L Taurine
9.5
Cell regeneration support
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I take taurine every morning, 30 minutes before breakfast. It acts as an antioxidant and improves cell regeneration. This supplement is effective in preventing obesity and reducing insulin resistance.
9.5
Regulates nervous system
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I regularly consume taurine as it regulates my nervous system. It serves as a neurotransmitter in the brain, possesses anticonvulsant properties, and stimulates bile acid production since it’s an essential component of bile. Taurine is crucial in regulating fat metabolism, vitamin assimilation, and preventing diabetes and obesity. It also assists with cholesterol regulation. I find it effective and of good quality.
Alpha Lipoic Acid
9.5
Reduces threat of obesity
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This acid was prescribed to help regulate weight and hormone levels before pregnancy planning. I have diabetes and was classified with "obesity". After treatment, my sugar levels are normal, and I no longer face threats of obesity. The Dukan diet lowered my carbohydrate intake, and ALA has been crucial in helping this transition by softening the fat layers in my body, aiding in achieving a healthier state.
9.5
Effective for obesity
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This dietary supplement has significantly improved my husband's health concerning fatty hepatosis and obesity. It has proven to be an effective treatment, and I would recommend it as an excellent choice for those facing similar issues.
Spirulina
9.5
Fights obesity
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Прекрасно! Helps fight obesity. Cleans organisms well.
9.5
Effective for obesity
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I will order it again and again. Helps against obesity. Great price.
Acetyl L Carnitine
9.5
Vital for energy production
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L-carnitine is an essential nutrient for fat burning. In its absence, one may experience fatigue, obesity, elevated blood lipids, and aging. Naturally occurring, it carries fatty acids to the mitochondria. Without sufficient levels, fatty acids accumulate as body fat, which can lead to obesity and related fatigue and muscle weakness. As such, L-carnitine is crucial for people today.
9.5
Prevents visceral fat
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L-carnitine is crucial for fat burning; without it, fatigue, obesity, elevated blood lipids, and aging are possible. It naturally occurs as an amino acid that transports fatty acids to the glands. A deficiency can lead to visceral fat accumulation, fatigue, and muscle weakness, making it an indispensable nutrient.
Turmeric Curcumin
9
Tetrahydrocurcumin mitigates liver fat
Tetrahydrocurcumin Alleviates Metabolic Dysfunction-Associated Steatohepatitis in Mice by Regulating Serum Lipids, Bile Acids, and Gut Microbiota.
Most Relevant Research
We investigated the effects of Tetrahydrocurcumin (THC) on metabolic dysfunction-related liver conditions in mice. The study involved feeding C57BL/6 mice a methionine-choline-deficient diet for eight weeks to create a model of metabolic dysfunction known as MASH. We compared the impacts of THC with a positive control, obeticholic acid, to see how well THC could alleviate the harmful effects of this diet.
Our findings indicated that THC significantly reduced oxidative stress and fat buildup in the liver. Additionally, it brought down liver triglyceride levels while improving overall liver health in the treated mice. Importantly, THC appeared to correct 34 different abnormalities in lipid levels caused by the diet, leading to changes in gut bacteria that are beneficial for health.
We saw an increase in the diversity and abundance of good bacteria in the intestines, which can aid in metabolic processes. THC also helped lower the levels of certain harmful bile acids in the serum. At the molecular level, THC downregulated genes related to fat production in the liver while enhancing those that aid in bile acid secretion.
Overall, we observed that THC potentially lessens the effects of diet-induced MASH by inhibiting fat synthesis, regulating bile acid levels, and promoting healthy gut flora. This study uncovers new mechanisms by which THC may be effective and suggests future directions for anti-MASH drug development, supporting the screening of clinical biomarkers for personalized diagnosis and treatment options.
Our findings indicated that THC significantly reduced oxidative stress and fat buildup in the liver. Additionally, it brought down liver triglyceride levels while improving overall liver health in the treated mice. Importantly, THC appeared to correct 34 different abnormalities in lipid levels caused by the diet, leading to changes in gut bacteria that are beneficial for health.
We saw an increase in the diversity and abundance of good bacteria in the intestines, which can aid in metabolic processes. THC also helped lower the levels of certain harmful bile acids in the serum. At the molecular level, THC downregulated genes related to fat production in the liver while enhancing those that aid in bile acid secretion.
Overall, we observed that THC potentially lessens the effects of diet-induced MASH by inhibiting fat synthesis, regulating bile acid levels, and promoting healthy gut flora. This study uncovers new mechanisms by which THC may be effective and suggests future directions for anti-MASH drug development, supporting the screening of clinical biomarkers for personalized diagnosis and treatment options.
8.8
Reduces inflammation
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The benefit of curcumin is its ability to reduce chronic inflammation, which can lead to metabolic disorders, including obesity. It also positively affects arthritis patients by alleviating joint swelling. Regular use of curcumin notably decreases the risk of liver diseases and mitigates symptoms of conditions like hepatitis, diabetes, and periodontitis.
Vitamins
7
Vitamin D3 aids obesity management
Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients.
Most Relevant Research
We set out to investigate how vitamin D3 affects obesity, particularly in obese patients facing obstructive sleep apnea (OSA). Our study included patients who were randomly assigned to receive either dapagliflozin (an SGLT2 inhibitor), vitamin D3, both treatments together, or no treatment at all over a period of 16 weeks.
The focus was on various health parameters such as body measurements, blood sugar levels, cholesterol, liver conditions, and quality of life. We discovered that combining vitamin D3 with SGLT2 inhibitors showed promising results. This combination seemed to improve not just physical health markers but also the overall quality of life in hypertensive, obese individuals with OSA.
By revealing these positive effects, we highlight how vitamin D3 can contribute to better management of obesity-related complications, particularly when paired with SGLT2 inhibitors. Our findings suggest a potential strategy to address the intertwined challenges of obesity, metabolic health, and sleep disturbances in this patient population.
The focus was on various health parameters such as body measurements, blood sugar levels, cholesterol, liver conditions, and quality of life. We discovered that combining vitamin D3 with SGLT2 inhibitors showed promising results. This combination seemed to improve not just physical health markers but also the overall quality of life in hypertensive, obese individuals with OSA.
By revealing these positive effects, we highlight how vitamin D3 can contribute to better management of obesity-related complications, particularly when paired with SGLT2 inhibitors. Our findings suggest a potential strategy to address the intertwined challenges of obesity, metabolic health, and sleep disturbances in this patient population.
8.8
Improves obesity issues
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Vitamin D3 deficiency is prevalent and affects many people. It can arise from various factors such as poor sunlight exposure and genetic issues. When taking vitamin D, start with small doses if you have anaemia. It’s advisable for seniors with gastrointestinal issues to use sublingual forms for better absorption. For breastfeeding mothers, ensure optimal levels before dosing infants. Those with obesity may need nearly double the recommended dose, and adequate levels of magnesium and vitamin A are vital.
5 Htp
9.5
Reduces appetite
Most Useful Review
Indications for use - insomnia, chronic headache, obesity, narcolepsy, sleep disturbances! 5-HTP is not placebo! In treating depression, it increases the release of beta-endorphins. 5-HTP consumption reduces appetite, resulting in weight loss! I tested it myself, and there are no side effects. The capsules are easy to use. An extremely effective supplement that deserves 5 out of 5. I will order more and recommend it.
8
Improves sleep quality
Most Useful Review
Antioxidant and safe antidepressant! "5-HTP" from "Now Foods" promotes relaxation of the nervous system and normalises mental function, enhancing mood. This supplement increases endurance and alleviates muscle pain during exercise. Based on Griffonia simplicifolia seed extract, "5-HTP" is an effective antioxidant and antidepressant that elevates serotonin levels, calming the nervous system. It assisted my husband in overcoming fatigue and stress, particularly addressing his excessive night-time teeth grinding. After taking one 100 mg capsule at bedtime for a month, he experienced recovery, with sound sleep returning. "5-HTP" is also recommended for individuals battling alcohol and tobacco addiction, along with obesity. The convenient vitamin container holds 120 capsules, ensuring longevity. We are pleased with the results and recommend "5-HTP" from "Now Foods" as needed.
Quercetin
8.8
Healthy weight management
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This supplement has assisted in managing a healthy weight and lowered the risk of obesity-related health issues. It is particularly useful for those wanting to control their weight or who are at risk for obesity-related health problems.
8.8
Supports obesity management
Most Useful Review
I purchased it because quercetin is beneficial for obesity and rhinitis.
Selenium
8.8
Fights inflammation risk
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Selenium is a micronutrient with significant antioxidant properties, working alongside vitamin E to protect the body from free radical damage. Easily absorbed, it supports thyroid function, enhances the immune system, reduces cardiovascular disease risks, and detoxifies heavy metals. Furthermore, it may help lower inflammatory processes and oxidative stress linked to metabolic syndrome, which includes obesity, high cholesterol, hypertension, and hyperglycemia. This supplement from NOW is of excellent quality and dosage.
8.5
Supports weight management
Most Useful Review
With low selenium levels, metabolic processes slow down, leading to excess weight and obesity. This issue is more prevalent among women. Prolonged selenium deficiency increases the risk of diseases such as heart attack, diabetes, and thyroid dysfunction. Additionally, low selenium can result in intrauterine abnormalities and premature births. Those deficient in this mineral may age faster and experience reduced skin elasticity. Selenium supplements are crucial in complex therapy for malignancies, preventing further pathological growth and aiding metabolic restoration. They can accelerate recovery post-chemotherapy, facilitate detoxification, and normalise digestive pH levels.
Magnesium
9.5
Thyroid Support
Most Useful Review
Chromium is vital for normal fat metabolism; a deficiency often leads to excess weight and obesity. It aids the thyroid gland's function, contributes to immune system formation, and influences tissue growth and regeneration. I was prescribed this by my endocrinologist!
8.8
Effective Magnesium
Most Useful Review
Magnesium aids sleep and alleviates migraines while strengthening bones. It also prevents obesity and diabetes, which is why I regularly take Dr. Best High-Absorption Magnesium. I find it to be quite effective.
Resveratrol
8.8
Improves diabetes control
Most Useful Review
Resveratrol is a powerful antioxidant. I've noticed its effects in reducing skin ageing and the risk of cancer. After taking it, my circulation improved, and it reduced my risk of Alzheimer's disease. Daily use increased my insulin secretion, which has helped with obesity and diabetes.
8.8
Aids weight loss
Most Useful Review
I have taken resveratrol multiple times, and it aids my weight loss and decreases cravings for sweets. I've also given it to my father, who has significant obesity and heart issues. I genuinely hope it helps him control his sugar levels.
Inositol
8
Effects of Inositol with Supplements
Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol.
Most Relevant Research
We examined the impact of a blend of carnitines, L-arginine, L-cysteine, and myo-inositol on metabolic and reproductive metrics in women with polycystic ovary syndrome (PCOS) who are overweight or obese. Our focus was on understanding how this combination might reshape insulin sensitivity and hormone levels.
Over a period of 12 weeks, we evaluated the effects of this daily oral regimen on various health markers. We observed significant improvements in several key areas, including insulin response and metabolic parameters.
Particularly, the treatment led to better insulin sensitivity, which was shown by reduced insulin and C-peptide responses during an oral glucose tolerance test. Furthermore, the treatment also positively affected hormone levels necessary for reproductive health.
While the results highlight noteworthy benefits, it’s important to recognize that myo-inositol was part of a multi-component treatment. Therefore, we can't isolate its specific effect on obesity in this context without further investigation.
Over a period of 12 weeks, we evaluated the effects of this daily oral regimen on various health markers. We observed significant improvements in several key areas, including insulin response and metabolic parameters.
Particularly, the treatment led to better insulin sensitivity, which was shown by reduced insulin and C-peptide responses during an oral glucose tolerance test. Furthermore, the treatment also positively affected hormone levels necessary for reproductive health.
While the results highlight noteworthy benefits, it’s important to recognize that myo-inositol was part of a multi-component treatment. Therefore, we can't isolate its specific effect on obesity in this context without further investigation.
9.5
Life-changing results
Most Useful Review
Having struggled with polycystic ovaries and obesity since 14, I found this product in early 2020 and it changed my life. Taking the recommended 3-4 pills daily, I lost around 6 kilos while reducing sugar intake, and my menstrual cycle became regular. It's an effective alternative to Glucophage without its side effects.
Prebiotic Fiber Inulin
8
Akkermansia muciniphila and obesity
Carbon dioxide enhances Akkermansia muciniphila fitness and anti-obesity efficacy in high-fat diet mice.
Most Relevant Research
We explored the role of a gut bacterium called Akkermansia muciniphila and how it may help with obesity. Our study provided insights into how this bacterium grows rapidly in the presence of carbon dioxide, which it produces itself. This growth is supported by specific enzymes that play critical roles in its metabolism.
Additionally, we investigated a unique delivery system that combined calcium carbonate, inulin, A. muciniphila, and sodium alginate. This system was designed to enhance the bacteria's growth and help it thrive in the intestinal environment of mice. Notably, when we administered this delivery system to mice on a high-fat diet, we saw significant weight loss.
While the study included inulin as a component of the delivery system, the isolated effects of inulin on obesity cannot be fully determined from our results alone. Overall, our findings suggest that using innovative delivery systems could lead to new strategies for weight management and improved gut health, particularly by boosting beneficial gut bacteria.
Additionally, we investigated a unique delivery system that combined calcium carbonate, inulin, A. muciniphila, and sodium alginate. This system was designed to enhance the bacteria's growth and help it thrive in the intestinal environment of mice. Notably, when we administered this delivery system to mice on a high-fat diet, we saw significant weight loss.
While the study included inulin as a component of the delivery system, the isolated effects of inulin on obesity cannot be fully determined from our results alone. Overall, our findings suggest that using innovative delivery systems could lead to new strategies for weight management and improved gut health, particularly by boosting beneficial gut bacteria.
9.5
Effective pairing
Most Useful Review
Excellent! Combining inulin with probiotics proves very effective for visceral obesity.
Omega 3 Fish Oil
8
Eicosapentaenoic Acid Enhances Insulin Sensitivity
Fish Oil and EPA Improve Insulin Sensitivity, in Part Through Adipocyte mTORC2 Activation in Diet-Induced Obese Male Mice.
Most Relevant Research
We investigated how eicosapentaenoic acid (EPA), a key component of fish oil, affects insulin sensitivity and glucose metabolism, especially in the context of high-fat diets. The study involved male mice that either had or lacked a specific protein called Rictor, associated with a pathway known to influence cellular functions.
Our findings revealed that a diet rich in fish oil significantly enhanced glucose tolerance and insulin sensitivity in these mice. Moreover, the intake of fish oil resulted in better glucose uptake in both adipose (fat) tissues and skeletal muscle, all while reducing the liver's glucose production. This improvement was marked by lower levels of insulin in the bloodstream and an increase in the phosphorylation of a protein called Akt in the fat tissues, suggesting a key role for mTORC2 activation.
Interestingly, when the mice were fed a high-fat diet supplemented with EPA, we noticed an increase in insulin sensitivity and Akt phosphorylation, although this supplementation did not significantly improve overall glucose tolerance. This suggests that while EPA promotes insulin sensitivity via mTORC2, the enhancement of glucose tolerance observed with fish oil seems to arise from other mechanisms in the body, particularly in the muscles and liver.
Our study highlights how EPA can contribute to better metabolic health by improving how the body manages insulin and glucose, particularly for those consuming high-fat diets.
Our findings revealed that a diet rich in fish oil significantly enhanced glucose tolerance and insulin sensitivity in these mice. Moreover, the intake of fish oil resulted in better glucose uptake in both adipose (fat) tissues and skeletal muscle, all while reducing the liver's glucose production. This improvement was marked by lower levels of insulin in the bloodstream and an increase in the phosphorylation of a protein called Akt in the fat tissues, suggesting a key role for mTORC2 activation.
Interestingly, when the mice were fed a high-fat diet supplemented with EPA, we noticed an increase in insulin sensitivity and Akt phosphorylation, although this supplementation did not significantly improve overall glucose tolerance. This suggests that while EPA promotes insulin sensitivity via mTORC2, the enhancement of glucose tolerance observed with fish oil seems to arise from other mechanisms in the body, particularly in the muscles and liver.
Our study highlights how EPA can contribute to better metabolic health by improving how the body manages insulin and glucose, particularly for those consuming high-fat diets.
9.5
Skin improvement
Most Useful Review
I found this omega-3 to be delightful with no off-putting smells. After a monthly course, my skin improved significantly, and it effectively lowers the risk of cardiovascular diseases and obesity. I recommend it highly!
Coenzyme Q10 Coq10
8
Co-Q10 enhances cognitive function
The Impact of Coenzyme Q10 on Cognitive Dysfunction, Antioxidant Defense, Cholinergic Activity, and Hippocampal Neuronal Damage in Monosodium Glutamate-Induced Obesity.
Most Relevant Research
We explored the impact of coenzyme Q10 (Co-Q10) on cognitive function and neuronal health in rats made obese by monosodium glutamate (MSG) exposure. This study involved forty-eight neonatal male Wistar rats divided into four groups: a control group, a group receiving MSG, and two groups treated with different dosages of Co-Q10.
The findings are impressive. Co-Q10 not only helped improve cognitive function but also showed protective effects on the hippocampus, a crucial brain region for memory. By enhancing antioxidant defenses and reducing harmful neuronal damage, Co-Q10 appears to offer a promising approach to addressing cognitive issues associated with obesity.
We conducted various tests to assess memory and learning performance, which showed notable improvements in the rats treated with Co-Q10. Additionally, we observed a significant reduction in the levels of markers associated with oxidative stress and cell damage in the hippocampus. Overall, these results suggest that Co-Q10 holds potential as a supportive treatment for cognitive deficits linked to obesity.
The findings are impressive. Co-Q10 not only helped improve cognitive function but also showed protective effects on the hippocampus, a crucial brain region for memory. By enhancing antioxidant defenses and reducing harmful neuronal damage, Co-Q10 appears to offer a promising approach to addressing cognitive issues associated with obesity.
We conducted various tests to assess memory and learning performance, which showed notable improvements in the rats treated with Co-Q10. Additionally, we observed a significant reduction in the levels of markers associated with oxidative stress and cell damage in the hippocampus. Overall, these results suggest that Co-Q10 holds potential as a supportive treatment for cognitive deficits linked to obesity.
8.8
Improved energy levels
Most Useful Review
Coenzyme Q10 is a compound produced by the liver that stimulates ATP production, the body's primary energy source. Its levels decline with age, necessitating additional intake, especially for older individuals. I've taken it for five days and noticed more energy, improved mood, and enhanced productivity. I recommend this excellent supplement from Doctor's Best!
Biotin
9.5
No obesity effects
Most Useful Review
It's wonderful! My hair has improved significantly with this, and it has not caused any obesity.
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