Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 28 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Blend Containing 1 billion live cultures† Lactobacillus acidophilus Lactobacillus salivarius Bifidobacterium bifidum Streptococcus thermophilus
175 mg
**
Top Medical Research Studies
9
We examined how the KS6I1 probiotic impacts cholesterol levels in mice fed a high-cholesterol diet. Over six weeks, mice receiving KS6I1 showed significant reductions in LDL cholesterol and total cholesterol compared to those only on a high-cholesterol diet.
Notably, the KS6I1 group also increased the amount of cholesterol and bile acids in their feces, suggesting better cholesterol excretion. While the results are promising, indicating potential for KS6I1 as a cholesterol-lowering probiotic, further research is necessary to confirm these effects in humans.
Notably, the KS6I1 group also increased the amount of cholesterol and bile acids in their feces, suggesting better cholesterol excretion. While the results are promising, indicating potential for KS6I1 as a cholesterol-lowering probiotic, further research is necessary to confirm these effects in humans.
Read More
9
This study focused on the impact of a high-cholesterol diet on nonalcoholic fatty liver disease (NAFLD) in rabbits and investigated how the probiotic Lactobacillus acidophilus could help.
We observed that a high-cholesterol diet led to increased liver fat and several unhealthy markers, including elevated liver enzymes and cholesterol levels.
However, when probiotics were added to the diet, these negative effects were significantly reduced, restoring liver functions and overall health. This suggests that L. acidophilus offers protective benefits against NAFLD and improves lipid profiles.
We observed that a high-cholesterol diet led to increased liver fat and several unhealthy markers, including elevated liver enzymes and cholesterol levels.
However, when probiotics were added to the diet, these negative effects were significantly reduced, restoring liver functions and overall health. This suggests that L. acidophilus offers protective benefits against NAFLD and improves lipid profiles.
Read More
9
Probiotics may help lower cholesterol
This study examined how certain probiotic strains might help lower cholesterol. We analyzed a mix of lactic acid bacteria, including Lactobacillus acidophilus, to see how they affect cholesterol metabolism.
The results were promising. Some strains significantly reduced cholesterol levels, triglycerides, and apolipoprotein B in tests. For instance, Lactobacillus acidophilus showed effective bile-salt hydrolase activity that helps break down bile acids.
However, while the findings are encouraging, it's essential to note that these probiotics are not a stand-alone solution for managing cholesterol.
The results were promising. Some strains significantly reduced cholesterol levels, triglycerides, and apolipoprotein B in tests. For instance, Lactobacillus acidophilus showed effective bile-salt hydrolase activity that helps break down bile acids.
However, while the findings are encouraging, it's essential to note that these probiotics are not a stand-alone solution for managing cholesterol.
Read More
Most Useful Reviews
9
Health strengthens observed
106 people found this helpful
The quality is superb, and the ingredients are excellent. I found the size to be average and suitable for adults. After a month of taking these probiotics, I noticed significant improvements: constipation disappeared, digestion improved, and my health strengthened overall. The packaging is also of high quality. I highly recommend these probiotics for their effectiveness.
Read More
9
Restores intestinal flora
14 people found this helpful
Highly recommend! The 21st Century Acidophilus Probiotic Blend is top rated and has received positive reviews from my family. My experience began when my duodenal ulcer flared up in January 2020. I followed a gastroenterologist's regimen, which involved strong antibiotics and proton pump inhibitors, unfortunately killing off beneficial gut bacteria. Following this, I took the probiotic mix for three weeks, and by March 2020, my intestinal issues had vanished. Now, I take one capsule weekly for maintenance. I appreciate that they can be stored at room temperature and highly recommend them!
Read More
9
Superb yogurt effect
7 people found this helpful
This probiotic is fantastic for making yogurt. One capsule yields three jars using my yogurt maker, producing excellent results. Additionally, it’s even more effective than a pricier probiotic I previously endorsed. My stomach cramps have vanished, and my acid reflux has improved significantly when using this in yogurt rather than as a capsule.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
We examined how the KS6I1 probiotic impacts cholesterol levels in mice fed a high-cholesterol diet. Over six weeks, mice receiving KS6I1 showed significant reductions in LDL cholesterol and total cholesterol compared to those only on a high-cholesterol diet.
Notably, the KS6I1 group also increased the amount of cholesterol and bile acids in their feces, suggesting better cholesterol excretion. While the results are promising, indicating potential for KS6I1 as a cholesterol-lowering probiotic, further research is necessary to confirm these effects in humans.
Notably, the KS6I1 group also increased the amount of cholesterol and bile acids in their feces, suggesting better cholesterol excretion. While the results are promising, indicating potential for KS6I1 as a cholesterol-lowering probiotic, further research is necessary to confirm these effects in humans.
Read More
9
Postbiotics effectively reduce cholesterol
We conducted studies to see if yogurt enriched with postbiotics from Lactobacillus acidophilus could help lower cholesterol levels. Using Wistar rats, we compared their cholesterol levels after being fed either a normal or a high-cholesterol diet.
The results were promising, showing that rats who consumed the postbiotic yogurt had notable decreases in total cholesterol and harmful LDL levels. However, while the yogurt did demonstrate strong antibacterial and antioxidant properties, the main focus remained on its potential for managing cholesterol.
The results were promising, showing that rats who consumed the postbiotic yogurt had notable decreases in total cholesterol and harmful LDL levels. However, while the yogurt did demonstrate strong antibacterial and antioxidant properties, the main focus remained on its potential for managing cholesterol.
Read More
9
This study focused on the impact of a high-cholesterol diet on nonalcoholic fatty liver disease (NAFLD) in rabbits and investigated how the probiotic Lactobacillus acidophilus could help.
We observed that a high-cholesterol diet led to increased liver fat and several unhealthy markers, including elevated liver enzymes and cholesterol levels.
However, when probiotics were added to the diet, these negative effects were significantly reduced, restoring liver functions and overall health. This suggests that L. acidophilus offers protective benefits against NAFLD and improves lipid profiles.
We observed that a high-cholesterol diet led to increased liver fat and several unhealthy markers, including elevated liver enzymes and cholesterol levels.
However, when probiotics were added to the diet, these negative effects were significantly reduced, restoring liver functions and overall health. This suggests that L. acidophilus offers protective benefits against NAFLD and improves lipid profiles.
Read More
9
Probiotics may help lower cholesterol
This study examined how certain probiotic strains might help lower cholesterol. We analyzed a mix of lactic acid bacteria, including Lactobacillus acidophilus, to see how they affect cholesterol metabolism.
The results were promising. Some strains significantly reduced cholesterol levels, triglycerides, and apolipoprotein B in tests. For instance, Lactobacillus acidophilus showed effective bile-salt hydrolase activity that helps break down bile acids.
However, while the findings are encouraging, it's essential to note that these probiotics are not a stand-alone solution for managing cholesterol.
The results were promising. Some strains significantly reduced cholesterol levels, triglycerides, and apolipoprotein B in tests. For instance, Lactobacillus acidophilus showed effective bile-salt hydrolase activity that helps break down bile acids.
However, while the findings are encouraging, it's essential to note that these probiotics are not a stand-alone solution for managing cholesterol.
Read More
9
We explored the effects of Lactobacillus acidophilus and other strains from Tibetan kefir grains on high cholesterol. In a study involving rats, those treated with specific Lactobacillus strains showed a significant drop in total cholesterol, triglycerides, and low-density lipoprotein cholesterol compared to control rats.
Additionally, while some strains boosted high-density lipoprotein cholesterol, the overall impact indicates potential benefits of using these probiotics in diets aimed at managing cholesterol. The results highlight how these probiotics could be strategically used in future food products.
Additionally, while some strains boosted high-density lipoprotein cholesterol, the overall impact indicates potential benefits of using these probiotics in diets aimed at managing cholesterol. The results highlight how these probiotics could be strategically used in future food products.
Read More
User Reviews
USERS' SCORE
Good
Based on 28 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Health strengthens observed
106 people found this helpful
The quality is superb, and the ingredients are excellent. I found the size to be average and suitable for adults. After a month of taking these probiotics, I noticed significant improvements: constipation disappeared, digestion improved, and my health strengthened overall. The packaging is also of high quality. I highly recommend these probiotics for their effectiveness.
Read More
9
Restores intestinal flora
14 people found this helpful
Highly recommend! The 21st Century Acidophilus Probiotic Blend is top rated and has received positive reviews from my family. My experience began when my duodenal ulcer flared up in January 2020. I followed a gastroenterologist's regimen, which involved strong antibiotics and proton pump inhibitors, unfortunately killing off beneficial gut bacteria. Following this, I took the probiotic mix for three weeks, and by March 2020, my intestinal issues had vanished. Now, I take one capsule weekly for maintenance. I appreciate that they can be stored at room temperature and highly recommend them!
Read More
9
Superb yogurt effect
7 people found this helpful
This probiotic is fantastic for making yogurt. One capsule yields three jars using my yogurt maker, producing excellent results. Additionally, it’s even more effective than a pricier probiotic I previously endorsed. My stomach cramps have vanished, and my acid reflux has improved significantly when using this in yogurt rather than as a capsule.
Read More
8
Effective digestion aid
6 people found this helpful
Many people are unaware of the benefits of acidophilus bacillus. It inhibits harmful bacteria and aids digestion, while also lowering blood cholesterol levels. It's beneficial for those with lactose absorption issues, improving gut health and metabolism.
Read More
8
Cholesterol reduction
3 people found this helpful
This complex of acidophilic bacteria aids in nutrient absorption, particularly for those with lactose intolerance, while suppressing harmful bacteria and promoting a healthy microflora balance. It supports detoxification and bolsters immune function, enhancing the production of vital vitamins and improving intestinal motility. Notably, it also lowers cholesterol levels.
Read More
Frequently Asked Questions
9
Significant improvement
1 people found this helpful
Highly recommend! After three days, my gastrointestinal condition improved significantly. My mother took it for flatulence issues, and her normal bowel function returned after a few weeks. Surprisingly, pancreatitis symptoms also ceased. Very pleased!
9
Health strengthens observed
106 people found this helpful
The quality is superb, and the ingredients are excellent. I found the size to be average and suitable for adults. After a month of taking these probiotics, I noticed significant improvements: constipation disappeared, digestion improved, and my health strengthened overall. The packaging is also of high quality. I highly recommend these probiotics for their effectiveness.
8
Cholesterol reduction
3 people found this helpful
This complex of acidophilic bacteria aids in nutrient absorption, particularly for those with lactose intolerance, while suppressing harmful bacteria and promoting a healthy microflora balance. It supports detoxification and bolsters immune function, enhancing the production of vital vitamins and improving intestinal motility. Notably, it also lowers cholesterol levels.
7.5
Enhanced gut health
2 people found this helpful
The quality is excellent, and the ingredients are top-notch. The quantity is adequate for maintaining the health of both body and intestines. It assists in alleviating constipation and facilitates nutrient absorption. This nutritional supplement contains useful microbiomes for digestion, and the sturdy packaging preserves its integrity. It contributes positively to overall body and brain health.
7.5
Daily use suitable
1 people found this helpful
A good working probiotic suited for long-term use, it contains a small dose of bifidobacteria. It improves gastrointestinal activity and aids digestion, particularly for those with lactose intolerance, also helping to control high cholesterol levels.
9
Stomach feels better
1 people found this helpful
Very good! After a month of use, my stomach improved and my stool became much smoother. I will definitely repurchase. Combined with superfood, constipation has been completely resolved!
7.5
Supports immune system
25 people found this helpful
An excellent preparation for maintaining gastrointestinal balance, it shows an immediate and noticeable effect. I take one capsule before bed and use it to ferment milk to create fresh yogurt. The affordability adds to its value. This product effectively addresses immune disorders, allergies, and dysbiosis, making it a godsend for health-conscious individuals. I highly recommend it!
9
Superb yogurt effect
7 people found this helpful
This probiotic is fantastic for making yogurt. One capsule yields three jars using my yogurt maker, producing excellent results. Additionally, it’s even more effective than a pricier probiotic I previously endorsed. My stomach cramps have vanished, and my acid reflux has improved significantly when using this in yogurt rather than as a capsule.
9
Restores intestinal flora
14 people found this helpful
Highly recommend! The 21st Century Acidophilus Probiotic Blend is top rated and has received positive reviews from my family. My experience began when my duodenal ulcer flared up in January 2020. I followed a gastroenterologist's regimen, which involved strong antibiotics and proton pump inhibitors, unfortunately killing off beneficial gut bacteria. Following this, I took the probiotic mix for three weeks, and by March 2020, my intestinal issues had vanished. Now, I take one capsule weekly for maintenance. I appreciate that they can be stored at room temperature and highly recommend them!
6
Helpful probiotic
As a budget option, this probiotic is very useful, effectively normalising digestive health and microflora. It strengthens the immune system and aids in the regulation of cholesterol and blood sugar levels.
9
Effective bacteria
9 people found this helpful
After months of using iHerb's leading probiotics with no improvement in my intestinal diarrhoea, I was astounded by this supplement. It has revitalised my intestines, eliminating diarrhoea and unpleasant odours. I recommend taking two tablets at bedtime and one in the morning, adjusting as needed for your condition. High-quality supplements can be found by individual trial.
7
Probiotics may improve cholesterol levels
We examined how probiotics, particularly Lactobacillus acidophilus, affect cholesterol levels and overall metabolic health in hamsters fed a high-fat diet.
For six weeks, we observed significant improvements in lipid metabolism and changes in gut microbiota, pointing to a potential connection between gut health and cholesterol management.
While our findings are promising, indicating that probiotics can help modify cholesterol levels, it's important to note that results were primarily shown in animal models and more research is needed to confirm these effects in humans.
For six weeks, we observed significant improvements in lipid metabolism and changes in gut microbiota, pointing to a potential connection between gut health and cholesterol management.
While our findings are promising, indicating that probiotics can help modify cholesterol levels, it's important to note that results were primarily shown in animal models and more research is needed to confirm these effects in humans.
7
We examined the impact of probiotic supplementation on cholesterol levels through a thorough meta-analysis of randomized clinical trials.
The findings revealed that while probiotics led to reductions in total cholesterol and LDL cholesterol, there was no significant change in HDL cholesterol or triglycerides.
Importantly, longer probiotic use seemed to result in better outcomes, especially for those with mildly elevated cholesterol levels. However, the effects were more pronounced with the Lactobacillus acidophilus strain.
Overall, probiotic supplementation may assist in preventing high cholesterol and reducing cardiovascular risks.
The findings revealed that while probiotics led to reductions in total cholesterol and LDL cholesterol, there was no significant change in HDL cholesterol or triglycerides.
Importantly, longer probiotic use seemed to result in better outcomes, especially for those with mildly elevated cholesterol levels. However, the effects were more pronounced with the Lactobacillus acidophilus strain.
Overall, probiotic supplementation may assist in preventing high cholesterol and reducing cardiovascular risks.
9
Probiotics may help lower cholesterol
This study examined how certain probiotic strains might help lower cholesterol. We analyzed a mix of lactic acid bacteria, including Lactobacillus acidophilus, to see how they affect cholesterol metabolism.
The results were promising. Some strains significantly reduced cholesterol levels, triglycerides, and apolipoprotein B in tests. For instance, Lactobacillus acidophilus showed effective bile-salt hydrolase activity that helps break down bile acids.
However, while the findings are encouraging, it's essential to note that these probiotics are not a stand-alone solution for managing cholesterol.
The results were promising. Some strains significantly reduced cholesterol levels, triglycerides, and apolipoprotein B in tests. For instance, Lactobacillus acidophilus showed effective bile-salt hydrolase activity that helps break down bile acids.
However, while the findings are encouraging, it's essential to note that these probiotics are not a stand-alone solution for managing cholesterol.
References
- Damodharan K, Palaniyandi SA, Yang SH, Balaji S. Cholesterol-Lowering Activity of KS6I1 in High-Cholesterol Diet-Induced Hypercholesterolemic Mice. J Microbiol Biotechnol. 2024;35:e2404029. 10.4014/jmb.2409.04029
- Davarzani S, Sanjabi MR, Mojgani N, Mirdamadi S, Soltani M. Investigating the Antibacterial, Antioxidant, and Cholesterol-lowering Properties of Yogurt Fortified with Postbiotic of Lactobacillus acidophilus and Lactiplantibacillus plantarum in the Wistar Rat Model. J Food Prot. 2024;87:100408. 10.1016/j.jfp.2024.100408
- Lacroix S, Leblanc N, Abolghasemi A, Paris-Robidas S, Martin C, et al. Probiotic interventions promote metabolic health in high fat-fed hamsters in association with gut microbiota and endocannabinoidome alterations. Benef Microbes. 2023;14:223. 10.3920/BM2022.0080
- Aziz M, Hemeda SA, Albadrani GM, Fadl SE, Elgendey F. Ameliorating effect of probiotic on nonalcoholic fatty liver disease and lipolytic gene expression in rabbits. Sci Rep. 2023;13:6312. 10.1038/s41598-023-32584-7
- Çiftci G, Çiftci A, Onuk B, Çenesiz M, Savaşan S, et al. Investigation of the effects of atorvastatin and Lactobacillus acidophilus on some hormones and oxidative stress in experimental hypercholesterolemia. Prostaglandins Other Lipid Mediat. 2023;165:106716. 10.1016/j.prostaglandins.2023.106716
- Çiftci G, Tuna E. Effects of cholesterol and Lactobacillus acidophilus on testicular function. Clin Exp Reprod Med. 2021;48:229. 10.5653/cerm.2020.04322
- Oh JK, Kim YR, Lee B, Choi YM, Kim SH. Prevention of Cholesterol Gallstone Formation by ATCC 43121 and MF27 in Lithogenic Diet-Induced Mice. Food Sci Anim Resour. 2021;41:343. 10.5851/kosfa.2020.e93
- Chiu HF, Fang CY, Shen YC, Venkatakrishnan K, Wang CK. Efficacy of Probiotic Milk Formula on Blood Lipid and Intestinal Function in Mild Hypercholesterolemic Volunteers: A Placebo-control, Randomized Clinical Trial. Probiotics Antimicrob Proteins. 2021;13:624. 10.1007/s12602-020-09728-6
- Guo CF, Yuan YH, Yue TL, Li JY. Hamsters Are a Better Model System than Rats for Evaluating the Hypocholesterolemic Efficacy of Potential Probiotic Strains. Mol Nutr Food Res. 2018;62:e1800170. 10.1002/mnfr.201800170
- Shimizu M, Hashiguchi M, Shiga T, Tamura HO, Mochizuki M. Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals. PLoS One. 2015;10:e0139795. 10.1371/journal.pone.0139795
- Tsai CC, Lin PP, Hsieh YM, Zhang ZY, Wu HC, et al. Cholesterol-lowering potentials of lactic acid bacteria based on bile-salt hydrolase activity and effect of potent strains on cholesterol metabolism in vitro and in vivo. ScientificWorldJournal. 2014;2014:690752. 10.1155/2014/690752
- Zheng Y, Lu Y, Wang J, Yang L, Pan C, et al. Probiotic properties of Lactobacillus strains isolated from Tibetan kefir grains. PLoS One. 2013;8:e69868. 10.1371/journal.pone.0069868
- Awaisheh SS, Khalifeh MS, Al-Ruwaili MA, Khalil OM, Al-Ameri OH, et al. Effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats. J Dairy Sci. 2013;96:9. 10.3168/jds.2012-5442
- Starovoitova SA, Babenko LP, Timoshok NA, Shynkarenko LN, Lazarenko LN, et al. Cholesterol-lowering activity of lactic acid bacteria probiotic strains in vivo. Mikrobiol Z. 2012;74:78.
- Moroti C, Souza Magri LF, de Rezende Costa M, Cavallini DC, Sivieri K. Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus. Lipids Health Dis. 2012;11:29. 10.1186/1476-511X-11-29
- Huang Y, Wang J, Cheng Y, Zheng Y. The hypocholesterolaemic effects of Lactobacillus acidophilus American type culture collection 4356 in rats are mediated by the down-regulation of Niemann-Pick C1-like 1. Br J Nutr. 2010;104:807. 10.1017/S0007114510001285
