Quercetin
9.5
Knee pain relief
Most Useful Review
I take one tablet 20 minutes before meals, twice a day. It’s essential in the morning before breakfast, and before lunch and dinner as well. I feel a surge of strength, and it has helped with allergies. While taking this, my knee pain disappeared.
9.5
Pain relief noted
Most Useful Review
Excellent! After a week of taking it, I've noticed that my knee pain, along with pain in my hands, back, and shoulders, has ceased during training.
Magnesium
9.5
Relieved joint pain
Most Useful Review
Magnesium citrate is an excellent remedy; it alleviated my night cramps and joint pain.
9.5
Knee pain resolved
Most Useful Review
My left knee pain, which prevented me from descending stairs, has significantly improved. Despite previously using various products, magnesium seemed to complete my treatment. I love this supplement and intend to continue using it.
9.5
Effective pain relief
Most Useful Review
I am very satisfied; my knee pain constantly hurts. This product relieves it quickly and effectively. I have bought it before and will continue to do so. I purchased it for my parents, and they also benefited. The joint pain significantly reduced and it's much cheaper than medical alternatives.
10
Pain symptoms vanished
Most Useful Review
Great product! I bought it for my 66-year-old mother, who suffered from knee pain (arthritis). Within seven days, her symptoms disappeared and she stopped taking anti-inflammatories. She continues to take this medication and it has proven to be effective. The price is excellent compared to other options in pharmacies.
Vitamins
7
Vitamin D's role in knee OA
Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis.
Most Relevant Research
We sought to understand the connection between vitamin D levels and knee pain in older adults suffering from osteoarthritis (OA). In our analysis, we looked at data from 105 OA patients alongside 152 control participants to explore how vitamin D deficiency might relate to functional impairment.
Our findings revealed that those with lower levels of vitamin D experienced more severe symptoms of OA. Specifically, the patients demonstrated higher levels of pain and were more functionally impaired according to the WOMAC questionnaire. Interestingly, we also found a connection between vitamin D deficiency and increased levels of inflammation markers, TNF-α and IL-6, suggesting that vitamin D may play a role in managing both pain and inflammation in OA.
Overall, this study highlights the potential importance of maintaining adequate vitamin D levels to alleviate knee pain and improve functionality in individuals with osteoarthritis. However, further research is needed to determine if vitamin D supplementation could effectively mitigate symptoms of arthritis and slow disease progression.
Our findings revealed that those with lower levels of vitamin D experienced more severe symptoms of OA. Specifically, the patients demonstrated higher levels of pain and were more functionally impaired according to the WOMAC questionnaire. Interestingly, we also found a connection between vitamin D deficiency and increased levels of inflammation markers, TNF-α and IL-6, suggesting that vitamin D may play a role in managing both pain and inflammation in OA.
Overall, this study highlights the potential importance of maintaining adequate vitamin D levels to alleviate knee pain and improve functionality in individuals with osteoarthritis. However, further research is needed to determine if vitamin D supplementation could effectively mitigate symptoms of arthritis and slow disease progression.
9.5
Pain relief achieved
Most Useful Review
A remarkable complex of minerals! At 39, I had severe knee pain from walking, but after a month of taking this, the pain vanished completely! I continue to take courses, drinking it for a month with breaks, and I wish to help others with my honest feedback.
Evening Primrose
9.8
Reduced knee pain
Most Useful Review
It aids in alleviating PMS symptoms significantly. The lower abdominal pain has diminished, and my mental health has improved.
9.5
Calmed knee pain
Most Useful Review
After trying it for over six months, I found that evening primrose oil significantly relieved my PMS symptoms and improved my skin's condition. Critical days are now calmer, with practically no pain. Additionally, it seems to have increased my libido.
Multivitamins
9.5
Knee pain relief
Most Useful Review
Since 2008, I’ve been keen to try these vitamins for joints, highly recommended by athletes. They include essential vitamins, minerals, and support for immunity, digestion, and joints. After nearly a month of use, my knee pain has nearly disappeared, allowing me to engage in sports fully. The only downside is the price, but it’s more economical than purchasing separate supplements.
8.8
Reduced knee pain
Most Useful Review
My review is for women over 45 seeking a joint and bone complex. After using Bone-Up alongside collagen, I noticed a decrease in joint crunching and back pain after 2.5-3 weeks. The composition is excellent, with Calcium Hydroxyapatite and supporting vitamins. It is fantastic for menopause. I highly recommend it, taking 2 capsules daily with meals.
Vitamin B Complex
9.5
Reduced knee pain
Most Useful Review
Great anti-inflammatory! I use this product primarily for my joints. Being overweight with arthritis, my joints often complain. This B complex from Solgar significantly reduces inflammation and pain, particularly in my knees! I'm not sure how it works, but combined with flaxseed oil, I almost feel no pain in my joints. I used to rely on OTC pain relief, but this B complex is a more natural alternative that lasts longer.
9
Increased vitality
Most Useful Review
I’m pleased these vitamins come in a glass container, reflecting Solgar's quality. Since starting this B complex, my tiredness, sleep issues, and hair loss have improved, plus heart discomfort is gone. My body's energy has increased effectively.
Tumeric
8
Curcumin and Vitamin D reduce pain
Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction.
Most Relevant Research
We investigated how curcumin, a compound found in turmeric, along with vitamin D, could affect knee pain and the progression of knee osteoarthritis (OA) in a specific rat model. In this study, male Wistar rats were divided into five groups: a control group, a group receiving curcumin, a group receiving vitamin D, a group receiving both supplements, and a sham-operated group. This well-structured approach allowed us to effectively evaluate the separate and combined impacts of these supplements.
Over a span of 12 weeks, we observed that both curcumin and vitamin D contributed to reduced pain levels on their own. When used together, their analgesic effects were even stronger, providing better pain relief for the rats. Beyond pain relief, supplemental curcumin and vitamin D also showed promising results when we examined inflammatory markers in their serum. We found a decrease in markers of inflammation while levels of the anti-inflammatory cytokine interleukin-10 (IL-10) increased.
Furthermore, we noted improvements in antioxidant levels as well as a significant reduction in the oxidative stress marker known as Cartilage Oligomeric Matrix Protein (COMP). Histological analysis revealed that these supplements helped preserve joint structure and maintain cartilage integrity, while also reducing inflammation in the synovium.
Our findings emphasize the potential of curcumin and vitamin D as effective natural agents in managing knee OA and associated pain. These results could suggest a way to delay the progression of knee OA and improve patient care.
Over a span of 12 weeks, we observed that both curcumin and vitamin D contributed to reduced pain levels on their own. When used together, their analgesic effects were even stronger, providing better pain relief for the rats. Beyond pain relief, supplemental curcumin and vitamin D also showed promising results when we examined inflammatory markers in their serum. We found a decrease in markers of inflammation while levels of the anti-inflammatory cytokine interleukin-10 (IL-10) increased.
Furthermore, we noted improvements in antioxidant levels as well as a significant reduction in the oxidative stress marker known as Cartilage Oligomeric Matrix Protein (COMP). Histological analysis revealed that these supplements helped preserve joint structure and maintain cartilage integrity, while also reducing inflammation in the synovium.
Our findings emphasize the potential of curcumin and vitamin D as effective natural agents in managing knee OA and associated pain. These results could suggest a way to delay the progression of knee OA and improve patient care.
9.5
Inflammation relief
Most Useful Review
Long-term use of curcumin has effectively relieved my knee pain and inflammation post-surgery.
Enzymes
8
CoQ10 reduces knee pain post-surgery
CoenzymeQ10 and Ischemic Preconditioning Potentially Prevent Tourniquet-Induced Ischemia/Reperfusion in Knee Arthroplasty, but Combined Pretreatment Possibly Neutralizes Their Beneficial Effects.
Most Relevant Research
This study examined the effects of coenzyme Q10 (CoQ10) and ischemic preconditioning (IPC) on knee pain following total knee arthroplasty (TKA). We enrolled 44 patients in four groups: a control group, a group receiving CoQ10, a group undergoing IPC, and a group that received both treatments.
CoQ10, taken at a dosage of 300 mg per day for 28 days, showed some positive effects by reducing pain scores and lowering the need for morphine up to 24 hours after surgery. We noted that CoQ10 improved baseline mitochondrial function, suggesting it may aid in recovery after the surgical and ischemic effects of the tourniquet used in TKA.
However, when CoQ10 was combined with IPC, the beneficial analgesic effects were negated. IPC alone did enhance mitochondrial function and provided a temporary boost in energy production, but it seems that the combination interfered with the individual advantages offered by each treatment. Overall, while CoQ10 appears to help in reducing knee pain post-surgery, its benefits could diminish when used alongside IPC.
CoQ10, taken at a dosage of 300 mg per day for 28 days, showed some positive effects by reducing pain scores and lowering the need for morphine up to 24 hours after surgery. We noted that CoQ10 improved baseline mitochondrial function, suggesting it may aid in recovery after the surgical and ischemic effects of the tourniquet used in TKA.
However, when CoQ10 was combined with IPC, the beneficial analgesic effects were negated. IPC alone did enhance mitochondrial function and provided a temporary boost in energy production, but it seems that the combination interfered with the individual advantages offered by each treatment. Overall, while CoQ10 appears to help in reducing knee pain post-surgery, its benefits could diminish when used alongside IPC.
9.5
Effective for arthritis
Most Useful Review
Best supplement for joint pain! I've taken Nattokinase, Serrapeptase, and Bromelain three times daily away from food, and they’ve become essential in managing my rheumatoid arthritis. My knee pain diminished after a couple of weeks of use. Highly recommend!
Vitamin B12
9.5
Pain relief achieved
Most Useful Review
Sciatica plagued me for over six months, causing pain from my buttocks to my thighs. Other supplements helped, but a dull pain persisted. After just three days of taking B12, touted for neuralgia, the pain vanished! I've experienced numbness in my feet for some time and hope this will improve too. The tablets are small and can dissolve on the tongue; I take one daily, but up to two is fine. For anyone suffering from knee pain, this is worth a try!
9.5
Knee pain relief
Most Useful Review
I have suffered from knee pain due to sciatica for over six months. After starting this supplement, my symptoms significantly improved, including the knee pain I experienced. I feel happier and more positive now, thanks to this product.
Oregano
9.5
Reduced knee pain
Most Useful Review
Great! Prescribed by a nutritionist, it has an anti-inflammatory effect for issues like pyelitis, cystitis, and kidney stones. It aids metabolism and acts as a hemostatic agent, alleviating varicose veins and haemorrhoids. It has helped with pain, swelling, and joint stiffness, including knee pain.
9.5
No more knee pain
Most Useful Review
This is my repeat order of Gaia Oil of Oregano. I used it as a herbal antibiotic instead of the muscle pain-inducing levofloxacin. I feel significantly better with the oregano oil, with no muscle pain and relief from my knee pain.
Turmeric Rhizome
9.5
Effective for inflammation
Most Useful Review
I love this ancient product. It works wonders for inflammation and pain, including knee pain.
9.5
Knee pain relief
Most Useful Review
I began using turmeric extract for arthritis pain in my hips, and my knee pain is gone. I continue taking it for maintenance, as it also boosts my immune system. I take it every evening with honey and non-dairy milk, and it helps me sleep peacefully.
Polygonum Cuspidatum Complex
9.5
Pain relief noted
Most Useful Review
About a year ago, I experienced pain in a varicose vein on my right leg. After taking troxerutin, the discomfort improved. I then tried resveratrol, and within a week, the pain had disappeared.
10
Shoulder pain relief
Most Useful Review
After starting resveratrol, my shoulder and back pain vanished within a month. It also helped my mother with her long-standing aches. I’ve introduced it to others, and its effectiveness has been remarkable.
Zinc
8.8
Pain relief
Most Useful Review
With chronic prostatitis, this is my go-to supplement. It ranks first among my top supplements. I've noticed less pain and improved sperm quality; zinc seems to enhance free testosterone levels. I highly recommend it for anyone facing similar difficulties. Studies indicate that zinc levels in prostate secretion decrease with prostatitis and need replenishment.
9.5
Pain reduction
Most Useful Review
This excellent prostate supplement contains pumpkin oil and has improved my prostate congestion since the first week. I've noticed a remarkable difference, including less pain when urinating. I advise taking it after meals to avoid nausea.
Vitamin Bs
8
Seaweed extract improves knee pain
A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis.
Most Relevant Research
We conducted an open-label study to assess how a seaweed extract formulation, which includes Vitamin B6, impacts knee osteoarthritis symptoms. Involving 12 participants with confirmed knee osteoarthritis, we divided them into two groups receiving either 100 mg or 1000 mg of the extract daily.
Our primary focus was to measure overall joint health through a score that looked at pain, stiffness, and physical activity challenges over twelve weeks. While we found a general improvement in osteoarthritis symptoms with increased dosage of the extract, it’s important to note that Vitamin B6 was part of a combined treatment with other nutrients. This means we cannot determine the isolated effect of Vitamin B6 on knee pain from our findings alone.
We observed no significant safety concerns during the study, and the treatment was well tolerated. However, further research in a larger, controlled study is needed to fully understand the role of Vitamin B6 within this formulation and its true effectiveness on knee osteoarthritis.
Our primary focus was to measure overall joint health through a score that looked at pain, stiffness, and physical activity challenges over twelve weeks. While we found a general improvement in osteoarthritis symptoms with increased dosage of the extract, it’s important to note that Vitamin B6 was part of a combined treatment with other nutrients. This means we cannot determine the isolated effect of Vitamin B6 on knee pain from our findings alone.
We observed no significant safety concerns during the study, and the treatment was well tolerated. However, further research in a larger, controlled study is needed to fully understand the role of Vitamin B6 within this formulation and its true effectiveness on knee osteoarthritis.
9.5
Resolved knee pain
Most Useful Review
I developed a straight neck from poor posture, leading to shoulder blade pain, a cervical hernia, and carpal tunnel syndrome. After taking B12 for a month, the numbness and pain improved significantly. It felt almost unbelievable that my symptoms disappeared, especially the knee pain, giving me hope against potential surgery.
Ubiquinol
NOW Foods Ubiquinol
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 11 Reviews
8.7
9.5
Essential supplement
Most Useful Review
Ubiquinol is the most effective form of Q10 for me. The dosage is just right, and it has helped my knee pain immensely. I even returned to sports and CrossFit.
9.5
Angina relief
Most Useful Review
I bought this supplement for my mother for heart-related pain, which I was told was potentially angina. After taking it daily for a year, she hasn’t experienced the pain that used to occur monthly. This alleviation possibly extends to her knee pain as well.
Herbal Extracts
9.5
Knee pain relief
Most Useful Review
My wife was diagnosed with severe knee pain and was advised she needed surgery. After trying Olive Leaf Extract for about three months, her pain has disappeared, and she no longer needs an operation. I highly recommend this product.
9.5
Reduced knee pain
Most Useful Review
I had nerve pain in my leg and severe headaches, but after three weeks of Ginkgo, the pain has dwindled. It also appears to enhance my cognitive functions. I'm pleased with my decision to try it.
Flax Seed Oil
9.5
Eases arthritis pain
Most Useful Review
I have been taking this for many years, and it helps with inflammation and knee pain from arthritis.
8.8
Joint pain relief
Most Useful Review
I purchased this for my mum, who normally takes flaxseed oil. The capsules are as effective as the oil for her knee pain and other health issues like fatigue and chest pains. However, excessive doses can lead to headaches.
Probiotics
8.8
Hemoglobin improvement
Most Useful Review
The goal is achieved - my haemoglobin levels are normal! I used these vitamins to raise my haemoglobin after suffering from chronic anaemia for ten years. I noticed a significant improvement; my haemoglobin rose from 102 to 120. Additionally, I experienced less knee pain, improved sleep, and far less hair loss. Remarkably, I recovered quickly from a cold. The best part is that this product is affordable compared to previous treatments!
9.5
Pain relief
Most Useful Review
These are the best vitamins for me. I tried numerous brands and acknowledged significant improvements with these. My haemoglobin increased from 92 to 125. After experiencing knee pain due to symphysis, I began taking them, and the discomfort disappeared. They have effectively enriched my health, and I highly recommend them to others.
Hyaluronic Acid
9.5
Significant relief
Most Useful Review
I’ve reordered this product multiple times. I’m very pleased with its effectiveness; it really works. If I miss a dose, my knee pain returns within days, so I take it daily without fail.
10
Pain-free experience
Most Useful Review
A year ago, I began suffering from knee pain due to arthritis and after trying various brands, this product truly transformed my life to be pain-free. I highly recommend it.
L Lysine
9.5
Reduced knee pain
Most Useful Review
I take L-lysine for my tendons and bones, and I've found it to be beneficial for knee pain. It has significantly reduced discomfort in my legs, contributes to collagen formation, and enhances joint mobility and pain relief.
8.8
Pain relief noted
Most Useful Review
After my Covid illness, my immunity significantly declined, and I experienced persistent knee pain. Various medications didn’t help, but after using this supplement, my knee pain disappeared, and my temperature returned to normal. Now, I take it whenever I suspect an illness, along with vitamin C and D3, and everything is fine.
Silybum Marianum
9.5
Remarkable relief
Most Useful Review
My joint pain has significantly eased, and I am impressed with the quality of this company's products.
9.5
Consistent improvement
Most Useful Review
I buy this regularly and take it in courses. The pain in my right hypochondrium has subsided, and my tests have improved.
Iron
8
Iron treatment aids knee recovery
Blood management of staged bilateral total knee arthroplasty in a single hospitalization period.
Most Relevant Research
We focused on the effects of iron treatment as part of a broader strategy for managing blood loss and pain in patients undergoing staged bilateral total knee arthroplasty (TKA) within a single hospital stay. In our study, we compared two groups of patients: one receiving a newly introduced multimodal blood management (MBM) approach that included preoperative oral iron treatment, and a control group that only received standard care.
Our findings were promising. The group treated with the MBM protocol experienced significantly lower rates of blood transfusion—only 9% of patients required one—compared to 32.4% in the control group. This approach not only reduced the need for additional blood transfusions but also led to improvements in postoperative hemoglobin levels and reduced pain and swelling in the knees after surgery.
The results suggest that incorporating iron treatment in a comprehensive management program can effectively help alleviate knee pain and enhance recovery from surgery. Best of all, this was achieved without leading to any significant complications, indicating a safe and economical option for improving outcomes in TKA patients.
Our findings were promising. The group treated with the MBM protocol experienced significantly lower rates of blood transfusion—only 9% of patients required one—compared to 32.4% in the control group. This approach not only reduced the need for additional blood transfusions but also led to improvements in postoperative hemoglobin levels and reduced pain and swelling in the knees after surgery.
The results suggest that incorporating iron treatment in a comprehensive management program can effectively help alleviate knee pain and enhance recovery from surgery. Best of all, this was achieved without leading to any significant complications, indicating a safe and economical option for improving outcomes in TKA patients.
9.5
Improved mobility
Most Useful Review
Excellent. I have suffered from terrible knee pain due to iron deficiency. Thankfully, I no longer feel light-headed or weak in my knees, and I can now walk and take the stairs without fatigue. I strongly recommend this treatment for anyone facing iron deficiency.
Potassium
9.5
Joint pain relief
Most Useful Review
Excellent! I take one potassium tablet daily with meals, and it has remarkably helped my knee pain, strengthening my musculoskeletal system.
8.3
Gout pain relief
Most Useful Review
It helped reduce gout pain. I found the capsules tasteless but effective. After starting this supplement while eating foods high in purines, I’ve seen great relief from joint pain and haven't had a gout flare-up for over six months.
Vitamin C
5
Vitamin C reduces blood loss
Ascorbic Acid Reduces the Blood Boss After Total Knee Arthroplasty: Insights From a Randomized Controlled Trial.
Most Relevant Research
We explored how vitamin C, or ascorbic acid, might impact knee pain and blood loss in patients undergoing total knee arthroplasty (TKA). In a well-designed randomized controlled trial, patients were divided into two groups: one group received intravenous vitamin C, while the other received a placebo. This setup helped us assess the effects of vitamin C on blood loss and associated outcomes accurately.
Our findings showed that the patients who received vitamin C experienced significantly less drop in hemoglobin levels—a marker for blood loss—compared to those in the placebo group. However, when it comes to knee pain and function, the scores on the various patient-reported measurements were quite similar between both groups.
This leads us to conclude that while vitamin C appears effective at reducing blood loss in the early postoperative period, it did not translate into any significant differences in postoperative knee pain relief. Therefore, while vitamin C can be combined with other blood-preserving agents like tranexamic acid, its direct effect on knee pain specifically remains inconclusive.
Our findings showed that the patients who received vitamin C experienced significantly less drop in hemoglobin levels—a marker for blood loss—compared to those in the placebo group. However, when it comes to knee pain and function, the scores on the various patient-reported measurements were quite similar between both groups.
This leads us to conclude that while vitamin C appears effective at reducing blood loss in the early postoperative period, it did not translate into any significant differences in postoperative knee pain relief. Therefore, while vitamin C can be combined with other blood-preserving agents like tranexamic acid, its direct effect on knee pain specifically remains inconclusive.
9.5
Reduced knee pain
Most Useful Review
My favourite vitamin C. While there are cheaper options, I prefer this one. It has no side effects, and I take it with Omega, Vitamin S, and MSM to support my knees due to arthritis. It helps, especially after training, as I no longer experience knee pain. When I have a cold, I double the dosage to recover faster.
Docosahexaenoic Acid
9
Omega-3 improves knee pain relief
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Most Relevant Research
We conducted a compelling study to investigate how docosahexaenoic acid (DHA), often found in omega-3 supplements, influences knee pain in individuals aged 40 and older. The research was carefully designed as a randomized, double-blind, controlled clinical trial with four groups over an 8-week period. The participants dealt with persistent knee discomfort, scoring more than 3 on a visual analog scale for pain.
Among the groups, some received DHA alongside an omega-3 product called AvailOm, while others were given the omega-3 product alone or a placebo. Notably, those consuming the combined treatment of DHA and AvailOm showed improvements in both quality of life and muscle strength. There was a significant reduction in pain levels for participants taking AvailOm compared to those on placebo, particularly noticeable by the eighth week.
The study findings suggested that the omega-3 product effectively reduced pain perception and enhanced physical functionalities, including better performance on the Up and Go test. While the overall increase in omega-3 fatty acids was encouraging, the specific contributions of DHA to these improvements remain ambiguous due to the lack of isolation of DHA's effects in the results.
Overall, our study presents promising evidence that omega-3 supplementation can provide relief from knee pain and enhance quality of life in older adults suffering from this condition, though the unique role of DHA warrants further exploration.
Among the groups, some received DHA alongside an omega-3 product called AvailOm, while others were given the omega-3 product alone or a placebo. Notably, those consuming the combined treatment of DHA and AvailOm showed improvements in both quality of life and muscle strength. There was a significant reduction in pain levels for participants taking AvailOm compared to those on placebo, particularly noticeable by the eighth week.
The study findings suggested that the omega-3 product effectively reduced pain perception and enhanced physical functionalities, including better performance on the Up and Go test. While the overall increase in omega-3 fatty acids was encouraging, the specific contributions of DHA to these improvements remain ambiguous due to the lack of isolation of DHA's effects in the results.
Overall, our study presents promising evidence that omega-3 supplementation can provide relief from knee pain and enhance quality of life in older adults suffering from this condition, though the unique role of DHA warrants further exploration.
9.5
Vegan supplement benefits
Most Useful Review
This supplement is fantastic for my knee pain. I need to take a DHA/EPA supplement regularly to avoid the pain, and I appreciate that this one is vegan sourced with quality ingredients.
Eicosapentaenoic Acid
9
Eicosapentaenoic Acid Reduces Knee Pain
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Most Relevant Research
We conducted a study to investigate how eicosapentaenoic acid (EPA), a component of omega-3 fatty acids, impacts knee pain in healthy adults over the age of 40 with persistent discomfort. The study was structured as a randomized, double-blind, controlled clinical trial, which means that participants were assigned to either an EPA product or a placebo without knowing which they were receiving.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
9.5
Knee pain relief
Most Useful Review
Excellent for knee pain. Take these capsules and you will forget your knee pain due to ageing. I advise purchasing this larger package as it offers better value.
Fish Oil
9
Eicosapentaenoic Acid Reduces Knee Pain
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Most Relevant Research
We conducted a study to investigate how eicosapentaenoic acid (EPA), a component of omega-3 fatty acids, impacts knee pain in healthy adults over the age of 40 with persistent discomfort. The study was structured as a randomized, double-blind, controlled clinical trial, which means that participants were assigned to either an EPA product or a placebo without knowing which they were receiving.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
9.3
Back pain relief
Most Useful Review
I’ve been taking this vitamin for a month now. My lower back pain from work has disappeared. The quality of life is worth the money.
Protein
9
CNP may ease knee osteoarthritis
C-type natriuretic peptide suppresses VEGFa gene expression by attenuating IL6-STAT3 signal pathway in primary synovial fibroblasts from rat knee.
Most Relevant Research
We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
9.5
Reduces joint pain
Most Useful Review
The lack of smell is great, and I use it daily. The product's quality is very high and yields amazing benefits. It moisturises incredibly and has a fantastic effect on my skin and knees. It even helps reduce weaknesses and improves my overall health while being sweet to taste.
Vitamin D3
8
Vitamin D3 aids post-operative pain
Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.
Most Relevant Research
We investigated the role of Vitamin D3 in managing post-operative knee pain after unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups based on their Vitamin D3 levels. One group had their deficiency corrected before surgery, another received treatment after the operation, and the last group had normal levels from the start.
We aimed to determine not only how Vitamin D3 levels affected post-operative pain but also the benefits of correcting any deficiencies pre-operatively. Our findings revealed that correcting Vitamin D3 levels before surgery significantly improved pain management for patients. Those who were treated pre-operatively experienced better control of post-operative pain compared to those whose deficiencies were addressed afterwards.
In summary, we found that Vitamin D3 is an essential component in pre-operative assessments for patients undergoing UKA. Addressing any deficiencies beforehand seems to lead to improved outcomes in pain relief, highlighting its importance as a modifiable risk factor in surgical recovery.
We aimed to determine not only how Vitamin D3 levels affected post-operative pain but also the benefits of correcting any deficiencies pre-operatively. Our findings revealed that correcting Vitamin D3 levels before surgery significantly improved pain management for patients. Those who were treated pre-operatively experienced better control of post-operative pain compared to those whose deficiencies were addressed afterwards.
In summary, we found that Vitamin D3 is an essential component in pre-operative assessments for patients undergoing UKA. Addressing any deficiencies beforehand seems to lead to improved outcomes in pain relief, highlighting its importance as a modifiable risk factor in surgical recovery.
9.5
Relieved knee pain
Most Useful Review
I ordered this medication in maximum dosage for my grandfather, who experiences knee pain due to his age. It worked well alongside joint support medications, providing excellent relief.
Elderberry
7
Elderberry gel may reduce knee pain
Efficacy and short-term safety of topical Dwarf Elder (Sambucus ebulus L.) versus diclofenac for knee osteoarthritis: A randomized, double-blind, active-controlled trial.
Most Relevant Research
We investigated the effectiveness of topical Dwarf Elder (Sambucus ebulus) gel in relieving knee pain associated with osteoarthritis (OA). In our research, we randomly assigned 79 participants to use either S. ebulus gel or 1% diclofenac gel for a period of four weeks, applying the treatment three times daily.
After the treatment period, we assessed the participants' pain levels using a visual analogue scale and a questionnaire that addresses various OA symptoms. Our findings indicated that the S. ebulus gel showed promise in alleviating pain and improving symptoms for individuals suffering from knee OA.
While the results were encouraging, we noted that further studies with larger groups and longer durations are necessary to fully establish the efficacy and safety of elderberry treatment for knee pain. Overall, this pilot trial suggests that S. ebulus gel may be a beneficial option for those exploring alternative treatments for their knee osteoarthritis symptoms.
After the treatment period, we assessed the participants' pain levels using a visual analogue scale and a questionnaire that addresses various OA symptoms. Our findings indicated that the S. ebulus gel showed promise in alleviating pain and improving symptoms for individuals suffering from knee OA.
While the results were encouraging, we noted that further studies with larger groups and longer durations are necessary to fully establish the efficacy and safety of elderberry treatment for knee pain. Overall, this pilot trial suggests that S. ebulus gel may be a beneficial option for those exploring alternative treatments for their knee osteoarthritis symptoms.
9.5
Improved leg strength
Most Useful Review
Originally, my knees felt uncomfortable after walking for long periods. Since taking this elderberry supplement, I no longer experience this problem. My leg strength has increased, and my overall physical strength is good. It’s a great product, and I plan to continue using it for further improvements.
Omega 3
9
Eicosapentaenoic Acid Reduces Knee Pain
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Most Relevant Research
We conducted a study to investigate how eicosapentaenoic acid (EPA), a component of omega-3 fatty acids, impacts knee pain in healthy adults over the age of 40 with persistent discomfort. The study was structured as a randomized, double-blind, controlled clinical trial, which means that participants were assigned to either an EPA product or a placebo without knowing which they were receiving.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
9.5
No knee pain
Most Useful Review
I drink these capsules with my husband every morning alongside breakfast. After three weeks, I've noticed improved endurance during cardio workouts, and intriguingly, I experienced no knee pain during squats and lunges that previously caused discomfort. No stomach issues either! I hope my review helps others.
Calcium
4
Calcium does not enhance PRP
Is There a Need for an Exogenous Activator Along with PRP for Early Knee Osteoarthritis? A Triple-Blinded Randomized Control Trial.
Most Relevant Research
We explored the role of calcium gluconate as an activator alongside platelet-rich plasma (PRP) injections for patients dealing with early knee osteoarthritis. In this study, participants were split into two groups: one received PRP alone, while the other got PRP mixed with calcium gluconate.
Both groups were evaluated over six months for pain relief and overall satisfaction. Interestingly, despite a noticeable decrease in pain and improvement in overall function in both groups, we found no significant differences when comparing the effectiveness of the two treatments.
This led us to conclude that adding calcium gluconate might not provide any extra benefit to PRP injections in managing knee pain for early-stage osteoarthritis, which is quite important for patients considering their treatment options.
Both groups were evaluated over six months for pain relief and overall satisfaction. Interestingly, despite a noticeable decrease in pain and improvement in overall function in both groups, we found no significant differences when comparing the effectiveness of the two treatments.
This led us to conclude that adding calcium gluconate might not provide any extra benefit to PRP injections in managing knee pain for early-stage osteoarthritis, which is quite important for patients considering their treatment options.
8.8
Reduced knee pain
Most Useful Review
Very cool! Calcium and magnesium work well together. I discovered that taking these in the evening allows for better absorption. The jar is large, and the tablets are sizeable. I've noticed significant relief; my knee pain has decreased, and osteochondrosis is less concerning. I prefer to take them in a course.
Melatonin
8.8
Improved sleep quality
Most Useful Review
I regularly purchase this melatonin as it has notably enhanced my sleep quality. While it hasn't fully alleviated my knee pain upon waking, my overall sleep has improved, making waking up in the morning slightly easier. I've been using this since my teenage years, especially for issues related to my orthostatic disorder. I'm relieved that it helps me sleep better and facilitates easier waking, which I truly appreciate.
8.5
Pain relief noticed
Most Useful Review
Since I began taking this melatonin, my sleep quality has remarkably improved. I used to awaken frequently during the night, but now I sleep soundly until morning. This change has positively affected my knee pain, making it easier to wake up and get moving in the morning.