Probiotics
7
Beta-glucan alleviates cognitive fatigue
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Most Relevant Research
We conducted a rigorous 36-week study with 65 patients diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Participants were given either yeast-derived beta-glucan with vitamins or a placebo.
The results revealed that those taking beta-glucan showed notable improvements in cognitive fatigue compared to those on the placebo. This suggests that beta-glucan could be a promising nutritional supplement for easing cognitive symptoms associated with ME/CFS.
However, more research is needed to fully understand its benefits and mechanisms.
The results revealed that those taking beta-glucan showed notable improvements in cognitive fatigue compared to those on the placebo. This suggests that beta-glucan could be a promising nutritional supplement for easing cognitive symptoms associated with ME/CFS.
However, more research is needed to fully understand its benefits and mechanisms.
9.5
Excellent health boost
Most Useful Review
High-quality multivitamin complex! I used these during pregnancy without any nausea, even during chronic fatigue syndrome. I often took two capsules, and my tests were always normal. The vitamins improved my overall health, energy levels, and even my hair and nails. The composition is ideal for me with well-absorbed vitamins and minerals in proper dosages. I take one tablet daily.
Vitamins
9.5
Increased energy
Most Useful Review
❤ Improved Well-being and Analysis❤ I've purchased this again due to the minimal packaging. It's a great vitamin! I took one capsule daily alongside vitamin D3 and omega as prescribed by my doctor. My vitamin D levels improved significantly, and I've experienced enhanced wellbeing, increased energy, better sleep, and reduced fatigue. I will definitely purchase more. I hope this helps. Stay healthy❤
9.5
Reduced fatigue
Most Useful Review
Required component for D-3. I take it daily. My ankles used to swell after long workdays, but the swelling disappeared within a week. I've felt lighter and more energetic. It’s amazing how such "vitamins" work. I recommend this; it's a genuine boost for battling chronic fatigue syndrome.
Magnesium
9.5
Improved sleep quality
Most Useful Review
After taking magnesium, I found I became much calmer, my sleep improved, and my legs stopped hurting. Magnesium is crucial for our bodies and is recommended for pregnant women. I take 2 capsules after meals or 30-40 minutes before bedtime. Since using this product, I sleep well, feel less fatigued, and manage my duties as a mother more effectively. I highly recommend it; the quality matches the price, and I appreciate the capsule size.
9.5
Mood enhancement
Most Useful Review
Periodically, I purchase this magnesium. It’s a great price and dosage. The quality is satisfactory – I take it for about two months. It significantly improves my mood, especially during premenstrual syndrome, normalises sleep, and alleviates anxiety. Previously, I often experienced muscle cramps in my feet, but I no longer feel this. I feel more energised, and the benefits are clear.
9.5
Improved mood
Most Useful Review
These capsules have been a revelation for me after enduring postpartum depression for five years. They notably improved my mood without any side effects, allowing me to feel calm and balanced. I'm no longer irritable with my children and find joy in my interactions. I highly recommend giving them a try!
9.5
Restored adrenal function
Most Useful Review
This dietary supplement was incredibly effective for my adrenal glands and hormonal balance. It's essential for anyone experiencing chronic stress, as it alleviates symptoms related to adrenal fatigue.
Vitamin Bs
8
Beta-glucan shows cognitive benefits
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Most Relevant Research
We conducted a study exploring the effects of beta-glucan combined with vitamins, including vitamin B6, on individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). This research involved a 36-week trial where 65 participants were split into two groups: one received a daily supplement containing beta-glucan and vitamins, while the other received a placebo.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.
Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
9.5
Visible energy improvement
Most Useful Review
I suffered from chronic fatigue syndrome for over five years. After trying countless vitamins, supplements, and exercises, I switched to this vitamin and finally noticed a significant improvement in my energy levels and mood. It's a fantastic product!
Nattokinase
9.5
Fast pressure relief
Most Useful Review
Nattokinase was incredibly helpful for my chronic fatigue syndrome and hypotension, quickly raising my blood pressure and reducing the noise in my head.
9.5
Deeper breathing
Most Useful Review
After contracting Covid multiple times, I've noticed that taking Nattokinase has allowed me to breathe more deeply. I experienced fatigue, but since starting this supplement and walking daily, my ability to inhale has improved.
Multivitamins
9.5
Increased strength
Most Useful Review
I was intrigued by the complex of B vitamins and opted for Now Foods B-50 as it offers excellent value. After just two days, I felt energetic and not fatigued, which is remarkable during the current illness season. I can complete my work and enjoy life again. I'm happy to recommend it.
9.5
Reduced fatigue
Most Useful Review
I enjoyed the B-complex! With my hypothyroidism, I often feel fatigued and irritable. After taking this B-50 complex, which enhances iron absorption, I experienced a surge of energy that lasted all day.
Herbal Extracts
9
Echinacea's effects mixed in treatment
[Effectiveness of medical rehabilitation of women of reproductive age with fatigue syndrome].
Most Relevant Research
We examined how a combination of Erbisol, Lymphomyosot, and Echinacea compositum C could help women of reproductive age dealing with fatigue syndrome and chronic gynecological issues.
Our findings indicated that this combination of treatments not only helped reduce the level of immune complexes in the serum but also led to better clinical outcomes. Patients experienced a significant decrease in fatigue symptoms, which contributed to a noticeable improvement in their quality of life.
However, it’s important to note that while echinacea was included in the treatment mix, we could not isolate its effects to determine its specific benefits. Therefore, instead of attributing all improvements solely to echinacea, we recognize that its influence cannot be distinctly measured given the combination treatment approach.
Our findings indicated that this combination of treatments not only helped reduce the level of immune complexes in the serum but also led to better clinical outcomes. Patients experienced a significant decrease in fatigue symptoms, which contributed to a noticeable improvement in their quality of life.
However, it’s important to note that while echinacea was included in the treatment mix, we could not isolate its effects to determine its specific benefits. Therefore, instead of attributing all improvements solely to echinacea, we recognize that its influence cannot be distinctly measured given the combination treatment approach.
10
Stopped staph outbreaks
Most Useful Review
Olive leaf extract has transformed my life. After suffering from two types of staph infections, I struggled to sleep and felt hopeless. Traditional treatments failed me. Discovering olive leaf with oleuropein was miraculous; I've been staph-free for four years! It not only cleared my infections but also improved my overall well-being. I recommend it to anyone suffering from chronic infections. This remarkable herb even helps fight viruses and strengthens the immune system.
Vitamin B Complex
9.5
Reduced fatigue
Most Useful Review
This is an exceptional vitamin B complex, derived from organic sources, notably reducing my chronic fatigue syndrome. I experience significantly fewer headaches now, which has been vital for my daily life. Highly recommended!
8.8
Increased energy
Most Useful Review
The bright yellow capsules are large but easy to swallow. After taking them for two months, I experienced increased energy, reduced irritability, and less mood fluctuation, which greatly helped with my chronic fatigue syndrome. I felt more strength to engage in activities and noticed a gradual improvement in my overall mood. It's important to take a break of six months after a two-month course.
L Theanine
9.5
Stress resistance
Most Useful Review
I regret not discovering L-theanine earlier. This amino acid, which I take daily, helps me combat chronic fatigue syndrome and stress. It effectively calms my mind, aiding in a protective mental state. I notice improvements in my cognitive functions, which are crucial at my age. Additionally, its neuroprotective properties support brain health and prevent age-related issues. I highly recommend combining L-theanine with caffeine for enhanced focus.
9.5
Improved focus
Most Useful Review
During a hectic period, I realised I couldn’t concentrate due to chronic fatigue syndrome. L-theanine saved me! After a week, my thoughts became more organised, and despite working long hours, I didn't feel the accompanying fatigue until bedtime. The supplement indeed works wonders, and I strongly recommend it.
Ubiquinol
9.5
Fatigue relief
Most Useful Review
Ubiquinol combats fatigue and supports my body during dieting. It has improved my energy levels and overall well-being. Additionally, Ubiquinol enhances blood lipid composition and slows cellular aging, making it essential for me.
9.5
Vital supplement
Most Useful Review
I cannot imagine my day without Ubiquinol! Having taken it for over a year, I feel much more active. Previously tired despite sleep, it has revitalised my mornings and improved my rest at night.
Tumeric
9
Curcumin alleviates fatigue symptoms
Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.
Most Relevant Research
We examined the connection between curcumin, a natural compound found in turmeric, and chronic fatigue syndrome in a mouse model. This model used purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigens to induce symptoms of fatigue.
The study involved a water-immersion stress test conducted for 10 minutes each day over 19 days. Notably, the mice treated with LPS or BA showed increased immobility time and heightened sensitivity to pain, which are markers for fatigue. As expected, these mice also exhibited elevated levels of tumor necrosis factor-alpha (TNF-alpha), a sign of inflammation.
Upon administering curcumin during this period, we observed significant improvements. The treatment reduced both the immobility time and pain sensitivity in the mice. Additionally, curcumin helped to lower oxidative stress and the levels of TNF-alpha.
These findings suggest that curcumin could be a promising option for addressing chronic fatigue syndrome, especially related to inflammation and oxidative stress. As we continue to explore this natural remedy, we may uncover more about its potential role in managing this challenging condition.
The study involved a water-immersion stress test conducted for 10 minutes each day over 19 days. Notably, the mice treated with LPS or BA showed increased immobility time and heightened sensitivity to pain, which are markers for fatigue. As expected, these mice also exhibited elevated levels of tumor necrosis factor-alpha (TNF-alpha), a sign of inflammation.
Upon administering curcumin during this period, we observed significant improvements. The treatment reduced both the immobility time and pain sensitivity in the mice. Additionally, curcumin helped to lower oxidative stress and the levels of TNF-alpha.
These findings suggest that curcumin could be a promising option for addressing chronic fatigue syndrome, especially related to inflammation and oxidative stress. As we continue to explore this natural remedy, we may uncover more about its potential role in managing this challenging condition.
9.5
Pain relief
Most Useful Review
I will buy more! Since taking this curcumin for my chronic fatigue syndrome, my burning sensation during urination has gradually disappeared. I haven't taken anything else for it, so I'm certain curcumin is providing me with relief. I will continue to take it!
Black Elderberry
9.5
No more colds
Most Useful Review
My salvation during cold season. I stock up on elderberries in autumn and drink them until spring. For three years, I've managed without pharmacies! I've forgotten what a sore throat is, despite having chronic fatigue syndrome since school. I take one capsule twice daily between meals.
8.8
Increased resistance
Most Useful Review
Excellent! It significantly increases my body's resistance to fatigue and illness.
Oleuropein
8.8
Immune system boost
Most Useful Review
Olive leaf extract provides antioxidant benefits, regulates blood pressure, reduces blood sugar, and enhances energy levels. I took it at my nutritionist's suggestion for chronic fatigue syndrome and saw a significant reduction in viral load. My immune system improved, leukocytes and platelets rose, and lymphocytes normalised. I took it twice daily with meals.
9.5
Cold prevention
Most Useful Review
I use this to treat chronic infections and if I sense a cold coming, I take a triple dose for three days, which prevents illness. It’s easy to take and now always in my medicine cabinet.
Oregano
8.3
Feeling better
Most Useful Review
My lab values were normal, yet I felt "weird" for some time. After a few days of taking oregano oil capsules, I noticed an improvement. My chronic fatigue syndrome has lessened, and I no longer feel weak or tired. The chronic head pressure has also subsided.
9.5
Health improvement noted
Most Useful Review
A nutritionist prescribed this for my chronic fatigue syndrome related to “leaky gut syndrome”. The capsules were easy to swallow, and I noticed improvements without complications. Despite initial doubts about natural ingredients, I have realised their benefits in combating pathogens. I will certainly purchase more of this supplement.
Vitamin E
8.3
Enhanced well-being
Most Useful Review
After tests revealed low levels of selenium and iodine, I began taking selenium. Within two weeks, my overall wellbeing improved significantly, and fatigue decreased. It also reduced heavy metal levels in my body, and I felt revitalised.
9.5
Boosted energy
Most Useful Review
After being diagnosed with Hashimoto's, I opted for a natural approach, avoiding prescription thyroid medication. Going gluten-free and taking selenium improved my chronic fatigue syndrome and gave me back my energy. I've been on this supplement for nearly a year now, and my energy has returned, allowing me to run again! My blood work is better than in the past decade.
Melatonin
9.5
Effective sleep aid
Most Useful Review
Melatonin is a natural adaptogen that has worked wonderfully for me. One 3 mg tablet taken before bed helps me sleep deeply without side effects. I wake up refreshed, ready to take on the day. It's effective for managing chronic fatigue syndrome and I recommend it to everyone.
9.5
Natural sleep solution
Most Useful Review
After suffering from chronic fatigue syndrome due to insomnia, I discovered melatonin. This product allowed me to fall asleep naturally, and I woke without any lingering fatigue. I feel great now and appreciate that there are no side effects.
Polygonum Cuspidatum Complex
9.5
Increased energy
Most Useful Review
After just a week on this natural resveratrol, I have noticeably more energy. I had struggled to find anything that helped with my chronic fatigue syndrome until now. I'm thrilled to be able to enjoy outdoor activities again without the fatigue that plagued me before. It's truly transformative.
7.5
Proven effect
Most Useful Review
After seeing the NHK TV broadcast, I started taking resveratrol from various brands. The 120 tablets you provide have been affordable and I've used them consistently for four years. Recently, I stopped taking it for a month while trying another supplement, and my chronic fatigue syndrome worsened. After resuming, I felt better. My gratitude for this product has only deepened over the years.
Garlic
9.5
Energy boost
Most Useful Review
This supplement improved my health, immunity, and mood. I bought it out of curiosity and have felt an energy boost, relieving fatigue caused by long flights and stress linked to chronic fatigue syndrome.
8.3
Effective supplement
Most Useful Review
I bought this to alleviate my chronic fatigue syndrome and found it the most effective among various garlic supplements I've tried. The slight garlic scent upon opening is manageable, and there's hardly any aftertaste, allowing me to take it without concern.
L Lysine
9.5
Reduces anxiety
Most Useful Review
This essential amino acid benefits the whole body, notably by protecting against herpes rashes, which often occur when immunity is low. L-Lysine helps prevent herpes outbreaks and speeds up healing, and it has been shown to reduce anxiety and cortisol levels.
9.5
Suppresses herpes
Most Useful Review
I take one tablet three times daily, increasing to two or three during acute herpes outbreaks. L-lysine is essential for numerous body processes and helps control symptoms of anxiety and intervenes against herpes viruses, reducing the frequency and severity of outbreaks effectively.
L Glutamine
9.5
Enhanced recovery
Most Useful Review
Glutamine has greatly improved my recovery after workouts and helped with chronic fatigue syndrome. I give my 5-year-old child 100 to 150 mg daily, and we both feel a positive effect. Combining it with Lysine intensifies its benefits.
9.5
Increased energy
Most Useful Review
The product arrived in Brazil within 15 days, and it’s one of the best supplements available. It has significantly improved my energy levels and alleviated muscle fatigue, which helps with my chronic fatigue syndrome.
Fish Oil
8
Eicosapentaenoic acid's potential in CFS
Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).
Most Relevant Research
We explored the connection between eicosapentaenoic acid (EPA) and chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis. The research indicates that individuals suffering from CFS may experience complications linked to persistent viral infections, which could hinder their body's ability to produce necessary fatty acids.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
9.5
Increased energy
Most Useful Review
I have been taking omega for three months now. Initially drawn by the price and dosage of DHA and EPC, I've found my skin to be much softer without any cosmetic procedures. I take one capsule daily in the morning and evening, alongside vitamin D3. My husband's chronic fatigue syndrome symptoms have improved, including the disappearance of bruises under his eyes and a noticeable increase in energy and mood. I highly recommend it!
Flax Seed Oil
9.5
Managed dry eyes
Most Useful Review
This is my preferred brand of flax oil softgels. My eye doctor advised 1000 units daily for my chronic fatigue syndrome and dry eyes. It has made a significant improvement when combined with warm compresses.
8.8
Improved fatigue levels
Most Useful Review
Great Omega 3! The quality of this supplement is excellent. After a month, my hair, skin, and nails are nourished and soft. My sports achievements improved, and I feel less fatigue. It's vital for long, healthy living! I highly recommend this brand.
Elderberry
9.5
Immune support success
Most Useful Review
Since March 2020, I discovered iHerb through a colleague and explored supplements due to COVID-19 concerns. I purchased elderberry extract for my daughter, who suffers from chronic tonsillitis. During her cold, I combined elderberry, echinacea, and vitamin C, leading to a miraculous recovery without medication. This motivated me to learn more about supplements, which have proven effective for my family during COVID-19.
8.3
Quick recovery noted
Most Useful Review
I give this to my parents for colds. They say it helps them recover quickly, preventing illness, especially for my mother with chronic bronchitis, as it eases her cough.
Zinc
8
Synbiotics improve post-COVID fatigue
The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial.
Most Relevant Research
We investigated the impact of a 3-month supplementation with a special synbiotic mixture on adults suffering from post-COVID-19 chronic fatigue syndrome (ME/CFS). This study was thoughtfully designed as a placebo-controlled, double-blind trial involving 26 participants. The intention was to see how this synbiotic, which notably contains zinc among other components, would influence patients' overall experiences, exercise tolerance, and metabolism in tissues affected by fatigue.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
9.5
Boosted energy
Most Useful Review
I find this zinc very effective as it causes no gastrointestinal side effects, which is crucial for my chronic fatigue syndrome. I take it in the morning after breakfast with vitamin C for absorption and feel it helps prevent illness. The tablets are easy to swallow, and the glass bottle is a bonus.
Astragalus Root
9.5
Improved symptoms
Most Useful Review
Excellent immune booster! I've used Now Foods Astragalus Extract for two years, especially during cold and flu season. My wife, who suffers from chronic bronchitis, has had only one mild flare-up since taking it, compared to several bad attacks yearly. This product has truly made a difference for us.
8.8
Boosted immune response
Most Useful Review
Astragalus membranaceus has been used in traditional Chinese medicine for over 2,000 years to support a healthy immune system. My experience with this product confirms its effectiveness, as I've noticed improved immunity and less fatigue. It's a remarkable adaptogen that has also helped my chronic fatigue syndrome significantly.
Silybum Marianum
9.5
Enhanced energy
Most Useful Review
I suffered from chronic fatigue syndrome for years and tried various treatments with little success. Upon starting Silymarin from Now Foods, I noticed a complete turnaround in my energy levels. I can now manage housework and work from home, and my overall mood has improved significantly.
8.8
Physical recovery
Most Useful Review
Silymarin has positively impacted my health. I purchased it to support my liver post-gallbladder removal. It has significantly reduced my chronic fatigue syndrome, and my skin now feels healthier. I plan to buy more.
Evening Primrose
9.5
Health improvement
Most Useful Review
I have been taking evening primrose oil for two years, and the results are remarkably positive. My chronic fatigue syndrome has lessened, and I’ve noticed a decrease in mastopathy symptoms. I stopped taking hormones after 15 years and, astonishingly, my daughter conceived after just a month of using primrose oil. Thanks to iHerb for this opportunity to improve our health.
7.5
Reduced PMS duration
Most Useful Review
I suffer from severe PMS monthly. Following a nutritionist's advice, I took evening primrose oil and DIM. I saw improvements within a month; my PMS duration decreased from 14 days to 7.
Potassium
9.5
Reduced fatigue
Most Useful Review
This potassium citrate has been excellent for my chronic fatigue syndrome following my heart issue. My doctor recommended it after stomach cancer treatment. I prefer the tablet form, and since I started, I've regained energy and improved memory. I take 3-4 capsules daily and plan to reorder. Highly recommended!
9.5
Essential for muscles
Most Useful Review
This potassium is vital on the keto diet and helps with muscle pain, especially for those with chronic fatigue syndrome. It alleviates restless legs at night and supports sleep. I continuously use it for relief.
Coenzyme Q10
7
CoQ10 shows potential, needs more research
Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review.
Most Relevant Research
We explored the role of coenzyme Q10 (CoQ10) in treating chronic fatigue syndrome (CFS), a complex condition often marked by debilitating fatigue. Our analysis draws from several studies assessing various dietary supplements, including CoQ10, and we put a spotlight on its effects specifically related to fatigue.
Among the fourteen studies reviewed, some reported positive outcomes with CoQ10, especially when combined with other treatments. However, the variations in study designs and the presence of methodological issues, like small sample sizes, made it difficult to draw any concrete conclusions about its efficacy.
While inconsistent results surfaced regarding enhancements in energy levels, we also noted several adverse effects reported by participants, such as nausea and insomnia. Thus, while CoQ10 shows promise, we need more rigorous research to better understand its potential benefits for CFS.
Among the fourteen studies reviewed, some reported positive outcomes with CoQ10, especially when combined with other treatments. However, the variations in study designs and the presence of methodological issues, like small sample sizes, made it difficult to draw any concrete conclusions about its efficacy.
While inconsistent results surfaced regarding enhancements in energy levels, we also noted several adverse effects reported by participants, such as nausea and insomnia. Thus, while CoQ10 shows promise, we need more rigorous research to better understand its potential benefits for CFS.
9
Boosted energy levels
Most Useful Review
I experienced a surge of energy after a couple of months taking CoQ10. I found it easier to get up in the mornings and felt great during training. Most importantly, I no longer suffered from fatigue post-training, which I struggled with after my second child. I take 1 capsule daily. If this review helps, I’m pleased! Wishing you all health and energy!
Docosahexaenoic Acid
7
Link Between Omega-3 and CFS
In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation.
Most Relevant Research
We explored the connection between omega-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), and chronic fatigue syndrome (CFS). In this study, researchers compared serum PUFA levels in 22 patients with CFS to 12 healthy controls.
Their findings revealed that CFS patients had higher levels of omega-6 fatty acids and lower omega-3 levels compared to those without the condition. Specifically, the ratio of omega-3 to omega-6 was significantly lower in CFS patients. This imbalance was correlated with more severe symptoms, such as fatigue and memory problems. The research also suggested that lower zinc levels might be linked to this imbalance and indicate problems with T cell activation, which plays an essential role in immune function.
While the study provides insights into the relationship between omega-3 fatty acids and CFS, it focuses on omega-3s in general and does not isolate the effects of DHA alone. However, it hints that increasing omega-3 PUFA intake, including DHA, could potentially help manage symptoms of CFS, even though further research is needed to confirm this finding.
Their findings revealed that CFS patients had higher levels of omega-6 fatty acids and lower omega-3 levels compared to those without the condition. Specifically, the ratio of omega-3 to omega-6 was significantly lower in CFS patients. This imbalance was correlated with more severe symptoms, such as fatigue and memory problems. The research also suggested that lower zinc levels might be linked to this imbalance and indicate problems with T cell activation, which plays an essential role in immune function.
While the study provides insights into the relationship between omega-3 fatty acids and CFS, it focuses on omega-3s in general and does not isolate the effects of DHA alone. However, it hints that increasing omega-3 PUFA intake, including DHA, could potentially help manage symptoms of CFS, even though further research is needed to confirm this finding.
9.5
Increased energy
Most Useful Review
I was initially hesitant about this substitute for another vegetarian Omega-3. However, this product has been perfect and has no unpleasant aftertaste. Since taking Omega-3, I feel far more energetic, shaking off the stress and fatigue that had plagued me, including symptoms of chronic fatigue syndrome. I'm committed to ordering this from Korea. Thank you, iHerb!
Omega 3
8
Eicosapentaenoic acid's potential in CFS
Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome).
Most Relevant Research
We explored the connection between eicosapentaenoic acid (EPA) and chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis. The research indicates that individuals suffering from CFS may experience complications linked to persistent viral infections, which could hinder their body's ability to produce necessary fatty acids.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
9.5
Eliminated fatigue
Most Useful Review
Works! My skin was excessively dry, and I was often fatigued and suffering from cold sores. Since taking these capsules alongside vitamin D, my issues have been resolved, and my hair appears healthier. It truly works, and I wholeheartedly recommend it for addressing chronic fatigue syndrome!
Lutein
9.5
Necessary supplement
Most Useful Review
Lutein and zeaxanthin are essential for protecting the retina and preventing chronic fatigue syndrome, especially for those working long hours at computers. They block blue light and protect against harmful radiation. I combine them with Omega-3 and blueberry extract, and I highly recommend these supplements.
9.5
Improved eyesight
Most Useful Review
After taking this supplement for a month, I experienced a significant improvement. My chronic fatigue syndrome felt relieved, and I noticed my eyes were no longer red, with fatigue disappearing and slight vision improvement.
Red Yeast Rice
7
CoQ10 shows potential, needs more research
Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review.
Most Relevant Research
We explored the role of coenzyme Q10 (CoQ10) in treating chronic fatigue syndrome (CFS), a complex condition often marked by debilitating fatigue. Our analysis draws from several studies assessing various dietary supplements, including CoQ10, and we put a spotlight on its effects specifically related to fatigue.
Among the fourteen studies reviewed, some reported positive outcomes with CoQ10, especially when combined with other treatments. However, the variations in study designs and the presence of methodological issues, like small sample sizes, made it difficult to draw any concrete conclusions about its efficacy.
While inconsistent results surfaced regarding enhancements in energy levels, we also noted several adverse effects reported by participants, such as nausea and insomnia. Thus, while CoQ10 shows promise, we need more rigorous research to better understand its potential benefits for CFS.
Among the fourteen studies reviewed, some reported positive outcomes with CoQ10, especially when combined with other treatments. However, the variations in study designs and the presence of methodological issues, like small sample sizes, made it difficult to draw any concrete conclusions about its efficacy.
While inconsistent results surfaced regarding enhancements in energy levels, we also noted several adverse effects reported by participants, such as nausea and insomnia. Thus, while CoQ10 shows promise, we need more rigorous research to better understand its potential benefits for CFS.
9.5
LDL reduction
Most Useful Review
Having struggled with cholesterol levels for years due to chronic hepatitis B, I sought natural alternatives after my GP suggested diet and exercise. After trying various supplements without success, I began taking red yeast rice five weeks ago. To my delight, my LDL dropped by over 35%, achieving a ratio change from 4.3:1 to 3.2:1. So far, I’ve experienced no side effects, and I hope the quality remains high.
Vitamin C
9
Vitamin C therapy shows potential
Effect of high dose vitamin C on Epstein-Barr viral infection.
Most Relevant Research
We investigated the effects of high dose intravenous vitamin C on patients suffering from chronic fatigue syndrome (CFS) linked to Epstein-Barr virus (EBV) infections. Our analysis included data from 178 patients who had elevated levels of EBV antibodies, alongside 40 who also showed signs of ongoing viral activity. Most of our participants were diagnosed with chronic fatigue syndrome, while others had related conditions such as mononucleosis or general fatigue.
What we found is quite promising. High doses of vitamin C appeared to reduce the duration of disease symptoms and helped decrease antibody levels associated with EBV. Notably, we observed that patients with higher levels of vitamin C in their plasma generally had lower levels of certain EBV antibodies, suggesting a potential link that might help manage symptoms of CFS.
Furthermore, there was an interesting connection between vitamin D levels and EBV antibodies as well. Patients who had high levels of vitamin D showed lower levels of EBV early antigen antibodies. This points towards a holistic approach to managing CFS, where both vitamin C and vitamin D may play beneficial roles. Overall, our findings hint at an encouraging effect of high dose vitamin C therapy in helping those grappling with CFS due to EBV.
What we found is quite promising. High doses of vitamin C appeared to reduce the duration of disease symptoms and helped decrease antibody levels associated with EBV. Notably, we observed that patients with higher levels of vitamin C in their plasma generally had lower levels of certain EBV antibodies, suggesting a potential link that might help manage symptoms of CFS.
Furthermore, there was an interesting connection between vitamin D levels and EBV antibodies as well. Patients who had high levels of vitamin D showed lower levels of EBV early antigen antibodies. This points towards a holistic approach to managing CFS, where both vitamin C and vitamin D may play beneficial roles. Overall, our findings hint at an encouraging effect of high dose vitamin C therapy in helping those grappling with CFS due to EBV.
9.5
Fatigue reduction
Most Useful Review
I recently started taking this vitamin C1000 alongside B complex in the morning and niacin at night. It’s very effective; I feel refreshed, less fatigued, and my skin is much clearer.
Iron
7
Iron boosts fatigue symptoms
The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
Most Relevant Research
We explored the effects of iron supplementation on individuals suffering from iron deficiency, specifically looking at its impact on symptoms like chronic fatigue syndrome (CFS). This was done through a well-structured study involving 176 blood donors who were iron deficient, with a randomized controlled trial design.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
9.5
Increased iron levels
Most Useful Review
Effective iron! It raised my ferritin levels. I felt overwhelmed and fatigued, with my ferritin at 18.3 in January. After much research, I opted for this iron bisglycinate, which has a good dosage and quality. I took it twice daily with vitamin C, and my energy improved significantly.
Vitamin D3
8
Beta-glucan shows cognitive improvements
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled trial to explore how yeast beta-glucan, along with multivitamins, affects individuals suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In our study, 65 participants received either beta-glucan combined with vitamins and zinc or a placebo for 36 weeks.
Interestingly, while our primary focus was on beta-glucan, which was shown to significantly improve cognitive fatigue, the role of vitamin D3 within this combination was not clearly established. This makes it challenging to directly assess the impact of vitamin D3 alone on chronic fatigue syndrome outcomes.
Overall, we discovered that beta-glucan supplementation could positively influence cognitive fatigue, offering promise for future research on nutritional support in ME/CFS patients. However, definitive conclusions about vitamin D3's effectiveness remain inconclusive due to the combined nature of the treatment.
Interestingly, while our primary focus was on beta-glucan, which was shown to significantly improve cognitive fatigue, the role of vitamin D3 within this combination was not clearly established. This makes it challenging to directly assess the impact of vitamin D3 alone on chronic fatigue syndrome outcomes.
Overall, we discovered that beta-glucan supplementation could positively influence cognitive fatigue, offering promise for future research on nutritional support in ME/CFS patients. However, definitive conclusions about vitamin D3's effectiveness remain inconclusive due to the combined nature of the treatment.
9.5
Boosted immune system
Most Useful Review
Very good vitamins at a reasonable price. The whole family takes one small capsule daily with food. I've noticed a significant reduction in chronic fatigue syndrome and an improvement in my health, particularly after illnesses. Vitamin D3 supports recovery, strengthens bones, boosts muscle strength, and enhances mood. I've been taking it consistently and find it essential for my wellbeing, especially during the winter months.
Vitamin D
8
Oral supplement aids long COVID symptoms
Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients.
Most Relevant Research
We conducted a double-blind, placebo-controlled trial to evaluate the effects of an oral food supplement (OFS) on long COVID patients, particularly focusing on chronic inflammation and fatigue. The supplement included components like rosehip, propolis, royal jelly, and zinc, with vitamin C being a key ingredient.
Through our two-month study, which involved giving participants either the OFS or a placebo, we made some interesting observations. Notably, patients who took the OFS experienced a significant reduction in inflammatory markers, which are often linked to chronic fatigue syndrome. This included improvements in the neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios.
We also noted a substantial increase in vitamin D levels among those taking the supplement, which correlated with enhanced quality of life and decreased fatigue as measured by the fatigue severity scale. Our findings suggest that the combination of ingredients in the OFS, particularly its vitamin D content, can help alleviate some symptoms associated with long COVID, especially chronic fatigue.
However, since the supplement included multiple active ingredients, isolating the specific impact of vitamin D on chronic fatigue syndrome is challenging. Still, the overall results indicate positive changes for patients dealing with the lingering effects of COVID.
Through our two-month study, which involved giving participants either the OFS or a placebo, we made some interesting observations. Notably, patients who took the OFS experienced a significant reduction in inflammatory markers, which are often linked to chronic fatigue syndrome. This included improvements in the neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios.
We also noted a substantial increase in vitamin D levels among those taking the supplement, which correlated with enhanced quality of life and decreased fatigue as measured by the fatigue severity scale. Our findings suggest that the combination of ingredients in the OFS, particularly its vitamin D content, can help alleviate some symptoms associated with long COVID, especially chronic fatigue.
However, since the supplement included multiple active ingredients, isolating the specific impact of vitamin D on chronic fatigue syndrome is challenging. Still, the overall results indicate positive changes for patients dealing with the lingering effects of COVID.
9.5
Calcium improvement
Most Useful Review
A great product! I take raw vitamins and supplements as I have chronic fatigue syndrome and need efficient absorption. The Raw Calcium is a wholefood and plant formula without tummy upset. My calcium levels have risen significantly since using this product, having previously been low. I appreciate Garden of Life products for their range of raw supplements.
Vitamin B12
8
Vitamin B12 drops show promise
Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders.
Most Relevant Research
We examined the impact of vitamin B12 nasal drops on individuals suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study involved fifty-one patients, predominantly female, with an average age of 42 and an average illness duration of 16 years.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
9
Increased energy levels
Most Useful Review
Vitamin B12 is crucial for the body. I take it for my parents as they experience chronic fatigue syndrome. Since starting the supplements, they feel more active and less lethargic. We take it in courses and follow a break. The tablets are tiny and slightly sour. For optimal absorption, they need to dissolve completely.
Quercetin
9.5
Headache relief
Most Useful Review
I began taking one tablet twice daily for chronic fatigue syndrome due to chronic sinusitis. After a month, my rhinitis headaches vanished, and I no longer experience morning congestion. When my symptoms worsened, I took two tablets twice a day and felt better the next day. I plan to keep this up.
9.5
Allergy disappearance
Most Useful Review
I struggled with chronic urticaria due to a delayed-type allergy that caused daily flare-ups. After starting two supplements with meals, my urticaria reduced within a day and completely disappeared after four days. I haven't experienced any recurrence, unlike with antihistamines, and I feel much better.
Folate
8
B12 and folic acid show promise
Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
Most Relevant Research
We aimed to evaluate how folic acid, in combination with vitamin B12, impacts individuals with chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME). Our study focused on a group of 38 patients who had received weekly B12 injections for six months to several years.
During our research, we categorized the patients into two groups: Good responders and Mild responders, based on their improvement in symptoms. We found that those who responded positively had received B12 injections more frequently and at higher doses compared to those with lesser improvement. They also tended to use more folic acid daily and were less likely to use strong analgesics.
Our findings suggested a clear relationship between the dosage of B12 and folic acid and the degree of improvement reported by the participants. However, we noted a higher occurrence of fibromyalgia among those with milder responses, indicating that the presence of additional conditions might affect outcomes.
Overall, we observed a dose-response effect suggesting that B12 and folic acid together could bring about meaningful improvements in CFS symptoms. Also, we identified the importance of being aware of possible thyroid issues and highlighted the need for more precise research regarding their interaction with other medications.
During our research, we categorized the patients into two groups: Good responders and Mild responders, based on their improvement in symptoms. We found that those who responded positively had received B12 injections more frequently and at higher doses compared to those with lesser improvement. They also tended to use more folic acid daily and were less likely to use strong analgesics.
Our findings suggested a clear relationship between the dosage of B12 and folic acid and the degree of improvement reported by the participants. However, we noted a higher occurrence of fibromyalgia among those with milder responses, indicating that the presence of additional conditions might affect outcomes.
Overall, we observed a dose-response effect suggesting that B12 and folic acid together could bring about meaningful improvements in CFS symptoms. Also, we identified the importance of being aware of possible thyroid issues and highlighted the need for more precise research regarding their interaction with other medications.
8.8
Improved absorption
Most Useful Review
EXCELLENT RESULT! If you don’t consume sufficient greens and spinach, this supplement is essential. It contains folic acid, crucial for women’s health, aiding organ function and cardiovascular recovery. Vitamin B12, paired with folic acid, combats chronic fatigue syndrome, irritability, and fatigue. These vitamins work together, hence taking them as a complex is advisable. I highly recommend this product! Thank you very much for your thumbs up!
L Carnosine
4
L-carnosine shows limited benefits
Carnosine treatment for gulf war illness: a randomized controlled trial.
Most Relevant Research
We conducted a randomized controlled trial to explore whether L-carnosine could significantly improve symptoms associated with Gulf War illness (GWI), a condition characterized by disabling fatigue, pain, and cognitive dysfunction.
In this 12-week study, 25 individuals suffering from GWI were given L-carnosine in increasing doses of 500 mg, 1000 mg, and finally 1500 mg, administered at four-week intervals. We utilized a double-blind and placebo-controlled design, which is a strong method for assessing treatment efficacy.
Our observations revealed that while L-carnosine seemed to have a positive effect on cognitive function, as indicated by improved scores on the WAIS-R test, it did not show significant improvements in fatigue, pain, or overall activity levels. Interestingly, there was a reduction in diarrhea linked to irritable bowel syndrome, which is a positive note for gastrointestinal health.
Overall, while L-carnosine may offer some cognitive benefits, it appears that other major symptoms of chronic fatigue associated with GWI remain resistant to this treatment.
In this 12-week study, 25 individuals suffering from GWI were given L-carnosine in increasing doses of 500 mg, 1000 mg, and finally 1500 mg, administered at four-week intervals. We utilized a double-blind and placebo-controlled design, which is a strong method for assessing treatment efficacy.
Our observations revealed that while L-carnosine seemed to have a positive effect on cognitive function, as indicated by improved scores on the WAIS-R test, it did not show significant improvements in fatigue, pain, or overall activity levels. Interestingly, there was a reduction in diarrhea linked to irritable bowel syndrome, which is a positive note for gastrointestinal health.
Overall, while L-carnosine may offer some cognitive benefits, it appears that other major symptoms of chronic fatigue associated with GWI remain resistant to this treatment.
9.5
Pain relief
Most Useful Review
I’m glad I bought this. Nearing 60, I’ve experienced chronic fatigue syndrome, muscle fatigue, and pain. After taking it with ADAM and Omega 3, my pain and numbness disappeared. It genuinely works, and I slept well.
D Mannose
8.3
Doctor visits reduced
Most Useful Review
D-Mannose is a miracle for my chronic fatigue syndrome. I've had countless bladder infections, but since I started using this product, I no longer need frequent medical visits. Thank you!
7.5
Effective method
Most Useful Review
I use this for chronic fatigue syndrome and find it effective. Start taking it as soon as symptoms appear, and take higher doses initially. It does have large capsules, but the results are worth it.