Vitamins
9
Vitamin D reduces stroke mortality
Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES.
Most Relevant Research
We carefully assessed how vitamin D levels and physical activity influence mortality among individuals who have survived a stroke. Analyzing data from 677 stroke survivors from the National Health and Nutrition Examination Survey over several years, we examined both the individual and combined effects of vitamin D and physical activity on overall mortality risk.
Our findings revealed that higher levels of 25-hydroxyvitamin D (25(OH)D) are associated with a lower risk of death from all causes, as well as from non-major adverse cardiovascular events (non-MACE). More specifically, individuals with high levels of vitamin D had significantly lower mortality rates compared to those with low levels. Moreover, being physically active showed similar protective effects against these mortality risks.
When we looked at individuals with both high 25(OH)D levels and who engaged in physical activities, they demonstrated the lowest risk of all-cause mortality and non-MACE events. This suggests a synergistic effect between vitamin D and physical activity that could improve longevity in stroke survivors. These insights may help shape future strategies for preventing and treating cardiovascular and cerebrovascular diseases.
Our findings revealed that higher levels of 25-hydroxyvitamin D (25(OH)D) are associated with a lower risk of death from all causes, as well as from non-major adverse cardiovascular events (non-MACE). More specifically, individuals with high levels of vitamin D had significantly lower mortality rates compared to those with low levels. Moreover, being physically active showed similar protective effects against these mortality risks.
When we looked at individuals with both high 25(OH)D levels and who engaged in physical activities, they demonstrated the lowest risk of all-cause mortality and non-MACE events. This suggests a synergistic effect between vitamin D and physical activity that could improve longevity in stroke survivors. These insights may help shape future strategies for preventing and treating cardiovascular and cerebrovascular diseases.
9.5
Blood thinner
Most Useful Review
This product acts as a blood thinner and effectively protects against strokes while also lowering excess cholesterol and calcium levels in the bloodstream.
Acetyl L Carnitine
9.5
Highly recommended for stroke
Most Useful Review
I ordered two packages for my father, who is 77 and has severe atherosclerosis. He suffered a stroke without losing motor function and is now satisfied with the results. He feels the medication's effects; his headaches have reduced and his understanding has improved. Despite being a challenging patient, he confirmed that this drug is beneficial. A neurologist also affirmed the necessity of this treatment. I highly recommend it for older adults.
9.5
Supports stroke recovery
Most Useful Review
Acetyl-L-Carnitine 500mg is crucial for producing compounds essential for health, like glutathione and coenzyme Q10. As we age, its production decreases, accelerating bodily deterioration. Supplementation enhances brain energy, mitigates stress, and can assist with stroke recovery and cognitive declines associated with Alzheimer’s and Parkinson’s. It also bolsters the immune system and can be particularly effective when taken before exercise.
Ginkgo Biloba
9.5
No medication needed
Most Useful Review
I drink it daily. After my stroke four years ago, I consulted many doctors until I found this site. My blood pressure is now stable. I take alpha-lipoic acid and fish oil for breakfast, and zinc with milk thistle at lunch. I no longer need medication for blood pressure. I also take Ginkgo for improved potency and magnesium before bed.
9.5
Restored circulation
Most Useful Review
Two years ago, I dealt with migraines and high blood pressure, finding no relief from traditional medicines. A nutritionist suggested a regimen that included Ginkgo Biloba, leading to significant improvements in my condition over a year. I rarely experience migraines now and have normal blood pressure. I also provide Ginkgo to my mother, a stroke survivor, and it aids her circulation as well.
Enzymes
9
Nattokinase shows promise in stroke
Nattokinase's Neuroprotective Mechanisms in Ischemic Stroke: Targeting Inflammation, Oxidative Stress, and Coagulation.
Most Relevant Research
We examined how nattokinase (NK), a powerful enzyme, can benefit patients who suffer from strokes. Our research focused on the effects of NK in a model of transient middle cerebral artery occlusion (tMCAO), which simulates ischemic stroke and its aftermath. By administering different doses of NK to rats before they underwent surgery, we wanted to see if it could reduce brain damage and improve recovery.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
Our observations revealed that NK treatment significantly reduced the size of brain injury and enhanced recovery from neurological issues. It also helped lower levels of harmful pro-inflammatory and coagulation substances while reducing oxidative stress markers in the affected brain area. These findings show NK’s potential in protecting the brain from the damaging effects of stroke.
Furthermore, we explored NK's protective properties in laboratory tests simulating neuron injury due to lack of oxygen and glucose. We found that it was effective in countering cell death across these models, working through various biological pathways. However, when we blocked NK's activity with a specific inhibitor, we noticed that its protective effects vanished, demonstrating that NK's enzymatic activity is crucial for its benefits.
Overall, this study highlights the multi-faceted protective role of nattokinase in brain injuries caused by ischemic events, confirming its potential as a therapeutic agent in stroke treatment.
9.5
Hydrates blood effectively
Most Useful Review
I use nattokinase instead of aspirin for thick blood, enhancing its fluidity. High blood viscosity poses a risk for strokes, hence I take it in the evening and on an empty stomach in the morning. It helps me forget my blood pressure issues!
Multivitamins
9.5
Effective vitamin solution
Most Useful Review
An excellent complex of B vitamins; I purchased it for my mother, who experiences constant cramps in her legs and arms following a stroke. It became clear that these vital vitamins are beneficial for her condition. This complex truly presents an excellent solution to our problem, and the vitamins have positively impacted her.
9.5
Brain protection benefits
Most Useful Review
The dietary supplement "Omega 3-6-9" significantly reduces the risk of heart attacks and strokes and enhances cell structure. It helps prevent cataracts, protects the eyes, and improves vision. This supplement effectively combats depression and improves metabolism regulation. Its antioxidant effects bolster the immune system, and it aids in preventing cardiovascular diseases, senile dementia, and various cancers. Overall, it strengthens bodily defences and supports weight loss through an improved metabolic rate.
L Taurine
9.5
Blood pressure normalised
Most Useful Review
Dad began taking taurine after his stroke, and his blood pressure started to normalise, allowing him to stop taking chemical pills. He now takes 1-2 capsules preventively. Our relative, who suffered four strokes and had persistent high blood pressure, also began consuming taurine on our advice, and her blood pressure normalised as well. Now, she also takes preventive measures. My husband has diabetes and his blood pressure is normal, yet he takes taurine to lower his blood sugar, which works effectively. There are numerous other benefits to taurine, so I highly recommend it. However, for individuals with low blood pressure, it is not advisable as it may lower it further. If this review was helpful, please like it; thank you!
8
Heart and stroke benefits
Most Useful Review
Taurine greatly benefits heart and circulatory health. Numerous studies indicate that it helps lower blood cholesterol levels and reduces the risk of cardiovascular diseases, including hypertension and stroke. The quality of the ingredients is also commendable. Overall, taurine enhances energy processes, stimulates cellular and tissue regeneration, boosts the nervous system, and positively impacts the cardiovascular system, especially the heart muscle.
Childrens Herbs
9.5
Immunity boost
Most Useful Review
Excellent! Echinacea positively affects the immune system and enhances the body's defences. It boosts immunity, cleanses the lymphatic system, blood, and liver, and combats viruses, bacteria, and fungi. This remarkable plant contains many medicinal substances, particularly betaine, which helps prevent heart attack and stroke.
9.5
Heart attack prevention
Most Useful Review
Perfectly! 🌿 Echinacea can heal severe wounds, ulcers, and eczema. It is rich in medicinal elements, particularly betaine, which helps prevent heart attack and stroke. Does not contain alcohol. Recommendations for use: 🔵 Babies from 6 months to 1 year: 5 drops four times a day. 🔵 Children 1-12 years: 10 drops four times daily. 😉 For best results, use four times daily in the recommended doses for ten consecutive days.
Resveratrol
8.8
Neuroprotective effects
Most Useful Review
As an antioxidant, resveratrol combats free radicals and has been linked to anti-inflammatory and anti-carcinogenic properties. It can help slow Alzheimer’s disease progression, reduce the risk of stroke, and improve blood flow in the brain. Resveratrol is generally safe with no serious side effects, but adults over 18 should consult a doctor, especially pregnant or lactating women, as it may interact with certain medications.
8.8
Restores blood vessels
Most Useful Review
The finest supplement for health and youth, resveratrol aids recovery post-covid by restoring blood vessels. With a minimum course of four months, it fights free radicals and shows neuroprotective effects, potentially slowing Alzheimer’s disease progression, vascular dementia, and reducing stroke risk. Studies have shown its benefits for patients after chemotherapy treatment as well.
Red Yeast Rice
8
CoQ10 aids stroke recovery
Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study.
Most Relevant Research
We investigated the potential benefits of coenzyme Q10 (CoQ10) supplementation in patients recovering from acute ischemic stroke. In this double-blind, randomized placebo-controlled study, fifty hospitalized patients were divided into two groups; one received 600 mg of CoQ10 daily for 30 days, while the other received a placebo starting 24 hours post-stroke.
Our findings revealed notable improvements among those taking CoQ10. The group supplemented with CoQ10 showed significant reductions in harmful substances linked to oxidative stress, such as malondialdehyde (MDA) and inflammatory interleukin-6 (IL-6). Additionally, we observed increases in beneficial antioxidants, including superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF), suggesting that CoQ10 may aid in neuroprotection and recovery after a stroke.
While some biomarkers did not show significant change, the overall results suggest that CoQ10 could be a valuable addition to rehabilitation programs for stroke patients, potentially improving recovery outcomes.
Our findings revealed notable improvements among those taking CoQ10. The group supplemented with CoQ10 showed significant reductions in harmful substances linked to oxidative stress, such as malondialdehyde (MDA) and inflammatory interleukin-6 (IL-6). Additionally, we observed increases in beneficial antioxidants, including superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF), suggesting that CoQ10 may aid in neuroprotection and recovery after a stroke.
While some biomarkers did not show significant change, the overall results suggest that CoQ10 could be a valuable addition to rehabilitation programs for stroke patients, potentially improving recovery outcomes.
9.5
Cholesterol reduction
Most Useful Review
I have been purchasing this for about three years; it has reduced my bad cholesterol level from 470 to normal, potentially saving me from a heart attack or stroke.
Alpha Lipoic Acid
7
ALA's potential in stroke treatment
A comprehensive review on alpha-lipoic acid delivery by nanoparticles.
Most Relevant Research
We investigated the potential of alpha-lipoic acid (ALA) in treating cerebral ischemia, a condition often associated with strokes. The idea behind using ALA is its antioxidant properties, which might help mitigate damage caused during a stroke.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
9.5
Restores nerve damage
Most Useful Review
A wonderful product. After a stroke, I started using "Tioktatsid" and continued with tablets. The price in MSC is 1900 rubles for 30 tablets of 600 mg. The difference in cost is immediately noticeable. It must be taken on an empty stomach 30 minutes before meals for proper absorption and should not be taken with metals such as magnesium or calcium, as it binds to them. I physically feel the restoration of the affected areas from the stroke, with long numbness in my fingers and toes diminishing. My doctor recommends this remedy continuously, and I have noticed a decrease in blood sugar levels.
Garlic
9.5
Good for health
Most Useful Review
An amazing supplement for my 94-year-old mother with a stroke, combined with other supplements, has had a remarkably positive effect on her health.
9.5
Long-term effects
Most Useful Review
I consistently give this to my mother after her stroke for many years. Besides benefiting her blood vessels, she hasn’t caught any colds, even when my father had COVID.
L Lysine
8.8
Improved quality of life
Most Useful Review
Excellent! I order from this site frequently. This is not the first time I have purchased this for my father-in-law, who has diabetes, hypertension, and has suffered a stroke. He takes several supplements alongside this one, and the benefits are evident. His quality of life has considerably improved, with many issues related to his blood vessels and nervous system no longer causing concern.
8.8
Heart health support
Most Useful Review
Lysine is an essential amino acid not produced by the body but obtained through food. It helps with calcium absorption, boosts bone strength, and reduces the likelihood of osteoporosis. Furthermore, lysine may enhance heart health by supporting carnitine production and lowering the risk of heart disease and stroke. Stay healthy❤ Thank you for your thumbs up!
L Glutathione
8
Silymarin may aid stroke recovery
Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats.
Most Relevant Research
We explored whether silymarin, extracted from milk thistle, can protect against neuronal damage during a stroke. In our study, male Wistar rats were given a daily dose of silymarin for 15 days before being subjected to a stroke simulation.
The results showed that silymarin significantly improved antioxidant levels and reduced cell death, aiding in functional recovery post-stroke. This suggests that silymarin could potentially slow down neurodegeneration linked to strokes, thanks to its natural antioxidant and anti-apoptotic benefits.
The results showed that silymarin significantly improved antioxidant levels and reduced cell death, aiding in functional recovery post-stroke. This suggests that silymarin could potentially slow down neurodegeneration linked to strokes, thanks to its natural antioxidant and anti-apoptotic benefits.
8.8
Detoxification benefits
Most Useful Review
Glutathione is a potent antioxidant that detoxifies hydrogen peroxide and lipid peroxides, hinders rust in the body, and combats skin ageing such as age spots, disease, and overall degradation. It is also beneficial for stroke, myocardial infarction, infertility, blood vessel rejuvenation, cataracts, diabetes prevention, hypoglycaemia, arthritis, and allergies.
Selenium
8.3
Eliminated blind spots
Most Useful Review
I was told I had a stroke when my left eye would go blind for about 45 seconds every week. After researching that I was lacking iodine and selenium in my diet, I started taking this product once a day for the past two months and have not experienced a single blind spot since.
7.5
Health improvement post-stroke
Most Useful Review
My dad drinks this after having a stroke. The results are good; there has been no deterioration in his health.
Phosphatidylserine
9.5
Significant brain improvement
Most Useful Review
PS 100, combined with Acetyl-L-Carnitine, has had a dramatic effect on my mind following my major operation and stroke. The painkillers affected my brain negatively, yet PS 100 has restored my mental sharpness and abilities. I believe my brain capacity plummeted to around 50%, but it's now back up to 90%. With my IQ of 173, the decline in my cognitive function was stark, just as was the improvement after I took the product for six months after feeling despondent. I highly recommend PS 100 to everyone.
8.8
Improved overall health
Most Useful Review
I purchased this for my mother, alongside citicoline and Alpha-GPC, to assist her recovery from a stroke. Together, they work harmoniously. Her activity levels have improved, headaches and cognitive fog have diminished, and even her hearing is gradually enhancing! I found out that taking one caused me headaches, so I stopped. Initially, my mother took two capsules at once, but that led to sleep issues. Now, she takes one each morning, and it suits her well.
Rutin
8.8
Prevents blood clots
Most Useful Review
Rutin significantly lowers capillary permeability, thereby enhancing blood circulation and displaying anti-inflammatory properties. Studies indicate that rutin helps avert blood clots, making it suitable for individuals at risk of heart attacks and strokes.
8.8
Strengthens blood vessels
Most Useful Review
This supplement supports healthy blood vessels significantly! I consume it to fortify the capillaries in my nasopharynx and eyes while treating varicose veins. I also take it to strengthen my heart and blood vessels to prevent strokes, pairing it with vitamin C for enhanced efficacy.
Sports Fish Oil Omegas
7
Impact on stroke unclear
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
Most Relevant Research
We explored the effects of eicosapentaenoic acid, commonly known as icosapent ethyl, on stroke among patients with high cardiovascular risk. This analysis was part of the REDUCE-IT trial, which involved statin-treated patients who had elevated triglycerides and baseline low-density lipoprotein cholesterol (LDL-C) levels.
Participants were divided into two groups: one receiving icosapent ethyl, taken twice daily, and the other receiving a placebo. When we looked specifically at the data for patients with low LDL-C levels (less than 55 mg/dL), we found that those treated with icosapent ethyl had a lower occurrence of the primary composite endpoint, which included stroke, compared to those in the placebo group.
In patients with higher LDL-C (55 mg/dL or more), a similar trend was observed, where the rate of primary composite outcomes, including strokes, was also lower in those receiving icosapent ethyl. Importantly, we noted that the treatment seemed effective in reducing cardiovascular events regardless of initial LDL-C levels, suggesting a beneficial role even for those with controlled cholesterol levels.
However, while the results showed promise for the overall reduction of cardiovascular events, including strokes, we acknowledge that the specific impact of icosapent ethyl on stroke alone remains part of a broader set of outcomes. Thus, while it seems to help reduce risks, we should be cautious in attributing benefits directly to stroke without further focused studies.
Participants were divided into two groups: one receiving icosapent ethyl, taken twice daily, and the other receiving a placebo. When we looked specifically at the data for patients with low LDL-C levels (less than 55 mg/dL), we found that those treated with icosapent ethyl had a lower occurrence of the primary composite endpoint, which included stroke, compared to those in the placebo group.
In patients with higher LDL-C (55 mg/dL or more), a similar trend was observed, where the rate of primary composite outcomes, including strokes, was also lower in those receiving icosapent ethyl. Importantly, we noted that the treatment seemed effective in reducing cardiovascular events regardless of initial LDL-C levels, suggesting a beneficial role even for those with controlled cholesterol levels.
However, while the results showed promise for the overall reduction of cardiovascular events, including strokes, we acknowledge that the specific impact of icosapent ethyl on stroke alone remains part of a broader set of outcomes. Thus, while it seems to help reduce risks, we should be cautious in attributing benefits directly to stroke without further focused studies.
9.5
Improves brain function
Most Useful Review
Omega 3 from RS provides a high level of fatty acids per capsule, accelerating metabolism and lowering blood viscosity and blood pressure. It effectively reduces the risk of stroke and heart attacks and enhances brain function while boosting skin and hair conditions. I highly recommend it for its genuine results.
Dha
8
DHA enhances stroke recovery
ROS-triggered biomimetic hydrogel soft scaffold for ischemic stroke repair.
Most Relevant Research
We examined the potential of docosahexaenoic acid (DHA) in a unique treatment approach for ischemic stroke patients. The study developed a specialized hydrogel soft scaffold that releases DHA, combined with other growth factors, to create a supportive environment for healing brain tissue after a stroke.
The scaffold was designed to respond to reactive oxygen species, which are elevated in stroke conditions. This triggers the release of protective substances to counteract oxidative stress, paving the way for improved cell survival. Additionally, DHA is known for its role in reducing inflammation and promoting the growth of new neurons—key factors in brain recovery.
Our results showed that this DHA-enriched hydrogel significantly influenced the environment in the affected brain areas. In laboratory tests, it successfully reduced cell death and boosted new blood vessel formation. In mice models, we noted improved movement and behavioral functions over time, suggesting that this treatment could support natural healing processes after a stroke.
Overall, the study reveals that incorporating DHA into stroke treatment via innovative hydrogel delivery could enhance recovery by fostering a pro-regenerative atmosphere in the brain.
The scaffold was designed to respond to reactive oxygen species, which are elevated in stroke conditions. This triggers the release of protective substances to counteract oxidative stress, paving the way for improved cell survival. Additionally, DHA is known for its role in reducing inflammation and promoting the growth of new neurons—key factors in brain recovery.
Our results showed that this DHA-enriched hydrogel significantly influenced the environment in the affected brain areas. In laboratory tests, it successfully reduced cell death and boosted new blood vessel formation. In mice models, we noted improved movement and behavioral functions over time, suggesting that this treatment could support natural healing processes after a stroke.
Overall, the study reveals that incorporating DHA into stroke treatment via innovative hydrogel delivery could enhance recovery by fostering a pro-regenerative atmosphere in the brain.
9.5
Stimulates recovery
Most Useful Review
This is a great supplement for the brain, particularly beneficial for schoolchildren and those recovering from a stroke, as it aids memory and concentration.
Potassium
8
Potassium’s Role in Stroke Outcomes
Prognostic Values of Homocysteine and Potassium Levels in Acute Ischemic Stroke Patients after Intravenous Thrombolysis with Recombinant Tissue-Type Plasminogen Activator.
Most Relevant Research
We aimed to investigate how levels of potassium, alongside homocysteine, influence the outcomes for patients experiencing acute ischemic stroke (AIS) after receiving treatment with intravenous thrombolysis using rt-PA. To do this, we enlisted 426 patients and monitored their health closely, categorizing them by whether they experienced early neurological deterioration (END) and assessing their recovery using established scales.
Our findings revealed that both high levels of homocysteine (Hcy) and low levels of potassium were more common in patients who faced END or a poor recovery three months after treatment. In fact, patients with a higher Hcy level demonstrated significantly worse outcomes, while low potassium levels also hinted at increased risk.
While this research didn’t showcase a direct therapeutic effect from potassium itself, it suggests that monitoring potassium levels could be helpful in understanding the stroke prognosis. Overall, high Hcy and low potassium levels could serve as meaningful indicators for patient management in AIS treatments involving thrombolysis.
Our findings revealed that both high levels of homocysteine (Hcy) and low levels of potassium were more common in patients who faced END or a poor recovery three months after treatment. In fact, patients with a higher Hcy level demonstrated significantly worse outcomes, while low potassium levels also hinted at increased risk.
While this research didn’t showcase a direct therapeutic effect from potassium itself, it suggests that monitoring potassium levels could be helpful in understanding the stroke prognosis. Overall, high Hcy and low potassium levels could serve as meaningful indicators for patient management in AIS treatments involving thrombolysis.
9.5
Stroke recovery
Most Useful Review
This excellent product has been given to my mother after her stroke. It effectively restores electrolyte balance and the results were noticeable after a week. The capsules are conveniently sized for easy swallowing post-stroke. I highly recommend it for anyone needing such a supplement.
Inositol
8
Inositol aids axon recovery
Inositol Polyphosphate-5-Phosphatase K () Enhances Sprouting of Corticospinal Tract Axons after CNS Trauma.
Most Relevant Research
We sought to understand how inositol polyphosphate-5-phosphatase K influences the recovery of axons in the context of stroke and other central nervous system (CNS) injuries. By studying intact corticospinal neurons from mice that had experienced a pyramidotomy, we found that this protein plays a crucial role in facilitating axon growth.
Our exploration involved various preclinical models and established that overexpressing inositol polyphosphate-5-phosphatase K in these neurons enhanced the sprouting of corticospinal tract terminals after a stroke, demonstrating promising effects not just after immediate injury but also in instances of chronic damage.
We observed that this enhancement occurs partly through the elevation of active cofilin within the growth cones of neurons, which catalyzes critical processes for maintaining healthy axon structures and supports the potential for neurological recovery post-stroke. The results indicate that inositol could be a significant factor in encouraging damaged CNS neurons to regrow axons, a key aspect of functional recovery following injuries like stroke or spinal cord trauma.
Ultimately, our findings reinforce the value of pursuing new strategies to boost axon growth in complex environments where traditional healing has been limited, showcasing the necessity of continued research into factors that promote nerve regeneration.
Our exploration involved various preclinical models and established that overexpressing inositol polyphosphate-5-phosphatase K in these neurons enhanced the sprouting of corticospinal tract terminals after a stroke, demonstrating promising effects not just after immediate injury but also in instances of chronic damage.
We observed that this enhancement occurs partly through the elevation of active cofilin within the growth cones of neurons, which catalyzes critical processes for maintaining healthy axon structures and supports the potential for neurological recovery post-stroke. The results indicate that inositol could be a significant factor in encouraging damaged CNS neurons to regrow axons, a key aspect of functional recovery following injuries like stroke or spinal cord trauma.
Ultimately, our findings reinforce the value of pursuing new strategies to boost axon growth in complex environments where traditional healing has been limited, showcasing the necessity of continued research into factors that promote nerve regeneration.
9.5
Supports recovery
Most Useful Review
It was instrumental in my father’s recovery following a stroke. He recovered satisfactorily from the effects of the stroke and the resulting physical weakness.
Omega 3 Fish Oil
7
Omega-3 benefits for heart health
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
Most Relevant Research
We explored the effects of icosapent ethyl, a type of omega-3 fatty acid, on stroke and other cardiovascular events among patients with good control of their cholesterol levels. The analysis came from the REDUCE-IT trial, which involved randomized patients at high cardiovascular risk with elevated triglyceride levels.
Interestingly, we found that icosapent ethyl significantly reduced the occurrence of cardiovascular problems, including stroke, regardless of whether patients had low or high baseline levels of LDL cholesterol. This suggests that even those who manage their cholesterol well can still benefit from this treatment.
Interestingly, we found that icosapent ethyl significantly reduced the occurrence of cardiovascular problems, including stroke, regardless of whether patients had low or high baseline levels of LDL cholesterol. This suggests that even those who manage their cholesterol well can still benefit from this treatment.
9.5
Stroke prevention aid
Most Useful Review
This supplement has remarkable positive effects on both the brain and cardiovascular system. It serves as effective prevention against strokes and coronary heart disease.
Lutein
8
Supports heart health
Most Useful Review
It has a beneficial effect on the cardiovascular system, reducing the risk of atherosclerosis, stroke, heart disease, and vascular issues. A sufficient intake of lutein in the diet helps prevent retinal detachment, cataracts, and other age-related eye diseases.
8
Heart disease prevention
Most Useful Review
The carotenoid has a beneficial effect on the cardiovascular system, reducing the risk of atherosclerosis, stroke, heart disease, and vascular issues. Regular intake of lutein in the diet helps prevent retinal detachment, cataracts, and other age-related eye diseases.
Folic Acid
7
SLCO1B1 polymorphisms affect homocysteine
The impact of SLCO1B1 polymorphisms on homocysteine concentrations: evidence for a stronger association in men.
Most Relevant Research
We explored how certain gene variants, particularly SLCO1B1, relate to homocysteine levels in ischemic stroke patients. Our analysis included 177 participants and focused on understanding which factors contribute to higher homocysteine concentrations.
We found that folic acid and vitamin B12 help lower homocysteine. Notably, men, especially those with specific SLCO1B1 gene polymorphisms, exhibited higher levels of this amino acid. This suggests that genetics play a crucial role in stroke risk related to homocysteine levels.
We found that folic acid and vitamin B12 help lower homocysteine. Notably, men, especially those with specific SLCO1B1 gene polymorphisms, exhibited higher levels of this amino acid. This suggests that genetics play a crucial role in stroke risk related to homocysteine levels.
9.5
Supports heart health
Most Useful Review
Excellent! Folic acid is an essential B vitamin (B9) that aids heart health. Regular consumption of the recommended dose with food reduces the risk of stroke and cardiovascular issues, normalises blood pressure, and lowers cholesterol levels. It also plays a vital role during pregnancy, promoting the creation and maintenance of healthy body cells, which is crucial during fetal development and early childhood, helping to prevent premature births and postpartum depression.
Ubiquinol Coq10
8
Ubiquinol shows promise in stroke
Therapeutic Effects of Coenzyme Q10 in the Treatment of Ischemic Stroke.
Most Relevant Research
We explored how ubiquinol, a form of coenzyme Q10, may help in treating ischemic stroke. The brain is particularly vulnerable after a stroke due to oxidative stress, which can lead to further damage. Thus, the potential of antioxidants like ubiquinol becomes very interesting.
Recent studies suggest that ubiquinol can protect the brain in several ways. It works against oxidative stress, inflammation, and cell death, potentially offering a multi-faceted approach to treating ischemic stroke. Evidence has been gathered from multiple angles—laboratory experiments, animal studies, and clinical observations—to highlight these protective effects.
Our findings emphasize the promising role of ubiquinol in neuroprotection following ischemic stroke. Given the significant deficiency of its reduced form in the brain, ubiquinol could serve as a valuable candidate for treatment and prevention strategies moving forward.
Recent studies suggest that ubiquinol can protect the brain in several ways. It works against oxidative stress, inflammation, and cell death, potentially offering a multi-faceted approach to treating ischemic stroke. Evidence has been gathered from multiple angles—laboratory experiments, animal studies, and clinical observations—to highlight these protective effects.
Our findings emphasize the promising role of ubiquinol in neuroprotection following ischemic stroke. Given the significant deficiency of its reduced form in the brain, ubiquinol could serve as a valuable candidate for treatment and prevention strategies moving forward.
9.5
Improved potency
Most Useful Review
Perfectly! It helped my husband cope with the side effects of statins after his stroke. We noticed a significant decline in potency as a side effect of the statins. However, since using this coenzyme along with astaxanthin from the same brand, things have greatly improved.
Calcium Magnesium
8
Calcium's impact on stroke recovery
The Role of Casr Inhibition-Mediated M2 Microglial Transformation in Ischemic Preconditioning Against Stroke.
Most Relevant Research
We explored the impact of the calcium-sensing receptor (Casr) on stroke protection, focusing on its inhibition and the resulting transformation of microglial cells. Through experiments on rats and neurons, we induced ischemic preconditioning (IP) using methods like middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation (OGD).
During our investigation, we discovered that IP encouraged the transformation of microglial cells into a protective M2 state following an ischemic event. We noted that MCAO injury elevated Casr expression and calcium levels, which was mitigated by the IP response. Interestingly, our findings suggest that activating Casr hindered the M2 transformation triggered by IP.
Ultimately, we observed that inhibiting Casr led to improved outcomes for stroke-affected subjects, such as increased survival rates and decreased brain tissue damage. This study illuminates the protective mechanisms of ischemic preconditioning against stroke, particularly highlighting the role of Casr and microglial transformation.
During our investigation, we discovered that IP encouraged the transformation of microglial cells into a protective M2 state following an ischemic event. We noted that MCAO injury elevated Casr expression and calcium levels, which was mitigated by the IP response. Interestingly, our findings suggest that activating Casr hindered the M2 transformation triggered by IP.
Ultimately, we observed that inhibiting Casr led to improved outcomes for stroke-affected subjects, such as increased survival rates and decreased brain tissue damage. This study illuminates the protective mechanisms of ischemic preconditioning against stroke, particularly highlighting the role of Casr and microglial transformation.
8.8
Reduces heart attack risk
Most Useful Review
This choice has eliminated stress while addressing magnesium deficit in my body. Magnesium mitigates blood clotting, alleviates stomach cramps, and helps with acidity levels. It’s crucial for hearing acuity, involved in brain function, and necessary for the absorption of B vitamins. Additionally, it has an anti-sclerotic effect and lowers elevated blood pressure, thereby reducing the risk of heart attack and stroke by relaxing blood vessels.
Vitamin B Complex
8
Vitamin B6 linked to stroke risk
Pyridoxal 5'-phosphate and risk of stroke: triangulation of evidence from a nationally representative cohort and bidirectional Mendelian randomization analysis.
Most Relevant Research
We examined the relationship between vitamin B6, specifically in its active form called pyridoxal 5'-phosphate (PLP), and the risk of stroke in a diverse group of over 6,800 participants from a national health survey. The study aimed to not only identify how serum PLP levels correlate with stroke occurrence but also to determine if there is a causal link between low PLP levels and an increased risk of stroke.
The results showed that individuals with lower PLP levels were more likely to report having suffered a stroke. This suggests that maintaining adequate levels of this vitamin could be important for stroke prevention. Furthermore, our analysis used advanced statistical methods, including bidirectional Mendelian randomization. This approach provided additional insights into the potential protective role of vitamin B6 against stroke, reinforcing the idea that it may be beneficial for cardiovascular health.
In summary, our findings point toward the possibility of using serum PLP as a predictive marker for assessing stroke risk. It highlights the importance of proper vitamin B6 levels for effective individual strategies in preventing and managing strokes, aligning with modern health approaches that prioritize personalized medicine.
The results showed that individuals with lower PLP levels were more likely to report having suffered a stroke. This suggests that maintaining adequate levels of this vitamin could be important for stroke prevention. Furthermore, our analysis used advanced statistical methods, including bidirectional Mendelian randomization. This approach provided additional insights into the potential protective role of vitamin B6 against stroke, reinforcing the idea that it may be beneficial for cardiovascular health.
In summary, our findings point toward the possibility of using serum PLP as a predictive marker for assessing stroke risk. It highlights the importance of proper vitamin B6 levels for effective individual strategies in preventing and managing strokes, aligning with modern health approaches that prioritize personalized medicine.
9.5
Reduced homocysteine levels
Most Useful Review
Does it really work? I previously ordered a more expensive product, but I decided to try this one to lower my homocysteine levels. For those unaware, homocysteine can damage our vessels, leading to high blood pressure, strokes, and other serious issues. After taking this medication, my homocysteine dropped from 9.3 to 5.5, which is perfect. I’m delighted with the results and have recommended it to my husband and mother. It’s crucial to manage homocysteine levels, especially for women planning to conceive, although many doctors overlook this.
Magnesium
8
Magnesium-Heart Health Connection
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
Most Relevant Research
We explored the connection between serum magnesium levels and the risk of stroke among non-dialysis patients with chronic kidney disease (CKD) stages 4 and 5. By analyzing data from a cohort of 1,271 patients over a ten-year period, we focused on how varying levels of magnesium could influence mortality rates related to fatal heart failure, coronary heart disease, and stroke.
Our findings revealed that higher serum magnesium concentrations were associated with a significantly reduced risk of death from stroke and other cardiovascular events. This suggests that maintaining adequate magnesium levels could play a crucial role in improving outcomes for CKD patients who are at a higher risk for these serious conditions.
While the study did have its limitations, such as potential confounding factors, the association between higher magnesium levels and lower mortality rates is an important consideration in managing the health of CKD patients. As such, ensuring that these patients maintain optimal magnesium levels may be a beneficial strategy in reducing their risk of fatal stroke and enhancing overall health.
Our findings revealed that higher serum magnesium concentrations were associated with a significantly reduced risk of death from stroke and other cardiovascular events. This suggests that maintaining adequate magnesium levels could play a crucial role in improving outcomes for CKD patients who are at a higher risk for these serious conditions.
While the study did have its limitations, such as potential confounding factors, the association between higher magnesium levels and lower mortality rates is an important consideration in managing the health of CKD patients. As such, ensuring that these patients maintain optimal magnesium levels may be a beneficial strategy in reducing their risk of fatal stroke and enhancing overall health.
9.5
Supports heart health
Most Useful Review
This is a superior alternative to the Russian asparkam. Potassium and magnesium asparaginate are essential for heart health and rhythm regulation. They enhance absorption, vital for normal cell function, especially in the heart. Alongside taurine, they work together to support cardiovascular health and provide protection against strokes. It's clear that magnesium’s role extends to regulating metabolic processes and sustaining energy production, reducing blood pressure and preventing heart complications.
B12
7
Vitamin B12 lowers homocysteine levels
The impact of SLCO1B1 polymorphisms on homocysteine concentrations: evidence for a stronger association in men.
Most Relevant Research
We investigated how vitamin B12 might influence homocysteine levels, which are important in the context of stroke risk. This research involved 177 ischemic stroke patients, with a keen focus on genetic factors like the SLCO1B1 polymorphism that may affect these levels.
In our findings, we observed that higher concentrations of homocysteine were linked to men more than women, highlighting a possible gender difference in stroke risk related to this amino acid. We discovered that vitamin B12, along with folic acid, plays a critical role in managing homocysteine levels.
Interestingly, the presence of specific genetic variations in the SLCO1B1 gene (CT and CC polymorphisms) correlated with higher homocysteine levels. Our study concluded that while vitamin B12 is beneficial in lowering these levels, its impact is notably stronger in men, suggesting that genetic factors might influence how effectively vitamin B12 works for stroke patients.
In our findings, we observed that higher concentrations of homocysteine were linked to men more than women, highlighting a possible gender difference in stroke risk related to this amino acid. We discovered that vitamin B12, along with folic acid, plays a critical role in managing homocysteine levels.
Interestingly, the presence of specific genetic variations in the SLCO1B1 gene (CT and CC polymorphisms) correlated with higher homocysteine levels. Our study concluded that while vitamin B12 is beneficial in lowering these levels, its impact is notably stronger in men, suggesting that genetic factors might influence how effectively vitamin B12 works for stroke patients.
9.5
Supports recovery
Most Useful Review
One of the best vitamins for those who have suffered a stroke or have brain-related issues. My husband, who had a cerebellar stroke in 2019, was advised by his neurologist to take it due to its importance for brain neurotransmitters. His blood levels of vitamin B12 were low, and I highly recommend this brand as it has proven effective.
Alpha Gpc
3
Alpha GPC linked to stroke risk
Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years.
Most Relevant Research
We set out to explore how the use of L-α glycerylphosphorylcholine (α-GPC) affects stroke risk over a 10-year period. This retrospective cohort study looked at a large population from South Korea, including over 12 million men and women aged 50 and older, all of whom did not have a history of stroke or Alzheimer's disease.
Participants were categorized based on whether they were prescribed α-GPC between 2006 and 2008. From there, we matched those who used α-GPC with nonusers to create a balanced comparison. Notably, we found that those who took α-GPC had a higher risk of experiencing a stroke—this included both total strokes and specific types like ischemic and hemorrhagic strokes.
The results indicated a dose-response relationship, which means that the longer the duration of α-GPC use, the greater the risk of stroke observed. These findings raise important questions about the safety of α-GPC, especially considering its common use among older adults seeking cognitive benefits. Future research could help us understand the underlying mechanisms that contribute to this increased risk.
Participants were categorized based on whether they were prescribed α-GPC between 2006 and 2008. From there, we matched those who used α-GPC with nonusers to create a balanced comparison. Notably, we found that those who took α-GPC had a higher risk of experiencing a stroke—this included both total strokes and specific types like ischemic and hemorrhagic strokes.
The results indicated a dose-response relationship, which means that the longer the duration of α-GPC use, the greater the risk of stroke observed. These findings raise important questions about the safety of α-GPC, especially considering its common use among older adults seeking cognitive benefits. Future research could help us understand the underlying mechanisms that contribute to this increased risk.
9.5
Restores recovery
Most Useful Review
An excellent remedy for my seriously ill child, helping to restore memory, speech, and mood. We have seen consistent improvement over 1.5 years. It's particularly beneficial for those recovering from stroke or TBI, with no side effects like headaches.