N Acetylglucosamine
9.5
Helpful relief
Most Useful Review
A life saver for my irritable bowel syndrome. Taking this on an empty stomach each morning works wonders and lubricates the bowel.
9.5
Significant aid
Most Useful Review
Excellent for bowel problems, including erosive colitis. It has helped me significantly and has been beneficial for my joints.
Quercetin
9.5
Effective relief
Most Useful Review
Quercetin and bromelain are powerful natural ingredients that alleviate allergic and inflammatory disorders, including irritable bowel syndrome. As someone with arthritis and allergies, Quercetin has been a salvation for me. I take it regularly and recommend it for its benefits.
8.8
Helpful for symptoms
Most Useful Review
This helped manage my irritable bowel syndrome and acid indigestion effectively.
Slippery Elm
9.5
Relieved symptoms
Most Useful Review
"Slippery elm really helped alleviate my irritable bowel symptoms. It’s a very effective product."
9.5
Skin improvement
Most Useful Review
"I discovered slippery elm during my journey to manage psoriasis. I realised that intestinal health affects skin conditions, so I focused on my gut health. After using slippery elm and cleansing my bowels, my skin improved significantly within weeks."
Proprietary Blendmanna Fraxinus Ornus L)
9.5
Supports bile flow
Most Useful Review
This delicious herbal tincture is part of my daily routine. I consume it 2-3 times a day before meals, and it fosters good digestion, bile flow, and regular bowel movements, which really helps my irritable bowel syndrome.
8.8
Helpful for IBS
Most Useful Review
I was introduced to Swedish Bitters by a friend who uses it for various ailments. I have lupus, and I've found that taking the bitters has helped me. It has also been beneficial for my irritable bowel syndrome.
8.8
Constipation relief
Most Useful Review
My intestines now function like clockwork. Although I tried eating more vegetables and fruits, I still faced constipation issues. I opted for this product because it contains both psyllium and apple pectin, a beneficial prebiotic. The capsule form is very convenient compared to powders. I take two capsules twice daily, drinking sufficient water, and I've noticed no more issues with my bowel movements. Interestingly, I’ve lost 2 kg since starting, though I'm unsure if it’s directly linked to the psyllium.
8.8
Improved digestion
Most Useful Review
I adore this husk for its excellent effect on my gastrointestinal system. I took it during meals, ensuring plenty of water to avoid constipation and support beneficial bacteria. I’ve gone through both powder and capsule forms, experiencing clear skin and improved mood. This fibre supplement is essential for proper intestinal function and regular emptying, especially if I don’t consume enough vegetables daily.
Flax Seed Oil
9.5
Gentle bowel movement
Most Useful Review
Flaxseed oil has helped with my irritable bowel syndrome. I initially struggled with the taste in its raw form but found these soft tablets easier to take, allowing my bowel to empty gently and regularly.
8.8
Moisturised skin
Most Useful Review
My skin has been moisturised and my bowel movements have improved, which has been beneficial for my irritable bowel syndrome.
Oregano
9.5
Complicated recovery
Most Useful Review
My nutritionist recommended this for stage 2 of my antiparasitic programme and for irritable bowel syndrome. After starting it, my cold symptoms improved, and I stayed healthy. I found the capsules easy to swallow and appreciated that, despite the bitter taste, they didn’t cause heartburn. I’ll definitely buy more.
8.8
Eliminated symptoms
Most Useful Review
I suffered from yeast issues and bacterial vaginosis and had bloating and gas for nearly a year. After starting on this oil, I gradually increased my dosage. Thankfully, my bloating has disappeared, and my bowel movements are normal. My discharge has also returned to a normal colour and odour. Although I initially used the oil longer due to my persistent problems, I will now take a break to see if any symptoms return. This brand is effective!
Psyllium Husks
9.5
Effective digestion aid
Most Useful Review
This isn’t just coarsely ground bran! Natural psyllium or organic husks promote gentle cleansing of the intestines, helping to alleviate irritable bowel syndrome and remove toxins. It regulates digestion and can help manage weight, sugar, and cholesterol levels. This product is especially helpful for pregnant women experiencing bowel movement issues. Combining it with inulin can enhance digestive health.
8.3
Ideal for weight loss
Most Useful Review
This super fibre has been effective for my irritable bowel syndrome. It comes in a convenient jar and has improved my bowel movements significantly.
Evening Primrose
9.5
Bowel improvement
Most Useful Review
I regularly take Evening Primrose Oil, and with the high concentration, I only need one pill a day. It aids my overall health and has improved my irritable bowel syndrome. I haven't experienced cramps, just mild bloating, so I won't stop taking them.
8.8
Reduced symptoms
Most Useful Review
I purchased it for my daughter who suffers from premenstrual syndrome, and since taking the primrose pills, she has significantly improved.
Nattokinase
9.5
Healthy digestion
Most Useful Review
After eating, I have no bowel movement issues, my stomach feels good, and my skin looks beautiful! Prior to the injection, I took two capsules a day without side effects, allowing me to return to work as usual. This is a remarkable product that can be taken without food!
9.5
Immune support
Most Useful Review
This supplement significantly boosts immune function and aids in stroke and heart attack prevention. Since taking it, I believe my bowel health has improved, making me feel more resilient post-COVID. The small tablets are easy to swallow.
Certified:peppermint Leaf
9.5
Immediate effect
Most Useful Review
I made the right choice purchasing this for my irritable bowel syndrome, which I've suffered from for years. After researching, I read that peppermint could help. It was effective and seemed to cure my symptoms almost immediately, especially when my stomach was upset. I would like a larger size in the future!
8.8
Refreshing relief
Most Useful Review
Refreshing flavour! The peppermint extract is effective for my irritable bowel syndrome. I usually add a few drops to tea after meals to soothe my stomach. The liquid does not cloud the tea as it contains no oil. It's a refreshing flavour!
Vitamins
9
Vitamin D improves IBS management
Impact of vitamin D supplementation on symptom severity and quality of life in patients with irritable bowel syndrome: A meta-analysis.
Most Relevant Research
We aimed to find out how vitamin D supplementation might help those suffering from irritable bowel syndrome (IBS). To do this, we conducted a thorough review of nine randomized controlled trials that included a total of 780 participants.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
9.5
Promotes immunity
Most Useful Review
Vitamin D3 is vital for everyone, reducing the risk of viral diseases and respiratory tract infections. It's essential for immunity and addresses irritable bowel syndrome. D3 controls the absorption of key minerals and supports bone health. Due to limited sunlight, many lack sufficient D3, so supplementation is beneficial. I recommend D3 from NOW; it's high quality and reasonably priced. Almost everyone needs this vitamin!
Probiotics
8
Lactobacillus aids IBS-related depression
A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome.
Most Relevant Research
We examined how consuming a cultured milk drink with Lactobacillus acidophilus might impact depression in patients with irritable bowel syndrome (IBS). The study involved 110 participants who were divided into groups to receive either the probiotic drink or a placebo over 12 weeks.
Those with subthreshold depression experienced significant reductions in depression scores. The probiotic group even saw boosts in serotonin levels and improvements in quality of life. Although everyone reported reduced IBS severity, the probiotics specifically showed notable potential in managing depressive symptoms linked to IBS.
Those with subthreshold depression experienced significant reductions in depression scores. The probiotic group even saw boosts in serotonin levels and improvements in quality of life. Although everyone reported reduced IBS severity, the probiotics specifically showed notable potential in managing depressive symptoms linked to IBS.
9.5
Effective alternative
Most Useful Review
Jarrow Formulas saccharomycetes do not settle in the intestines but pass through the gastrointestinal tract unscathed, offering a healing effect. It effectively treats acne, diarrhoea, irritable bowel syndrome, and enhances nutrient absorption. Completely safe, I take it with me on journeys instead of bacterial probiotics. Highly recommended!
Spirulina
9.5
Eczema improvement
Most Useful Review
After suffering from eczema, I integrated Spirulina into my regimen alongside a healthier diet, and the results have been tremendous. My rash has improved significantly, and I’ve also noticed that my bowel movements have become much more regular, suggesting a positive effect on my irritable bowel syndrome.
8.8
Weight loss achieved
Most Useful Review
Spirulina has worked wonders for me! Initially, I experienced stomach disturbances, increased bowel movements, and even vomiting. After reducing my dose to 500mg twice daily, everything normalised. I've been using it for four weeks now, and my skin is clearer, the puffiness under my eyes has vanished, and I’m gradually losing weight. I believe if you're experiencing bloating or colic, it might signal the presence of irritable bowel syndrome or parasites, and Spirulina could assist in cleansing your body.
Magnesium
8
Magnesium boosts colonic activity
Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome.
Most Relevant Research
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
9.5
Effective soothing relief
Most Useful Review
The effect is noticeable from the very first capsule! I have a neurological disability and regularly take magnesium supplements. This magnesium is very good; it quickly relaxes my spasticity and helps me sleep better if taken in the evening. It also soothes my irritable bowel syndrome, with abdominal pains easing quickly. I'm very pleased with my purchase and shared it with my mum. I'll definitely order more.
Vitamin Bs
8
Folic Acid reduces IBS-related pain
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production.
Most Relevant Research
We investigated the effects of Folic Acid (FA) on chronic visceral pain linked to Irritable Bowel Syndrome (IBS). Chronic visceral hyperalgesia (pain sensitivity) was induced in rats through neonatal colonic inflammation, enabling us to examine how FA might alleviate this condition.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
9.5
Improved gut health
Most Useful Review
Leaky Gut syndrome led to a deficiency in vitamin B12. While overcoming this condition, my teacher Cairo recommended a lozenge form for better absorption. Since the absorption was poor due to my weak stomach mucosa, I take it twice a day, enjoying its lemon flavour. My sleep improved, and I feel my leaky gut symptoms have almost disappeared after six months. This affordable option has been effective for me.
Lactoferrin
8
Lactoferrin may treat stress-induced IBS
Vitamin D and lactoferrin attenuate stress-induced colitis in Wistar rats via enhancing AMPK expression with inhibiting mTOR-STAT3 signaling and modulating autophagy.
Most Relevant Research
We explored how lactoferrin might alleviate symptoms of irritable bowel syndrome (IBS) by examining its effects on stress-induced colitis in Wistar rats. In our study, we used a chronic wrap-restraint stress model to simulate the psychological stress that contributes to IBS.
The rats were divided into four groups: naïve rats, those subjected to stress, and two groups that received either vitamin D or lactoferrin. Our findings indicated that both lactoferrin and vitamin D improved various health markers compared to the stressed rats. Notably, lactoferrin treatment resulted in enhanced social behavior, increased levels of beneficial interleukin-10, and improved autophagy in the colon.
Furthermore, lactoferrin demonstrated a remarkable ability to decrease inflammatory markers and stress levels, suggesting it may modulate the body’s response to the inflammation linked with IBS. The results indicate that lactoferrin could be more effective than vitamin D for treating stress-induced colitis, making it a promising nutritional supplement for those struggling with IBS.
The rats were divided into four groups: naïve rats, those subjected to stress, and two groups that received either vitamin D or lactoferrin. Our findings indicated that both lactoferrin and vitamin D improved various health markers compared to the stressed rats. Notably, lactoferrin treatment resulted in enhanced social behavior, increased levels of beneficial interleukin-10, and improved autophagy in the colon.
Furthermore, lactoferrin demonstrated a remarkable ability to decrease inflammatory markers and stress levels, suggesting it may modulate the body’s response to the inflammation linked with IBS. The results indicate that lactoferrin could be more effective than vitamin D for treating stress-induced colitis, making it a promising nutritional supplement for those struggling with IBS.
9.5
Symptoms alleviated
Most Useful Review
As a result, I developed gastrointestinal issues including irritable bowel syndrome. After taking probiotics and consulting doctors, I started this supplement, taking one capsule daily for a month alongside a probiotic. I was pleasantly surprised by the results: stomach anxiety and bloating disappeared. Now, I always keep this supplement on hand.
Calcium
9
Calcium may aid IBS treatment
A double-blind randomized clinical trial of Boiss. in the patients with diarrhea-predominant irritable bowel syndrome.
Most Relevant Research
We conducted a double-blind, randomized clinical trial involving 76 patients diagnosed with diarrhea-predominant irritable bowel syndrome (IBS) to evaluate the effectiveness of a dried extract combined with calcium treatment. Participants were split into two groups: one receiving a placebo, and the other receiving a combination of 75 mg of the dried extract and 175 mg of dibasic calcium phosphate (calcium).
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
9.5
Reduced irritability
Most Useful Review
The magnesium helped alleviate my anxiety and irritability, making me more productive and enabling quicker sleep. I took it alongside vitamin D and omega-3, which improved my overall well-being. The dosages are individual, but I felt a notable difference once I incorporated it into my routine.
L Glutamine
7
Effects of l-glutamine on IBS
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model.
Most Relevant Research
We explored the effects of l-glutamine, a dietary supplement, on irritable bowel syndrome (IBS) through a study using a chronic-restraint stress model. In our research, mice were subjected to stress and treated with various compounds, including l-glutamine, curcumin, and bioactive fish peptides, to assess their impact on intestinal permeability and inflammation.
When we examined the results, we noticed that while the stressed mice showed increased plasma corticosterone levels and colonic permeability, the treatments with l-glutamine alone, curcumin, and the fish peptides resulted in reduced colonic permeability compared to the stressed-only group. This suggests that these treatments might help restore some intestinal function during times of stress.
However, it's important to note that despite these observations, there were no significant changes in plasma corticosterone levels after treatment, indicating that l-glutamine's effect may not extend to stress hormone regulation. Overall, while l-glutamine appeared beneficial in reducing permeability, it didn’t remarkably change stress-related metrics in this study, highlighting the complexity of IBS and its treatment.
When we examined the results, we noticed that while the stressed mice showed increased plasma corticosterone levels and colonic permeability, the treatments with l-glutamine alone, curcumin, and the fish peptides resulted in reduced colonic permeability compared to the stressed-only group. This suggests that these treatments might help restore some intestinal function during times of stress.
However, it's important to note that despite these observations, there were no significant changes in plasma corticosterone levels after treatment, indicating that l-glutamine's effect may not extend to stress hormone regulation. Overall, while l-glutamine appeared beneficial in reducing permeability, it didn’t remarkably change stress-related metrics in this study, highlighting the complexity of IBS and its treatment.
9.5
Pain alleviation
Most Useful Review
I have Leaky Gut Syndrome and find this product excellent. It has significantly relieved my pain, which I believe is healing my condition.
Tumeric
8
Turmeric aids IBS symptoms effectively
Positive Effect of Lecithin-Based Delivery Form of Curcuma and Boswellia Extracts on Irritable Bowel Syndrome After COVID-19 Infection.
Most Relevant Research
We explored how curcuma, also known as turmeric, and boswellia extracts could help alleviate symptoms of irritable bowel syndrome (IBS) in people who have recently recovered from COVID-19. This study included two groups: 16 individuals with post-COVID IBS and 28 control participants with IBS who had never contracted COVID-19.
For 30 days, both groups received a formulation of curcuma and boswellia along with a low-FODMAP diet. They reported their experiences regarding abdominal bloating, pain, and changes in gut health measured by urinary indican levels.
At the end of the study, we noted that both groups experienced a significant reduction in bloating and pain, with satisfaction levels regarding treatment being quite similar. However, improvements in gut health, as shown by a decrease in urinary indican, were only observed in the IBS group without COVID-19.
Overall, our findings suggest that curcuma and boswellia could be beneficial for those suffering from abdominal discomfort, particularly in the post-COVID context. Yet, we also acknowledge the need for further research to fully understand why gut health issues persist in individuals with post-COVID IBS.
For 30 days, both groups received a formulation of curcuma and boswellia along with a low-FODMAP diet. They reported their experiences regarding abdominal bloating, pain, and changes in gut health measured by urinary indican levels.
At the end of the study, we noted that both groups experienced a significant reduction in bloating and pain, with satisfaction levels regarding treatment being quite similar. However, improvements in gut health, as shown by a decrease in urinary indican, were only observed in the IBS group without COVID-19.
Overall, our findings suggest that curcuma and boswellia could be beneficial for those suffering from abdominal discomfort, particularly in the post-COVID context. Yet, we also acknowledge the need for further research to fully understand why gut health issues persist in individuals with post-COVID IBS.
9.5
Improved bowel condition
Most Useful Review
I recommend everything for Crohn's disease! I've struggled with bowel issues for over 10 years and tried various medications. I discovered curcumin online, impressed by its natural composition, and decided to order it. It has anti-inflammatory and antimicrobial effects and is gentle on my stomach. By the second week, my irritable bowel syndrome symptoms improved, and my overall well-being enhanced. It's essential to maintain the correct diet for those with Crohn's. Best of health!
Silybum Marianum
7
Effective supplement for IBS relief
Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in diabetic patients with dyslipidemia.
Most Relevant Research
We explored the effects of a supplement called Berberol®K, which contains silybum marianum, on patients dealing with irritable bowel syndrome (IBS) alongside diabetes and dyslipidemia.
In a retrospective study with 59 subjects, those who were treated showed notable improvements after six months, including reduced diarrhea symptoms.
The results suggest that this food supplement could be beneficial, especially for those who cannot tolerate standard treatments like statins.
In a retrospective study with 59 subjects, those who were treated showed notable improvements after six months, including reduced diarrhea symptoms.
The results suggest that this food supplement could be beneficial, especially for those who cannot tolerate standard treatments like statins.
9.5
Immediate relief
Most Useful Review
I suffer from severe Myofascial Pain Syndrome (MPS), which causes very painful muscle knots known as trigger points. After taking three capsules of Milk Thistle three times a day, I noticed an immediate improvement, particularly regarding vertigo and toxicity. This allowed my clinician to increase my trigger point injections significantly, from about four or five to tolerating 180 per session, twice a week. Eventually, I reduced to the recommended dosage of just three capsules a day when the toxic load decreased.
L Theanine
8
Supplement improves IBS symptoms
Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome.
Most Relevant Research
We explored how a mixture of beta-glucan, inositol, and digestive enzymes could alleviate gastrointestinal symptoms in patients with inflammatory bowel disease (IBD) and concurrent irritable bowel syndrome (IBS).
The study involved 43 patients who were already in clinical remission and treated only with mesalamine. They were divided into two groups: one received the usual treatment plus the supplement, while the other only received the standard care.
After four weeks, we observed notable improvements in symptoms such as bloating, flatulence, and abdominal pain in the group taking the supplement. Our findings suggest that this combination may significantly enhance the overall well-being of IBD-IBS patients, making their daily lives a bit easier.
The study involved 43 patients who were already in clinical remission and treated only with mesalamine. They were divided into two groups: one received the usual treatment plus the supplement, while the other only received the standard care.
After four weeks, we observed notable improvements in symptoms such as bloating, flatulence, and abdominal pain in the group taking the supplement. Our findings suggest that this combination may significantly enhance the overall well-being of IBD-IBS patients, making their daily lives a bit easier.
7.5
Weight loss noted
Most Useful Review
I will purchase this product again! My digestion and bowel function have improved, and I've lost weight since taking it on an empty stomach, one or two daily. L-theanine, a unique amino acid in green tea, lowers anxiety and cortisol levels, thereby enhancing sleep quality. It's noted as beneficial in anti-aging and for calmness. I feel significantly less stressed and have lost weight, along with taking butyrate and EGCG preparations.
Iron
4
Iron Supplementation and Gut Microbiota
The Impact of Low-Level Iron Supplements on the Faecal Microbiota of Irritable Bowel Syndrome and Healthy Donors Using In Vitro Batch Cultures.
Most Relevant Research
We explored how low-level iron supplementation impacts the gut microbiota in individuals with Irritable Bowel Syndrome (IBS) and in healthy donors. To do this, we conducted anaerobic, pH-controlled in vitro batch cultures using fecal samples from both groups, supplemented with various forms of iron, including ferrous sulphate, nanoparticulate iron, and pea ferritin.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
9.5
No discomfort noted
Most Useful Review
Excellent iron dosage! I take it with vitamin C. This iron is very gentle; my digestive tract has experienced no discomfort, only darker stools. It’s a great product at a low price with excellent quality, and my bowels function well while taking this supplement.
Omega 3
5
Fatty acids affect IBS metabolism
Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome.
Most Relevant Research
Our study focused on understanding how eicosapentaenoic acid, alongside other fatty acids, influences irritable bowel syndrome (IBS). We designed an experiment where we treated both maternally separated and non-separated rats with Bifidobacterium breve and explored its effect on colonic sensitivity and fatty acid metabolism over a period of seven weeks.
Throughout our research, we observed significant changes in fatty acid profiles, especially in liver and serum tissues, after administering Bifidobacterium breve. Notably, in the maternally separated rats, the treatment appeared to enhance levels of palmitoleic acid, arachidonic acid, and docosahexaenoic acid in various tissues, which are fatty acids that others believe could be influential in managing symptoms related to IBS.
However, while eicosapentaenoic acid was present in the research context, it was largely studied in combination with other treatments. This made it challenging to evaluate its isolated effect on IBS directly. Thus, while we noted some positive metabolic changes with our treatment approach, the specific impact of eicosapentaenoic acid on IBS symptoms wasn’t definitively established.
Overall, our findings suggest that while Bifidobacterium breve and fatty acid supplementation may influence host fatty acid metabolism, further focused studies are necessary to clarify the role of eicosapentaenoic acid in managing irritable bowel syndrome.
Throughout our research, we observed significant changes in fatty acid profiles, especially in liver and serum tissues, after administering Bifidobacterium breve. Notably, in the maternally separated rats, the treatment appeared to enhance levels of palmitoleic acid, arachidonic acid, and docosahexaenoic acid in various tissues, which are fatty acids that others believe could be influential in managing symptoms related to IBS.
However, while eicosapentaenoic acid was present in the research context, it was largely studied in combination with other treatments. This made it challenging to evaluate its isolated effect on IBS directly. Thus, while we noted some positive metabolic changes with our treatment approach, the specific impact of eicosapentaenoic acid on IBS symptoms wasn’t definitively established.
Overall, our findings suggest that while Bifidobacterium breve and fatty acid supplementation may influence host fatty acid metabolism, further focused studies are necessary to clarify the role of eicosapentaenoic acid in managing irritable bowel syndrome.
8.8
Metabolism enhancement
Most Useful Review
This is an excellent quality product with well-selected ingredients. I experienced no allergies, and the large package will last a long time. I began to notice better bowel function and improved metabolism within a week. My nervous system started to perform better too, which made me feel less anxious. I have complete confidence in its effectiveness.
Fish Oil
5
Fatty acids affect IBS metabolism
Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome.
Most Relevant Research
Our study focused on understanding how eicosapentaenoic acid, alongside other fatty acids, influences irritable bowel syndrome (IBS). We designed an experiment where we treated both maternally separated and non-separated rats with Bifidobacterium breve and explored its effect on colonic sensitivity and fatty acid metabolism over a period of seven weeks.
Throughout our research, we observed significant changes in fatty acid profiles, especially in liver and serum tissues, after administering Bifidobacterium breve. Notably, in the maternally separated rats, the treatment appeared to enhance levels of palmitoleic acid, arachidonic acid, and docosahexaenoic acid in various tissues, which are fatty acids that others believe could be influential in managing symptoms related to IBS.
However, while eicosapentaenoic acid was present in the research context, it was largely studied in combination with other treatments. This made it challenging to evaluate its isolated effect on IBS directly. Thus, while we noted some positive metabolic changes with our treatment approach, the specific impact of eicosapentaenoic acid on IBS symptoms wasn’t definitively established.
Overall, our findings suggest that while Bifidobacterium breve and fatty acid supplementation may influence host fatty acid metabolism, further focused studies are necessary to clarify the role of eicosapentaenoic acid in managing irritable bowel syndrome.
Throughout our research, we observed significant changes in fatty acid profiles, especially in liver and serum tissues, after administering Bifidobacterium breve. Notably, in the maternally separated rats, the treatment appeared to enhance levels of palmitoleic acid, arachidonic acid, and docosahexaenoic acid in various tissues, which are fatty acids that others believe could be influential in managing symptoms related to IBS.
However, while eicosapentaenoic acid was present in the research context, it was largely studied in combination with other treatments. This made it challenging to evaluate its isolated effect on IBS directly. Thus, while we noted some positive metabolic changes with our treatment approach, the specific impact of eicosapentaenoic acid on IBS symptoms wasn’t definitively established.
Overall, our findings suggest that while Bifidobacterium breve and fatty acid supplementation may influence host fatty acid metabolism, further focused studies are necessary to clarify the role of eicosapentaenoic acid in managing irritable bowel syndrome.
8.3
Better bowel function
Most Useful Review
Unlike other companies' Omega-3 supplements, these do not have a fishy smell and are easy to swallow. I’ve noticed lesser skin issues before my period and improved bowel movements. This is my second purchase, and I will repurchase once I finish.
Zinc
4
Zinc intake may reduce IBS risk
Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank.
Most Relevant Research
We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.
Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.
However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.
Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.
Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.
However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.
Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.
9.5
Supports immunity
Most Useful Review
I have been using Zinc Glycinate from Now Foods for a long time. Zinc is essential for health, affecting immunity, the nervous system, and bones. A deficiency can lead to issues such as frequent colds, irritable bowel syndrome, and hair loss. This product is of excellent quality, and I am satisfied with its content and effectiveness. I certainly recommend it before making a purchase!
