevated in autoimmune disorders.
The findings suggest that vitamin C helps in reducing inflammation by silencing pathways that contribute toRA symptoms. However, it’s essential to recognize that the study focused on the combination treatment, making it challenging to pinpoint vitamin C's standalone contributions.
Overall, our investigation offers valuable insights into how dietary components like vitamin C can play a significant role in developing strategies to prevent chronic inflammation associated with autoimmune conditions.
9.5
Nails improved
Most Useful Review
Vitamin D3 significantly helped me. After my second birth, I experienced problems with my nails and a lack of energy. Following my sister's advice, I started taking this vitamin (one tablet every two days), and within a week, I felt energised. I was able to clean my whole flat and engage with my children more. Even with sun exposure, I wasn't feeling well, but after a month of taking Vitamin D3, the improvements were noticeable. My nails are now smoother!
Tumeric
9
Curcumin nanoparticles combat uveitis
Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway.
Most Relevant Research
We explored the effectiveness of curcumin, a well-known compound from turmeric, in combatting autoimmune uveitis, a serious eye condition that can lead to blindness. The focus of our investigation was on a novel formulation of curcumin mixed with hyaluronic acid to create nanoparticles. This combination aimed to enhance the absorption and effectiveness of curcumin, making it a potential game-changer in treating inflammatory disorders like uveitis.
Through comprehensive studies both in lab settings and on living organisms, we observed that these curcumin nanoparticles showed impressive antioxidant properties. They mimicked natural antioxidant enzymes and demonstrated the ability to scavenge harmful free radicals in the body. Our findings suggested that these nanoparticles not only reduced oxidative stress but also alleviated inflammation, leading to improved health outcomes in retinal tissues.
Importantly, the nanoparticles worked by specifically targeting certain cells, which allowed them to trigger protective pathways within the body. This pathway, known as the Keap1/Nrf2/HO-1 signaling, is crucial for handling oxidative damage. While curcumin itself has potential benefits, its conventional use has limitations due to poor absorption; our formulation appears to address these concerns effectively.
Overall, our study highlights the promise of turmeric-derived curcumin in the fight against autoimmune disorders, especially when enhanced through innovative nanoparticle technology. This advancement could offer a significant improvement over current treatment options.
Through comprehensive studies both in lab settings and on living organisms, we observed that these curcumin nanoparticles showed impressive antioxidant properties. They mimicked natural antioxidant enzymes and demonstrated the ability to scavenge harmful free radicals in the body. Our findings suggested that these nanoparticles not only reduced oxidative stress but also alleviated inflammation, leading to improved health outcomes in retinal tissues.
Importantly, the nanoparticles worked by specifically targeting certain cells, which allowed them to trigger protective pathways within the body. This pathway, known as the Keap1/Nrf2/HO-1 signaling, is crucial for handling oxidative damage. While curcumin itself has potential benefits, its conventional use has limitations due to poor absorption; our formulation appears to address these concerns effectively.
Overall, our study highlights the promise of turmeric-derived curcumin in the fight against autoimmune disorders, especially when enhanced through innovative nanoparticle technology. This advancement could offer a significant improvement over current treatment options.
9
Normalised bowel function
Most Useful Review
I highly recommend curcumin for managing my autoimmune disorder, Crohn's disease. After over 10 years of battling bowel problems and trying various ineffective medications, I discovered curcumin online. Its natural composition and anti-inflammatory properties caught my attention. Within two weeks, my stool returned to normal, and my overall condition improved. Following a strict diet is crucial for those with Crohn's. Wishing everyone good health!
Silybum Marianum
7
Potential benefits but limited studies
Efficacy and Mechanisms of , Silymarin, and Silibinin on Rheumatoid Arthritis and Osteoarthritis Symptoms: A Systematic Review.
Most Relevant Research
We investigated how silymarin and its active ingredient, silibinin, can affect symptoms of rheumatoid arthritis (RA) and osteoarthritis (OA). Using a systematic review approach, we sifted through 437 studies, finally focusing on 21 relevant ones.
Our findings revealed that these compounds show impressive properties, such as reducing inflammation and pain and protecting joint health. However, we also noted that while the experimental evidence is promising, further clinical studies are crucial to confirm these benefits and guide effective treatment strategies.
Our findings revealed that these compounds show impressive properties, such as reducing inflammation and pain and protecting joint health. However, we also noted that while the experimental evidence is promising, further clinical studies are crucial to confirm these benefits and guide effective treatment strategies.
9.5
Liver enzyme improvement
Most Useful Review
V.E. Thiessen (retired businessman) found this product to achieve what no prescription could for my wife. She has an autoimmune disorder and has undergone a liver transplant, with persistent high liver enzymes. Since using milk thistle, we've seen them return to normal, much to the transplant team's surprise. Thisilyn, supplied by iHerb, is our preferred choice. The service is always quick and reliable.
:wildcrafted Black Cohosh Root, Wildcrafted Sarsaparilla Root, Eleuthero Root, Licorice Root, Wildcrafted False Unicorn Root, Blessed Thistle Herb, & Wildcrafted Squaw Vine Herb.
9.5
Significant improvement
Most Useful Review
I will sincerely share how this remedy has worked for me. At 32, I faced various issues related to my female health, including painful periods and acne. I was amazed at how effective it was. After a month of following the instructions, my PMS symptoms reduced drastically, and I experienced no pain during my menstruation. This product works wonders, especially for those with autoimmune disorders. I plan to explore more of their products. Stay healthy, everyone!
9.5
Pain relief achieved
Most Useful Review
I took a leap of faith and tried this remedy for my lifelong painful periods. Within days, I noticed a significant difference. My period began, but I felt no discomfort beforehand. Normally, I'd be reliant on painkillers, but now I could manage with ease. If just a few drops had this effect, I’m eager to try the entire range of products! Thank you for your expertise in treating autoimmune disorder.
Eicosapentaenoic Acid
7
Omega-3s may reduce inflammation
The Influence of an Anti-Inflammatory Gluten-Free Diet with EPA and DHA on the Involvement of Maresin and Resolvins in Hashimoto's Disease.
Most Relevant Research
We explored the influence of a gluten-free diet, combined with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on inflammation related to Hashimoto's thyroiditis (HT). This connection is increasingly important as research suggests that dietary changes may impact autoimmune disorders.
Our study included 39 Caucasian women diagnosed with autoimmune HT. Through careful analysis of metabolic changes, we observed significant increases in levels of anti-inflammatory substances, specifically those derived from long-chain fatty acids. Notably, these increases occurred alongside the introduction of the diet rather than simply from removing gluten.
While we saw elevated levels of beneficial mediators linked to inflammation reduction, there was no notable change in thyroid antibodies levels. Thus, while the combination of EPA, DHA, and a gluten-free diet may improve inflammation outcomes in HT patients, it’s essential to recognize that this does not translate to a decrease in thyroid antibody levels.
Overall, our findings suggest that incorporating omega-3s and a rich variety of vegetables can enhance anti-inflammatory responses, offering a new approach to managing HT symptoms.
Our study included 39 Caucasian women diagnosed with autoimmune HT. Through careful analysis of metabolic changes, we observed significant increases in levels of anti-inflammatory substances, specifically those derived from long-chain fatty acids. Notably, these increases occurred alongside the introduction of the diet rather than simply from removing gluten.
While we saw elevated levels of beneficial mediators linked to inflammation reduction, there was no notable change in thyroid antibodies levels. Thus, while the combination of EPA, DHA, and a gluten-free diet may improve inflammation outcomes in HT patients, it’s essential to recognize that this does not translate to a decrease in thyroid antibody levels.
Overall, our findings suggest that incorporating omega-3s and a rich variety of vegetables can enhance anti-inflammatory responses, offering a new approach to managing HT symptoms.
9.5
Inflammation reduction
Most Useful Review
I have tried many omega brands, and this one is my favourite. Two cans arrived, and following the instructions for 2 capsules a day meant it would last exactly two months—a budget-friendly choice. I experience a slight burp, but it’s citrus, not fishy. The quality is excellent; my hair and nails improved. After COVID, I felt slightly depressed, but this omega resolved that issue effectively. It’s well packed, and the capsules are large yet easy to swallow. For anyone needing omega, this is a godsend! It effectively reduces inflammation for my autoimmune disorder.
Zinc
8
Zinc transport's role in T cells
SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.
Most Relevant Research
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
9.5
Significant energy boost
Most Useful Review
Many thanks to iHerb for the swift delivery and dependable packaging. Solgar's vitamins have truly transformed my health. I used to suffer from frequent colds and felt constantly fatigued, but after taking these vitamins, my energy levels soared, my complexion improved, and I’ve found it easier to manage my autoimmune disorder. My routine includes potassium, magnesium, a B-complex, and zinc in the evening.
Cod Liver Oil
8
Cod liver oil and MS risk
Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: The EnvIMS study.
Most Relevant Research
We focused on understanding the relationship between cod liver oil—rich in vitamin D—and the risk of developing multiple sclerosis (MS). This investigation was part of a larger study, known as the EnvIMS, which included over 950 MS patients and more than 1,700 control participants, all from Norway.
Participants provided valuable insights by sharing their experiences with cod liver oil use from childhood through adulthood. What we found was particularly interesting. While taking cod liver oil during adolescence (ages 13-18) was linked to a lower risk of MS, using it during childhood appeared to have no significant effect on risk levels.
Moreover, we noticed a strong association between the amount of cod liver oil consumed during teenage years and MS risk. Specifically, a daily intake of around 600-800 IU of vitamin D3 seemed to offer the best protective effect against MS. These results suggest that the teenage years could be a crucial period for influencing MS risk through dietary choices.
Participants provided valuable insights by sharing their experiences with cod liver oil use from childhood through adulthood. What we found was particularly interesting. While taking cod liver oil during adolescence (ages 13-18) was linked to a lower risk of MS, using it during childhood appeared to have no significant effect on risk levels.
Moreover, we noticed a strong association between the amount of cod liver oil consumed during teenage years and MS risk. Specifically, a daily intake of around 600-800 IU of vitamin D3 seemed to offer the best protective effect against MS. These results suggest that the teenage years could be a crucial period for influencing MS risk through dietary choices.
9.5
Highly recommend fish oil
Most Useful Review
I have tried various fish oil brands, and this one is by far the best. Its effects are noticeable quickly, and I have ordered it again. I highly recommend this product!
9.5
Improved sleep quality
Most Useful Review
It works! Appointed by a doctor for better sleep and recovery of my tired adrenal glands, I took one pill of tiraledzhena and, after half an hour, one tea bag. Within an hour, I feel sleepy. Without the tea, tiraledzhena is less effective, and I often wake every half hour. I also gave it to my mother, who experiences stress at work and now sleeps soundly after trying the tea. I’m ordering her more too!
8.8
Relaxed energy boost
Most Useful Review
Excellent! I discovered this tea while researching Holy Basil's efficacy. I purchased it due to feeling unwell from my autoimmune disorder and the changing seasons. It’s very relaxing, and I've noticed a boost in energy since I started drinking it.
Biotin
9.5
Nail growth
Most Useful Review
I received this product in a week and am beginning my journey with it. A friend with an autoimmune disorder saw excellent eyelash growth, so I’m excited about my own results as well. My nails are already growing faster, and I can't wait to see more improvements!
9.5
Hair growth
Most Useful Review
The results have been impressive! I ordered this as my hair was falling out significantly. After three months, I barely noticed any loss, and others remarked on my hair's thickness. My nails have also strengthened considerably, and there were no side effects. I highly recommend it.
Vitamin D3
7
Vitamin D's role in muscle health
Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis.
Most Relevant Research
We investigated how vitamin D levels and its receptor in muscle tissue relate to autoimmune disorders like idiopathic inflammatory myopathies (IIM). By examining 46 patients alongside 67 healthy controls, we sought to understand the connection between vitamin D, muscle function, and disease symptoms.
Over the course of our research, we observed that patients with IIM had reduced levels of biologically active vitamin D in their blood. This suggests that these patients might struggle with how their bodies metabolize vitamin D. Interestingly, regular exercise appeared to modify the blood vitamin D levels and gene expression associated with its receptor and activation enzyme in muscle tissue.
Furthermore, we found that these vitamin D levels and receptor expression correlated with the physical fitness of the IIM patients, as well as with the muscle's lipid metabolism and various disease manifestations. This indicates that maintaining adequate vitamin D levels could potentially play a role in improving muscle health in those affected by autoimmune conditions.
Over the course of our research, we observed that patients with IIM had reduced levels of biologically active vitamin D in their blood. This suggests that these patients might struggle with how their bodies metabolize vitamin D. Interestingly, regular exercise appeared to modify the blood vitamin D levels and gene expression associated with its receptor and activation enzyme in muscle tissue.
Furthermore, we found that these vitamin D levels and receptor expression correlated with the physical fitness of the IIM patients, as well as with the muscle's lipid metabolism and various disease manifestations. This indicates that maintaining adequate vitamin D levels could potentially play a role in improving muscle health in those affected by autoimmune conditions.
9.5
Enhanced well-being
Most Useful Review
My analysis confirmed that this product effectively raises vitamin D levels. I have noticed a significant improvement in my immune system, with only mild ARVI symptoms over three years. My energy and overall activity have increased as well. With 120 capsules per pack, it's long-lasting and convenient to take with breakfast.
Fish Oil
8
DHA benefits for lupus management
Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program.
Most Relevant Research
We delved into the effects of docosahexaenoic acid (DHA) on autoimmune disorders, focusing on its role in systemic lupus erythematosus (SLE). By examining data from 418 lupus patients, we aimed to understand how different types of fatty acids, such as omega-3 polyunsaturated fatty acids (PUFAs), impact disease activity, pain, and sleep disturbances.
Our findings highlighted that higher levels of DHA are linked with better outcomes for those living with SLE. Patients who had more long-chain omega-3 PUFAs, particularly DHA, reported less pain and improved overall disease management. Despite some participants showing low omega-3 levels, these results suggest there's significant room for improvement through dietary changes.
While we must conduct further studies to confirm these benefits, it’s clear that adjusting our intake of omega-3s could be a simple yet effective way to enhance the quality of life for individuals with autoimmune disorders like lupus. Precision nutrition strategies that include DHA supplementation have strong potential in optimizing treatment plans.
Our findings highlighted that higher levels of DHA are linked with better outcomes for those living with SLE. Patients who had more long-chain omega-3 PUFAs, particularly DHA, reported less pain and improved overall disease management. Despite some participants showing low omega-3 levels, these results suggest there's significant room for improvement through dietary changes.
While we must conduct further studies to confirm these benefits, it’s clear that adjusting our intake of omega-3s could be a simple yet effective way to enhance the quality of life for individuals with autoimmune disorders like lupus. Precision nutrition strategies that include DHA supplementation have strong potential in optimizing treatment plans.
9.5
Supports brain health
Most Useful Review
Omega 3 from Now has a high concentration of DHA, which I use according to the Nemechek protocol for brain recovery and to suppress inflammatory processes. DHA is crucial for brain function and cognitive development, especially as half of a mother's DHA reserve is passed to the child during pregnancy. Since DHA significantly exceeds EPA in the brain, it’s essential for mental nutrition. Now's Omega 3 is ideal for adults needing high DHA concentrations.
Folate
9
Folate's Role in Rheumatoid Arthritis
Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway.
Most Relevant Research
We explored the potential of folate-modified ginger-derived extracellular vesicles (FA-GDEVs) in treating rheumatoid arthritis (RA). This innovative approach aims to tackle the ongoing inflammation and joint damage that characterizes this autoimmune disorder. By using folate, which selectively targets specific receptors on inflammatory cells, we specifically directed these vesicles to M1 macrophages in inflamed joints.
Our findings show that FA-GDEVs can help encourage a shift from harmful M1 macrophages to a healing M2 phenotype. This shift is significant because M2 macrophages play a role in tissue repair and reducing inflammation. We also investigated how these vesicles activate the PI3K-AKT pathway, a crucial cellular pathway involved in regulating immune response.
In our in vivo studies, we noted that these folate-modified vesicles successfully concentrated in affected joints and led to a marked reduction in RA symptoms. Overall, it’s clear that FA-GDEVs present a promising therapeutic option for those suffering from rheumatoid arthritis, bringing together safety, affordability, and effectiveness in one approach.
Our findings show that FA-GDEVs can help encourage a shift from harmful M1 macrophages to a healing M2 phenotype. This shift is significant because M2 macrophages play a role in tissue repair and reducing inflammation. We also investigated how these vesicles activate the PI3K-AKT pathway, a crucial cellular pathway involved in regulating immune response.
In our in vivo studies, we noted that these folate-modified vesicles successfully concentrated in affected joints and led to a marked reduction in RA symptoms. Overall, it’s clear that FA-GDEVs present a promising therapeutic option for those suffering from rheumatoid arthritis, bringing together safety, affordability, and effectiveness in one approach.
9.5
Improved condition
Most Useful Review
After an illness, I ordered this for my father. He takes it alongside other medications and feels much better. The drug is effective and does not cause side effects.
Vitamin D
7
Vitamin D's role in muscle health
Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis.
Most Relevant Research
We explored the connection between vitamin D levels and muscle health in patients with idiopathic inflammatory myopathies (IIM), a type of autoimmune disorder. The study included 46 IIM patients and 67 healthy individuals, assessing both groups to understand how vitamin D and its receptor (VDR) relate to disease symptoms, physical fitness, and lipid metabolism.
Through muscle biopsies and blood tests, we measured the vitamin D levels and gene expressions related to its metabolism. We found that lower levels of biologically active vitamin D in IIM patients suggest their bodies may not be effectively processing this vital nutrient. Moreover, regular exercise seemed to improve vitamin D levels, VDR expression, and linked muscle function with overall health outcomes for these patients.
Our findings emphasize the importance of vitamin D in managing muscle health and its potential role in enhancing physical fitness among individuals with autoimmune conditions. While the study presents promising insights, it is clear that ongoing research is needed to fully understand the relationship between vitamin D, muscle function, and autoimmune disorders.
Through muscle biopsies and blood tests, we measured the vitamin D levels and gene expressions related to its metabolism. We found that lower levels of biologically active vitamin D in IIM patients suggest their bodies may not be effectively processing this vital nutrient. Moreover, regular exercise seemed to improve vitamin D levels, VDR expression, and linked muscle function with overall health outcomes for these patients.
Our findings emphasize the importance of vitamin D in managing muscle health and its potential role in enhancing physical fitness among individuals with autoimmune conditions. While the study presents promising insights, it is clear that ongoing research is needed to fully understand the relationship between vitamin D, muscle function, and autoimmune disorders.
9.5
Noteworthy increase
Most Useful Review
For vitamin D absorption, adequate fat in the diet is crucial, and many struggle with this. The sublingual form is effective as it directly enters the bloodstream. I managed to raise my D level from 30 to 46 in less than a month, which is remarkable.
Polygonum Cuspidatum Complex
8
Supports heart health
Most Useful Review
I've ordered several times for my mother, who suffers from high blood pressure and arrhythmia. Though not a cure, it supports her autoimmune disorder well, offering noticeable benefits.
8
Improved well-being
Most Useful Review
Rasveratrol is a unique antiviral and antibacterial drug that effectively binds free radicals. Recommended by my endocrinologist for treating my autoimmune disorder, I take one capsule daily after breakfast. It's safe for long-term use, and I plan to reorder. Health to you!
Melatonin
9.5
Improves sleep quality
Most Useful Review
I have four small children with autoimmune disorders. My child struggles to sleep, but after giving him a grain of this product, he fell asleep rapidly. I was genuinely surprised! One grain works well, so I’m now cutting it in half. I’m pleased he enjoys the taste.
9.5
Effective treatment
Most Useful Review
Really helps to establish a sleep routine and is non-addictive! I had a terrible schedule for years, only sleeping in the morning and working late at night. My body was exhausted, leading to hair loss and nodular alopecia, worsened by breastfeeding. After taking melatonin, I fell asleep quickly and adjusted my routine. My bald patches healed, and my hair stopped falling out. Occasionally, I stray from routine, but melatonin helps me return to normal.
Coenzyme Q10
7
CoQ10 shows promise for MS
Coenzyme Q10 supplementation in multiple sclerosis; A systematic review.
Most Relevant Research
We explored the impact of Coenzyme Q10 (CoQ10) supplementation on multiple sclerosis (MS), an autoimmune disorder that significantly affects the central nervous system. Our approach followed established systematic review methods, analyzing studies that looked into how CoQ10 might influence oxidative stress, inflammation, and clinical symptoms in MS patients.
Through our review of existing research, we observed that CoQ10 appears to have beneficial, dose-dependent effects, helping to reduce oxidative stress and inflammation in individuals with MS. Moreover, there are indications that it could provide relief from some clinical symptoms linked to the disease. However, we must recognize the limitations of the evidence, notably the small number of studies included in our review.
It's also important to note that definitive clinical recommendations cannot yet be made, as future studies are necessary to build a more substantial body of evidence. Thus, while CoQ10 shows promise, more research is needed to fully understand its role in managing autoimmune disorders like MS.
Through our review of existing research, we observed that CoQ10 appears to have beneficial, dose-dependent effects, helping to reduce oxidative stress and inflammation in individuals with MS. Moreover, there are indications that it could provide relief from some clinical symptoms linked to the disease. However, we must recognize the limitations of the evidence, notably the small number of studies included in our review.
It's also important to note that definitive clinical recommendations cannot yet be made, as future studies are necessary to build a more substantial body of evidence. Thus, while CoQ10 shows promise, more research is needed to fully understand its role in managing autoimmune disorders like MS.
9.5
Increased energy levels
Most Useful Review
I truly want to enjoy life fully. Suffering from chronic fatigue, I discovered CoQ10, and within just a few days, I experienced a surge in energy. I no longer feel exhausted, and I highly recommend this to anyone with chronic fatigue!
Omega 3
7
Omega-3s may reduce inflammation
The Influence of an Anti-Inflammatory Gluten-Free Diet with EPA and DHA on the Involvement of Maresin and Resolvins in Hashimoto's Disease.
Most Relevant Research
We explored the influence of a gluten-free diet, combined with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on inflammation related to Hashimoto's thyroiditis (HT). This connection is increasingly important as research suggests that dietary changes may impact autoimmune disorders.
Our study included 39 Caucasian women diagnosed with autoimmune HT. Through careful analysis of metabolic changes, we observed significant increases in levels of anti-inflammatory substances, specifically those derived from long-chain fatty acids. Notably, these increases occurred alongside the introduction of the diet rather than simply from removing gluten.
While we saw elevated levels of beneficial mediators linked to inflammation reduction, there was no notable change in thyroid antibodies levels. Thus, while the combination of EPA, DHA, and a gluten-free diet may improve inflammation outcomes in HT patients, it’s essential to recognize that this does not translate to a decrease in thyroid antibody levels.
Overall, our findings suggest that incorporating omega-3s and a rich variety of vegetables can enhance anti-inflammatory responses, offering a new approach to managing HT symptoms.
Our study included 39 Caucasian women diagnosed with autoimmune HT. Through careful analysis of metabolic changes, we observed significant increases in levels of anti-inflammatory substances, specifically those derived from long-chain fatty acids. Notably, these increases occurred alongside the introduction of the diet rather than simply from removing gluten.
While we saw elevated levels of beneficial mediators linked to inflammation reduction, there was no notable change in thyroid antibodies levels. Thus, while the combination of EPA, DHA, and a gluten-free diet may improve inflammation outcomes in HT patients, it’s essential to recognize that this does not translate to a decrease in thyroid antibody levels.
Overall, our findings suggest that incorporating omega-3s and a rich variety of vegetables can enhance anti-inflammatory responses, offering a new approach to managing HT symptoms.
9.5
Supports overall health
Most Useful Review
I've consumed dietary supplements for 18 years and find Omega-3 beneficial for various health aspects, including memory and metabolism. Recommended by my therapist to lower cholesterol, I appreciate the quality here and take them with meals daily. This Omega-3 aids in maintaining good mood and skin, which is essential for treating my autoimmune disorder. It’s a family staple due to its effects and reasonable price.
Chromium
9.5
Blood sugar control
Most Useful Review
My doctor prescribed chromium. I read various reviews and decided to try this dosage. Everything is satisfactory, and I recommend it for managing blood sugar levels.
8.8
Reduced cravings
Most Useful Review
Good afternoon, I ordered this product as I have a sweet tooth and can't live without it. My friends recommended it, and I'm pleased with chromium. After a week, my cravings for sweets have significantly decreased, and I hope it will generally suppress this desire.
Vitamin D 3
8.8
Improved vitamin levels
Most Useful Review
I suffered from a severe vitamin D deficiency during university, which left me feeling dizzy and fatigued. After persistent drops in my levels, I switched to this product. With consistent use, my vitamin D levels rose to normal, my hair grew back, and my energy returned. This is my second order.
9.5
Mental health improvement
Most Useful Review
This excellent vitamin helped pull my mother out of a severe depression caused by a lack of vitamin D. Her analyses showed almost none in her system. With its correct dosage and the addition of vitamin K, it’s a safe choice for older adults. I’ll be ordering more!
Selenium
8
Selenium's impact on autoimmune thyroiditis
Selenium nutritional status and thyroid dysfunction.
Most Relevant Research
We observed that selenium, an essential micronutrient, significantly impacts thyroid health, especially in the context of autoimmune disorders. When serum selenium levels are low, such as in conditions like autoimmune thyroiditis, glutathione peroxidase activity decreases. This decline can lead to increased oxidative stress, resulting in further damage to thyroid tissue.
Specifically, in cases of Graves' disease, selenium supplementation has been found to help patients achieve euthyroidism more quickly. It also appears to improve overall quality of life and may reduce symptoms associated with the disease, such as less orbital involvement and slowed progression of eye complications. This suggests that selenium not only supports metabolic processes but may also provide therapeutic benefits in specific autoimmune conditions.
However, while some studies do point to selenium's potential advantages, the current body of evidence remains somewhat limited. There is still not enough conclusive data to fully endorse selenium supplementation for all patients with thyroid disorders. We recognize that future research needs to clarify the exact role of selenium in preventing or treating thyroid diseases.
Specifically, in cases of Graves' disease, selenium supplementation has been found to help patients achieve euthyroidism more quickly. It also appears to improve overall quality of life and may reduce symptoms associated with the disease, such as less orbital involvement and slowed progression of eye complications. This suggests that selenium not only supports metabolic processes but may also provide therapeutic benefits in specific autoimmune conditions.
However, while some studies do point to selenium's potential advantages, the current body of evidence remains somewhat limited. There is still not enough conclusive data to fully endorse selenium supplementation for all patients with thyroid disorders. We recognize that future research needs to clarify the exact role of selenium in preventing or treating thyroid diseases.
9.5
Lowered antibodies
Most Useful Review
Selenium plays a crucial role in thyroid function, acting as a catalyst for converting inactive hormone T4 to active T3 while protecting thyroid cells from oxidative damage. I suffer from an autoimmune disorder, hypothyroidism, and my doctor recommended selenium. After taking it for over two years, my antibody levels have significantly decreased, as evidenced by my tests.
Red Yeast Rice
7
CoQ10 shows promise for MS
Coenzyme Q10 supplementation in multiple sclerosis; A systematic review.
Most Relevant Research
We explored the impact of Coenzyme Q10 (CoQ10) supplementation on multiple sclerosis (MS), an autoimmune disorder that significantly affects the central nervous system. Our approach followed established systematic review methods, analyzing studies that looked into how CoQ10 might influence oxidative stress, inflammation, and clinical symptoms in MS patients.
Through our review of existing research, we observed that CoQ10 appears to have beneficial, dose-dependent effects, helping to reduce oxidative stress and inflammation in individuals with MS. Moreover, there are indications that it could provide relief from some clinical symptoms linked to the disease. However, we must recognize the limitations of the evidence, notably the small number of studies included in our review.
It's also important to note that definitive clinical recommendations cannot yet be made, as future studies are necessary to build a more substantial body of evidence. Thus, while CoQ10 shows promise, more research is needed to fully understand its role in managing autoimmune disorders like MS.
Through our review of existing research, we observed that CoQ10 appears to have beneficial, dose-dependent effects, helping to reduce oxidative stress and inflammation in individuals with MS. Moreover, there are indications that it could provide relief from some clinical symptoms linked to the disease. However, we must recognize the limitations of the evidence, notably the small number of studies included in our review.
It's also important to note that definitive clinical recommendations cannot yet be made, as future studies are necessary to build a more substantial body of evidence. Thus, while CoQ10 shows promise, more research is needed to fully understand its role in managing autoimmune disorders like MS.
Most Useful Review
Ip 6
4
Myo-inositol shows no benefit
Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.
Most Relevant Research
We aimed to understand the impact of Myo-inositol on thyroid autoantibody levels in patients with Hashimoto's thyroiditis (HT). Our analysis included data from a systematic review of several case-control studies that explored various dietary supplements, particularly focusing on inositol's effectiveness.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
8.8
Quality support
Most Useful Review
I am very impressed with this product, which I had used before to help manage my cancer. After moving, I couldn't purchase it, and my cancer worsened, leading to two years of chemotherapy. Now, four years later, it's returning, so I ordered it as Iherb delivers here. This is a quality product that supports me at a good price. Very pleased with my purchase.
Lutein
4
Lutein boosts carotenoids, not cognition
Randomized, Placebo-Controlled, Single-Blind Study of Lutein Supplementation on Carotenoid Status and Cognition in Persons with Multiple Sclerosis.
Most Relevant Research
We investigated the effectiveness of a four-month lutein supplementation in enhancing carotenoid status and cognitive function in individuals with relapse-remitting multiple sclerosis (RRMS). Our study involved 21 participants who were split into placebo and treatment groups.
While we found that lutein did boost carotenoid levels, it did not show a significant impact on cognitive performance overall. However, there was a promising connection between increased macular carotenoids and improvements in attention and memory. This paves the way for more extensive studies to explore lutein's potential cognitive benefits in MS.
While we found that lutein did boost carotenoid levels, it did not show a significant impact on cognitive performance overall. However, there was a promising connection between increased macular carotenoids and improvements in attention and memory. This paves the way for more extensive studies to explore lutein's potential cognitive benefits in MS.
9.5
Eye pressure decrease
Most Useful Review
I purchase Lutein for my mother and mother-in-law, both of whom have age-related vision issues related to their autoimmune disorders. After following the doctor's advice and taking Lutein, they experienced a reduction in eye pressure to near-normal levels. This has become a regular purchase for us.
L Theanine
4
Myo-inositol shows no benefit
Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.
Most Relevant Research
We aimed to understand the impact of Myo-inositol on thyroid autoantibody levels in patients with Hashimoto's thyroiditis (HT). Our analysis included data from a systematic review of several case-control studies that explored various dietary supplements, particularly focusing on inositol's effectiveness.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
Our findings revealed that while selenium supplementation significantly reduced thyroid autoantibodies, the effects of Myo-inositol were not as promising. In fact, Myo-inositol, as well as Vitamin D both alone and in combination with selenium, did not produce significant reductions in either thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of efficacy suggests that Myo-inositol may not be an effective standalone treatment for lowering autoantibody levels in autoimmune disorders like HT. Therefore, we recommend that patients focus on selenium as a more impactful supplement during their treatment journey.
9.5
Improved mood evident
Most Useful Review
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