Vitamins
8
Gamma-tocopherol and prostate cancer
Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties.
Most Relevant Research
We dove into the fascinating realm of gamma-tocopherol, a key form of vitamin E, to understand its impact on prostate cancer treatment. Research indicates that gamma-tocopherol possesses strong antioxidant and anti-inflammatory properties, which could potentially translate into benefits for those facing prostate cancer.
Specifically, we observed that gamma-tocopherol neutralizes harmful reactive oxygen and nitrogen species in the body. This action not only protects cells from oxidative damage but also helps reduce chronic inflammation, a factor often linked to cancer progression.
What truly caught our attention was gamma-tocopherol's multifaceted role in cancer therapy. Evidence suggests that it may inhibit tumor growth, induce apoptosis (the process of programmed cell death), and even suppress the formation of new blood vessels that tumors require to grow. This makes it particularly interesting for managing prostate cancer, alongside its impact on other cancers.
Despite this promising profile, we find that high doses of gamma-tocopherol require careful consideration to avoid potential adverse effects. Overall, while gamma-tocopherol shows potential in understanding and managing prostate cancer, further research is necessary to fully grasp its effectiveness in clinical settings.
Specifically, we observed that gamma-tocopherol neutralizes harmful reactive oxygen and nitrogen species in the body. This action not only protects cells from oxidative damage but also helps reduce chronic inflammation, a factor often linked to cancer progression.
What truly caught our attention was gamma-tocopherol's multifaceted role in cancer therapy. Evidence suggests that it may inhibit tumor growth, induce apoptosis (the process of programmed cell death), and even suppress the formation of new blood vessels that tumors require to grow. This makes it particularly interesting for managing prostate cancer, alongside its impact on other cancers.
Despite this promising profile, we find that high doses of gamma-tocopherol require careful consideration to avoid potential adverse effects. Overall, while gamma-tocopherol shows potential in understanding and managing prostate cancer, further research is necessary to fully grasp its effectiveness in clinical settings.
9.5
Enhances sexual health
Most Useful Review
This product has numerous benefits, including improving sperm health, increasing sexual desire, and aiding in achieving erections. Vitamin D3 may help prevent prostate cancer and also promotes bone and joint health. Understanding these benefits makes one fortunate.
Quercetin
9.5
Recommended brand
Most Useful Review
My doctor, a leading oncologist, has recommended Jarrow brand as part of my treatment for prostate cancer. He says Jarrow is the brand that most accurately represents what’s on its label.
8
Pain reduction noted
Most Useful Review
I chose this quercetin product as it's a best-seller. I’m using it alongside other supplements to combat my incurable advanced prostate cancer. I'm pleased to report that the pain in my legs and feet is diminishing. My oncology professor had predicted I wouldn't survive past early 2020, so I am very satisfied with this product's impact.
9.5
Quick recovery noted
Most Useful Review
I give it to my children for prostate cancer symptoms, and they recover quickly.
9.5
Effective for cold
Most Useful Review
Absolutely brilliant! I give my child 0.5 ml every two days for symptoms of prostate cancer, and it effectively ends the cold.
Inositol Hexaphosphate
9.5
Cancer management support
Most Useful Review
I have been taking IP6 for four years after my cancer operation. My initial outlook was grim, but following a friend's recommendation, I continued taking them. I’m still cancer-free, so I’ll keep using them as a precaution.
8.8
Cancer cell reduction
Most Useful Review
Jarrow produces quality supplements. I take one or two daily to decrease my chances of developing prostate cancer. Many studies support IP6 in killing cancer cells and its effectiveness as a chelator.
Polygonum Cuspidatum Complex
9.5
Improved prostate levels
Most Useful Review
My father purchased this to help with my prostate cancer, and after taking it, my levels have significantly improved.
8.8
Fighting cancer support
Most Useful Review
Without hesitation, I bought my favourite Now Foods product, 'Resveratrol,' as recommended in a cancer-fighting book. I intend to continue using it for my health.
Zinc
8
Zinc's complex role in prostate cancer
Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming.
Most Relevant Research
We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.
Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.
We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.
Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.
Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.
We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.
Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.
9.5
Pain relief
Most Useful Review
With chronic prostatitis, this supplement has become my top choice. I experience less pain and improved sperm quality, and zinc has increased my free testosterone levels. I highly recommend it to anyone dealing with issues related to prostate cancer.
D Mannose
8
Tratt polysaccharides impact prostate cancer
Inhibition of Proliferation and Induction of Apoptosis in Prostatic Carcinoma DU145 Cells by Polysaccharides from Yunnan Tratt.
Most Relevant Research
We explored how polysaccharides extracted from Yunnan Tratt fruits affect prostate cancer DU145 cells. Our study investigated their ability to inhibit cell proliferation, migration, and invasion, along with their role in inducing apoptosis.
We utilized various methods, including assays for cell viability and migration, as well as flow cytometry to assess the effects on the cell cycle. The results revealed that Tratt polysaccharides can indeed suppress the growth of DU145 cells while promoting cell death through changes in important proteins and genes.
We utilized various methods, including assays for cell viability and migration, as well as flow cytometry to assess the effects on the cell cycle. The results revealed that Tratt polysaccharides can indeed suppress the growth of DU145 cells while promoting cell death through changes in important proteins and genes.
9.5
Nearly eliminated UTIs
Most Useful Review
This product has been a lifesaver after facing severe complications from prostate cancer surgery, leading to recurring UTIs. Despite trying various remedies, D-Mannose has almost eradicated my UTIs, and my surgeon fully supports its use. I take two 500mg capsules nightly and have reduced UTI occurrences by about 95%.
Selenium
9
Selenium's potential in prostate cancer
Enhancing Radiotherapy Sensitivity in Prostate Cancer with Lentinan-Functionalized Selenium Nanoparticles: Mechanistic Insights and Therapeutic Potential.
Most Relevant Research
We sought to understand how selenium, specifically in the form of lentinan-functionalized selenium nanoparticles (LET-SeNPs), can improve radiotherapy outcomes for prostate cancer. Our investigation showed that when these nanoparticles were combined with X-ray therapy, they significantly hampered the growth of prostate cancer cells and their ability to form colonies. This effect was greater than either treatment alone.
The mechanism behind this enhanced sensitivity involved a complex interplay of cellular pathways. We observed that LET-SeNPs helped induce more robust apoptosis, or programmed cell death, by targeting various signaling routes in the cancer cells, such as the p53, MAPK, and AKT pathways. Moreover, they elevated levels of reactive oxygen species (ROS), which are known to promote apoptosis, while also decreasing the expression of Thioredoxin reductase, an enzyme that aids in DNA repair.
In animal models, the combination therapy proved effective in slowing down tumor growth, reinforcing our findings from the lab. These results suggest that using LET-SeNPs alongside X-ray therapy could potentially transform prostate cancer treatment, enhancing its effectiveness while possibly reducing side effects. Overall, we believe that selenium-modified nanoparticles hold significant promise for advancing cancer therapies.
The mechanism behind this enhanced sensitivity involved a complex interplay of cellular pathways. We observed that LET-SeNPs helped induce more robust apoptosis, or programmed cell death, by targeting various signaling routes in the cancer cells, such as the p53, MAPK, and AKT pathways. Moreover, they elevated levels of reactive oxygen species (ROS), which are known to promote apoptosis, while also decreasing the expression of Thioredoxin reductase, an enzyme that aids in DNA repair.
In animal models, the combination therapy proved effective in slowing down tumor growth, reinforcing our findings from the lab. These results suggest that using LET-SeNPs alongside X-ray therapy could potentially transform prostate cancer treatment, enhancing its effectiveness while possibly reducing side effects. Overall, we believe that selenium-modified nanoparticles hold significant promise for advancing cancer therapies.
9.5
Cancer prevention
Most Useful Review
Selenium is an essential supplement for preventing cancer. To maintain my health and reduce tumour risks, I believe this supplement is crucial.
Tumeric
8
Curcumin delivery improves prostate cancer treatment
Fluorescent Microorganism-Based Composite: Enhancing Curcumin Delivery Efficiency and its Antitumor Application in Prostate Cancer.
Most Relevant Research
We explored the challenges surrounding curcumin, a compound found in turmeric known for its antioxidant and anti-inflammatory properties, particularly in the context of treating prostate cancer. The study aimed to improve its effectiveness by creating a specialized carrier, a microorganism-metal-organic framework, designed to enhance curcumin's solubility and stability.
Our research demonstrated that this new composite carrier, when loaded with curcumin, significantly increased the compound's delivery efficiency. We observed that the enhanced formulation was able to reduce the viability of prostate cancer cells dramatically—by around 50%—at a concentration of 20 µM after 48 hours of treatment.
Moreover, through our analysis of gene expression related to apoptosis, we found that the composite effectively induced cell death in cancer cells—a key goal in cancer therapies. This suggests that curcumin, when properly delivered, can have a powerful antitumor effect, presenting promising potential for future prostate cancer treatments. Ultimately, our findings highlight the importance of improving drug delivery systems for enhancing the therapeutic possibilities of natural compounds like curcumin in prostate cancer care.
Our research demonstrated that this new composite carrier, when loaded with curcumin, significantly increased the compound's delivery efficiency. We observed that the enhanced formulation was able to reduce the viability of prostate cancer cells dramatically—by around 50%—at a concentration of 20 µM after 48 hours of treatment.
Moreover, through our analysis of gene expression related to apoptosis, we found that the composite effectively induced cell death in cancer cells—a key goal in cancer therapies. This suggests that curcumin, when properly delivered, can have a powerful antitumor effect, presenting promising potential for future prostate cancer treatments. Ultimately, our findings highlight the importance of improving drug delivery systems for enhancing the therapeutic possibilities of natural compounds like curcumin in prostate cancer care.
8.3
Joint support
Most Useful Review
I appreciate the effectiveness of curcumin for reducing inflammation. It is particularly helpful for my joints and cartilage during my cancer therapy.
Protein
8
Effective combination therapy explored
Neoadjuvant fuzuloparib combined with abiraterone for localized high-risk prostate cancer (FAST-PC): A single-arm phase 2 study.
Most Relevant Research
We conducted a study to assess how a combination of fuzuloparib, a PARP inhibitor, and abiraterone, an androgen receptor inhibitor, can affect localized high-risk prostate cancer. In this phase 2 trial involving 35 treatment-naive men, participants received six cycles of the therapy followed by radical prostatectomy.
We aimed to measure the effectiveness of this combination therapy by evaluating two main outcomes: pathological complete response (pCR) and minimal residual disease (MRD). The results were promising, showing a combined pCR/MRD rate of 46%, indicating that nearly half of the patients had no detectable disease after treatment. Additionally, 53% of participants remained free of biochemical progression two years post-treatment.
Interestingly, we found that specific molecular alterations, particularly involving biallelic homologous recombination repair and BRCA2 genes, were tied to quicker declines in prostate-specific antigen levels, which is a key marker for prostate cancer. Genomic analyses done after treatment revealed a reduction in MYC amplification and growth markers, suggesting that the therapy effectively targeted aggressive cancer attributes.
However, it’s important to note that about 23% of patients encountered grade ≥3 adverse events, highlighting some risks associated with this treatment. Overall, this study demonstrated the potential of combining these therapies in treating prostate cancer while establishing a foundation for exploring various biomarkers that could inform future research.
We aimed to measure the effectiveness of this combination therapy by evaluating two main outcomes: pathological complete response (pCR) and minimal residual disease (MRD). The results were promising, showing a combined pCR/MRD rate of 46%, indicating that nearly half of the patients had no detectable disease after treatment. Additionally, 53% of participants remained free of biochemical progression two years post-treatment.
Interestingly, we found that specific molecular alterations, particularly involving biallelic homologous recombination repair and BRCA2 genes, were tied to quicker declines in prostate-specific antigen levels, which is a key marker for prostate cancer. Genomic analyses done after treatment revealed a reduction in MYC amplification and growth markers, suggesting that the therapy effectively targeted aggressive cancer attributes.
However, it’s important to note that about 23% of patients encountered grade ≥3 adverse events, highlighting some risks associated with this treatment. Overall, this study demonstrated the potential of combining these therapies in treating prostate cancer while establishing a foundation for exploring various biomarkers that could inform future research.
8.3
Prostate cancer protection
Most Useful Review
Rich in iron and protein, I consume a handful of pumpkin seeds between meals. They also contain zinc, selenium, kelp, and copper, which I believe help protect my prostate cancer.
Urtica Dioica
7
Urtica dioica affects prostate cancer
Examination of the Association Between 3,4-Divanillyltetrahydrofuran Lignan ( Origin) and Prostate Cancer Cells by I Radiolabeling.
Most Relevant Research
We explored how 3,4-divanillyltetrahydrofuran (DTH), derived from Urtica dioica roots, affects prostate cancer cells with varying androgen sensitivity. Using advanced techniques, we radiolabeled DTH to understand its uptake in two types of prostate cancer cells: LNCaP, which is androgen-sensitive, and PC3, which is not.
Our findings revealed that DTH exhibited a higher toxicity towards LNCaP cells compared to PC3 cells. While the study uncovers potential roles of DTH in treating certain prostate cancer types, it emphasizes the need for further research to fully understand its effectiveness.
Our findings revealed that DTH exhibited a higher toxicity towards LNCaP cells compared to PC3 cells. While the study uncovers potential roles of DTH in treating certain prostate cancer types, it emphasizes the need for further research to fully understand its effectiveness.
9.5
Various benefits
Most Useful Review
The best stinging nettle roots aid in urination issues related to prostate cancer, such as frequent night urination and painful urination. They're also beneficial for various ailments, including urinary tract infections, allergies, and menopausal symptoms. Some individuals use it for internal bleeding and conditions like anemia and diabetes. The above-ground parts support blood circulation, promote kidney health, and may even help with signs of ageing and wound healing.
Fish Oil
2
No effect of MAG-EPA observed
A phase IIb randomized placebo-controlled trial testing the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation.
Most Relevant Research
We conducted a phase II double-blind, randomized placebo-controlled trial to understand the effects of a dietary supplement called MAG-EPA, which is rich in eicosapentaenoic acid (EPA), on prostate cancer. Involving 130 men diagnosed with grade group 2 or higher prostate cancer, we aimed to see if this omega-3 fatty acid could effectively slow down cancer growth.
Participants were randomly assigned to take either 3 grams of MAG-EPA daily or a placebo for 7 weeks before undergoing radical prostatectomy. The main measure of our study was the cancer proliferation index, which we assessed by analyzing tumor samples for a specific protein known as Ki-67.
Unfortunately, our findings showed that MAG-EPA did not significantly change the rate of cancer proliferation as indicated by Ki-67 expression. While we did gather additional information on inflammatory cytokines and fatty acid profiles, the lack of any observable benefits from the MAG-EPA treatment stands out.
This study illuminates the complexities of dietary supplements like omega-3 fatty acids in cancer treatment. Further research is essential to better understand their potential impact on prostate cancer, but for now, we found no evidence to suggest that MAG-EPA is effective in reducing cancer growth.
Participants were randomly assigned to take either 3 grams of MAG-EPA daily or a placebo for 7 weeks before undergoing radical prostatectomy. The main measure of our study was the cancer proliferation index, which we assessed by analyzing tumor samples for a specific protein known as Ki-67.
Unfortunately, our findings showed that MAG-EPA did not significantly change the rate of cancer proliferation as indicated by Ki-67 expression. While we did gather additional information on inflammatory cytokines and fatty acid profiles, the lack of any observable benefits from the MAG-EPA treatment stands out.
This study illuminates the complexities of dietary supplements like omega-3 fatty acids in cancer treatment. Further research is essential to better understand their potential impact on prostate cancer, but for now, we found no evidence to suggest that MAG-EPA is effective in reducing cancer growth.
8
Helpful for father
Most Useful Review
I purchased this pill based on my friend's recommendation for my father's prostate cancer issue. The ingredients should be beneficial for him, although it does taste of fish.
Coenzyme Q10
7
Coenzyme Q10's role unclear
A systematic review of dietary, nutritional, and physical activity interventions for the prevention of prostate cancer progression and mortality.
Most Relevant Research
We systematically reviewed various lifestyle interventions, including dietary and nutritional changes, aimed at influencing prostate cancer progression and mortality. Among the interventions we examined were trials that integrated coenzyme Q10, often alongside other supplements like lycopene and selenium.
Notably, the trials incorporating coenzyme Q10 were part of a larger group of 44 randomized controlled studies involving a total of 3,418 prostate cancer patients from 13 countries. Although some trials showed beneficial effects on disease outcomes, the specific impact of coenzyme Q10 was hard to isolate, as it was paired with other supplements in the trials.
The results indicated that while several combinations yielded promising outcomes, many trials suffered from limitations such as small sample sizes, high risk of bias, or inadequate reporting, which prevent us from definitively concluding that coenzyme Q10 alone is effective against prostate cancer. In summary, we found that more robust, well-structured trials focusing on coenzyme Q10 would be necessary to clarify its role and effectiveness.
Notably, the trials incorporating coenzyme Q10 were part of a larger group of 44 randomized controlled studies involving a total of 3,418 prostate cancer patients from 13 countries. Although some trials showed beneficial effects on disease outcomes, the specific impact of coenzyme Q10 was hard to isolate, as it was paired with other supplements in the trials.
The results indicated that while several combinations yielded promising outcomes, many trials suffered from limitations such as small sample sizes, high risk of bias, or inadequate reporting, which prevent us from definitively concluding that coenzyme Q10 alone is effective against prostate cancer. In summary, we found that more robust, well-structured trials focusing on coenzyme Q10 would be necessary to clarify its role and effectiveness.
7.8
Increased energy focus
Most Useful Review
Doctor’s Best High Absorption CoQ10 with BioPerine is superb! I've noted increased energy, improved focus, and reduced mental fog. It enhances my overall wellbeing and supports my body. CoQ10 is an antioxidant that defends against free radical damage while BioPerine may help combat the growth of cancer cells and aids nutrient absorption.