Best Supplements for Obesity

Products best matching Obesity

Product	Science Score	User Score
Turmeric Curcumin
Jarrow Formulas, Curcumin 95, Turmeric Extract, 500 mg, 120 Veggie Capsules	8.6	8.2
9 Turmeric nanovesicles aid obesity treatment Development and Evaluation of Reconstructed Nanovesicles from Turmeric for Multifaceted Obesity Intervention. Wang J, Zhang T, Gu R, Ke Y, Zhang S, et al. Development and Evaluation of Reconstructed Nanovesicles from Turmeric for Multifaceted Obesity Intervention. ACS Nano. 2024;18:23117. doi:10.1021/acsnano.4c05309 We explored the potential of turmeric in challenging obesity, driven by its natural properties and numerous health benefits. Our focus was on a newly developed formulation called "Reconstructed Turmeric-derived Nanovesicles" (Rec-tNVs), which aimed to enhance the effects of curcumin, the active component of turmeric. By using advanced techniques, we increased the curcumin content significantly in these nanovesicles, allowing us to measure their impact more effectively. The Rec-tNVs showed a remarkable capacity to promote fat breakdown and prevent fat creation in fat cells, while also encouraging the conversion of fat cells to a more metabolically active form. In rigorous tests involving high-fat diet mouse models, we observed weight reductions of about 18.68% and 14.56% with intragastric and subcutaneous delivery of the Rec-tNVs, respectively, over four weeks. Importantly, these results were better than what we saw with free curcumin treatment alone, suggesting that these nanovesicles could target fat tissues effectively and influence overall metabolism and gut health. This study highlights the multi-dimensional benefits of turmeric and opens doors for new plant-based treatments for obesity. It's an exciting step forward in the quest for safer weight management solutions. 7.5 Reduces inflammation Most Useful Review 1 people found this helpful The benefit of curcumin is its ability to reduce chronic inflammation, which can lead to metabolic disorders, including obesity. It also positively affects arthritis patients by alleviating joint swelling. Regular use of curcumin notably decreases the risk of liver diseases and mitigates symptoms of conditions like hepatitis, diabetes, and periodontitis.
Milk Thistle Silymarin
NOW Foods, Milk Thistle Extract, Double Strength, 300 mg, 200 Veg Capsules	7.9	8.3
8 Silymarin reduces obesity effects Silymarin Prevents High-Fat Diet-Induced Muscle Atrophy by Regulating Protein Degradation and Synthesis in Mice. Kim S, You Y, Kim OK, Lee J, Chung JW, et al. Silymarin Prevents High-Fat Diet-Induced Muscle Atrophy by Regulating Protein Degradation and Synthesis in Mice. J Med Food. 2022;25:793. doi:10.1089/jmf.2021.K.0175 We explored how silymarin helps with obesity and muscle atrophy in mice. In our study, we divided the mice into three groups: a control group on a normal diet, another group on a high-fat diet, and a third group receiving silymarin alongside the high-fat diet. The results showed that the silymarin group had less weight gain and maintained better muscle mass compared to the high-fat diet group. Moreover, the grip strength of the mice on silymarin improved. Overall, silymarin seems beneficial for not only tackling obesity but also preserving muscle health. 9 Enhanced energy levels Most Useful Review 6 people found this helpful Initially sceptical, I found Silymarin effective for my fatty liver caused by obesity. Within two weeks, my GGT levels decreased by 20, and I feel significantly better—more energetic and free from heartburn. I’m pleased with the results from taking two capsules daily.
Prebiotic Fiber Inulin
NOW Foods, Certified Organic Inulin, Prebiotic Pure Powder, 8 oz (227 g)	7.7	8.3
8 Chicory ITFs aid weight management The effects of chicory inulin-type fructans supplementation on weight management outcomes: systematic review, meta-analysis, and meta-regression of randomized controlled trials. Reimer RA, Theis S, Zanzer YC. The effects of chicory inulin-type fructans supplementation on weight management outcomes: systematic review, meta-analysis, and meta-regression of randomized controlled trials. Am J Clin Nutr. 2024;120:1245. doi:10.1016/j.ajcnut.2024.09.019 We examined how inulin-type fructans (ITFs) from chicory can help manage weight. In a thorough systematic review that considered studies up until early 2023, we identified 32 trials that looked at the effects of chicory ITF supplementation on various weight-related outcomes. The results were promising. Participants taking chicory ITFs experienced a significant reduction in body weight, with an average loss of about 0.97 kg compared to those receiving a placebo. We also noted decreases in body mass index (BMI), fat mass, and waist circumference. For those who continued the supplementation for more than eight weeks, there was an additional reduction in body fat percentage. Interestingly, we did not find that the type of ITF or the dosage significantly affected these outcomes. Moreover, these benefits appeared consistent regardless of participants' health status. However, we should mention that there was notable variability in the results for body weight and body fat percentage, which suggests some differences in individual responses to the treatment. 9 Effective pairing Most Useful Review Excellent! Combining inulin with probiotics proves very effective for visceral obesity.
Inositol
NOW Foods, Choline & Inositol, 100 Veg Capsules	7.8	8.2
8 Inositol's role in diet-induced obesity Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice. Stilgenbauer L, Chen Q, Pungi D, James N, Jayarathne H, et al. Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice. Mol Metab. 2025;95:102128. doi:10.1016/j.molmet.2025.102128 We examined the impact of a key sensor of endoplasmic reticulum stress, IRE1α, on obesity related to high-fat diets. By removing IRE1α specifically in microglial cells in male mice, we noticed a significant decrease in inflammation and metabolic dysfunction associated with diet-induced obesity. The results revealed that deleting IRE1α helped protect these male mice from weight gain and glucose intolerance. However, similar benefits were not found in female mice, indicating a gender-specific response to IRE1α deletion. 8 Improves stress resilience Most Useful Review Choline and inositol, belonging to the B vitamin group, significantly influence brain and nervous system health. Choline (vitamin B4) supports cognitive function, helps manage stress, and prevents depression. It promotes sleep quality and regulates glucose levels to avert diabetes. Additionally, choline boosts metabolism and liver function, aiding in obesity prevention. Inositol (vitamin B8) enhances brain performance and counters fatigue, helping maintain proper metabolism while benefitting skin health as well.
NOW Foods, Inositol Capsules, 500 mg, 100 Veg Capsules	7.8	7.9
8 Inositol's role in diet-induced obesity Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice. Stilgenbauer L, Chen Q, Pungi D, James N, Jayarathne H, et al. Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice. Mol Metab. 2025;95:102128. doi:10.1016/j.molmet.2025.102128 We examined the impact of a key sensor of endoplasmic reticulum stress, IRE1α, on obesity related to high-fat diets. By removing IRE1α specifically in microglial cells in male mice, we noticed a significant decrease in inflammation and metabolic dysfunction associated with diet-induced obesity. The results revealed that deleting IRE1α helped protect these male mice from weight gain and glucose intolerance. However, similar benefits were not found in female mice, indicating a gender-specific response to IRE1α deletion. 9 Improves overall wellbeing Most Useful Review 3 people found this helpful This wonderful drug is effective for carbohydrate metabolism disorders, obesity, and liver conditions. It speeds up metabolism and enhances reproductive function. Taken alone and in combination with choline inositol and l-methionine, I experienced improved health, reduced sweet cravings, and steady weight loss over time.
Vitamins
NOW Foods, Vitamin D-3, Max Potency, 50,000 IU, 50 Softgels	7.6	8.2
8 Vitamin D reduces triglycerides effectively Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. doi:10.1093/nutrit/nuae226 We explored the effects of vitamin D supplementation on lipid profiles in overweight and obese women. Our investigation included data from various randomized controlled trials (RCTs) that specifically examined how vitamin D might influence cholesterol and triglyceride levels in this population. Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL. Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group. Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides. 9 Essential for health Most Useful Review Very useful! I cannot do without vitamin D. I highly recommend it for those suffering from unexplained obesity, fatigue, lethargy, and weak muscles and bones.
NOW Foods, Vitamin D-3, High Potency, 5,000 IU, 120 Softgels	7.6	7.9
8 Vitamin D reduces triglycerides effectively Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. doi:10.1093/nutrit/nuae226 We explored the effects of vitamin D supplementation on lipid profiles in overweight and obese women. Our investigation included data from various randomized controlled trials (RCTs) that specifically examined how vitamin D might influence cholesterol and triglyceride levels in this population. Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL. Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group. Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides. 9 Boosts overall health Most Useful Review I find this vitamin D to be an effective product. The 5,000 IU dosage suits my needs perfectly. While taking it, I was ill only once, which I attribute to my use of vitamin D, especially while working in a hospital environment during colds and Covid-19.
NOW Foods, Super Omega 3-6-9, 1,200 mg, 90 Softgels	N/A	8.2

Omega 3 Fish Oil
NOW Foods, Omega-3 Fish Oil, 1,000 mg, 180 EPA - 120 DHA, 100 Softgels	7.6	8.1
8 Eicosapentaenoic Acid Reduces Obesity EPA/DHA but Not ALA Reduces Visceral Adiposity and Adipocyte Size in High Fat Diet-Induced Obese Delta-6 Desaturase Knockout Mice. Smorenburg JN, Hodun K, McTavish PV, Wang C, Pinheiro MA, et al. EPA/DHA but Not ALA Reduces Visceral Adiposity and Adipocyte Size in High Fat Diet-Induced Obese Delta-6 Desaturase Knockout Mice. Mol Nutr Food Res. 2025;69:e202400721. doi:10.1002/mnfr.202400721 In our exploration of omega-3 fatty acids, we aimed to understand how eicosapentaenoic acid (EPA), compared to α-linolenic acid (ALA), impacts obesity, particularly in a specific mouse model designed for this purpose. We fed both wildtype and delta-6 desaturase knockout (KO) mice a high-fat diet rich in different fats over a period of 21 weeks. These diets included lard, which contains no omega-3s, flaxseed (rich in ALA), and menhaden fish oil (rich in EPA and docosahexaenoic acid, DHA). What we found was quite revealing. While the final body weights of the mice did not vary significantly, those fed menhaden oil experienced reduced epididymal white adipose tissue (eWAT) weight, smaller adipocyte sizes, and lower triacylglycerol (TAG) content compared to those on a lard diet. Interestingly, the eWAT of flaxseed-fed wildtype mice showed similar improvements as those on menhaden oil, but this positive effect did not extend to the KO mice, which exhibited characteristics more similar to the lard group. It's important to note that despite these differences in adipose characteristics, we did not observe any changes in inflammatory markers between the different groups. This suggests that while a diet enriched in EPA/DHA may help reduce fat storage and cell size, it does not appear to influence inflammatory responses in this particular model of obesity. Overall, this study highlights the specific benefits of EPA/DHA in addressing obesity-related issues without exacerbating inflammation. 9 Skin improvement Most Useful Review I found this omega-3 to be delightful with no off-putting smells. After a monthly course, my skin improved significantly, and it effectively lowers the risk of cardiovascular diseases and obesity. I recommend it highly!
Other
NOW Foods, Sunflower Lecithin, 1,200 mg, 200 Softgels	N/A	8.6
9 Ideal for families Most Useful Review I've purchased this vitamin for three years; it's perfect for our family, particularly for those facing liver, pancreatic, and intestinal issues, as well as obesity. Lecithin effectively breaks down liver fat, lowers cholesterol, and aids in the functioning of nerve cells. It also assists children with speech disorders and hyperactivity. The natural ingredients and effective dosage show noticeable benefits. 9 Promotes liver health Most Useful Review I have been purchasing this vitamin for a considerable time; it is ideal for the entire family if you face issues with the liver, pancreas, intestines, or obesity. Lecithin is the sole vitamin that effectively breaks down liver fat, lowers cholesterol, aids hormone function, and enhances nerve cell operation. If your children experience speech disorders or hyperactivity, lecithin is essential. The quality is excellent, made from natural ingredients, with a sizeable, swallowable dosage. The benefits are clear, and the taste is neutral. If you find my review helpful, please give it a like.
Jarrow Formulas, Vegan Saccharomyces Boulardii + MOS, 5 Billion CFU, 180 Veggie Capsules	N/A	8.2
7.5 Improves liver health Most Useful Review 238 people found this helpful Bacteria Saccharomyces Boulardii, a unique biological probiotic, is renowned for its beneficial properties in diabetes and obesity. This yeast effectively alters the intestinal microbiota, leading to reduced body fat and improved liver steatosis. It is also used to treat constipation and diarrhoea, as well as fungal infections. 7.5 Easy to consume Most Useful Review 4 people found this helpful Known for its beneficial effects in diabetes and obesity, Saccharomyces Boulardii swiftly alters intestinal microbiota, resulting in lowered body fat and enhanced liver steatosis. Its capsules are of great quality, large yet easy to swallow, contributing to my selection of preferred supplements.
L Taurine
Jarrow Formulas, Taurine , 1,000 mg, 100 Capsules	N/A	8.5
9 Cell regeneration support Most Useful Review I take taurine every morning, 30 minutes before breakfast. It acts as an antioxidant and improves cell regeneration. This supplement is effective in preventing obesity and reducing insulin resistance. 9 Regulates nervous system Most Useful Review I regularly consume taurine as it regulates my nervous system. It serves as a neurotransmitter in the brain, possesses anticonvulsant properties, and stimulates bile acid production since it’s an essential component of bile. Taurine is crucial in regulating fat metabolism, vitamin assimilation, and preventing diabetes and obesity. It also assists with cholesterol regulation. I find it effective and of good quality.
NOW Foods, Double Strength Taurine, 1,000 mg, 250 Veg Capsules	N/A	8.3
7.5 Increases energy Most Useful Review 4 people found this helpful I started taking taurine after learning it could improve obesity and depression. Now, I take one in the morning and one in the evening along with DMAE. I struggled with motivation at work, but taurine has boosted my energy and efficiency. It seems to aid lipid metabolism, so I hope it will help with my diet. 9 Protects against obesity Most Useful Review Good product! Studies indicate that taurine protects against obesity, aids with diabetes, supports cardiovascular health, and increases stamina.
Alpha Lipoic Acid
Doctor's Best, Alpha-Lipoic Acid 600, 600 mg, 180 Veggie Caps	N/A	8.5
9 Reduces threat of obesity Most Useful Review 22 people found this helpful This acid was prescribed to help regulate weight and hormone levels before pregnancy planning. I have diabetes and was classified with "obesity". After treatment, my sugar levels are normal, and I no longer face threats of obesity. The Dukan diet lowered my carbohydrate intake, and ALA has been crucial in helping this transition by softening the fat layers in my body, aiding in achieving a healthier state. 9 Effective for obesity Most Useful Review 12 people found this helpful This dietary supplement has significantly improved my husband's health concerning fatty hepatosis and obesity. It has proven to be an effective treatment, and I would recommend it as an excellent choice for those facing similar issues.
Spirulina
NOW Foods, Certified Organic Spirulina, Double Strength, 1,000 mg, 120 Tablets	N/A	8.5
9 Fights obesity Most Useful Review Прекрасно! Helps fight obesity. Cleans organisms well. 9 Effective for obesity Most Useful Review I will order it again and again. Helps against obesity. Great price.
Acetyl L Carnitine
NOW Foods, Acetyl-L-Carnitine, 500 mg, 200 Veg Capsules	N/A	8.3
9 Vital for energy production Most Useful Review 10 people found this helpful L-carnitine is an essential nutrient for fat burning. In its absence, one may experience fatigue, obesity, elevated blood lipids, and aging. Naturally occurring, it carries fatty acids to the mitochondria. Without sufficient levels, fatty acids accumulate as body fat, which can lead to obesity and related fatigue and muscle weakness. As such, L-carnitine is crucial for people today. 9 Prevents visceral fat Most Useful Review 10 people found this helpful L-carnitine is crucial for fat burning; without it, fatigue, obesity, elevated blood lipids, and aging are possible. It naturally occurs as an amino acid that transports fatty acids to the glands. A deficiency can lead to visceral fat accumulation, fatigue, and muscle weakness, making it an indispensable nutrient.
L Carnitine
NOW Foods, L-Carnitine, 1,000 mg, 50 Tablets	N/A	8.2
7.5 Optimises energy production Most Useful Review The Carnitine Capsules supplement is an excellent aid for exercise and fitness. Carnitine converts fat into energy, enhancing workouts and optimising energy production, which helps manage obesity effectively. However, results can vary based on individual constitution and lifestyle. Consulting a medical professional before beginning carnitine supplementation is advisable. 7.5 Helps burn fat Most Useful Review I take an excellent dietary supplement before training, which aids in burning fat and has helped with obesity.
Quercetin
NOW Foods, Quercetin with Bromelain, 120 Veg Capsules	N/A	8.2
7.5 Healthy weight management Most Useful Review This supplement has assisted in managing a healthy weight and lowered the risk of obesity-related health issues. It is particularly useful for those wanting to control their weight or who are at risk for obesity-related health problems. 7.5 Supports obesity management Most Useful Review I purchased it because quercetin is beneficial for obesity and rhinitis.
Selenium
NOW Foods, Selenium, 100 mcg, 100 Tablets	N/A	8.1
9 Promotes weight loss Most Useful Review It aids weight loss, particularly for those suffering from obesity. Selenium plays a crucial role in producing thyroid hormones that regulate various metabolic processes, including calorie burning. 7.5 Fights inflammation risk Most Useful Review Selenium is a micronutrient with significant antioxidant properties, working alongside vitamin E to protect the body from free radical damage. Easily absorbed, it supports thyroid function, enhances the immune system, reduces cardiovascular disease risks, and detoxifies heavy metals. Furthermore, it may help lower inflammatory processes and oxidative stress linked to metabolic syndrome, which includes obesity, high cholesterol, hypertension, and hyperglycemia. This supplement from NOW is of excellent quality and dosage.
Resveratrol
NOW Foods, Resveratrol, 200 mg, 120 Veg Capsules	N/A	8.1
7.5 Improves diabetes control Most Useful Review 2 people found this helpful Resveratrol is a powerful antioxidant. I've noticed its effects in reducing skin ageing and the risk of cancer. After taking it, my circulation improved, and it reduced my risk of Alzheimer's disease. Daily use increased my insulin secretion, which has helped with obesity and diabetes. 7.5 Aids weight loss Most Useful Review I have taken resveratrol multiple times, and it aids my weight loss and decreases cravings for sweets. I've also given it to my father, who has significant obesity and heart issues. I genuinely hope it helps him control his sugar levels.
Magnesium
Doctor's Best, High Absorption Magnesium, 200 mg, 120 Tablets, (100 mg per Tablet)	N/A	8
9 Thyroid Support Most Useful Review Chromium is vital for normal fat metabolism; a deficiency often leads to excess weight and obesity. It aids the thyroid gland's function, contributes to immune system formation, and influences tissue growth and regeneration. I was prescribed this by my endocrinologist! 7.5 Effective Magnesium Most Useful Review Magnesium aids sleep and alleviates migraines while strengthening bones. It also prevents obesity and diabetes, which is why I regularly take Dr. Best High-Absorption Magnesium. I find it to be quite effective.