Vitamin D3 improves immune function[Immunocorrecting properties and effect on the phosphorus-calcium metabolism of oxidevit (1 alpha-hydroxyvitamin D3)].
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We explored the impact of 1 alpha-hydroxyvitamin D3, commonly known as vitamin D3, on patients with chronic bronchitis, focusing on its potential benefits for the immune system and calcium-phosphorus metabolism. In this study, 45 patients received doses of either 2 or 4 micrograms of the vitamin over a period of 1 to 2 weeks.
Our findings revealed that the treatment led to observable changes in the metabolism of calcium and phosphorus. The alterations depended on the specific dose and duration of the treatment. Notably, the higher dose of 4 micrograms daily over two weeks was identified as excessive.
We also assessed various immune system components, such as total and rosette-forming cells, T-lymphocyte helpers and suppressors, and B lymphocytes. All these immune parameters showed significant normalization, regardless of the patients' initial levels. Elevated values tended to decrease, while those that were low increased back towards normal. It’s essential to note that despite these positive changes, the immune patterns remained stable throughout the treatment period.
Interestingly, we found a correlation between blood inorganic phosphorus levels and the dynamics of leukocytes, suggesting an interaction between immune responses and mineral metabolism. Overall, vitamin D3 treatment demonstrates a noteworthy effect on improving immune system function in chronic bronchitis patients, supporting its role as an adjunct therapy in managing this condition.