Potassium
9.5
Supports kidney health
Most Useful Review
Potassium citrate is an important electrolyte that helps against kidney stone build-up. It can prevent deficiency, and I take four capsules daily (two in the morning and two in the afternoon with meals). I noticed increased energy, reduced leg cramps, and improved bowel movements after starting this supplement.
10
Stones disappeared
Most Useful Review
I bought this product to eliminate kidney stones after my diagnosis in July 2023. I took two royal lithotripsy pills and one potassium citrate pill daily. After two months, an ultrasound in December showed the stones had disappeared.
D Mannose
NOW Foods D-Mannose
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 17 Reviews
8.9
9.5
Kidney stones relief
Most Useful Review
I have suffered from cystitis for 2.5 years and recently developed kidney stones. After trying various natural remedies, I started taking D-mannose. Initially, I saw no improvement, but after increasing the dosage, I noticed significant relief from urinary discomfort. I now take three tablets every four hours, followed by plenty of water. I'm already on my second month of use and highly recommend it for anyone struggling with kidney stones.
9.5
Quick kidney pain relief
Most Useful Review
I bought D-mannose after seeing positive reviews, and I was pleasantly surprised by its rapid effect. After taking two pills for three days, my kidney pain vanished. I highly recommend it for bladder infections.
Vitamins
5
Vitamin D's impact on kidney stones
Association between serum 25-hydroxyvitamin D concentrations and kidney stone: a cohort study in the UK Biobank.
Most Relevant Research
We set out to investigate whether there’s a connection between vitamin D levels and kidney stone disease (KSD) using data from the UK Biobank, which included a large group of participants. By analyzing this data through survival models, we aimed to find out if higher levels of serum 25-hydroxyvitamin D (25(OH)D) could influence the likelihood of developing kidney stones.
Our analysis covered over 444,000 people, and we tracked the incidence of kidney stones over an average of 12.6 years. Interestingly, while higher 25(OH)D levels didn’t show a clear connection to kidney stones across the general population, we noted a significant finding in women over 60 years old. For this group, higher serum vitamin D concentrations were actually linked to a lower risk of KSD, suggesting a potential protective effect.
Despite these observations, it's noteworthy that an increase in vitamin D didn't correlate with a higher incidence of kidney stones, especially when serum calcium levels remained normal. This news could ease concerns around vitamin D supplementation solely aimed at boosting 25(OH)D levels. Overall, we could conclude that while there are nuances depending on age and sex, vitamin D’s role in kidney stone prevention appears limited.
Our analysis covered over 444,000 people, and we tracked the incidence of kidney stones over an average of 12.6 years. Interestingly, while higher 25(OH)D levels didn’t show a clear connection to kidney stones across the general population, we noted a significant finding in women over 60 years old. For this group, higher serum vitamin D concentrations were actually linked to a lower risk of KSD, suggesting a potential protective effect.
Despite these observations, it's noteworthy that an increase in vitamin D didn't correlate with a higher incidence of kidney stones, especially when serum calcium levels remained normal. This news could ease concerns around vitamin D supplementation solely aimed at boosting 25(OH)D levels. Overall, we could conclude that while there are nuances depending on age and sex, vitamin D’s role in kidney stone prevention appears limited.
9.5
Safe for kidneys
Most Useful Review
Calcium citrate is 2.5 times better than calcium carbonate for absorption. It can be taken on an empty stomach without causing kidney stones. For those over 50, it's absorbed better than calcium carbonate. Highly recommended for better health!
Silybum Marianum
9.5
Kidney function improved
Most Useful Review
Milk thistle really works for liver and kidney health. As a diabetic on statins, my liver and kidney function deteriorated, showing elevated liver enzymes and protein in my urine. After taking milk thistle for several months, my liver enzymes are now normal, and my urine protein levels significantly dropped from 315 to 22. I believe in its effectiveness and intend to continue taking it for life.
9.5
Kidney stones cleared
Most Useful Review
I was diagnosed with kidney stones and faced the option of gallbladder removal. Fortunately, an integrative doctor recommended milk thistle and artichoke for six months. After diligent use, my ultrasound results came back clear, much to the ultrasound technician's astonishment.
Vitamin K2
9.5
Helps with absorption
Most Useful Review
There is a result! This dietary supplement contains a suitable dosage of vitamin K2, important for those who take high doses of vitamin D3. Since beginning my intake, I've noticed that my vitamin K levels in the blood are rising. It’s essential to accompany vitamin D with K2 to prevent kidney stones. Take it with fatty food as it's fat-soluble.
9.5
Kidney calcifications improved
Most Useful Review
I took K2MK7 with D3 for nine months, and my D3 levels improved significantly. I also noted the disappearance of calcifications in my kidneys, liver, and male gland, and my muscle endurance increased. I recommend it to anyone with issues related to calcium-phosphorus metabolism.
Cranberry
9.5
Urinary tract health
Most Useful Review
Cranberries contain organic acids that prevent urinary tract infections. The extract effectively combats bacteria and fungi while having a gentle diuretic effect, aiding in flushing out kidney stones and bacteria during infections.
8.5
Effective kidney treatment
Most Useful Review
Good medicine for the kidneys. Cranberries are incredibly beneficial, preventing the formation of kidney stones. Their diuretic properties help cleanse the kidneys gently. I take one capsule twice daily, experiencing good diuretic effects without any side effects.
Astragalus Root
9.5
Useful for kidneys
Most Useful Review
This is very good for those with kidney problems.
8
Improved kidney function
Most Useful Review
Great product! I've been taking it for a few days and noticed some extra energy. I hope it helps improve my kidney function as stated.
Fish Oil
8
Eicosapentaenoic acid may prevent stones
The Efficacy of Polyunsaturated Fatty Acids as Protectors against Calcium Oxalate Renal Stone Formation: A Review.
Most Relevant Research
We investigated the impact of eicosapentaenoic acid (EPA), particularly found in fish oil, on the formation of kidney stones. Our review focused on how this omega-3 fatty acid might help reduce urinary levels of calcium and oxalate, which are key players in stone formation.
Throughout our review, we analyzed various studies, including a total of 16 trials involving human participants. These trials looked into the effects of dietary modifications, particularly those incorporating EPA alongside other supplements like evening primrose oil. Notably, we found that while most trials reported reductions in urinary calcium and oxalate, the effects were most pronounced in those that employed fish oil, which contains both EPA and docosahexaenoic acid (DHA).
By examining these findings, we recommend using fish oil rich in EPA and DHA as a management strategy for calcium oxalate urolithiasis, or kidney stones formed from calcium and oxalate. However, while EPA has demonstrated potential benefits, it's essential to view these results in the context of broader dietary influences and other fats being tested.
Throughout our review, we analyzed various studies, including a total of 16 trials involving human participants. These trials looked into the effects of dietary modifications, particularly those incorporating EPA alongside other supplements like evening primrose oil. Notably, we found that while most trials reported reductions in urinary calcium and oxalate, the effects were most pronounced in those that employed fish oil, which contains both EPA and docosahexaenoic acid (DHA).
By examining these findings, we recommend using fish oil rich in EPA and DHA as a management strategy for calcium oxalate urolithiasis, or kidney stones formed from calcium and oxalate. However, while EPA has demonstrated potential benefits, it's essential to view these results in the context of broader dietary influences and other fats being tested.
8.8
Improved health
Most Useful Review
I started using Now supplements to enhance my overall health, and I have noticed significant improvement. I have Chronic Kidney Disease (CKD) and must be cautious about the supplements I take. These have notably helped me with the anaemia related to CKD. The pills are easy to swallow, offer great value, and I barely notice any taste when I take them.
Magnesium
7
Magnesium's protective role uncertain
The association between domestic water hardness and kidney stone disease: a prospective cohort study from the UK Biobank.
Most Relevant Research
We investigated how magnesium levels in domestic water may affect the risk of kidney stones, a common and painful health issue. This study followed 288,041 participants in the UK Biobank who had no previous history of kidney stones, gathering data over an 18-year period from 2006 to 2024.
Our findings highlighted an interesting relationship between magnesium and kidney stones. We observed that higher magnesium levels in water could actually lower the risk of developing these stones, particularly in younger men and those without kidney issues. However, for the broader population, domestic water hardness and calcium concentrations did not seem to have a significant impact on kidney stone formation.
We also noted that participants over 60 years old and females were more susceptible to kidney stones in relation to hard water and its calcium content. This insight prompts a closer look at the role of minerals like magnesium and calcium in kidney stone prevention, particularly in different age groups and demographics. Overall, while magnesium appeared beneficial, our results underscore the complex nature of how various minerals interact and influence kidney stone risks.
Our findings highlighted an interesting relationship between magnesium and kidney stones. We observed that higher magnesium levels in water could actually lower the risk of developing these stones, particularly in younger men and those without kidney issues. However, for the broader population, domestic water hardness and calcium concentrations did not seem to have a significant impact on kidney stone formation.
We also noted that participants over 60 years old and females were more susceptible to kidney stones in relation to hard water and its calcium content. This insight prompts a closer look at the role of minerals like magnesium and calcium in kidney stone prevention, particularly in different age groups and demographics. Overall, while magnesium appeared beneficial, our results underscore the complex nature of how various minerals interact and influence kidney stone risks.
9.5
Improved blood pressure
Most Useful Review
Magnesium citrate is easily absorbed and has significantly helped my husband and me. After consuming three bottles, I've noticed reduced soreness and stable blood pressure. It aids in activating vitamin D in the kidneys and is beneficial for muscle and bone health, as well as energy production.
Vitamin B6
8
Vitamin B6 may prevent stones
Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study.
Most Relevant Research
We explored the connection between vitamin B6 intake and the prevalence of kidney stones through a large-scale analysis of health data. Our research included data from the National Health and Nutrition Examination Survey (NHANES), where we looked at the effects of nine common vitamins on kidney stone development. By using advanced clustering techniques and logistic regression models, we aimed to identify patterns that could shed light on this relationship.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
9.5
Muscle spasms
Most Useful Review
These tablets are excellent for muscle spasms. They are well-coated and easy to swallow, with no side effects. The absorption is quick, making them effective. I've found that the combination of B6 and magnesium is beneficial for kidney stones. I take up to three tablets daily with meals.
Vitamin C
8
CDAI may reduce kidney stones
High composite dietary antioxidant index is associated with reduced risk of kidney stones: a cross-sectional analysis of NHANES 2007-2020.
Most Relevant Research
We examined the relationship between dietary antioxidant intake, particularly vitamin C, and the risk of developing kidney stones. Utilizing data from the National Health and Nutrition Examination Survey, we found that individuals with higher levels of antioxidants, as indicated by the Composite Dietary Antioxidant Index (CDAI), had lower odds of forming kidney stones.
Stone formers, those who have experienced kidney stones, typically had a lower CDAI, showcasing significant differences based on gender. An interesting aspect of our findings was that vitamin C stood out as having the strongest negative correlation with kidney stones, suggesting that increased intake may be beneficial.
The results indicated that those in moderate and high CDAI groups had reduced odds of experiencing kidney stones compared to the lowest group. This was reflected in the odds ratios, which showed a significant decrease for those with higher antioxidant consumption. Therefore, it seems that a diet rich in antioxidants, particularly vitamin C, could play a role in lowering kidney stone risks.
However, while our findings are promising, we emphasize the need for more in-depth cohort studies to further investigate this potential connection and confirm its causal nature.
Stone formers, those who have experienced kidney stones, typically had a lower CDAI, showcasing significant differences based on gender. An interesting aspect of our findings was that vitamin C stood out as having the strongest negative correlation with kidney stones, suggesting that increased intake may be beneficial.
The results indicated that those in moderate and high CDAI groups had reduced odds of experiencing kidney stones compared to the lowest group. This was reflected in the odds ratios, which showed a significant decrease for those with higher antioxidant consumption. Therefore, it seems that a diet rich in antioxidants, particularly vitamin C, could play a role in lowering kidney stone risks.
However, while our findings are promising, we emphasize the need for more in-depth cohort studies to further investigate this potential connection and confirm its causal nature.
9.5
No kidney stones
Most Useful Review
Great, easily absorbable Vitamin C that doesn't cause kidney stones! I have metabolism issues and am unable to process many synthetic vitamins. This product is one of the few I can take without the risk of kidney stones or detox problems. Its dosage is higher than others, making it more affordable. A fantastic option for those needing a natural, absorbable Vitamin C.
8
Effective cleaning
Most Useful Review
Super, I like it! It cleans well, has a pleasant mint taste and does not burn. Even dental stones seem to dissolve.
9.5
No plaque formation
Most Useful Review
I highly recommend this product! I no longer have to worry about plaque. I used to see my dentist every three months, but now, in a year and a half, I haven't needed to. I brush twice daily, and my friends and family appreciate the results.
N Acetyl L Cysteine
9
Cystine stone prevention with NAC
Cystine Renal Calculi: New Aspects Related to Their Formation and Development.
Most Relevant Research
We observed how n-acetyl-L-cysteine can impact the formation of cystine kidney stones. The study utilized crystallization experiments to mimic conditions similar to those in the kidneys. Cystine typically requires high supersaturation to crystallize, presenting a challenge since inhibitors, like n-acetyl-cysteine, tend to have reduced effects under such conditions.
Our findings highlighted that in the absence of crystallization inhibitors, crystallization begins within just 15 minutes. However, when n-acetyl-L-cysteine and other thiol agents like penicillamine and tiopronin were present, they completely blocked the crystallization process. Notably, n-acetyl-L-cysteine didn't just stop the formation of cystine crystals; it also altered their shape, which could play a vital role in how stones develop.
Moreover, we explored the structure of 30 cystine stones and found that they start from small crystals, continuously growing into larger structures depending on where they form in the kidney. The prevention of stone development hinges on keeping urinary cystine levels low, which n-acetyl-L-cysteine emerged as the most effective method among those tested. Increased hydration and physical activity further showed promise in helping remove cystine crystals and preventing stone formation.
Our findings highlighted that in the absence of crystallization inhibitors, crystallization begins within just 15 minutes. However, when n-acetyl-L-cysteine and other thiol agents like penicillamine and tiopronin were present, they completely blocked the crystallization process. Notably, n-acetyl-L-cysteine didn't just stop the formation of cystine crystals; it also altered their shape, which could play a vital role in how stones develop.
Moreover, we explored the structure of 30 cystine stones and found that they start from small crystals, continuously growing into larger structures depending on where they form in the kidney. The prevention of stone development hinges on keeping urinary cystine levels low, which n-acetyl-L-cysteine emerged as the most effective method among those tested. Increased hydration and physical activity further showed promise in helping remove cystine crystals and preventing stone formation.
9.5
Protects kidneys
Most Useful Review
This N-acetyl-L-cysteine (600 mg) from Life Extension is an effective antioxidant that protects my kidneys and liver from toxins. It also maintains respiratory health and supports the synthesis of intracellular glutathione, crucial for cellular processes. NAC is beneficial for both active and older individuals. I highly recommend this supplement.
Ginkgo
7.5
Positive effect
Most Useful Review
The herbal preparation Ginkgo Biloba, certified by ProfileProven, is reported to enhance blood circulation and stimulate brain activity without side effects. Doctors suggest it for treating kidney stones as it appears to improve kidney filtration.
Most Useful Review
Calcium
5
Calcium's role in kidney stones
Associations between 25-hydroxyvitamin D/calcium/alkaline phosphatase levels and the risk of developing kidney stones: Results from NHANES (2013-2018)-based and Mendelian randomization studies.
Most Relevant Research
We explored the connections between calcium levels and kidney stones using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2013 to 2018, along with more advanced genetic analyses. Our aim was to understand how the levels of 25-hydroxyvitamin D, calcium, and alkaline phosphatase (ALP) might influence the risk of developing kidney stones.
While observational analyses suggested a relationship between ALP levels and kidney stones, we found that calcium levels did not display a significant association with kidney stones when looking at the data directly. However, utilizing Mendelian randomization analysis, we observed a potential causal link, indicating that elevated calcium levels could indeed raise the risk of developing kidney stones.
The key takeaway from our research is that while observational studies show no strong link between calcium and kidney stones, our genetic analysis implies that higher calcium may contribute to stone formation. Our work provides valuable insights and directions for future studies focused on preventing and treating this painful condition.
While observational analyses suggested a relationship between ALP levels and kidney stones, we found that calcium levels did not display a significant association with kidney stones when looking at the data directly. However, utilizing Mendelian randomization analysis, we observed a potential causal link, indicating that elevated calcium levels could indeed raise the risk of developing kidney stones.
The key takeaway from our research is that while observational studies show no strong link between calcium and kidney stones, our genetic analysis implies that higher calcium may contribute to stone formation. Our work provides valuable insights and directions for future studies focused on preventing and treating this painful condition.
9.5
Kidney health
Most Useful Review
Excellent 2:1 calcium to magnesium ratio. These minerals complement each other for better absorption, with magnesium preventing kidney stones by aiding calcium dissolution in the blood.