We conducted an in-depth review to understand whether curcumin, a natural compound found in turmeric, could serve as an effective alternative treatment for oral yeast infections, specifically oral candidiasis. Our research involved sifting through various studies that used a method called antimicrobial photodynamic therapy (aPDT) combined with curcumin to see its effects on Candida species, the fungi responsible for these infections.
From an initial pool of 757 studies, we focused on 26 that met our strict criteria, including laboratory studies and clinical trials. Our findings revealed that in several lab-based tests, curcumin-mediated aPDT completely eliminated yeast cells in some cases. However, for biofilms, which are clusters of yeast that can be more resistant to treatment, we only observed partial growth inhibition and reduction in biofilm mass.
When examining the effectiveness in live animal models, the results were encouraging, with notable antifungal activity observed. Yet, while the preclinical insights are promising, we found that the clinical implications still require further exploration through additional randomized control trials.
In summary, while curcumin shows potential in battling oral candidiasis, we are clear that more research is essential before it can be established as a standard treatment option.