Echinacea boosts cold immunityEchinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences.
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We explored the effects of Echinacea purpurea, a popular herbal remedy, on our immune response to the common cold. The study employed advanced techniques to measure how a standardized extract of Echinacea affects THP-1 monocytes, a type of immune cell. Through transcriptome, epigenome, and kinome profiling, we identified significant immunomodulatory effects from the Echinacea treatment.
Our findings revealed that Echinacea stimulates antiviral pathways responsible for activating immune responses. This includes enhancing signaling from interferons, which act as messengers in our immune system, and boosting the activity of pattern recognition receptors, which help identify pathogens. We also observed changes in genes related to inflammation and the body's metabolic processes, indicating a comprehensive strengthening of our innate immunity.
Furthermore, Echinacea treatment was linked to increased DNA methylation at specific genomic sites. This may inhibit the expression of endogenous retroviral sequences, contributing to a protective evolutionary response to viral infections. Such changes suggest that Echinacea may not only help alleviate symptoms but could also reduce the duration of colds caused by various coronaviruses, including new variants like SARS-CoV-2.
Overall, we believe Echinacea purpurea shows promise as a supportive treatment for common colds, particularly in boosting our inherent antiviral defenses during infections.