Vitamin K2
9.5
Reduced pains
Most Useful Review
I took vitamin K2 following a body cleanse with Triphala. After two weeks, I experienced severe pain in my upper abdomen and struggled to sleep or sit. My dyskinesia made it worse. Remembering that K2 aids in liver disease recovery, I tried it. After taking it, the pain vanished and I slept well. I also noticed that my friend with stomach issues benefited from it, as it helped alleviate her pain too. I believe this vitamin is essential not just for bones but also for gastrointestinal health.
9.5
Bone health support
Most Useful Review
Wordless. I take this alongside the Vitamin D I purchased here, as it enhances the effectiveness—ensuring Vitamin D supports the bones, rather than causing calcification in the liver and heart. The combination of Vitamin D3 and K2 MK7 is highly beneficial. I recommend both this product and the supplier, which delivers promptly to Brazil in seven days. Absolutely brilliant!
Oregano
9
Oregano extract improves liver health
Ethyl acetate fraction of oregano seed protects non-alcoholic fatty liver in high-fat diet-induced obese mice through modulation of .
Most Relevant Research
We evaluated how oregano seed extract, specifically its ethyl acetate fraction, affects liver health in mice that were fed a high-fat diet. Over a period of 10 weeks, we found that when these mice were given 100 mg/kg of oregano seed extract alongside their high-fat diet, their weight and various liver enzyme levels significantly improved.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
9.5
Supports liver health
Most Useful Review
This is a powerful herbal antibiotic! My SIBO syndromes disappeared after I took three capsules three times daily for a month. It's crucial to use it alongside medications to support liver health, as the liver removes toxins. After two weeks, I began taking a delayed-release probiotic to help restore healthy flora in my intestines.
Vitamins
9
Vitamin D benefits liver health
Vitamin D Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obesity Murine Model.
Most Relevant Research
We set out to understand how vitamin D might influence liver disease, particularly non-alcoholic fatty liver disease (NAFLD) related to obesity. For our research, we used a high-fat diet to create a mouse model that mimics the condition. We then supplemented these mice with vitamin D via injections over several weeks to see if it could alleviate the liver issues associated with their diet.
Our findings revealed that a high-fat diet led to vitamin D deficiency, insulin resistance, and a notable increase in liver weight. This also resulted in elevated liver enzymes and triglyceride levels, contributing to steatohepatitis, a concerning liver condition. When we introduced vitamin D supplementation, we observed a significant recovery in liver weight and overall improvement in liver health. The treatment also lowered harmful enzymes and triglycerides while helping control markers related to inflammation and fibrosis.
This study highlights that vitamin D supplementation can positively impact liver health in cases linked to obesity, offering an accessible and potentially effective strategy for addressing NAFLD. Notably, we found no adverse effects from the vitamin D treatment, suggesting it could be a safe option for individuals at risk.
Our findings revealed that a high-fat diet led to vitamin D deficiency, insulin resistance, and a notable increase in liver weight. This also resulted in elevated liver enzymes and triglyceride levels, contributing to steatohepatitis, a concerning liver condition. When we introduced vitamin D supplementation, we observed a significant recovery in liver weight and overall improvement in liver health. The treatment also lowered harmful enzymes and triglycerides while helping control markers related to inflammation and fibrosis.
This study highlights that vitamin D supplementation can positively impact liver health in cases linked to obesity, offering an accessible and potentially effective strategy for addressing NAFLD. Notably, we found no adverse effects from the vitamin D treatment, suggesting it could be a safe option for individuals at risk.
9.5
Absorbs well
Most Useful Review
Don't be misled by other tocopherol forms; we need alpha-tocopherol. This product offers the alpha form, which is what the body absorbs. Other tocopherols get destroyed in the liver. Alpha-tocopherol has a specific protein to aid absorption, so avoid overloading your liver with forms that cannot be absorbed easily.
9.5
Improves detox functions
Most Useful Review
Castor compresses can assist with various health issues. Castor oil enhances the body's detoxification, alleviating lymphatic congestion and boosting immunity. It helps with conditions such as liver disease, cholecystitis, and skincare ailments like eczema. If you found this review helpful, please give it a thumbs up!
9.5
Enhances skin and hair
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Castor oil has historically been used for its medicinal properties. Nowadays, it’s valued for its beauty benefits, particularly for hair. The antioxidants promote keratin production, essential for healthy hair growth, and it rejuvenates the scalp and skin while combating bacteria that lead to acne. It's a versatile product for beauty and health.
Garlic
9.5
Blood pressure improvement
Most Useful Review
After taking this supplement, my blood test results improved significantly, leading to a reduction in my prescribed medication. I think it’s effective for managing my underlying conditions.
8.8
Heart disease improvement
Most Useful Review
I have used this garlic extract for three years following my valve replacement surgery due to heart disease. Regular echocardiograms show significant improvement, and I can enjoy walking again. This supplement is essential for me and is highly recommended for those with heart disease.
Vitamin Bs
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Most Relevant Research
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
8
Improved energy levels
Most Useful Review
Vitamin B1 plays a vital role by converting carbohydrates into energy and aiding protein and fat digestion. It is essential for normal hydrochloric acid production in the stomach, crucial for processing proteins. I have autoimmune thyroiditis, often resulting in low gastric acidity. Thiamine helps maintain blood sugar and adrenal function, enhancing my energy levels. I take one small tablet in the morning with a meal and feel more energetic.
Proprietary Blendmanna Fraxinus Ornus L)
9.5
Optimises digestion
Most Useful Review
Swedish Bitters have improved my digestion and normalised nutrient absorption. By stimulating liver function, it increases bile production and digestive juices, aiding in fat breakdown and cholesterol removal. I take it before meals and highly recommend it.
9.5
Cleansing tincture
Most Useful Review
A blend of medicinal herbs, Swedish Bitters is indispensable in my home first aid kit. Just two teaspoons significantly improve gastrointestinal function and metabolism, alleviating symptoms like bloating and heartburn. It's vital for everyone's medicine cabinet.
Flax Seed Oil
9.5
Reduces cardiovascular risks
Most Useful Review
This product strengthens blood vessel walls and enhances elasticity, helping to normalise blood pressure. It reduces the risk of developing cardiovascular diseases, which is beneficial for liver disease management.
8.8
Improves liver function
Most Useful Review
Excellent flax oil! The taste is natural and the packaging is large. The capsules are of good quality, with a standard dosage of 1-2 capsules per day. This product is an omega alternative, essential for normalising liver function and reducing cholesterol. However, for significant improvement in liver disease, it’s advisable to take additional supplements like silymarin and fish oil. I recommend purchasing!
Vitamin A
9
Vitamin D3 aids liver health
Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.
Most Relevant Research
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
9.5
Boosted immunity
Most Useful Review
I trust this brand completely. My family is recovering well from covid with this product, which I find great for immunity. The small capsules are easy to take; adults can take the full dose, while children can take half. The retinol palmitate from fish liver replenishes vitamin A deficiency and regulates tissue metabolism. It’s best taken with food and is undoubtedly beneficial during the autumn-winter virus season.
L Lysine
9.5
Reduced hair loss
Most Useful Review
I bought this supplement to combat hair loss, and over the years, I’ve noticed improvements. My hair loss has diminished significantly, and my liver values have improved during health check-ups. I recommend it to anyone dealing with hair loss and concerned about liver disease.
9.5
Effective for herpes
Most Useful Review
I can confirm that this amino acid really works. I have herpes type 1.2, and when it flared up, I took one tablet on an empty stomach before meals. Within a day, the outbreak subsided, and my skin cleared in four days. Previously, I used ointments and acyclovir, which is tough on the liver, but now I'll only rely on l-lysine. I wholeheartedly recommend this!
Spirulina
9.5
Improved anemia
Most Useful Review
Spirulina is useful for anyone with gastrointestinal issues, anaemia, or liver disease. I highly recommend looking into these beneficial algae. I took spirulina for my anaemia, and my haemoglobin levels increased.
8.3
Detoxing liver
Most Useful Review
This product helped detoxify my liver of toxins, along with Jarrows Yaeyama chlorella. It's packed with nutrients and has been effective in my regimen.
Tumeric
8
Curcumin may protect liver health
Oxidative stress in a cellular model of alcohol-related liver disease: protection using curcumin nanoformulations.
Most Relevant Research
We investigated how curcumin, a natural antioxidant found in turmeric, can help protect the liver from damage caused by alcohol consumption. In our study, we used HepG2 cells, which are a model for liver cells, and treated them with different concentrations of alcohol to mimic alcohol-related liver disease (ARLD).
We noticed that a high alcohol concentration led to decreased cell survival and an increase in harmful reactive oxygen species (ROS)—molecules that can cause oxidative stress in the liver. This oxidative stress not only damaged the cells but also resulted in cell death and mitochondrial dysfunction over time.
Curcumin nanofunctions showed promise; when we pre-treated the liver cells with these formulations, we observed an increase in cell viability and a reduction in ROS levels after just a few hours. This suggests that curcumin could play a role in mitigating the adverse effects of alcohol on liver health.
Our findings indicate that curcumin and its nanoformulations could be beneficial in reducing oxidative damage in liver disease, but further research is needed to explore this potential in more detail.
We noticed that a high alcohol concentration led to decreased cell survival and an increase in harmful reactive oxygen species (ROS)—molecules that can cause oxidative stress in the liver. This oxidative stress not only damaged the cells but also resulted in cell death and mitochondrial dysfunction over time.
Curcumin nanofunctions showed promise; when we pre-treated the liver cells with these formulations, we observed an increase in cell viability and a reduction in ROS levels after just a few hours. This suggests that curcumin could play a role in mitigating the adverse effects of alcohol on liver health.
Our findings indicate that curcumin and its nanoformulations could be beneficial in reducing oxidative damage in liver disease, but further research is needed to explore this potential in more detail.
10
Breast cancer remission
Most Useful Review
Elizabeth B, curcumin has anti-cancer properties. I’ve taken 2 grams daily since my stage 4 breast cancer diagnosis. I went into remission within three months, and there hasn't been any evidence of disease for eight months now.
Polygonum Cuspidatum Complex
9.5
Lyme relief
Most Useful Review
Resveratrol is the only thing that allowed me to stop antibiotics after 14 months of serious Lyme disease. Within a week, I had more energy and it suppressed the Lyme disease, enabling me to increase my exercise from 1 mile to 3.5 or 4 miles. I was astounded that any product could be this effective. The scientific data on resveratrol is compelling, and it is also anti-cancer, so I plan to take 1g daily for the foreseeable future.
Most Useful Review
Vitamin B Complex
9.5
Supports liver function
Most Useful Review
I used this for nutritional support during my weight loss journey. I found that this vitamin B complex helped to significantly lower my liver values. After undergoing gastric surgery, my test results improved, and I no longer needed it. It's a solid choice for those dealing with liver disease.
8.3
Boosts energy levels
Most Useful Review
These vitamins indeed do their job. I take one every second day, which is sufficient for me to notice enhanced skin and energy. Daily intake felt excessive for my body, particularly for my liver and kidneys to process.
Astragalus Root
9.5
Strengthened liver function
Most Useful Review
Very strong astragalus has significantly supported my immune system and detoxified my liver disease. It has also fortified my adrenal glands, aiding my thyroid. It's crucial to strengthen the adrenal glands first, as they produce hormones necessary for thyroid function.
9.5
Enhanced immunity support
Most Useful Review
Our family has found this product to be a great immunity booster, particularly during cold seasons. It was especially beneficial while I underwent chemotherapy, as it helped maintain my immunity during white blood count reductions and may protect the liver from chemo's toxic effects.
Quercetin
8.8
Allergy relief
Most Useful Review
I've repurchased quercetin with bromelain for its enhanced anti-inflammatory properties. Quercetin improves blood circulation and helps alleviate allergy symptoms, while bromelain aids digestion. Together, they support overall wellness, prevent lifestyle-related diseases, and enhance immunity. However, care should be taken to avoid overdosing, as effects are confirmed in healthy individuals only.
9.5
Allergy management
Most Useful Review
Aged 30, I turned to quercetin after suffering from allergies that evolved into asthma and liver disease. It provides an antihistamine effect, reducing allergic reactions and inflammation while strengthening blood vessel walls. The improvements during allergy season are significant, and my symptoms have markedly diminished since I started taking it daily with bromelain.
Coconut Oil
8
Potential benefit noted
Most Useful Review
Coconut oil is beneficial for Alzheimer's disease.
9.5
Supports liver health
Most Useful Review
Everyone knows the efficacy of coconut oil. I consume it frequently to prevent liver disease and dementia. I highly recommend it.
Probiotics
9
Saccharomyces boulardii reduces liver fat
Mitigates Fructose-Induced Non-Alcoholic Fatty Liver in Rats.
Most Relevant Research
We explored how Saccharomyces boulardii might alleviate non-alcoholic fatty liver disease (NAFLD) in rats suffering from fructose-induced liver damage. Thirty rats were divided into control, fatty liver, and treatment groups.
Our findings revealed that the rats receiving S. boulardii showed lower levels of harmful substances and improved liver health indicators compared to those without treatment. Notably, there was less fat buildup in their livers.
This suggests that S. boulardii could serve as a promising way to protect the liver from fatty damage linked to high fructose diets.
Our findings revealed that the rats receiving S. boulardii showed lower levels of harmful substances and improved liver health indicators compared to those without treatment. Notably, there was less fat buildup in their livers.
This suggests that S. boulardii could serve as a promising way to protect the liver from fatty damage linked to high fructose diets.
9.5
Healthy liver function
Most Useful Review
The best vitamins: My body struggles with synthetic vitamins. I had no adverse reactions from these, and they’ve helped keep my liver disease tests stable while improving my overall health, including strong nails and clear skin. I highly recommend them to pregnant women.
Elderberry
7
Liver health benefits from elderberry
Long-Term Supplementation of Black Elderberries Promotes Hyperlipidemia, but Reduces Liver Inflammation and Improves HDL Function and Atherosclerotic Plaque Stability in Apolipoprotein E-Knockout Mice.
Most Relevant Research
We conducted a study to evaluate the effects of long-term supplementation of black elderberry extract on liver inflammation and cholesterol levels in a specific type of mouse known as apoE mice. These mice were divided into three groups, with some receiving a low-fat diet supplemented with varying amounts of elderberry extract for 24 weeks.
Our findings revealed that the highest dosage of elderberry extract led to notable increases in total serum cholesterol levels. Interestingly, this didn’t seem to negatively impact liver health. In fact, both lower and higher doses of elderberry extract improved the ability of HDL cholesterol to function effectively, which is crucial for cardiovascular health.
While elderberry supplementation did contribute to elevated cholesterol levels, it also reduced liver inflammation and improved markers associated with liver function. We observed that the extract led to an increase in connective tissue in the aortic region, which may suggest a stabilization of atherosclerotic plaques, potentially lowering the risk of heart disease.
Overall, our study highlights the potential of black elderberry extract to not only support liver health but also enhance HDL functionality. This finding is particularly exciting as it opens avenues for using antioxidant-rich foods as part of a diet that promotes overall cardiovascular wellness.
Our findings revealed that the highest dosage of elderberry extract led to notable increases in total serum cholesterol levels. Interestingly, this didn’t seem to negatively impact liver health. In fact, both lower and higher doses of elderberry extract improved the ability of HDL cholesterol to function effectively, which is crucial for cardiovascular health.
While elderberry supplementation did contribute to elevated cholesterol levels, it also reduced liver inflammation and improved markers associated with liver function. We observed that the extract led to an increase in connective tissue in the aortic region, which may suggest a stabilization of atherosclerotic plaques, potentially lowering the risk of heart disease.
Overall, our study highlights the potential of black elderberry extract to not only support liver health but also enhance HDL functionality. This finding is particularly exciting as it opens avenues for using antioxidant-rich foods as part of a diet that promotes overall cardiovascular wellness.
9
Liver health support
Most Useful Review
The vegan Black Elderberry supplement is fantastic for eye health and offers other benefits, including protection against liver disease. Packed with anthocyanins, it boosts the immune system, reduces inflammation, and aids heart health. I appreciate that it's suitable for vegans, making it a great addition to my health regimen.
Alpha Lipoic Acid
8
Alpha-lipoic acid protects liver health
α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte.
Most Relevant Research
We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.
This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.
9.5
Improves liver health
Most Useful Review
Great price! I would choose alpha-lipoic acid for health. Its effects benefit the nerves, liver, and blood sugar levels. This quality product is offered at a great price—highly recommended!
Coenzyme Q10
9
CoQ10 and Se improve liver health
Coenzyme Q and Selenium Co-Supplementation Alleviate Methionine Choline-Deficient Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice.
Most Relevant Research
We explored the potential of coenzyme Q10 (CoQ) in combination with selenium (Se) to improve liver health in a mouse model of metabolic dysfunction-associated steatohepatitis (MASH). Our recent study involved male C57BL/6J mice fed a methionine choline-deficient diet, known to induce liver problems. The treatment groups received CoQ, Se, or both substances together for four weeks, while a control group received a methionine choline-sufficient diet.
The results revealed that both CoQ and Se, particularly when used in combination, significantly reduced liver inflammation, fibrosis, and fat accumulation. We observed that these antioxidants alleviated oxidative stress and decreased markers of lipid peroxidation, alongside improving liver enzyme levels in the mice's blood. Importantly, the combination therapy also appeared to support cellular health by regulating proteins related to a specific type of cell death known as ferroptosis.
Our findings suggest that CoQ, especially in tandem with selenium, has therapeutic potential for managing liver diseases like MASH. This research opens doors for deeper investigations into antioxidant treatments for liver health, showcasing how we might leverage natural compounds for better outcomes in metabolic liver conditions.
The results revealed that both CoQ and Se, particularly when used in combination, significantly reduced liver inflammation, fibrosis, and fat accumulation. We observed that these antioxidants alleviated oxidative stress and decreased markers of lipid peroxidation, alongside improving liver enzyme levels in the mice's blood. Importantly, the combination therapy also appeared to support cellular health by regulating proteins related to a specific type of cell death known as ferroptosis.
Our findings suggest that CoQ, especially in tandem with selenium, has therapeutic potential for managing liver diseases like MASH. This research opens doors for deeper investigations into antioxidant treatments for liver health, showcasing how we might leverage natural compounds for better outcomes in metabolic liver conditions.
9.5
Improved liver health
Most Useful Review
I want to share my experience with coenzyme Q10. I noticed numbness in my legs while sitting for long hours. After taking coenzyme Q10 daily for over two years, along with fish oil, my liver responded well, and the nocturnal pain diminished. I recently made a long car trip without leg issues, and I no longer feel cold in winter. Coenzyme Q10 has had a remarkable impact on my health, so I recommend trying it!
Potassium
8.8
Reduced uric acid
Most Useful Review
A highly digestible form of potassium! After tests, I was advised to reduce my uric acid levels to avoid allopurinol, which is harmful for liver disease. Combined with magnesium citrate and cherry concentrate, this potassium citrate works well. It helps to alkalise the body, is beneficial for heart health, and I've noticed that joint pains from excess uric acid are much less frequent.
Most Useful Review
Iron
7
Iron's impact on liver disease
Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels-a single-centre retrospective study.
Most Relevant Research
We explored the long-term effects of iron supplementation in four patients suffering from X-linked erythropoietic protoporphyria (XLEPP), a rare genetic disorder that can lead to serious liver problems due to the buildup of a substance called protoporphyrin IX (PPIX) in the blood. This condition often causes severe photosensitivity and can result in liver damage, which, in some cases, may necessitate a liver transplant.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
9.5
Significant improvement
Most Useful Review
Awesome working additive! This iron supplement has notably improved my friend’s condition with liver disease. She struggled with low haemoglobin due to her medications. After taking this iron for three months, her haemoglobin rose significantly! Unlike other treatments, this one didn't cause nausea. She feels great now, and I’ve started it for prevention myself. Many thanks to the manufacturers!
Choline
8
Myo-inositol improves insulin resistance
The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD.
Most Relevant Research
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
9.5
Improved liver function
Most Useful Review
This supplement was prescribed to enhance my liver health, addressing discomfort in my right hypochondrium. Although tests were normal, there were some changes indicating liver disease. The product comprises natural ingredients, and I found it easy to take. The pain and heaviness have vanished, and my digestion has improved significantly. My follow-up tests showed stabilised indicators.
Silybum Marianum
8
Lipid balance and liver protection
Silybin A from reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids.
Most Relevant Research
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
9.5
Improved health
Most Useful Review
To support my hardworking liver, this herbal remedy is fantastic! After my operation, I experienced pain in the right side, but silymarin was prescribed. I initially took one capsule before meals, then increased to two, and my health has since improved, with my face regaining colour and no pain in my side. This mixture of milk thistle and curcumin gently detoxifies the body while enhancing liver function. For optimal results, consult a nutritionist before using.
Vitamin B12
9
Methylcobalamin aids liver health
Methylcobalamin protects against liver failure via engaging gasdermin E.
Most Relevant Research
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
9.5
Improved blood count
Most Useful Review
This form of B12 genuinely works, as confirmed by lab results. I struggled with liver disease and pernicious anaemia, leading to severe drops in haemoglobin. After changing to this methylated B12, my haemoglobin levels stabilised and even began to rise. This product, alongside iron supplements, has been crucial in managing my red blood cell count, which has remained above 8.5.
Fish Oil
8
Eicosapentaenoic acid improves liver fibrosis
EPA-rich Nannochloropsis oceanica biomass regulates gut microbiota, alleviates inflammation and ameliorates liver fibrosis in rats.
Most Relevant Research
We investigated how eicosapentaenoic acid (EPA), derived from the marine microalgae Nannochloropsis oceanica, affects liver disease, particularly focusing on its potential to address liver fibrosis in rats. In a structured study, we divided the rats into groups that received varying doses of the EPA-rich algae alongside a control group given fish oil, known for its omega-3 content.
Our research revealed that the rats fed with the highest dose of the N. oceanica biomass experienced marked improvements. The serum levels of liver enzymes and cholesterol, which typically rise due to liver damage, saw a significant decline in those rats. We also noted that the histological examinations indicated less inflammation and lesser damage to liver cells in the groups consuming the algal biomass.
Additionally, the study showed positive changes in gut microbiota. We observed an increase in beneficial bacteria associated with short-chain fatty acid production in the groups fed with EPA. This suggests that not only does EPA help with liver health, but it might also positively influence gut health.
Ultimately, our findings suggest that N. oceanica biomass, with its high EPA content, can be an effective supplement for reducing liver fibrosis, offering an alternative to traditional fish oil in promoting liver health.
Our research revealed that the rats fed with the highest dose of the N. oceanica biomass experienced marked improvements. The serum levels of liver enzymes and cholesterol, which typically rise due to liver damage, saw a significant decline in those rats. We also noted that the histological examinations indicated less inflammation and lesser damage to liver cells in the groups consuming the algal biomass.
Additionally, the study showed positive changes in gut microbiota. We observed an increase in beneficial bacteria associated with short-chain fatty acid production in the groups fed with EPA. This suggests that not only does EPA help with liver health, but it might also positively influence gut health.
Ultimately, our findings suggest that N. oceanica biomass, with its high EPA content, can be an effective supplement for reducing liver fibrosis, offering an alternative to traditional fish oil in promoting liver health.
8.8
Cholesterol benefits
Most Useful Review
The quality is excellent with no age restrictions. The packaging is impressive, and the benefits for women's health are significant! My hair condition has improved markedly. Omega 3 fish oil is essential for women, as it reduces cholesterol and alleviates inflammation. Though I find the taste bland, its importance for health cannot be overstated, and I recommend it for those with heart disease.
Red Yeast Rice
9
CoQ10 and Se improve liver health
Coenzyme Q and Selenium Co-Supplementation Alleviate Methionine Choline-Deficient Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice.
Most Relevant Research
We explored the potential of coenzyme Q10 (CoQ) in combination with selenium (Se) to improve liver health in a mouse model of metabolic dysfunction-associated steatohepatitis (MASH). Our recent study involved male C57BL/6J mice fed a methionine choline-deficient diet, known to induce liver problems. The treatment groups received CoQ, Se, or both substances together for four weeks, while a control group received a methionine choline-sufficient diet.
The results revealed that both CoQ and Se, particularly when used in combination, significantly reduced liver inflammation, fibrosis, and fat accumulation. We observed that these antioxidants alleviated oxidative stress and decreased markers of lipid peroxidation, alongside improving liver enzyme levels in the mice's blood. Importantly, the combination therapy also appeared to support cellular health by regulating proteins related to a specific type of cell death known as ferroptosis.
Our findings suggest that CoQ, especially in tandem with selenium, has therapeutic potential for managing liver diseases like MASH. This research opens doors for deeper investigations into antioxidant treatments for liver health, showcasing how we might leverage natural compounds for better outcomes in metabolic liver conditions.
The results revealed that both CoQ and Se, particularly when used in combination, significantly reduced liver inflammation, fibrosis, and fat accumulation. We observed that these antioxidants alleviated oxidative stress and decreased markers of lipid peroxidation, alongside improving liver enzyme levels in the mice's blood. Importantly, the combination therapy also appeared to support cellular health by regulating proteins related to a specific type of cell death known as ferroptosis.
Our findings suggest that CoQ, especially in tandem with selenium, has therapeutic potential for managing liver diseases like MASH. This research opens doors for deeper investigations into antioxidant treatments for liver health, showcasing how we might leverage natural compounds for better outcomes in metabolic liver conditions.
9.5
Liver disease improvement
Most Useful Review
I don't consume alcohol but suspect I have liver disease. I previously took omega-3s and liver supplements to manage cholesterol, but after menopause, results were lacking. However, after using this product, my latest blood test showed normal LDH levels for the first time in over a decade. It's the only new supplement I've tried, and my diet hasn't changed. I'm curious if this product contributed to the result and plan to continue monitoring.
Cod Liver Oil
9
Cod liver oil protects liver health
Cod liver oil in sodium nitrite induced hepatic injury: does it have a potential protective effect?
Most Relevant Research
We examined the effects of cod liver oil on liver inflammation caused by sodium nitrite, a common food additive known for its harmful effects at high levels. In this study, we treated thirty-two adult male rats with sodium nitrite and observed the potential protective role of cod liver oil.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
9.5
Promising recovery
Most Useful Review
To be honest, it is excellent in all its flavours. I ordered it a month ago to address my liver disease and related stomach issues. My immunity is low, and my weight has drastically dropped. Since using it, I’ve felt better, and I’ve started eating more. I will continue to buy it until I am fully healed. It assists in healing, but if the taste is too strong, one can use empty capsules, filling them and storing them properly. I wish for a speedy recovery for all.
Omega 3
8
Eicosapentaenoic acid improves liver fibrosis
EPA-rich Nannochloropsis oceanica biomass regulates gut microbiota, alleviates inflammation and ameliorates liver fibrosis in rats.
Most Relevant Research
We investigated how eicosapentaenoic acid (EPA), derived from the marine microalgae Nannochloropsis oceanica, affects liver disease, particularly focusing on its potential to address liver fibrosis in rats. In a structured study, we divided the rats into groups that received varying doses of the EPA-rich algae alongside a control group given fish oil, known for its omega-3 content.
Our research revealed that the rats fed with the highest dose of the N. oceanica biomass experienced marked improvements. The serum levels of liver enzymes and cholesterol, which typically rise due to liver damage, saw a significant decline in those rats. We also noted that the histological examinations indicated less inflammation and lesser damage to liver cells in the groups consuming the algal biomass.
Additionally, the study showed positive changes in gut microbiota. We observed an increase in beneficial bacteria associated with short-chain fatty acid production in the groups fed with EPA. This suggests that not only does EPA help with liver health, but it might also positively influence gut health.
Ultimately, our findings suggest that N. oceanica biomass, with its high EPA content, can be an effective supplement for reducing liver fibrosis, offering an alternative to traditional fish oil in promoting liver health.
Our research revealed that the rats fed with the highest dose of the N. oceanica biomass experienced marked improvements. The serum levels of liver enzymes and cholesterol, which typically rise due to liver damage, saw a significant decline in those rats. We also noted that the histological examinations indicated less inflammation and lesser damage to liver cells in the groups consuming the algal biomass.
Additionally, the study showed positive changes in gut microbiota. We observed an increase in beneficial bacteria associated with short-chain fatty acid production in the groups fed with EPA. This suggests that not only does EPA help with liver health, but it might also positively influence gut health.
Ultimately, our findings suggest that N. oceanica biomass, with its high EPA content, can be an effective supplement for reducing liver fibrosis, offering an alternative to traditional fish oil in promoting liver health.
8.8
Reduces inflammation
Most Useful Review
This is a basic health supplement. Omega reduces inflammation in the body and is essential for the health of the cardiovascular system, nervous system, brain, and liver.
Olive Leaf
9.5
Recommended for cleansing
Most Useful Review
I recommend using it to cleanse the liver for those suffering liver disease from medications and bodybuilding supplements.
8
Health improvement
Most Useful Review
Oh, my preferred olive leaf extract! On my doctor's advice, I've used it for a long time in both liquid and capsule forms. The capsules are much more convenient for travel. I have issues with skin and liver disease, and I find olive leaves beneficial for reducing inflammation, boosting immunity, and aiding various health conditions. Each pack contains 120 capsules, taken once daily, offering a long-lasting supply. I hope you notice improvements after using the extract.
Eicosapentaenoic Acid
8
Eicosapentaenoic acid improves liver fibrosis
EPA-rich Nannochloropsis oceanica biomass regulates gut microbiota, alleviates inflammation and ameliorates liver fibrosis in rats.
Most Relevant Research
We investigated how eicosapentaenoic acid (EPA), derived from the marine microalgae Nannochloropsis oceanica, affects liver disease, particularly focusing on its potential to address liver fibrosis in rats. In a structured study, we divided the rats into groups that received varying doses of the EPA-rich algae alongside a control group given fish oil, known for its omega-3 content.
Our research revealed that the rats fed with the highest dose of the N. oceanica biomass experienced marked improvements. The serum levels of liver enzymes and cholesterol, which typically rise due to liver damage, saw a significant decline in those rats. We also noted that the histological examinations indicated less inflammation and lesser damage to liver cells in the groups consuming the algal biomass.
Additionally, the study showed positive changes in gut microbiota. We observed an increase in beneficial bacteria associated with short-chain fatty acid production in the groups fed with EPA. This suggests that not only does EPA help with liver health, but it might also positively influence gut health.
Ultimately, our findings suggest that N. oceanica biomass, with its high EPA content, can be an effective supplement for reducing liver fibrosis, offering an alternative to traditional fish oil in promoting liver health.
Our research revealed that the rats fed with the highest dose of the N. oceanica biomass experienced marked improvements. The serum levels of liver enzymes and cholesterol, which typically rise due to liver damage, saw a significant decline in those rats. We also noted that the histological examinations indicated less inflammation and lesser damage to liver cells in the groups consuming the algal biomass.
Additionally, the study showed positive changes in gut microbiota. We observed an increase in beneficial bacteria associated with short-chain fatty acid production in the groups fed with EPA. This suggests that not only does EPA help with liver health, but it might also positively influence gut health.
Ultimately, our findings suggest that N. oceanica biomass, with its high EPA content, can be an effective supplement for reducing liver fibrosis, offering an alternative to traditional fish oil in promoting liver health.
9.5
Reduced asthma symptoms
Most Useful Review
Wonderful for asthma! My 6-year-old daughter has suffered from asthma, with constant coughing and severe attacks. After trying numerous medications with little relief, I introduced cod liver oil upon my mother's suggestion. Within two weeks, she was nearly symptom-free. Several months later, she remains significantly better, experiencing only a few flare-ups. I appreciate Nordic Naturals for their high processing standards, ensuring the product is safe for children without excess vitamins D and A.
Magnesium
9.5
Migraine relief
Most Useful Review
I regularly purchase magnesium supplements, as many people are deficient, especially those under stress or with demanding lifestyles. After struggling with chronic migraines and using harsh medications that burdened my liver, I took 400 mg of magnesium with Vit D before bed. My migraines vanished, and my blood pressure normalised. A follow-up blood test revealed my magnesium levels were at the lower limit of normal. I highly recommend this product.
8
Heart pain alleviation
Most Useful Review
This product has been fantastic for easing my muscles and relieving restless leg syndrome, as well as reducing heart pain associated with ME/CFS. However, I've recently discovered chelated magnesium might be better for avoiding heavy metal accumulation, so I intend to switch to that in the future. Thank you for the excellent service.
Zinc
8
Zinc levels correlate with liver disease
Correlation of Serum Zinc Levels with Hepatic Encephalopathy Severity in Patients with Decompensated Liver Cirrhosis: A Prospective Observational Study from Egypt.
Most Relevant Research
We explored the impact of zinc on liver disease by focusing on its levels in patients with decompensated liver cirrhosis. This study involved 100 individuals with advanced liver issues and another 100 healthy individuals for comparison.
Our findings revealed that serum zinc levels were significantly lower in cirrhotic patients compared to healthy controls. In fact, the levels were remarkably diminished, indicating a potential deficiency in those suffering from liver complications.
Moreover, we observed a strong inverse relationship between zinc levels and the severity of liver disease, as measured by the Child-Pugh score and the grading of hepatic encephalopathy. This means that as zinc levels dropped, the severity of liver disease increased.
Notably, those with the most severe forms of liver disease also had critical zinc deficiencies. We also highlighted the positive correlation between zinc levels and albumin, suggesting that albumin might play a crucial role in the transport of zinc within the body.
Given these findings, we recommend that monitoring and potentially supplementing zinc in patients with liver cirrhosis could be beneficial, especially for those experiencing complications tied to their liver condition.
Our findings revealed that serum zinc levels were significantly lower in cirrhotic patients compared to healthy controls. In fact, the levels were remarkably diminished, indicating a potential deficiency in those suffering from liver complications.
Moreover, we observed a strong inverse relationship between zinc levels and the severity of liver disease, as measured by the Child-Pugh score and the grading of hepatic encephalopathy. This means that as zinc levels dropped, the severity of liver disease increased.
Notably, those with the most severe forms of liver disease also had critical zinc deficiencies. We also highlighted the positive correlation between zinc levels and albumin, suggesting that albumin might play a crucial role in the transport of zinc within the body.
Given these findings, we recommend that monitoring and potentially supplementing zinc in patients with liver cirrhosis could be beneficial, especially for those experiencing complications tied to their liver condition.
9.5
Effective during illness
Most Useful Review
For a year, I’ve taken this zinc as advised by a trichologist, and I’m pleased with the results, particularly during the coronavirus period. My relatives now take it too. When unwell, it helps me recover from illness rapidly, including concerns related to liver disease.
