Rhodiola benefits heart injury recoverySalidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury.
We explored the effects of salidroside, a natural extract from Rhodiola rosea, on heart damage caused by a lack of blood flow, known as ischemia-reperfusion (I/R) injury, in rats. The study involved inducing this injury in Wistar rat hearts and then treating them with salidroside.
Our findings showed that salidroside significantly improved cardiac function. It reduced the size of heart damage, and lowered levels of important cardiac markers like CK-MB and LDH, indicating better heart health. Additionally, salidroside showed an ability to manage oxidative stress in the heart.
Importantly, we also observed that salidroside inhibited processes of cell death and self-digestion, known as apoptosis and autophagy respectively. This effect could be reversed by introducing an agent that promotes autophagy, suggesting that salidroside controls these processes effectively. Lastly, salidroside's benefits appear to be linked to increasing levels of a specific circular RNA, hsa_circ_0000064, which plays a role in cell regulation.
All in all, our study indicates that salidroside may offer a protective effect against heart damage during I/R injury, potentially through its influence on certain biological processes and molecules related to cellular health.