Tumeric
9
Tetrahydrocurcumin mitigates liver fat
Tetrahydrocurcumin Alleviates Metabolic Dysfunction-Associated Steatohepatitis in Mice by Regulating Serum Lipids, Bile Acids, and Gut Microbiota.
Most Relevant Research
We investigated the effects of Tetrahydrocurcumin (THC) on metabolic dysfunction-related liver conditions in mice. The study involved feeding C57BL/6 mice a methionine-choline-deficient diet for eight weeks to create a model of metabolic dysfunction known as MASH. We compared the impacts of THC with a positive control, obeticholic acid, to see how well THC could alleviate the harmful effects of this diet.
Our findings indicated that THC significantly reduced oxidative stress and fat buildup in the liver. Additionally, it brought down liver triglyceride levels while improving overall liver health in the treated mice. Importantly, THC appeared to correct 34 different abnormalities in lipid levels caused by the diet, leading to changes in gut bacteria that are beneficial for health.
We saw an increase in the diversity and abundance of good bacteria in the intestines, which can aid in metabolic processes. THC also helped lower the levels of certain harmful bile acids in the serum. At the molecular level, THC downregulated genes related to fat production in the liver while enhancing those that aid in bile acid secretion.
Overall, we observed that THC potentially lessens the effects of diet-induced MASH by inhibiting fat synthesis, regulating bile acid levels, and promoting healthy gut flora. This study uncovers new mechanisms by which THC may be effective and suggests future directions for anti-MASH drug development, supporting the screening of clinical biomarkers for personalized diagnosis and treatment options.
Our findings indicated that THC significantly reduced oxidative stress and fat buildup in the liver. Additionally, it brought down liver triglyceride levels while improving overall liver health in the treated mice. Importantly, THC appeared to correct 34 different abnormalities in lipid levels caused by the diet, leading to changes in gut bacteria that are beneficial for health.
We saw an increase in the diversity and abundance of good bacteria in the intestines, which can aid in metabolic processes. THC also helped lower the levels of certain harmful bile acids in the serum. At the molecular level, THC downregulated genes related to fat production in the liver while enhancing those that aid in bile acid secretion.
Overall, we observed that THC potentially lessens the effects of diet-induced MASH by inhibiting fat synthesis, regulating bile acid levels, and promoting healthy gut flora. This study uncovers new mechanisms by which THC may be effective and suggests future directions for anti-MASH drug development, supporting the screening of clinical biomarkers for personalized diagnosis and treatment options.
8.8
Reduces inflammation
Most Useful Review
The benefit of curcumin is its ability to reduce chronic inflammation, which can lead to metabolic disorders, including obesity. It also positively affects arthritis patients by alleviating joint swelling. Regular use of curcumin notably decreases the risk of liver diseases and mitigates symptoms of conditions like hepatitis, diabetes, and periodontitis.
Vitamins
8
Vitamin D reduces triglycerides effectively
Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials.
Most Relevant Research
We explored the effects of vitamin D supplementation on lipid profiles in overweight and obese women. Our investigation included data from various randomized controlled trials (RCTs) that specifically examined how vitamin D might influence cholesterol and triglyceride levels in this population.
Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL.
Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group.
Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides.
Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL.
Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group.
Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides.
8.8
Improves obesity issues
Most Useful Review
Vitamin D3 deficiency is prevalent and affects many people. It can arise from various factors such as poor sunlight exposure and genetic issues. When taking vitamin D, start with small doses if you have anaemia. It’s advisable for seniors with gastrointestinal issues to use sublingual forms for better absorption. For breastfeeding mothers, ensure optimal levels before dosing infants. Those with obesity may need nearly double the recommended dose, and adequate levels of magnesium and vitamin A are vital.
Polygonum Cuspidatum Complex
8.8
Improves diabetes control
Most Useful Review
Resveratrol is a powerful antioxidant. I've noticed its effects in reducing skin ageing and the risk of cancer. After taking it, my circulation improved, and it reduced my risk of Alzheimer's disease. Daily use increased my insulin secretion, which has helped with obesity and diabetes.
8.8
Aids weight loss
Most Useful Review
I have taken resveratrol multiple times, and it aids my weight loss and decreases cravings for sweets. I've also given it to my father, who has significant obesity and heart issues. I genuinely hope it helps him control his sugar levels.
Fish Oil
8
Eicosapentaenoic Acid Enhances Insulin Sensitivity
Fish Oil and EPA Improve Insulin Sensitivity, in Part Through Adipocyte mTORC2 Activation in Diet-Induced Obese Male Mice.
Most Relevant Research
We investigated how eicosapentaenoic acid (EPA), a key component of fish oil, affects insulin sensitivity and glucose metabolism, especially in the context of high-fat diets. The study involved male mice that either had or lacked a specific protein called Rictor, associated with a pathway known to influence cellular functions.
Our findings revealed that a diet rich in fish oil significantly enhanced glucose tolerance and insulin sensitivity in these mice. Moreover, the intake of fish oil resulted in better glucose uptake in both adipose (fat) tissues and skeletal muscle, all while reducing the liver's glucose production. This improvement was marked by lower levels of insulin in the bloodstream and an increase in the phosphorylation of a protein called Akt in the fat tissues, suggesting a key role for mTORC2 activation.
Interestingly, when the mice were fed a high-fat diet supplemented with EPA, we noticed an increase in insulin sensitivity and Akt phosphorylation, although this supplementation did not significantly improve overall glucose tolerance. This suggests that while EPA promotes insulin sensitivity via mTORC2, the enhancement of glucose tolerance observed with fish oil seems to arise from other mechanisms in the body, particularly in the muscles and liver.
Our study highlights how EPA can contribute to better metabolic health by improving how the body manages insulin and glucose, particularly for those consuming high-fat diets.
Our findings revealed that a diet rich in fish oil significantly enhanced glucose tolerance and insulin sensitivity in these mice. Moreover, the intake of fish oil resulted in better glucose uptake in both adipose (fat) tissues and skeletal muscle, all while reducing the liver's glucose production. This improvement was marked by lower levels of insulin in the bloodstream and an increase in the phosphorylation of a protein called Akt in the fat tissues, suggesting a key role for mTORC2 activation.
Interestingly, when the mice were fed a high-fat diet supplemented with EPA, we noticed an increase in insulin sensitivity and Akt phosphorylation, although this supplementation did not significantly improve overall glucose tolerance. This suggests that while EPA promotes insulin sensitivity via mTORC2, the enhancement of glucose tolerance observed with fish oil seems to arise from other mechanisms in the body, particularly in the muscles and liver.
Our study highlights how EPA can contribute to better metabolic health by improving how the body manages insulin and glucose, particularly for those consuming high-fat diets.
9.5
Skin improvement
Most Useful Review
I found this omega-3 to be delightful with no off-putting smells. After a monthly course, my skin improved significantly, and it effectively lowers the risk of cardiovascular diseases and obesity. I recommend it highly!
Coenzyme Q10
8
Co-Q10 enhances cognitive function
The Impact of Coenzyme Q10 on Cognitive Dysfunction, Antioxidant Defense, Cholinergic Activity, and Hippocampal Neuronal Damage in Monosodium Glutamate-Induced Obesity.
Most Relevant Research
We explored the impact of coenzyme Q10 (Co-Q10) on cognitive function and neuronal health in rats made obese by monosodium glutamate (MSG) exposure. This study involved forty-eight neonatal male Wistar rats divided into four groups: a control group, a group receiving MSG, and two groups treated with different dosages of Co-Q10.
The findings are impressive. Co-Q10 not only helped improve cognitive function but also showed protective effects on the hippocampus, a crucial brain region for memory. By enhancing antioxidant defenses and reducing harmful neuronal damage, Co-Q10 appears to offer a promising approach to addressing cognitive issues associated with obesity.
We conducted various tests to assess memory and learning performance, which showed notable improvements in the rats treated with Co-Q10. Additionally, we observed a significant reduction in the levels of markers associated with oxidative stress and cell damage in the hippocampus. Overall, these results suggest that Co-Q10 holds potential as a supportive treatment for cognitive deficits linked to obesity.
The findings are impressive. Co-Q10 not only helped improve cognitive function but also showed protective effects on the hippocampus, a crucial brain region for memory. By enhancing antioxidant defenses and reducing harmful neuronal damage, Co-Q10 appears to offer a promising approach to addressing cognitive issues associated with obesity.
We conducted various tests to assess memory and learning performance, which showed notable improvements in the rats treated with Co-Q10. Additionally, we observed a significant reduction in the levels of markers associated with oxidative stress and cell damage in the hippocampus. Overall, these results suggest that Co-Q10 holds potential as a supportive treatment for cognitive deficits linked to obesity.
8.8
Improved energy levels
Most Useful Review
Coenzyme Q10 is a compound produced by the liver that stimulates ATP production, the body's primary energy source. Its levels decline with age, necessitating additional intake, especially for older individuals. I've taken it for five days and noticed more energy, improved mood, and enhanced productivity. I recommend this excellent supplement from Doctor's Best!