We explored the impact of vitamin D3, also known as calcitriol, on outcomes following intracerebral hemorrhage (ICH), especially in individuals with vitamin D deficiency (VDD). Previous observations suggested that VDD might worsen clinical outcomes for stroke patients, prompting our research into whether acute vitamin D supplementation could make a significant difference.
Using mice models, we induced ICH in both vitamin D deficient and sufficient subjects. By assessing factors like the size of the hematomas and levels of hemorrhage, we aimed to understand how VDD might influence post-stroke survival and neurofunctional recovery.
Our findings revealed that mice experiencing VDD faced higher mortality rates and more significant motor deficits compared to their vitamin D sufficient counterparts after ICH. Additionally, their blood-brain barrier (BBB) appeared more disrupted, leading to worse overall outcomes. However, the silver lining came with acute vitamin D treatment, which showed promising results for improving those affected by VDD after stroke.
Overall, this research gives us valuable insights into how vitamin D3 could potentially help mitigate the adverse effects of VDD in stroke situations, emphasizing the importance of addressing vitamin deficiencies in stroke recovery.