 NOW Foods, Hyaluronic Acid, Double Strength, 100 mg, 60 Veg Capsules | | |
Hyaluronic acid's role in RA painApplication of 35 kDa Hyaluronic Acid Fragment in Managing Persistent Localized Pain in Rheumatoid Arthritis : A Case Report. We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments. Prescription-Free Relief Most Useful Review 14 people found this helpful A few years ago, I was diagnosed with Rheumatoid Arthritis and prescribed medications. However, after a friend's recommendation, I started taking Hyaluronic Acid. Since then, I’ve stopped taking my prescription drugs! I can hardly believe the difference it has made to how I feel. I absolutely love it and can't thank you enough! |
 Doctor's Best, Hyaluronic Acid + Chondroitin Sulfate with BioCell Collagen, 180 Veggie Capsules | | |
Hyaluronic acid's role in RA painApplication of 35 kDa Hyaluronic Acid Fragment in Managing Persistent Localized Pain in Rheumatoid Arthritis : A Case Report. We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments. Joint pain relief Most Useful Review 4 people found this helpful I purchased this supplement as I suffer from rheumatoid arthritis. Initially, I was sceptical about its ability to relieve joint pain, but I was pleasantly surprised by the improvement I experienced in just two months. I hardly recall having any joint pain now and have already ordered more to ensure I don't run out! |
 NOW Foods, Folic Acid, 800 mcg, 250 Tablets | | |
Vitamin B12 may treat arthritisVitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice. We explored the impact of vitamin B12 on rheumatoid arthritis, focusing on its ability to inhibit a specific enzyme known as PADI-4, which plays a key role in the disease's progression. Our findings suggest that vitamin B12 preferentially targets PADI-4 compared to another similar enzyme, PADI-2. This inhibition corresponds with a significant reduction in overall citrullination levels in cells, including histone H3 citrullination, which is relevant to the condition.
In our experiment, we utilized a specific model of arthritis in mice, known as collagen type II antibody-induced arthritis (CAIA). We administered hydroxocobalamin, a form of vitamin B12, and observed a marked improvement in the severity of arthritis symptoms in these mice. Moreover, the treatment led to a decrease in the expression of various inflammatory factors and cytokines associated with rheumatoid arthritis, such as IL17A, TNFα, and IL-6, as well as PADI-4 itself.
These findings indicate that vitamin B12 might represent a promising avenue for treating rheumatoid arthritis and warrant further investigation. High-quality supplement Most Useful Review Excellent! This is perfect for anyone with immune conditions. My mother has rheumatoid arthritis, and this supplement should not be split; its quality is outstanding. |
 21st Century, Calcium Citrate + D3 Maximum, 75 Tablets | | |
Vitamin D3 reduces rheumatoid arthritis inflammation1,25-Dihydroxyvitamin D regulates macrophage activation through FBP1/PKR and ameliorates arthritis in TNF-transgenic mice. We investigated the role of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, in managing rheumatoid arthritis (RA). Our study focused on how this vitamin influences macrophage activation, especially in patients with RA.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis. Significant symptom relief Most Useful Review Ordered for my father, who has rheumatoid arthritis, he experienced very painful and swollen joints during flare-ups. After taking it for two months, the symptoms virtually disappeared, but they returned, so I bought it again. I hope the results from this calcium continue to be positive. The complex is low in vitamin D3, so my dad takes an additional vitamin supplement. |
 NOW Foods, Vitamin D-3, Max Potency, 50,000 IU, 50 Softgels | | |
Vitamin D3 reduces rheumatoid arthritis inflammation1,25-Dihydroxyvitamin D regulates macrophage activation through FBP1/PKR and ameliorates arthritis in TNF-transgenic mice. We investigated the role of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, in managing rheumatoid arthritis (RA). Our study focused on how this vitamin influences macrophage activation, especially in patients with RA.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis. Increased immunity Most Useful Review 2 people found this helpful I have taken Vitamin D three times now for my rheumatoid arthritis. A high dose has significantly helped me. The quality is excellent and the quantity lasts a considerable time. This high dosage boosts immunity. It’s tasteless and very effective. |
 NOW Foods, Vitamin D-3, High Potency, 5,000 IU, 120 Softgels | | |
Vitamin D3 reduces rheumatoid arthritis inflammation1,25-Dihydroxyvitamin D regulates macrophage activation through FBP1/PKR and ameliorates arthritis in TNF-transgenic mice. We investigated the role of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, in managing rheumatoid arthritis (RA). Our study focused on how this vitamin influences macrophage activation, especially in patients with RA.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis. Improved joint health Most Useful Review 1 people found this helpful Vitamin D! I can sing praises for this drug! My entire family takes it year-round. My dose is 5,000 IU every other day during autumn to spring, as I have rheumatoid arthritis, and my doctor monitors my vitamin D levels closely. Now Foods offers the best price-quality ratio for this medication. Thank you! |
 NOW Foods, MK-7 Vitamin K-2 , 100 mcg, 120 Veg Capsules | | |
Inhibits heart disease Most Useful Review Excellent vitamin! Vitamin K regulates proteins that prevent calcium from depositing in blood vessels, thus maintaining bone density and heart health. It plays a crucial role in blood coagulation and helps increase insulin production. Vitamin K2 has anti-inflammatory properties and reduces inflammation in rheumatoid arthritis. It also protects nerve cells from oxidative damage. Increases insulin production Most Useful Review Vitamin K is essential for calcium absorption and regulates proteins crucial to prevent calcium from being deposited in blood vessels, promoting bone health. It helps with blood coagulation and supports brain activity. Furthermore, it increases insulin production and shows anti-inflammatory properties in rheumatoid arthritis. Its antioxidant nature protects maturing nerve cells from damage. |
 NOW Foods, Glucosamine & Chondroitin with MSM, 180 Veg Capsules | | |
Glucosamine and vitamin E benefitsSynergistic effect of glucosamine and vitamin E against experimental rheumatoid arthritis in neonatal rats. We investigated how glucosamine sulfate, especially in combination with vitamin E, affects rheumatoid arthritis (RA) using a neonatal rat model. Through our study, we measured various biological markers, including lipid peroxidation, antioxidant levels, and inflammatory factors to understand better how this treatment could help counteract the effects of RA.
Our findings showed that when glucosamine was paired with vitamin E, there was a notable reduction in the levels of malondialdehyde (MDA), a marker of oxidative stress. Specifically, we observed a reduction of 61.9% in MDA levels, which suggests a positive effect on oxidative stress associated with RA. Additionally, key antioxidants like superoxide dismutase (SOD), catalase, and glutathione were elevated, indicating improved antioxidant activity.
We also noted significant decreases in various inflammatory markers, including matrix metalloproteinase-3 (MMP-3) and prostaglandin E (PGE), suggesting that this combination therapy may effectively reduce inflammation related to RA. The results indicated a synergistic effect between glucosamine and vitamin E in mitigating symptoms of RA, highlighting potential benefits for those grappling with this condition. Significant health improvement Most Useful Review Glucosamine chondroitin is an excellent supplement. I have back issues and joint pain. After a week of use, my health improved remarkably. My mother took this supplement for rheumatoid arthritis alongside hormones, resulting in a good outcome with pain relief. We sourced this from another manufacturer, and this one is clearly superior in quality and dosage. I highly recommend it. |
 Doctor's Best, Glucosamine Chondroitin MSM with OptiMSM®, 240 Capsules | | |
MSM and BA show limited effectsThe "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. In our clinical trial, we investigated the effects of methylsulfonylmethane (MSM) combined with boswellic acids (BA) on individuals suffering from knee arthritis, a chronic condition often characterized by joint pain and inflammation. We enrolled 60 participants who were randomly divided into two groups: one group received the MSM and BA treatment for 60 days, and the other group was given a placebo.
Over the follow-up periods of 2 and 6 months, we measured pain levels using a visual analog scale (VAS) and assessed joint function with the Lequesne index (LI). While we found that participants taking MSM and BA reported higher pain levels than those on the placebo after 2 months, these differences did not persist at the 6-month mark. Furthermore, when evaluating joint function, we noted no significant differences between the two groups.
However, one notable finding was that those receiving the combination treatment needed fewer anti-inflammatory drugs compared to the placebo group at both follow-up points. Despite the reduced reliance on these medications, we concluded that combined treatment with MSM and BA did not significantly improve pain or joint function compared to placebo. Significant improvement Most Useful Review 250 people found this helpful There is an effect - it works! I delayed writing a review as I wanted to observe the results. I ordered this drug for my mother-in-law, who has rheumatoid arthritis, and for my mother, suffering from intervertebral disc issues. Initially sceptical, they began taking the drug when pain forced them to agree. Within ten days, my mother-in-law noticed it was easier to rise from a chair, and the swelling in her knees diminished, though pain persisted. After two weeks, my mother could wake up on her side, something she hadn't managed due to back pain. They have now been taking the drug for over a month, and I'm reordering. They recommend it! |
 NOW Foods, UC-II® Joint Health with Undenatured Type II Collagen, 120 Capsules | | |
GSZD shows anti-RA potential decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis. We investigated the effects of GSZD, a traditional decoction, on bone erosion in a rat model of rheumatoid arthritis. Fifty rats were divided into control and treatment groups. Over 21 days, those receiving GSZD showed improved signs of inflammation and reduced joint damage compared to controls.
Specifically, GSZD lowered osteoclast numbers and enhanced protective factors, indicating its potential as a treatment option for rheumatoid arthritis. This study suggests GSZD could serve as a valuable supplement in managing RA symptoms. Knees stopped hurting Most Useful Review 122 people found this helpful I began taking collagen on my rheumatologist's advice due to my rheumatoid arthritis. After 10 days, my knees stopped hurting and my hands felt easier. While miracles don’t happen and damaged joints can't be restored, at least my mobility has improved. If you have joint pain, don’t delay treatment! I highly recommend it! |
 Nature's Bounty, Evening Primrose Oil, 1,000 mg, 60 Rapid Release Softgels | | |
Moderate benefits, mixed evidenceHerbal therapy for treating rheumatoid arthritis. We examined the latest insights into herbal therapies for rheumatoid arthritis, including evening primrose oil. Our analysis included 22 studies, revealing moderate evidence suggesting that gamma linolenic acid (GLA), found in evening primrose oil, may ease pain and disability related to RA.
However, while some benefits were noted, the evidence remains mixed and the risk of side effects should not be overlooked. More comprehensive studies are needed to firmly establish its effectiveness for RA treatment. Boosts immunity Most Useful Review I combine evening primrose oil with B vitamins to enhance immunity for managing rheumatoid arthritis. This oil also improves skin turgor and benefits the overall condition of hair and nails. Regular use provides antimicrobial, regenerating, and anti-inflammatory effects. |
 Solgar, Evening Primrose Oil, 1,300 mg, 60 Softgels | | |
Moderate benefits, mixed evidenceHerbal therapy for treating rheumatoid arthritis. We examined the latest insights into herbal therapies for rheumatoid arthritis, including evening primrose oil. Our analysis included 22 studies, revealing moderate evidence suggesting that gamma linolenic acid (GLA), found in evening primrose oil, may ease pain and disability related to RA.
However, while some benefits were noted, the evidence remains mixed and the risk of side effects should not be overlooked. More comprehensive studies are needed to firmly establish its effectiveness for RA treatment. Pain relief noted Most Useful Review 4 people found this helpful I have been using evening primrose oil for a long while, and I can only share positive experiences. At 52, I started taking it for hot flashes, and it certainly helped. Additionally, it provided relief for my knee problems associated with rheumatoid arthritis. It’s noted that gamma-linolenic acid can alleviate the chronic inflammation pain typical of rheumatoid arthritis, making this oil a valuable addition to my routine. |
 NOW Foods, Super Primrose, 1,300 mg, 120 Softgels | | |
Moderate benefits, mixed evidenceHerbal therapy for treating rheumatoid arthritis. We examined the latest insights into herbal therapies for rheumatoid arthritis, including evening primrose oil. Our analysis included 22 studies, revealing moderate evidence suggesting that gamma linolenic acid (GLA), found in evening primrose oil, may ease pain and disability related to RA.
However, while some benefits were noted, the evidence remains mixed and the risk of side effects should not be overlooked. More comprehensive studies are needed to firmly establish its effectiveness for RA treatment. Pain reduction noted Most Useful Review Excellent evening primrose oil effectively reduces pain associated with rheumatoid arthritis. |
 Nordic Naturals, Omega-3, Great Lemon, 690 mg, 120 Soft Gels (345 mg per Soft Gel) | | |
Omega-3 shows potential benefitsEffects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. We examined the effects of omega-3 supplementation on rheumatoid arthritis through a meta-analysis of 18 randomized controlled trials involving over 1,000 patients.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall. High efficacy Most Useful Review Great! Omega-3 fatty acids prevent osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They effectively combat bone loss and reduce inflammation, addressing the symptoms of rheumatoid arthritis and slowing down the destruction of articular cartilage in arthrosis. The quality is excellent, the ingredients are natural, and the effectiveness is at its peak. |
 Carlson, Wild Norwegian, Elite Omega-3 Gems®, Natural Lemon, 120 Soft Gels | | |
Omega-3 shows potential benefitsEffects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. We examined the effects of omega-3 supplementation on rheumatoid arthritis through a meta-analysis of 18 randomized controlled trials involving over 1,000 patients.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall. Reduced morning pain Most Useful Review 1 people found this helpful I ordered it for therapy in combination with rheumatoid arthritis to alleviate inflammation. After a couple of weeks, the morning pains have decreased, and now I can almost sleep through the night! |
 NOW Foods, Omega-3 Fish Oil, 1,000 mg, 180 EPA - 120 DHA, 100 Softgels | | |
Omega-3 shows potential benefitsEffects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. We examined the effects of omega-3 supplementation on rheumatoid arthritis through a meta-analysis of 18 randomized controlled trials involving over 1,000 patients.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall. Supports cardiovascular health Most Useful Review 14 people found this helpful Omega-3 is vital for preventing conditions like atherosclerosis and regulating cholesterol levels. Recommended doses vary, but significantly higher amounts are suggested for serious health issues, including rheumatoid arthritis. It’s essential to read labels for the EPA and DHA content to ensure you're getting a quality product. This supplement’s properties extend to numerous health benefits and should be taken seriously. |
 Natrol, Omega-3 Fish Oil, Lemon, 1,000 mg, 150 Softgels | | |
Omega-3 shows potential benefitsEffects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. We examined the effects of omega-3 supplementation on rheumatoid arthritis through a meta-analysis of 18 randomized controlled trials involving over 1,000 patients.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall. Excellent supplement Most Useful Review Excellent! Omega-3 fatty acids help prevent osteoporosis and maintain joint health while alleviating pain during flare-ups. They fight bone loss, reduce inflammation, and help lessen the symptoms of rheumatoid arthritis, slowing the process of cartilage destruction during arthrosis. |
 NOW Foods, Ultra Omega 3-D, 600 EPA / 300 DHA, 90 Fish Softgels | | |
Omega-3 shows potential benefitsEffects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. We examined the effects of omega-3 supplementation on rheumatoid arthritis through a meta-analysis of 18 randomized controlled trials involving over 1,000 patients.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall. Effective for arthritis Most Useful Review It has been shown that fish oil prevents osteoporosis. The EPA and DHA in fish oil stop processes that lead to bone loss and lessen inflammation. Daily Omega-3 PUFA consumption alleviates joint pain. Additionally, fish oil is an essential source of vitamin D for osteoporosis treatment. Regular intake of high concentrations of omega-3s can significantly decrease inflammatory processes in rheumatoid arthritis and relieve pain and morning stiffness, at times completely. Furthermore, omega-3 fatty acids can lessen the need for non-steroidal anti-inflammatory drugs, which often cause gastrointestinal issues. |
 Solgar, Omega 3, EPA & DHA, Triple Strength, 950 mg, 100 Softgels | | |
Omega-3 shows potential benefitsEffects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. We examined the effects of omega-3 supplementation on rheumatoid arthritis through a meta-analysis of 18 randomized controlled trials involving over 1,000 patients.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall. Vitamin D increase Most Useful Review 3 people found this helpful This is a splendid product! My rheumatologist first prescribed this omega for my rheumatoid arthritis. Initially, my vitamin D level was just 17 ng/ml, but after consuming an entire bottle of vitamin D3, it rose to 40. Now, I take one capsule every morning starting in the autumn. I highly recommend this brand! |
 Doctor's Best, MSM with OptiMSM®, 3,000 mg, 360 Capsules (1,000 mg per Capsule) | | |
MSM and BA show limited effectsThe "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. In our clinical trial, we investigated the effects of methylsulfonylmethane (MSM) combined with boswellic acids (BA) on individuals suffering from knee arthritis, a chronic condition often characterized by joint pain and inflammation. We enrolled 60 participants who were randomly divided into two groups: one group received the MSM and BA treatment for 60 days, and the other group was given a placebo.
Over the follow-up periods of 2 and 6 months, we measured pain levels using a visual analog scale (VAS) and assessed joint function with the Lequesne index (LI). While we found that participants taking MSM and BA reported higher pain levels than those on the placebo after 2 months, these differences did not persist at the 6-month mark. Furthermore, when evaluating joint function, we noted no significant differences between the two groups.
However, one notable finding was that those receiving the combination treatment needed fewer anti-inflammatory drugs compared to the placebo group at both follow-up points. Despite the reduced reliance on these medications, we concluded that combined treatment with MSM and BA did not significantly improve pain or joint function compared to placebo. Almost painlessly living Most Useful Review 7 people found this helpful Works for rheumatoid arthritis! I’ve been diagnosed with rheumatoid arthritis and have been drinking this product. Maybe the immunomodulator isn't effective and should be increased, but thanks to this, I can live almost painlessly! I believe it’s due to this, as it causes pain in 2-3 days if I don't take it and rely solely on the immunomodulator. |
 NOW Foods, MSM, Methylsulfonylmethane, 1,000 mg, 120 Veg Capsules | | |
MSM and BA show limited effectsThe "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. In our clinical trial, we investigated the effects of methylsulfonylmethane (MSM) combined with boswellic acids (BA) on individuals suffering from knee arthritis, a chronic condition often characterized by joint pain and inflammation. We enrolled 60 participants who were randomly divided into two groups: one group received the MSM and BA treatment for 60 days, and the other group was given a placebo.
Over the follow-up periods of 2 and 6 months, we measured pain levels using a visual analog scale (VAS) and assessed joint function with the Lequesne index (LI). While we found that participants taking MSM and BA reported higher pain levels than those on the placebo after 2 months, these differences did not persist at the 6-month mark. Furthermore, when evaluating joint function, we noted no significant differences between the two groups.
However, one notable finding was that those receiving the combination treatment needed fewer anti-inflammatory drugs compared to the placebo group at both follow-up points. Despite the reduced reliance on these medications, we concluded that combined treatment with MSM and BA did not significantly improve pain or joint function compared to placebo. Improved wellbeing noted Most Useful Review An excellent product! Since starting MSM, I feel much better, particularly with my rheumatoid arthritis. I intend to continue taking it and highly recommend it to others. |
 Doctor's Best, High Absorption Magnesium, 200 mg, 120 Tablets, (100 mg per Tablet) | | |
Sleep enhancement Most Useful Review THIS WORKS! I waited until I finished the first bottle before posting this review. Having watched a video on how magnesium can aid sleep, I decided to try it as I often struggle to fall asleep due to my rheumatoid arthritis. During flare-up periods, I feel achy all over. This product has been incredibly helpful; with its muscle-relaxing properties, I now fall asleep before 10 PM. The quality is excellent, and I would absolutely recommend it and repurchase it repeatedly! Significant improvement Most Useful Review I have rheumatoid arthritis and face persistent pain. Recently, I started experiencing night cramps and tightness in my calves, along with knee pain. Following some advice, I began taking these vitamins. Within 10 days, the pain and stiffness in my legs vanished. My sleep improved too, and I became less reactive to stress. This has been a lifesaver for me. |
 NOW Foods, Magnesium Citrate, 400 mg, 120 Veg Capsules (133 mg per Capsule) | | |
Joint pain relief Most Useful Review 1 people found this helpful I purchased magnesium on my doctor's advice and am very pleased. I take it alongside D3, K2, and a B-group complex. This combination has effectively reduced my pains from rheumatoid arthritis in my joints and muscles; I've been using it for almost two months now. Effective treatment Most Useful Review Excellent! This magnesium is a lifesaver for my rheumatoid arthritis! |
 Jarrow Formulas, Curcumin 95, Turmeric Extract, 500 mg, 120 Veggie Capsules | | |
Joint pain relief Most Useful Review 25 people found this helpful This product is excellent for managing my joint pain caused by rheumatoid arthritis. I am very pleased with it and highly recommend it. Pain reduction noted Most Useful Review 4 people found this helpful Helps with rheumatoid arthritis. It reduced the pain significantly. However, you must consume it with piperine for a more effective impact; otherwise, the effect is mild. I recommend limiting yourself to two capsules per day. I took three whilst having a cold to recover quicker, which unfortunately caused diarrhoea. Overall, I believe it is a good product. |
 Himalaya, Turmeric 95 with Curcumin, 60 Vegetarian Capsules | | |
Pain relief achieved Most Useful Review 10 people found this helpful High-quality turmeric from the renowned brand Himalaya serves as an anti-inflammatory agent, particularly for joints. It alleviated pain associated with rheumatoid arthritis and reduced swelling in my hands. I took it for two months consecutively and plan to repeat the course in six months. I highly recommend it! Highly effective treatment Most Useful Review An amazing product! Turmeric is well-known for its anti-inflammatory properties, and this particular product has helped my rheumatoid arthritis in my hands remarkably well. I recommend it along with other Himalaya USA products, as they are among the best available. |
 NOW Foods, Turmeric Curcumin Phytosome With Meriva, 500 mg, 60 Veg Capsules | | |
Life-changing supplement Most Useful Review 37 people found this helpful Fantastic miracle supplement for arthritis sufferers! I have Rheumatoid arthritis in my wrists, knees, and sometimes my back. I've been taking Jarrow and Now brands Curcumin for months. I don’t take painkillers, but Curcumin has made my life manageable with significantly less pain and flare-ups. Someone suggested trying the Bio or Super form of Curcumin from Now brands for even better results. To this day, it's a miracle supplement for arthritis like mine, and I now feel almost pain-free. I take one capsule in the morning and one before bed. It energises me, but be cautious with exercise as it can lead to acute pain if overdone. Thanks, iHerb for great prices and fresh supplements. Miracle for pain Most Useful Review 1 people found this helpful I have rheumatoid arthritis in my wrists, knees, and back, and I've been using curcumin for months. I don't take prescription or over-the-counter pain relievers, but curcumin has made life much more manageable with significantly less pain. Someone recommended trying the Bio or super form of curcumin to see if it could help further. This truly is a miracle supplement for arthritis sufferers like me, and I feel nearly pain-free. I take one capsule in the morning and one at bedtime. I feel energised, but be cautious with exercise to avoid pain from overdoing it. Thanks to iHerb for the excellent service. |
 NOW Foods, Oregano Oil, 90 Softgels | | |
Relief from arthritis Most Useful Review 1 people found this helpful Excellent. This dietary supplement is perfect for alleviating my rheumatoid arthritis. Great results Most Useful Review Excellent for managing rheumatoid arthritis. |
 NOW Foods, Turmeric & Bromelain, 90 Veg Capsules | | |
Joint pain relief Most Useful Review 2 people found this helpful It helps! I started taking this dietary supplement recently and I already feel a difference. I have rheumatoid arthritis, and my joints have stopped hurting. My hands work better now, and the rheumatism no longer bothers the joints. The only downside is that the capsules seem a bit large and are yellow, reminiscent of turmeric. Effective pain relief Most Useful Review 4 people found this helpful I bought this supplement for my mum because she has rheumatoid arthritis and often complains of pain. She said it helps with her pain, numbness, and the pins-and-needles sensation. After running out a week ago, she has continually asked me to buy another bottle. So here I am, ordering another one for her. |
 NOW Foods, Mega D-3 & MK-7, 5,000 IU / 180 mcg, 60 Capsules | | |
Significant improvement Most Useful Review This product is excellent! It has helped reduce my rheumatoid arthritis pain by 99%. Hormonal therapy replacement Most Useful Review I introduced an olive supplement to my mother, who suffers from rheumatoid arthritis and was undergoing hormonal therapy. Following a nutritionist's advice, I tried it first. The high-quality ingredients, combined with potassium citrate and celery, plus vitamin D3 due to high dosage requirements, proved effective. After taking it for four months, she was able to discontinue the hormonal treatment and went into remission. We continue to use just this supplement, and the rheumatoid bumps are diminishing. |
 NOW Foods, Calcium & Magnesium, 250 Tablets | | |
Relieved symptoms Most Useful Review Calcium and magnesium, nothing more. Two capsules suffice for my daily needs, lasting approximately four months per package—very economical! They help my grandmother alleviate her rheumatoid arthritis. Highly recommended! If this review is helpful, please give it a thumbs up. Bless you! ♥️ Improved health Most Useful Review 7 people found this helpful Wonderful calcium! I started taking it regularly six months ago on my doctor’s advice, primarily for my rheumatoid arthritis. I have tried various calcium forms, but this is the only one without side effects. It's well absorbed, evident as my nails have stopped separating—something I struggled with for ten years. It has also eased my stomach issues, and I’m sleeping better after enduring insomnia for over 25 years. I believe magnesium contributes to this improvement. Now, my husband and son have ordered as well. I’ve read extensively about calcium and concur with doctors that it should be taken daily, making it a staple in my purchases. Wishing everyone health and well-being! |
 Jarrow Formulas, Pantothenic Acid B5, 500 mg, 100 Veggie Caps | | |
Helps symptoms Most Useful Review 2 people found this helpful It reduces high cholesterol and triglycerides while helping to control the symptoms of Rheumatoid arthritis. I began using it shortly after my blood tests. Eases symptoms Most Useful Review 1 people found this helpful Jarrow's Pantothenic Acid has aided in lowering my high cholesterol and triglycerides and also alleviates the symptoms of Rheumatoid arthritis. |
 NOW Foods, Double Strength DHA-500 Fish Oil, 180 Softgels | | |
Maintains healthy joints Most Useful Review A good product, Omega-3 fatty acids help to prevent osteoporosis, keeping joints healthy, and alleviating pain during flare-ups. They combat bone loss, reduce inflammation, diminish symptoms of rheumatoid arthritis, and slow the destruction of articular cartilage in arthrosis. Reduces joint pain Most Useful Review This high-quality fish oil aids in diminishing pain, enhancing morning stiffness, and alleviating joint tenderness for those with rheumatoid arthritis. |
 Sports Research, Omega-3 Fish Oil, Triple Strength , 30 Softgels | | |
Anti-inflammatory effect Most Useful Review Perfectly! Fish oil, with its polyunsaturated omega-3 fatty acids, provides an anti-inflammatory effect, aiding in chronic inflammation treatment. With Rheumatoid arthritis, biologically active supplements with omega-3s help diminish joint pain and enhance mobility and functionality. Long-term benefits Most Useful Review This omega has a DHA to EPA ratio of 2:1—good composition. Made from small fish, indicating quality. This triglyceride form is well absorbed but requires long-term use. I experience Rheumatoid arthritis, and taking omega twice daily has reduced my inflammation. |
 NOW Foods, Solutions, Glucosamine, MSM & Arnica, Liposome Lotion, 8 fl oz (237 ml) | | |
Remarkable relief Most Useful Review 10 people found this helpful To me, it's just one word: superb! I have rheumatoid arthritis and I am 43. Two months ago, my elbows began to swell and became painful to bend—so much so that I could not rub my head with my left hand. I remembered that a few years ago I ordered a New Food liposome lotion for a friend and decided it was time to try it myself. The result was like magic; just two applications yesterday and today, and I regained the use of my arms. I can hardly believe it! Thank God and thank you, iHerb and Now Foods! Effective MSM cream Most Useful Review 2 people found this helpful I developed rheumatoid arthritis and tried various treatments; MSM has proven effective for me. This product was sold out, so while using other MSM creams, I noticed it was restocked. I bought it immediately. Initially, I was a bit concerned about the smell, but I actually liked it. As it contains arnica, there's a warning regarding long-term use and sensitivity for skin. |
 Doctor's Best, High Potency Bromelain, 500 mg, 90 Veggie Caps | | |
Pain relief achieved Most Useful Review 25 people found this helpful Best supplement for joint pain. I take Bromelain, Serrapeptase, and Nattokinase three times daily, away from food. They have become essential in my battle with Rheumatoid arthritis. The quality, size, and dosage of these products are excellent. After a couple of weeks, my pain disappeared. I wholeheartedly recommend them; you'll soon notice the benefits and regain a normal life. Effective post-infection Most Useful Review 2 people found this helpful A brilliant preparation for working with blood vessels and acting as an anti-inflammatory nutraceutical. I have Rheumatoid arthritis, an autoimmune disease, and have found it essential to rely on nutraceuticals. Following a coronavirus infection which caused bilateral lung inflammation, this drug containing quercetin has been tremendously helpful. |
 Animal, Flex, Comprehensive Joint Care, 44 Pill Packs | | |
Genuine improvement noted Most Useful Review 3 people found this helpful I was diagnosed with rheumatoid arthritis, and after six months on pharmaceutical chondroprotectors to no avail, I decided to try Animal Flex as recommended. Within 3-5 days, I experienced significant improvement; my hands and fingers stopped hurting. This supplement truly works and contains all essential nutrients for effective absorption of chondroitin and glucosamine. I have chosen to stick with Animal Flex moving forward. My lifesaver Most Useful Review This supplement is truly my salvation. Battling rheumatoid arthritis and connective tissue dysplasia, I've been using it for years. I take a yearly course, and nothing has worked better. My knee pain dissipates and stays away for a lengthy period, allowing me to lead an active life and engage in regular gym activities. |
 Solgar, No. 7, Advanced Joint Support Complex, 90 Vegetable Capsules | | |
Effective long-term use Most Useful Review 2 people found this helpful I have been taking it for a year now, one capsule daily. I suffer from rheumatoid arthritis and intervertebral hernia. This product alleviates inflammation and reduces pain effectively. I will continue taking it, especially since I previously used Chinese capsules which were banned in my country. Father's relief Most Useful Review 1 people found this helpful My dad suffers from sore joints due to rheumatoid arthritis, so I purchase this complex for him. He feels its effect significantly—his knees and joints no longer hurt or crunch. We find this product much more affordable than elsewhere, and I genuinely love Solgar. |
 NOW Foods, Super Omega 3-6-9, 1,200 mg, 90 Softgels | | |
Pain relief noted Most Useful Review 8 people found this helpful Unsaturated fatty acids lower the risk of coronary heart disease, regulate cholesterol, and help manage high blood pressure, thanks to prostaglandins that relieve pain and inflammation in those suffering from rheumatoid arthritis. These essential fatty acids must be consumed through diet or supplements and benefit various conditions. Improves joint condition Most Useful Review 3 people found this helpful The delivery was swift and the product high quality. It helps regulate my female cycle, enhances skin health, and reduces hair loss. Fatty acids combat osteoporosis, maintain joint health, alleviate pain, and lessen rheumatoid arthritis symptoms. |
 Osteo Bi-Flex, Joint Health, Triple Strength, 40 Coated Tablets | | |
Effective for mother Most Useful Review 8 people found this helpful I regularly purchase this drug for my mother (69, suffering from rheumatoid arthritis for over 15 years). She is very pleased; the effect surpasses sulfasalazine, which caused severe side effects. She takes it for 2 months on, 2 months off (but continues Boswelia separately) for nearly 2 years. The effect was noticeable by the 7th day of first use. Now, her small joints, especially in her hands, are less inflamed and painful. However, it does not change existing joint deformities. Positive health improvement Most Useful Review 11 people found this helpful Excellent composition and effect is felt within 10 days! I took it for my spinal issues. My knees stopped crunching, and the bone on my foot has reduced. My overall health has improved. On my recommendation, two friends with gout and rheumatoid arthritis were also pleased with the results, as were their doctors. The only drawback is the large tablet size, but I've adapted. Thanks to the manufacturer for the composition and the supplier for the quick delivery! |
 NOW Foods, Apple Pectin, 700 mg, 120 Veg Capsules | | |
Effective treatment Most Useful Review 3 people found this helpful Helps with rheumatoid arthritis. A colleague at elementary school had a high RA index, nearly qualifying for a major injury card. He introduced me to apple pectin, as recommended by Dr. Gu Xiaopei, who described its ability to produce butyrate, beneficial for autoimmunity. Since then, his index has significantly dropped, and he has been diagnosed with rheumatoid arthritis, eliminating the need for injections. It’s truly remarkable. Significant improvement Most Useful Review Apple Pectin and Niacin have greatly improved several types of rheumatoid arthritis after following this diet for six years. |
 NOW Foods, Stinging Nettle Root Extract, 250 mg, 90 Veg Capsules | | |
Effective pain relief Most Useful Review 2 people found this helpful The nettle plant is very beneficial for alleviating pain and reducing inflammation. It comes in two forms: roots, which are believed to be more effective for pain compared to the leaves, both having their advantages. I took the roots to ease the pain and inflammation associated with rheumatoid arthritis, consuming 3 capsules daily. I found it effective in relieving my pain as mentioned. For those seeking further information, Nada Harfoush discusses it on YouTube, and Dr. Berg alongside Karim also elaborated on its natural ingredients, quality, appropriate dosage, and herbal scent. Very effective relief Most Useful Review 1 people found this helpful Excellent! This is the fourth pack I’ve used for rheumatoid arthritis, and it effectively alleviates pain. |
 Doctor's Best, High Potency Serrapeptase, 120,000 SPU, 270 Veggie Caps | | |
Promotes good health Most Useful Review 30 people found this helpful Help with arthritis! High-quality serrapeptase without taste or odour. The convenient dosage—1 capsule in the morning and evening on an empty stomach—takes effect after a month. I've used various brands for ten years, and with rheumatoid arthritis, this has kept me healthy! I highly recommend it as a natural alternative to pharmaceuticals. Remarkable pain reduction Most Useful Review 27 people found this helpful INCREDIBLE! I wish I could give this 7 stars. I have had rheumatoid arthritis for 45 of my 48 years. Taking 2 capsules three times a day has improved my condition significantly. I've experienced 80% less post-operative pain during joint replacements. Despite years of NSAIDs, my internal organs are healthy, thanks to Serrapeptase. It has optimised my blood pressure and resolved swelling in my eyes. Everyone I've recommended it to has benefitted too. |
 Doctor's Best, Nattokinase, 2,000 FUs, 270 Veggie Caps | | |
Pain relief Most Useful Review 34 people found this helpful I’m taking nattokinase along with serrapeptase and bromelain three times a day away from food, and they have become my best allies in managing rheumatoid arthritis. The quality, size, and dosage of these products are excellent. After a few weeks of use, my pain vanished. I wholeheartedly recommend them; you will soon notice the benefits and reclaim your normal life. Effective treatment Most Useful Review 13 people found this helpful A truly effective combination! Faced with the diagnosis of rheumatoid arthritis, I learned about many new and unusual drugs, including nattokinase. I found that taking special care of the kidneys is recommended. Nattokinase is noted for thinning the blood, reducing fibrin, and having antiseptic and antiparasitic effects while normalising blood pressure and cholesterol levels. I did not experience any discomfort during treatment. Initially, I had pulling pains in my lower back and joint pain, but these symptoms disappeared while taking the supplement. Today is the last day of this round, so I’m unsure how long the results will persist. I plan to take it again in spring, and I hope my review helps you. |
 NOW Foods, Selenium, 100 mcg, 100 Tablets | | |
Combats deficiencies Most Useful Review Selenium is crucial for the immune system and has potent antioxidant and anticancer effects. Individuals with Rheumatoid arthritis often experience selenium deficiency, which can affect their immune response. I found that taking selenium alongside vitamin E enhances its benefits. Although the effects might take some time to manifest, ensuring adequate selenium levels is vital for overall health, particularly for the thyroid. It’s also effective in supporting individuals battling metal poisoning and has aided in my overall well-being. Effective pain relief Most Useful Review After being diagnosed with Rheumatoid arthritis, I decided to try selenium as a supplement to alleviate pain. Remarkably, within four days, I began to notice positive effects. This vitamin has contributed significantly to reducing my discomfort and improving my overall health, showing that targeted supplementation can make a meaningful difference in managing symptoms associated with Rheumatoid arthritis. |
 Life Extension, Super Selenium Complex & Vitamin E, 200 mcg, 100 Vegetarian Capsules | | |
Helpful for patients Most Useful Review Selenium and vitamin E are very beneficial for those with rheumatoid arthritis. Improves joint mobility Most Useful Review I requested selenium due to its numerous benefits. It helps enhance joint mobility and is beneficial for rheumatoid arthritis. I believe it will assist me. I recommend it. |
 Citrucel, Methylcellulose Fiber Therapy for Irregularity, 180 Fiber Caplets | | |
Significant improvement Most Useful Review 250 people found this helpful There is an effect - it works! I delayed writing a review as I wanted to observe the results. I ordered this drug for my mother-in-law, who has rheumatoid arthritis, and for my mother, suffering from intervertebral disc issues. Initially sceptical, they began taking the drug when pain forced them to agree. Within ten days, my mother-in-law noticed it was easier to rise from a chair, and the swelling in her knees diminished, though pain persisted. After two weeks, my mother could wake up on her side, something she hadn't managed due to back pain. They have now been taking the drug for over a month, and I'm reordering. They recommend it! Life-changing supplement Most Useful Review 37 people found this helpful Fantastic miracle supplement for arthritis sufferers! I have Rheumatoid arthritis in my wrists, knees, and sometimes my back. I've been taking Jarrow and Now brands Curcumin for months. I don’t take painkillers, but Curcumin has made my life manageable with significantly less pain and flare-ups. Someone suggested trying the Bio or Super form of Curcumin from Now brands for even better results. To this day, it's a miracle supplement for arthritis like mine, and I now feel almost pain-free. I take one capsule in the morning and one before bed. It energises me, but be cautious with exercise as it can lead to acute pain if overdone. Thanks, iHerb for great prices and fresh supplements. |
 NOW Foods, Boron, 3 mg, 250 Veg Capsules | | |
Bloating relief Most Useful Review 11 people found this helpful I began taking boron for my rheumatoid arthritis. There appears to be a connection between soil nutrient deficits and arthritis prevalence. However, what truly compels me to continue taking boron is the complete disappearance of my bloating, pain, and cramps. I used to experience severe symptoms before my period, but now nothing. I suggested it to my daughter, and she's also had similar benefits within two weeks; she's committed to taking it as well. We’re certainly spreading the word! Joint improvement Most Useful Review 7 people found this helpful I requested boron multiple times due to the noticeable improvement in my joints and exercise capability. I increased the dose to two pills daily, as those who exercise should take 6mg. The ingredients are excellent and the value is satisfactory. Boron is crucial for bone health and enhances the absorption of vitamin D, calcium, and magnesium, beneficial for conditions like osteoporosis and rheumatoid arthritis. Moreover, it bolsters antioxidant production, protects against several cancers, and aids in hormone regulation. It’s a rare mineral, and I find it difficult to get enough without supplementation. |
 ChildLife Essentials, Essentials, Echinacea, Natural Orange, 1 fl oz (30 ml) | | |
Reduces inflammation Most Useful Review Preparations containing echinacea assist in reducing systemic inflammation in rheumatoid arthritis and uveitis, which is inflammation of the eye's vascular membrane. Due to its anti-inflammatory and immunomodulatory effects, echinacea can combat upper respiratory tract diseases like asthma. Systemic inflammation relief Most Useful Review Preparations containing echinacea aid in diminishing systemic inflammation in rheumatoid arthritis and uveitis, the inflammation of the vascular membrane of the eye. Owing to its anti-inflammatory and immunomodulatory properties, echinacea is effective against upper respiratory tract diseases like asthma. |
 NOW Foods, Cat's Claw, 500 mg, 250 Veg Capsules | | |
Quality of life restored Most Useful Review 5 people found this helpful I purchased this after extensive research on homeopathic solutions for managing rheumatoid arthritis. Having previously dealt with autoimmune issues, I was desperate for effective relief. After just four days of adding these supplements, my lower back pain disappeared, and my hands and feet felt considerably less stiff. I’m genuinely astonished by the rapid improvement in my quality of life! Inflammation reduction Most Useful Review 5 people found this helpful This product has effectively reduced my inflammation from rheumatoid arthritis. |