Inositol
9
We explored the role of the sodium/myo-inositol co-transporter SLC5A3 in non-small cell lung cancer (NSCLC). Our research aimed to uncover how inositol impacts cancer cell growth and survival.
Through our analysis, we discovered that SLC5A3 levels were significantly higher in NSCLC tissues than in normal lung tissues. When we reduced SLC5A3 using specific techniques, we observed a notable decrease in cell growth, migration, and an increase in cell death. This suggests that SLC5A3 plays a pivotal role in maintaining cancer cell viability.
Furthermore, we found that adding myo-inositol or activating a related protein pathway helped reverse the effects seen with SLC5A3 depletion. In animal models, we noted that directly targeting SLC5A3 reduced tumor growth significantly, reinforcing the idea that it is a critical factor in NSCLC progression.
Overall, our findings highlight that SLC5A3 promotes cancer cell growth potentially by enhancing myo-inositol levels and activating specific signaling pathways. This offers new insights into potential treatment strategies targeting SLC5A3 for lung cancer patients.
Through our analysis, we discovered that SLC5A3 levels were significantly higher in NSCLC tissues than in normal lung tissues. When we reduced SLC5A3 using specific techniques, we observed a notable decrease in cell growth, migration, and an increase in cell death. This suggests that SLC5A3 plays a pivotal role in maintaining cancer cell viability.
Furthermore, we found that adding myo-inositol or activating a related protein pathway helped reverse the effects seen with SLC5A3 depletion. In animal models, we noted that directly targeting SLC5A3 reduced tumor growth significantly, reinforcing the idea that it is a critical factor in NSCLC progression.
Overall, our findings highlight that SLC5A3 promotes cancer cell growth potentially by enhancing myo-inositol levels and activating specific signaling pathways. This offers new insights into potential treatment strategies targeting SLC5A3 for lung cancer patients.
10
Optimal anti-cancer use
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18 people found this helpful
Number 1 anti-cancer supplement! Just make sure to take it with distilled or reverse osmosis water and at least 3 hours away from any food. It’s easiest to take first thing in the morning and then wait to eat for three hours.
Turmeric Curcumin
9
We explored the potential of a curcumin derivative, CU17, in enhancing the effectiveness of Gemcitabine (Gem) against lung cancer. The study examined how this combination therapy affects A549 non-small-cell lung cancer (NSCLC) cells in laboratory settings and in mouse models.
Our findings revealed that CU17 significantly increased the anti-cancer strength of Gem, leading to better control over cancer cell survival. This was achieved by prolonging the S phase of the cell cycle and inducing G2/M phase arrest, which involved proteins like p21 and p53. Furthermore, CU17 boosted the apoptotic effects of Gem by altering the balance of pro-apoptotic and anti-apoptotic factors.
Additionally, in the in vivo experiments, CU17 not only enhanced the anti-cancer effects of Gem but also reduced its toxicity to vital organs such as the liver, kidneys, and spleen. Overall, our research highlights CU17 as a promising chemosensitizer that could improve treatment outcomes for patients with NSCLC without significantly increasing the side effects of Gem.
Our findings revealed that CU17 significantly increased the anti-cancer strength of Gem, leading to better control over cancer cell survival. This was achieved by prolonging the S phase of the cell cycle and inducing G2/M phase arrest, which involved proteins like p21 and p53. Furthermore, CU17 boosted the apoptotic effects of Gem by altering the balance of pro-apoptotic and anti-apoptotic factors.
Additionally, in the in vivo experiments, CU17 not only enhanced the anti-cancer effects of Gem but also reduced its toxicity to vital organs such as the liver, kidneys, and spleen. Overall, our research highlights CU17 as a promising chemosensitizer that could improve treatment outcomes for patients with NSCLC without significantly increasing the side effects of Gem.
9
In remission
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103 people found this helpful
Elizabeth B: Curcumin is known for its anti-cancer properties. I have been taking 2g (4 capsules) daily since shortly after my stage 4 lung cancer diagnosis a year ago. I went into remission within three months, and all my tumours have since disappeared. I have been in remission with no evidence of disease for eight months now.
Ip6
9
We explored the effects of intrathecal pemetrexed (IP) on lung cancer patients facing leptomeningeal metastases (LM), particularly after they had not responded to previous treatments with EGFR-TKIs. The study analyzed 50 patients who received a 50 mg dose of IP after their cancer progressed, looking closely at their clinical responses and survival outcomes over two years.
Remarkably, we observed a 64% clinical response rate, indicating that many patients saw improvements in their neurological symptoms and overall performance. The median intracranial progression-free survival was 5.3 months, while overall survival reached up to 12 months for these patients. Those who responded positively to the treatment experienced significantly longer survival compared to non-responders, which is encouraging for both patients and doctors seeking options after traditional therapies fail.
The treatment was generally well tolerated, with manageable side effects mostly related to myelosuppression and liver functions. Additionally, genetic testing revealed consistency between the tumors and the cerebrospinal fluid, which opens up further investigation into the underlying mechanisms of treatment resistance. Overall, our findings suggest that IP could be a promising option for patients battling advanced lung cancer with LM after existing therapies have stopped working.
Remarkably, we observed a 64% clinical response rate, indicating that many patients saw improvements in their neurological symptoms and overall performance. The median intracranial progression-free survival was 5.3 months, while overall survival reached up to 12 months for these patients. Those who responded positively to the treatment experienced significantly longer survival compared to non-responders, which is encouraging for both patients and doctors seeking options after traditional therapies fail.
The treatment was generally well tolerated, with manageable side effects mostly related to myelosuppression and liver functions. Additionally, genetic testing revealed consistency between the tumors and the cerebrospinal fluid, which opens up further investigation into the underlying mechanisms of treatment resistance. Overall, our findings suggest that IP could be a promising option for patients battling advanced lung cancer with LM after existing therapies have stopped working.
9
Boosts immunity
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1 people found this helpful
This product is wonderful in the battle against lung cancer and mitigates the effects of chemotherapy by boosting immunity.
Selenium
9
Effective selenium treatment for lung cancer
We aimed to explore the potential of selenium nanoparticles synthesized from Epimedium brevicornum in combating lung cancer. Using various techniques, we characterized these nanoparticles and evaluated their effects in both lab and live models.
Although the nanoparticles were not harmful to healthy liver cells, they effectively triggered cell death in lung cancer cells, reducing tumor growth and suppressing migration.
Our findings suggest that these selenium nanoparticles could be a promising and safe avenue for lung cancer treatment.
Although the nanoparticles were not harmful to healthy liver cells, they effectively triggered cell death in lung cancer cells, reducing tumor growth and suppressing migration.
Our findings suggest that these selenium nanoparticles could be a promising and safe avenue for lung cancer treatment.
7.5
Cancer prevention focus
Most Useful Review
12 people found this helpful
The antioxidant properties of selenium, especially in combination with amino acids, are significant for cancer patients. I decided to purchase it after reading Professor Tokumi Fujikawa's work, highlighting selenium's role beyond vitamin C and E. Its small, easy-to-swallow veggie capsule is advantageous. The higher ingredient content compared to Japanese supplements makes it effective. Though my cancer is nearly in remission, I will continue its use to prevent recurrence.
Vitamins
9
Vitamin D and cisplatin synergy
We explored whether adding vitamin D to cisplatin treatment could be a more effective strategy against non-small cell lung cancer (NSCLC). This research focused on how these treatments affect certain critical cellular pathways involved in cancer progression.
The study tested the impact of vitamin D on various cancer cell lines, highlighting that H1299 and A549 cells were particularly responsive. Using techniques like the sulforhodamine-B assay, we discovered that vitamin D treatment significantly altered the expression of genes linked to cancer growth and spread, such as JAK2, STAT3, TGF-β, and SMAD4.
Moreover, when we combined vitamin D with cisplatin, there was a notable decrease in the activity of proteins associated with cancer cell migration and invasion. This combination therapy seems promising as it potentially targets the genes and proteins that enable lung cancer cells to thrive and spread. Overall, the results suggest that vitamin D could enhance the anticancer effects of cisplatin, opening doors for improved treatment strategies for lung cancer patients.
The study tested the impact of vitamin D on various cancer cell lines, highlighting that H1299 and A549 cells were particularly responsive. Using techniques like the sulforhodamine-B assay, we discovered that vitamin D treatment significantly altered the expression of genes linked to cancer growth and spread, such as JAK2, STAT3, TGF-β, and SMAD4.
Moreover, when we combined vitamin D with cisplatin, there was a notable decrease in the activity of proteins associated with cancer cell migration and invasion. This combination therapy seems promising as it potentially targets the genes and proteins that enable lung cancer cells to thrive and spread. Overall, the results suggest that vitamin D could enhance the anticancer effects of cisplatin, opening doors for improved treatment strategies for lung cancer patients.
9
Immune system support
Most Useful Review
16 people found this helpful
I took Mega-Zim to replace the German Wobenzym and found it effective due to its enzyme composition. I consumed 20 tablets daily for 10 days. The enzymes expose lung cancer cells to the immune system, aiding in combating the disease. I always took it before meals with warm water. I'm pleased with the quality and results. I recommend it for anyone in a similar situation.
Green Tea Extract
9
We explored how high-dose ascorbic acid, commonly known as vitamin C, can enhance the effectiveness of anti-PD1 therapy in treating non-small cell lung cancer (NSCLC). Through a combination of laboratory and animal studies, we aimed to understand if this vitamin could help overcome challenges that some patients face with immunotherapy resistance.
Our findings showed that when we pretreat lung cancer cells with high doses of vitamin C, they become more sensitive to the immune system's attacks. Specifically, we observed that vitamin C intensified the ability of CD8+ T cells—key players in the body's immune response—to destroy cancer cells. The results were particularly striking when vitamin C was combined with anti-PD1 therapy, significantly boosting tumor-killing effects and enhancing immune activity.
Additionally, our analysis revealed that vitamin C treatment altered various immune-related pathways, potentially improving the overall anti-tumor response. This suggests that high-dose vitamin C could serve as a valuable ally in lung cancer therapy, particularly in aiding the effects of established immunotherapies like anti-PD1.
The insights from this study could lead to new strategies for enhancing treatment options for patients battling lung cancer, promising a more effective approach in utilizing immune therapies.
Our findings showed that when we pretreat lung cancer cells with high doses of vitamin C, they become more sensitive to the immune system's attacks. Specifically, we observed that vitamin C intensified the ability of CD8+ T cells—key players in the body's immune response—to destroy cancer cells. The results were particularly striking when vitamin C was combined with anti-PD1 therapy, significantly boosting tumor-killing effects and enhancing immune activity.
Additionally, our analysis revealed that vitamin C treatment altered various immune-related pathways, potentially improving the overall anti-tumor response. This suggests that high-dose vitamin C could serve as a valuable ally in lung cancer therapy, particularly in aiding the effects of established immunotherapies like anti-PD1.
The insights from this study could lead to new strategies for enhancing treatment options for patients battling lung cancer, promising a more effective approach in utilizing immune therapies.
7.5
Breast cancer reduction
Most Useful Review
7 people found this helpful
Green tea is renowned as a beauty drink for women, aiding in weight loss and slowing the body's ageing process due to its antioxidants. It significantly reduces the risk of breast cancer by 20-30% with regular consumption.
N Acetyl Cysteine Nac
9.5
We explored the effects of modified β-glucan derivatives from Saccharomyces cerevisiae on lung cancer. The study revealed promising results for a sulfated derivative (SCGS), which showed strong anti-tumor and anti-metastatic properties.
In a mouse model, SCGS significantly inhibited lung metastasis, reducing tumor nodules by 86.7% and enhancing immune response. These findings suggest SCGS's potential not only as an effective treatment for metastasis but also for future cancer drug development.
In a mouse model, SCGS significantly inhibited lung metastasis, reducing tumor nodules by 86.7% and enhancing immune response. These findings suggest SCGS's potential not only as an effective treatment for metastasis but also for future cancer drug development.
9
Energises lungs
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140 people found this helpful
NAC is a top-notch antioxidant, particularly beneficial for lung health. It effectively cleanses the lungs, especially for smokers or those with lung issues. I always take it on an empty stomach and feel revitalised afterward.
Quercetin
9
We explored how high-dose ascorbic acid, commonly known as vitamin C, can enhance the effectiveness of anti-PD1 therapy in treating non-small cell lung cancer (NSCLC). Through a combination of laboratory and animal studies, we aimed to understand if this vitamin could help overcome challenges that some patients face with immunotherapy resistance.
Our findings showed that when we pretreat lung cancer cells with high doses of vitamin C, they become more sensitive to the immune system's attacks. Specifically, we observed that vitamin C intensified the ability of CD8+ T cells—key players in the body's immune response—to destroy cancer cells. The results were particularly striking when vitamin C was combined with anti-PD1 therapy, significantly boosting tumor-killing effects and enhancing immune activity.
Additionally, our analysis revealed that vitamin C treatment altered various immune-related pathways, potentially improving the overall anti-tumor response. This suggests that high-dose vitamin C could serve as a valuable ally in lung cancer therapy, particularly in aiding the effects of established immunotherapies like anti-PD1.
The insights from this study could lead to new strategies for enhancing treatment options for patients battling lung cancer, promising a more effective approach in utilizing immune therapies.
Our findings showed that when we pretreat lung cancer cells with high doses of vitamin C, they become more sensitive to the immune system's attacks. Specifically, we observed that vitamin C intensified the ability of CD8+ T cells—key players in the body's immune response—to destroy cancer cells. The results were particularly striking when vitamin C was combined with anti-PD1 therapy, significantly boosting tumor-killing effects and enhancing immune activity.
Additionally, our analysis revealed that vitamin C treatment altered various immune-related pathways, potentially improving the overall anti-tumor response. This suggests that high-dose vitamin C could serve as a valuable ally in lung cancer therapy, particularly in aiding the effects of established immunotherapies like anti-PD1.
The insights from this study could lead to new strategies for enhancing treatment options for patients battling lung cancer, promising a more effective approach in utilizing immune therapies.
9
Recommended brand
Most Useful Review
17 people found this helpful
My doctor, a leading oncologist, recommended the Jarrow brand for my treatment for prostate cancer. He stated it is the brand that most accurately reflects its label.
Oregano Oil Supplements
8
We investigated how the methanol extract of Origanum syriacum, commonly known as oregano, affects lung cancer cells, particularly A549 cells. Our study aimed to understand whether this natural extract could suppress cell growth and induce programmed cell death, or apoptosis, which is crucial in targeting cancer cells.
We first checked the cell viability of A549 cells after exposure to various concentrations of oregano extract. Our observations revealed that higher concentrations led to a notable decline in cell growth and prompted significant changes in cell structure. At the 200 mg/ml dose, many cell membranes appeared to break down, indicating a strong response to the treatment.
Moreover, at a lower dose of 25 μg/ml, we noted an increase in Bax expression—a protein that promotes apoptosis—as well as a rise in late apoptotic cells. We also identified key phenolic compounds like vanillic acid and luteolin in the extract, which may contribute to its beneficial effects.
Overall, the evidence suggests that oregano extract can effectively block lung cancer cell growth and induce apoptosis, showcasing its potential as a natural therapeutic agent.
We first checked the cell viability of A549 cells after exposure to various concentrations of oregano extract. Our observations revealed that higher concentrations led to a notable decline in cell growth and prompted significant changes in cell structure. At the 200 mg/ml dose, many cell membranes appeared to break down, indicating a strong response to the treatment.
Moreover, at a lower dose of 25 μg/ml, we noted an increase in Bax expression—a protein that promotes apoptosis—as well as a rise in late apoptotic cells. We also identified key phenolic compounds like vanillic acid and luteolin in the extract, which may contribute to its beneficial effects.
Overall, the evidence suggests that oregano extract can effectively block lung cancer cell growth and induce apoptosis, showcasing its potential as a natural therapeutic agent.
7.5
Reduces lung infection
Most Useful Review
42 people found this helpful
Fun fact: The ancient Greeks used Oregano oil as an antidote! The manufacturer recommends 1 softgel 1–3 times daily. Oregano is an effective natural antibiotic. During my illness, my husband and I took numerous IHERB supplements, but Oregano twice daily was essential! Combined with other treatments, it prevented the virus from infecting my lungs, resulting in a "mild form" of the disease. It can sometimes cause belching, but that doesn't happen constantly. Even children can swallow the small gelatine capsules. I suggest starting Oregano in autumn or winter; it has helped our family immensely!
Milk Thistle Silymarin
7
We explored the effects of silibinin, a compound derived from milk thistle, on the transcription factor ID3, which is known to promote cancer metastasis. Through various methods, including bioinformatics and lab assays, we assessed how silibinin could inhibit ID3 in non-small cell lung cancer (NSCLC) models.
Our findings suggest that while ID3 is difficult to target, silibinin shows promise as a potential treatment to reduce metastatic spread in lung cancer. This reveals an exciting avenue for further research into using silibinin as a therapeutic option.
Our findings suggest that while ID3 is difficult to target, silibinin shows promise as a potential treatment to reduce metastatic spread in lung cancer. This reveals an exciting avenue for further research into using silibinin as a therapeutic option.
9
Liver function improvement
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1 people found this helpful
My sister is undergoing chemotherapy for lung cancer. Her liver enzyme levels increased after starting treatment, but after I suggested this product, her doctor prescribed it too. Now, her liver function is normal, and the chemotherapy is effective for her lung cancer.
Broccoli
7
We evaluated whether broccoli-derived vesicles (BDVs) could impact cancer cell activity, specifically in lung cancer. Using an in vitro setup, we isolated BDVs, tested their effects on different cancer cell lines, and measured various indicators of cell metabolism and antioxidant activity.
While BDVs showed some ability to reduce harmful reactive oxygen species in certain cell types, we found that their overall anti-cancer effects were not consistently significant, particularly in lung adenocarcinoma cells. More research is needed to fully understand these vesicles' potential for treatment.
While BDVs showed some ability to reduce harmful reactive oxygen species in certain cell types, we found that their overall anti-cancer effects were not consistently significant, particularly in lung adenocarcinoma cells. More research is needed to fully understand these vesicles' potential for treatment.
9
Inflammation reduction
Most Useful Review
3 people found this helpful
Broccoli sprouts are effective in cancer prevention and reducing digestive inflammation. Sulforaphane induces cancer cell apoptosis and diminishes DNA damage. These vegetable capsules serve as a convenient and beneficial alternative for me, as they help maintain intestinal health and prevent cancer.
Enzymes
9
Cardiovascular improvement
Most Useful Review
47 people found this helpful
Nattokinase has significantly improved my cardiovascular health. After taking it, I felt more energetic and my blood viscosity seems to have decreased, potentially reducing the risk of lung cancer. This natural alternative to aspirin has no side effects, and I appreciate that it’s safe for long-term use.
9
Dissolved scar tissue
Most Useful Review
26 people found this helpful
I recently recovered from a lung biopsy and experienced hard knots of scar tissue in my chest even four months post-surgery. After taking serrapeptase for two to three weeks, the scar tissue dissolved, and the tightness disappeared. Now, I hardly feel I underwent surgery. The biopsy indicated I had pulmonary fibrosis, but I am now breathing much clearer than I have in the past two years.
Elderberry Sambucus
9
Enhanced lung function
Most Useful Review
My experience with Gaia Herbs Rapid Relief Black Elderberry Syrup has been excellent. iHerb provided timely delivery and the product was in perfect condition. After my 4-year-old daughter had bronchial pneumonia last winter, I sought a natural remedy to help restore her lung function. This syrup significantly helped us, keeping colds and flus at bay for the rest of winter. I also appreciate the bulk order option from iHerb. Thank you, iHerb! Lynne Williams, Western Australia.
7.5
Boosted immune system
Most Useful Review
1 people found this helpful
I love Gaia Herbs Black Elderberry Syrup due to its numerous benefits. The packaging is great, and it boosted my immune system while helping to clear my lungs. It’s an excellent supplement with a lovely taste and highly beneficial. This is a must-have for enhancing your respiratory health. If asthma and bronchitis are concerns, I recommend trying it today! I adore iHerb for the excellent quality and swift delivery. It's my go-to for all herbal product purchases.
Tea Tree Oil
9
Super effective oil
Most Useful Review
Very good; this essential oil is highly effective for treating lung infections. It's the most frequently used essential oil in my life.
9
Cleans lungs well
Most Useful Review
I always keep tea tree oil in my medicine cabinet: for acne, herpes, and insect bites. I also add it to clay masks for an antibacterial effect and use it in baths with salt to clean my nose and lungs, which is also crucial. If my review proved useful, please leave "YES" and you’ll receive a plus karma.
Astragalus
9
Increases energy
Most Useful Review
4 people found this helpful
This Astragalus extract offers me extra energy during my cancer treatments.
7.5
Improves lung function
Most Useful Review
7 people found this helpful
Excellent product! As a former smoker of 35 years, I've taken this product to enhance my lung function. I would recommend it to anyone with a history of smoking.
Melatonin
9
Apoptosis assistance
Most Useful Review
I take it for cancer purposes, as numerous studies indicate that high dosages (up to 160mg) aid in apoptosis. I recommend increasing the dosage gradually and consulting your doctor about higher amounts, as no side effects were noted.
7.5
Minimising risk
Most Useful Review
1 people found this helpful
I bought this for its potential anti-metastatic properties. Studies suggest that a dose of 20mg per night may reduce the incidence of metastases, particularly in kidney and breast cancer.
Spirulina
10
Improved health status
Most Useful Review
I have consumed spirulina for three years. In my mid-twenties, following a bout of chickenpox, I struggled with weight. During the pandemic, I started taking spirulina and gradually gained some weight, also alleviating issues like hair loss and brittle nails. Recently, my mother was diagnosed with cancer. After her hemoglobin level dropped to 64 during radiation therapy, she began taking spirulina and remarkably raised it to 120 in just two days. The doctor was astounded. We remain hopeful for progress!
7.5
Women's health benefits
Most Useful Review
I purchased it due to its benefits for women's health. It possesses numerous anti-cancer and anti-ageing properties. Consistent consumption is necessary.
Mullein
9
Instant asthma relief
Most Useful Review
5 people found this helpful
This product is amazing; it stops my son's asthmatic coughing almost immediately! My husband takes it too and feels it clearing his lungs. Really great stuff!
9
Effective lung clearing
Most Useful Review
1 people found this helpful
This works better than guaifenesin for clearing out the lungs. I'm a huge fan and have already purchased a few bottles. I'm buying more now!
Peppermint Oil
7.5
Lung recovery
Most Useful Review
1 people found this helpful
My experience with this product has been positive, as I feel a sense of lung recovery. I also consumed it in a warm mint drink, hoping to see beneficial effects for my colon issues.
7.5
Helps breathing
Most Useful Review
This peppermint oil is excellent. I apply it to my chest and back when my lungs are congested, and I also use it on my sinuses to clear the nasal passages.
Ginkgo Biloba
9
Supports cancer recovery
Most Useful Review
2 people found this helpful
Following a serious head injury, I took Ginkgo biloba sent by a friend from Japan to improve my memory and concentration. I noticed improvements within a few weeks. This supplement has a wide range of health benefits, including fighting lung cancer and boosting metabolism, which is vital for healthy ageing. I feel calmer and more focused, and headaches have diminished significantly. I highly recommend this supplement for enhanced brain function and overall health.
7.5
Cancer treatment benefits
Most Useful Review
3 people found this helpful
The Ginkgo biloba extract has been utilised in traditional Chinese medicine for its benefits to memory and overall well-being. It's effective in treating conditions such as lung cancer and is included in several pharmaceuticals. The extract promotes blood flow to the brain and supports cellular growth, aiding in the prevention and treatment of serious diseases, including cancer. It also improves vascular elasticity and is beneficial in cognitive decline associated with Alzheimer's disease.