Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
The product is found useful for the following medical conditions
Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Excellent
Based on 10 Reviews
9
8
We explored how 25-hydroxyvitamin D3 (25OHD), a form of vitamin D, influences upper respiratory tract infections (URTIs), commonly known as colds. In a carefully designed clinical study, we followed 428 participants aged 45 to 74 over a 16-week period. They were randomly assigned to receive either 10 μg of 25OHD daily or a placebo, all while maintaining a double-blind setup to ensure accurate results.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
10
Cold prevention success
Most Useful Review
Vitamins D3 effectively boost the immune system. Throughout my life, I have suffered from herpes and tried many things to raise my immunity, but nothing worked. I decided to try these vitamins, and now, in autumn, all my colleagues except me got a cold; even those who were sceptical now take them.
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.1
USERS' SCORE
Good
Based on 26 Reviews
8.9
9
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
9.5
Reduced back pain
Most Useful Review
I recommend this to anyone lacking calcium. The price-to-quality ratio is good, and I did not experience any aftertaste or side effects. My back pain has significantly decreased in the morning, especially with my osteochondrosis.
Bacterial Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.9
9.5
Prevents bacterial infection
Most Useful Review
Calcium citrate is an excellent choice for those needing supplemental calcium. It's eco-friendly and has been shown to be 22-27% more effective in absorption compared to carbonate. It's advisable to consider the source of calcium, as those from animal origins can pose the risk of lead contamination, affecting health adversely. Calcium citrate not only aids in calcium absorption but also assists in preventing kidney stones and suppressing infection in the bladder due to its alkalising effect on urine. I wholeheartedly recommend it to anyone.
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 78 Reviews
8.9
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
8.8
Bone fusion success
Most Useful Review
A few months ago, I suffered a compound fracture in my leg, which required an operation. I used calcium supplements in chelate form during my recovery, and by the third month, my X-ray showed good bone healing. The doctor allowed me to remove the cast early. Now, I’ve switched to calcium citrate, and I’m pleased with the results. After two weeks of using it, my ability to walk has significantly improved. I continue to heal and strengthen my bones.
Knee Pain details
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
USERS' SCORE
Good
Based on 38 Reviews
8.9
1
We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
9.5
Alleviated knee pain
Most Useful Review
I recommend it to anyone with a calcium deficiency. The price-to-quality ratio is good, and it has no unpleasant aftertaste or side effects. My back pain due to osteochondrosis has eased significantly in the mornings.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.9
9.5
Pain relief
Most Useful Review
I ordered this due to its price, not expecting much. I had pain in my shoulder joints and was pleasantly surprised when, after two weeks, I realised the pelvic pain had disappeared. I highly recommend it; it truly works!
Premenstrual Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.9
9.5
Migraine relief
Most Useful Review
GREAT It normalises sleep with a regular intake of 2 capsules. It improves the course of my migraines; special effects begin, I take pills as usual, add magnesium, and the migraine dissipates easily within a few hours. Previously, I was out for half a day. The frequency has also decreased, though I also have medicinal support. Regular intake of magnesium makes both premenstrual syndrome and menstruation easier to endure. I don't become irritable nor need painkillers on the first day. Chronic nasopharyngeal pain rarely worsens. I think magnesium, alongside omega-3 and new supplements, has been beneficial. Collagen has shown great effects as well. No allergies or rashes. Quality ingredients and easy to use.
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 11 Reviews
8.8
8
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
9.5
Alleviates allergies
Most Useful Review
Calcium citrate is excellent value. It absorbs well without side effects, unlike other forms like carbonate. It’s particularly beneficial for allergies and urolithiasis, as it can break down kidney stones. I’ve noticed improvements in my mood and sleep since starting it. For adults, a dose of 800-1200 mg is recommended, which I believe protects against conditions like osteoporosis while also relieving irritability.
Hair Loss details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
USERS' SCORE
Good
Based on 16 Reviews
8.8
9
This study dives into how 1,25-(OH)D, a potent form of vitamin D, influences hair growth. Through a combination of experiments in live mice, hair follicle organ culture, and detailed cellular investigations, we uncovered that this vitamin enhances hair regeneration.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
9.5
Stronger, thicker hair
Most Useful Review
After giving birth, hair loss became my most pressing concern. The endocrinologist suggested taking calcium citrate with D3 for two months. Following this treatment, I noticed a significant improvement; my hair has grown much stronger and thicker. I hope my review helps others.
Bloating details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.7
9
We explored the effectiveness of OsteoCalVitFort, a supplement combining 500 mg of calcium and 400 IU of vitamin D3, focusing specifically on its impact on bloating. The study involved 186 participants aged 18 to 65 years, who took two tablets daily—one after breakfast and one after dinner.
Through follow-up phone calls, we gathered information about any side effects and the overall satisfaction with the supplement. Notably, we observed a significant reduction in bloating, with the rate decreasing from 12.5% before taking the supplement to just 0.6% after. This impressive drop highlights the potential benefits of vitamin D3 in alleviating bloating discomfort.
Overall, the findings suggest that OsteoCalVitFort is not only effective but also well-received by users, with 94% reporting satisfaction with their experience. Importantly, we noted that no significant adverse effects were reported, setting OsteoCalVitFort apart from other supplements often linked with gastrointestinal issues.
Through follow-up phone calls, we gathered information about any side effects and the overall satisfaction with the supplement. Notably, we observed a significant reduction in bloating, with the rate decreasing from 12.5% before taking the supplement to just 0.6% after. This impressive drop highlights the potential benefits of vitamin D3 in alleviating bloating discomfort.
Overall, the findings suggest that OsteoCalVitFort is not only effective but also well-received by users, with 94% reporting satisfaction with their experience. Importantly, we noted that no significant adverse effects were reported, setting OsteoCalVitFort apart from other supplements often linked with gastrointestinal issues.
9.5
Improved mood
Most Useful Review
After taking this product for two weeks, I've noticed an improvement in my mood and energy, as well as my overall health. I no longer experience bloating when consuming this food!
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.7
8
Vitamin D3 improves cold symptoms
We conducted a thorough investigation into how 25-hydroxyvitamin D3, commonly referred to as vitamin D3, impacts upper respiratory tract infections (URTIs), particularly the common cold. This study was carried out as a randomized, double-blind, placebo-controlled trial, engaging 428 participants, all aged between 45 and 74, across three clinics in Japan.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
9.5
Boosted immunity
Most Useful Review
Vitamins D3 have significantly improved my immune system. I used to struggle with herpes and tried many things for my immunity. After taking these vitamins, I noticed that all my colleagues fell ill with the common cold, but I remained fine. Now, even the sceptics around me take these vitamins.
Ear Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Prevents urinary issues
Most Useful Review
Calcium citrate is crucial for maintaining bone health, especially as dietary sources can be insufficient. Despite not having a clear calcium deficiency, I was advised to supplement due to low levels. This calcium formulation has excellent absorption rates compared to carbonate and effectively prevents urinary tract diseases by making urine alkaline, which also helps combat bladder infections. I recommend this product for its quality and efficacy in supporting overall health.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
9.5
Calcium normalised
Most Useful Review
My mum has taken calcium as prescribed by her doctor for over ten years, but it was never absorbed properly and her levels often dropped to a dangerous low, causing seizures. After trying this product, her calcium is now normal, which hasn't happened for a long time! I highly recommend this supplement, especially as it costs half the price of previous ones.
Kidney Stones details
SCIENTIFIC SCORE
Likely Ineffective
Based on 7 Researches
4.4
USERS' SCORE
Good
Based on 34 Reviews
8.7
7
We examined the effects of calcium, with or without calcitriol, on kidney stone risk in postmenopausal Thai women. The study involved 53 women who took either calcium alone or calcium plus calcitriol for three months.
We found that while calcium levels in urine increased, there was no significant rise in the risk of kidney stones. Overall, most subjects did not experience significant changes in factors that would predispose them to kidney stones.
Our results suggest that calcium and vitamin D supplementation does not contribute to an increased risk of kidney stones, making it a safer option for bone health in this population.
We found that while calcium levels in urine increased, there was no significant rise in the risk of kidney stones. Overall, most subjects did not experience significant changes in factors that would predispose them to kidney stones.
Our results suggest that calcium and vitamin D supplementation does not contribute to an increased risk of kidney stones, making it a safer option for bone health in this population.
9.5
Safe for kidneys
Most Useful Review
Calcium citrate is 2.5 times better than calcium carbonate for absorption. It can be taken on an empty stomach without causing kidney stones. For those over 50, it's absorbed better than calcium carbonate. Highly recommended for better health!
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.8
USERS' SCORE
Good
Based on 51 Reviews
8.7
9
We examined a collection of randomized controlled trials to determine the impact of calcium plus vitamin D supplementation on fracture prevention.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
10
Essential for women
Most Useful Review
Calcium citrate with vitamin D3 is a true find. It absorbs completely and is vital for women to prevent osteoporosis while improving hair, nails, and teeth health.
Urinary Tract Infection details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Calcium fosfomycin effective for UTIs
We explored the potential of calcium fosfomycin, a well-known antibiotic, in treating urinary tract infections (UTIs). Our focus was on how effectively it works when taken orally by healthy women. We dove into the drug’s urine concentration levels after administration, noting that about 18% of the drug is excreted through urine. This low level of excretion relates back to its poor oral absorption and reliance on the kidneys to filter it out.
By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.
Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.
By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.
Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.
9.5
Effective calcium citrate
Most Useful Review
I chose calcium citrate for its high bioavailability and absorption. It significantly reduces the risk of urinary tract infections as it alkalises urine and helps prevent kidney stones. The chemical purity of calcium citrate is also reassuring compared to calcium carbonate. Moreover, my doctor advised regular calcium supplementation to maintain bone and muscle health, especially since I have periodic issues with my nails. I recommend this product for its multiple benefits.
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
9.5
Helps with osteoarthritis
Most Useful Review
Excellent! This citrate formula genuinely aids with osteoarthritis. I buy it regularly; however, it's disappointing that the 1kg cans have been discontinued, leaving only smaller sizes available.
Autoimmune Disorder details
SCIENTIFIC SCORE
Questionable
Based on 30 Researches
6.6
USERS' SCORE
Good
Based on 17 Reviews
8.6
9
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
9.5
Normal calcium levels
Most Useful Review
21st Century Calcium Citrate + D Maximum has been effective for me. After trying various calcium supplements with minimal results, this one restored my levels to normal within three weeks. I've ordered multiple tubs as it's excellent value for money.
Blood Clot details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.5
USERS' SCORE
Good
Based on 5 Reviews
8.6
8
We explored the connection between vitamin D levels and coronary thrombus load in patients who experienced ST-elevation myocardial infarction (STEMI). The study included 77 patients where we measured serum vitamin D levels, thrombus degree, and other relevant factors.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
9.5
Strengthened blood clotting
Most Useful Review
On my doctor’s advice, I tried this supplement and was amazed. My nails and hair transformed, and I experienced enhanced immunity and mood. Calcium is essential for healthy teeth, bones, and blood clotting. Vitamin D3 sufficiently absorbs calcium and is vital for overall health. I hope my detailed review assists you in making a choice.
Diarrhea details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
2
We conducted a thorough investigation into how vitamin D3 supplementation affects diarrhea in young children. The study involved 3,046 infants aged 1 to 11 months living in high-risk areas of Kabul, Afghanistan. They were randomly assigned to receive either six doses of vitamin D3 or a placebo over 18 months.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
9.5
No discomfort noted
Most Useful Review
This calcium has been taken for some time without any discomfort or diarrhoea. It is calcium citrate, which is easy to absorb. Taking 2 tablets a day provides 630mg of calcium. Additionally, it contains D3 to assist with calcium absorption. The price is reasonable. It is my preferred choice for calcium supplements. Recommended! (However, the particles are somewhat large, so those with swallowing difficulties should choose carefully.)
Flu details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.5
USERS' SCORE
Good
Based on 5 Reviews
8.6
8
We carried out a study to investigate whether vitamin D3 supplements could help prevent seasonal influenza A in schoolchildren. Our approach involved a randomized, double-blind, placebo-controlled trial conducted from December 2008 to March 2009.
This ensured that neither the participants nor the researchers knew who was receiving the vitamin D3 or the placebo, making our findings more reliable. During the trial, we provided 1200 IU of vitamin D3 daily to one group while the other received a placebo.
The results were promising; we found that only 10.8% of the children taking vitamin D3 contracted influenza A, compared to 18.6% in the placebo group. This reduced incidence led us to a relative risk of 0.58, suggesting that vitamin D3 supplementation may lower the chances of getting the flu.
Interestingly, we noticed the most significant benefits among children who hadn’t been taking any other vitamin D supplements and those who began nursery school after age three. Additionally, in children with a past asthma diagnosis, vitamin D3 seemed to dramatically reduce asthma attacks.
Overall, our findings indicate that taking vitamin D3 in the winter could be beneficial for schoolchildren, especially for certain groups. We believe this study adds valuable insights into preventive health measures against influenza A.
This ensured that neither the participants nor the researchers knew who was receiving the vitamin D3 or the placebo, making our findings more reliable. During the trial, we provided 1200 IU of vitamin D3 daily to one group while the other received a placebo.
The results were promising; we found that only 10.8% of the children taking vitamin D3 contracted influenza A, compared to 18.6% in the placebo group. This reduced incidence led us to a relative risk of 0.58, suggesting that vitamin D3 supplementation may lower the chances of getting the flu.
Interestingly, we noticed the most significant benefits among children who hadn’t been taking any other vitamin D supplements and those who began nursery school after age three. Additionally, in children with a past asthma diagnosis, vitamin D3 seemed to dramatically reduce asthma attacks.
Overall, our findings indicate that taking vitamin D3 in the winter could be beneficial for schoolchildren, especially for certain groups. We believe this study adds valuable insights into preventive health measures against influenza A.
8.8
Joint improvement noted
Most Useful Review
Good calcium at a great price. This is not the first time I've taken it for myself and my parents. They noticed the positive effect on their joints and health overall. Calcium is essential for those recovering from fractures, as coffee flushes out calcium from the body. The only drawback is the large size of the tablets, which aren’t easy for everyone to swallow.
Heart Disease details
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.6
8
Vitamin D improves heart health
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
9.5
Valuable for health
Most Useful Review
Calcium is vital for developing healthy bones and teeth, regulating the heartbeat, and preventing heart disease. A deficiency leads to fragility of bones and teeth. Having vitamin D is necessary for calcium absorption, making it crucial for overall bodily functions.
Hypothyroidism details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.4
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
9.5
Reduced muscle cramps
Most Useful Review
Calcium citrate has become an essential part of my routine and began working in just ten days. I take 6 tablets daily, along with alfacalcidol to enhance calcium absorption. The quality is excellent for a reasonable price. Following surgery for hypothyroidism and hypoparathyroidism, I noticed improved nerve conduction, and muscle twitching and cramps have ceased. This formulation has been suitable for me.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 3 Reviews
8.6
8
Vitamin D3 improves adolescent insomnia
We studied how high-dose vitamin D3 supplementation might affect insomnia in adolescent girls. Over nine weeks, 940 participants received a weekly dose of 50,000 IU of vitamin D3 while we tracked changes in their sleep patterns.
Interestingly, we observed a notable reduction in insomnia rates after the treatment. The number of girls reporting insomnia dropped from 15.0% to 11.3%, indicating that this vitamin can potentially improve sleep quality.
We also noticed a slight decrease in daytime sleepiness, with cases falling from 15.6% to 14.7%. Furthermore, those experiencing both insomnia and sleepiness saw a decline from 8.0% to 6.1%.
These findings suggest that high-dose vitamin D can play a significant role in alleviating sleep issues among adolescent girls. However, further studies are needed to see if these effects are consistent across diverse age and gender groups.
Interestingly, we observed a notable reduction in insomnia rates after the treatment. The number of girls reporting insomnia dropped from 15.0% to 11.3%, indicating that this vitamin can potentially improve sleep quality.
We also noticed a slight decrease in daytime sleepiness, with cases falling from 15.6% to 14.7%. Furthermore, those experiencing both insomnia and sleepiness saw a decline from 8.0% to 6.1%.
These findings suggest that high-dose vitamin D can play a significant role in alleviating sleep issues among adolescent girls. However, further studies are needed to see if these effects are consistent across diverse age and gender groups.
9.5
Decreased insomnia
Most Useful Review
Budget calcium that I buy for my mother. She notices the effects, and her insomnia has diminished.
Leg Cramps details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
5.9
USERS' SCORE
Good
Based on 34 Reviews
8.6
9
Calcium dobesilate reduces leg cramps
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
9.5
Healed broken leg
Most Useful Review
After breaking my leg, I used calcium in chelate form for three months, which significantly aided my recovery. Now I’ve switched to citrate form and ordered a larger pack. It seems effective in strengthening my bones, easing my ability to walk, reducing leg cramps, and expediting my healing process.
Menopause details
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.1
USERS' SCORE
Good
Based on 13 Reviews
8.6
1
We set out to explore the impact of calcium and vitamin D supplements on menopause-related symptoms among postmenopausal women. In the Women's Health Initiative Calcium/Vitamin D Trial, over 34,000 women participated, receiving either the supplements or a placebo over an average of 5.7 years.
Our results revealed that women taking the calcium and vitamin D supplements experienced no significant differences in menopause symptoms, including sleep disturbances and emotional well-being, compared to those on the placebo. This suggests that the combination does not have the expected benefits for managing menopause symptoms.
Our results revealed that women taking the calcium and vitamin D supplements experienced no significant differences in menopause symptoms, including sleep disturbances and emotional well-being, compared to those on the placebo. This suggests that the combination does not have the expected benefits for managing menopause symptoms.
9.5
Improved health benefits
Most Useful Review
Gorgeous calcium. My family and I take 2 capsules daily along with vitamin K2, ensuring calcium reaches our bones and teeth rather than soft tissues. Since starting, our nails have improved, and my teeth no longer react to sweets or temperature. I found this helpful, especially during menopause.
Rheumatoid Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
We investigated the role of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, in managing rheumatoid arthritis (RA). Our study focused on how this vitamin influences macrophage activation, especially in patients with RA.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.
9.5
Significant symptom relief
Most Useful Review
Ordered for my father, who has rheumatoid arthritis, he experienced very painful and swollen joints during flare-ups. After taking it for two months, the symptoms virtually disappeared, but they returned, so I bought it again. I hope the results from this calcium continue to be positive. The complex is low in vitamin D3, so my dad takes an additional vitamin supplement.
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Seeking competent doctor
Most Useful Review
I needed these vitamins urgently. Twice a year, in spring and autumn, my foot joints worsen, making it painful to walk and causing my shoes to feel too tight due to swelling. I have consulted doctors, but the only advice I've received is that it's due to my age, which I believe is not that advanced yet. I'm currently in search of a knowledgeable doctor, and I have foot X-rays available. Meanwhile, I've been taking these vitamins at my own risk, but they seem to help!
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
8.8
Positive results noted
Most Useful Review
This calcium supplement has proven effective with a good combination of vitamin D3. I purchased it for a friend's parents dealing with cancer, relying on positive reviews from cancer patients' forums. The packaging is great and priced reasonably. There has already been noticeable improvement after taking it, so I highly recommend it!
Cardiovascular Disease details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
Vitamin D improves heart disease factors
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
8
Calcium benefits
Most Useful Review
Good calcium in the form of citrate doesn't cause kidney deposits. I've never had a fracture. I need to order vitamin K2 in the natural menaquinone-7 (MK-7) form. Vitamin K2 helps direct calcium to bones; without it, calcium may calcify blood vessels, which is dangerous for cardiovascular disease.
Chest Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.7
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
We looked at the case of a 69-year-old woman experiencing intermittent shortness of breath and chest pain. Interestingly, she also described a peculiar symptom—a phantom odor sensation that preceded her episodes. During an exercise stress echocardiography, she demonstrated abnormal smell perception alongside transient changes in her heart's electrical activity, which indicated possible cardiac issues.
After conducting invasive coronary angiography, no significant blockages were found in her coronary arteries. This led to a diagnosis of vasospastic angina, a condition that can cause chest pain due to spasms in the coronary arteries rather than physical blockages. To alleviate her symptoms, she was started on calcium channel blocker therapy. Thankfully, this treatment helped in resolving her discomfort.
While the study highlights the role of calcium treatment in managing her symptoms effectively, it's essential to note that this isn't a guaranteed solution for everyone with chest pain. Phantom odors as an indicative symptom of cardiovascular issues are quite rare, suggesting a need for healthcare providers to remain vigilant when patients present with atypical symptoms.
After conducting invasive coronary angiography, no significant blockages were found in her coronary arteries. This led to a diagnosis of vasospastic angina, a condition that can cause chest pain due to spasms in the coronary arteries rather than physical blockages. To alleviate her symptoms, she was started on calcium channel blocker therapy. Thankfully, this treatment helped in resolving her discomfort.
While the study highlights the role of calcium treatment in managing her symptoms effectively, it's essential to note that this isn't a guaranteed solution for everyone with chest pain. Phantom odors as an indicative symptom of cardiovascular issues are quite rare, suggesting a need for healthcare providers to remain vigilant when patients present with atypical symptoms.
9.5
Reduced chest pain
Most Useful Review
An excellent preparation of calcium that has been beneficial for my stomach. After experiencing early menopause with severe bone pain and muscle weakness, I switched from a pharmacy calcium with no results and stomach issues. The pharmacist suggested this easily absorbed form. After one can of 240 tablets, my cramps lessened, and my chest pain decreased. I now take it regularly and have no pain. I highly recommend it.
Heartburn details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 7 Reviews
8.5
8
We explored the effectiveness of calcium in alleviating heartburn, especially in pregnant women. Our findings highlighted that many expectant mothers experience heartburn due to hormonal changes and the physical pressure of a growing fetus on the stomach.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
9.5
No heartburn relief
Most Useful Review
I loved it; very beautiful, and it does not cause heartburn like other formulations. Calcium is beneficial for bone and dental health, as well as maintaining electrolyte balance in the body. The package is large and sufficient, and the quality is among the best. I recommend it.
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 17 Reviews
8.5
7
We explored the effects of oral calcium and vitamin D on patients suffering from dengue fever. In our study involving five cases, we observed significant improvement in the overall clinical condition of the patients. Additionally, there was a noticeable reduction in the duration of symptoms, including nausea. Despite these improvements, it is vital to note that the study's small size limits the generalizability of these findings. More extensive research is necessary to confirm these effects.
9.5
Best for nausea
Most Useful Review
I wish I had discovered this vitamin sooner, having tried numerous others without success. This one is by far the most effective for arthritis and is gentle on the stomach. If you're seeking something to combat nausea, I highly recommend giving this a try.
Adenoiditis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
Health improvements noted
Most Useful Review
I've been using this vitamin for a while now and have noticed some improvements in my health since starting it. It also helps me get through the day without suffering from a severe headache or sore throat.
Diabetes details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.4
2
Vitamin D3 shows no diabetes benefit
We conducted a thorough investigation to understand how vitamin D3 supplementation influences the risk of developing type 2 diabetes in healthy older adults. Over the course of five years, we carried out a randomized, placebo-controlled trial involving 2,271 participants aged 60 and over. This diverse group of adults was free from cardiovascular disease and cancer, ensuring a focus on individuals not at high risk for diabetes.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
9
Pain relief noted
Most Useful Review
Great for diabetics. The complications linked to a deficiency of calcium manifest significantly in individuals with diabetes mellitus. Therefore, it's essential to ensure a regular intake of calcium. The citrate form, along with vitamin D, enhances absorption. Moreover, coffee can deplete calcium from the body. I take two tablets each evening, and after just two weeks, the persistent ache in my hand has vanished. It's reasonably priced and well-balanced. I recommend it.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.4
8.8
Improved energy levels
Most Useful Review
The capsules are of a clean composition, convenient size, and easy to swallow. I have been taking this supplement for only two weeks to address insulin resistance, and I feel I have more energy, snack less, and my sweet cravings have diminished. The rashes on my face have reduced, and I find myself calming down more quickly after stress. The results so far are unmistakable, and I hope to enhance my metabolism with this supplement. Thank you for the prompt delivery and excellent quality.
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.3
9
We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.
By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.
Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.
Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
8.3
Sleep issue resolution
Most Useful Review
Inexpensive yet excellent vitamin. Initially, I experienced slight bloating, but it subsided. After using it, I noticed stronger teeth, and my joints stopped making noise. Surprisingly, it helped with my insomnia; within half an hour of taking the tablet, I fell asleep. An outstanding product, I'll definitely repurchase.
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
9
We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
9.5
Heart palpitations relief
Most Useful Review
This is the only type of calcium that alleviates my heart palpitations when combined with magnesium at bedtime. I appreciate this large bottle as it lasts a long time and is reasonably priced. I intend to keep purchasing it in the future, God willing.
Constipation details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Medium or Average
Based on 23 Reviews
6.1
7
We explored how calcium intake relates to constipation, particularly focusing on individuals with metabolic syndrome, a condition that significantly impacts health. Using data from the National Health and Nutrition Examination Survey conducted between 2005 and 2010, we assessed the dietary habits of participants and looked at how often they experienced constipation.
Our findings suggest a noteworthy connection: as dietary calcium intake increases, the risk of constipation decreases among those with metabolic syndrome. This suggests that calcium could play a beneficial role in gastrointestinal health.
By analyzing dietary recalls and bowel movement frequency, we provided valuable insights into how making dietary changes can potentially improve symptoms for those affected by metabolic syndrome. This emphasizes the importance of dietary calcium as a simple yet impactful strategy for managing gastrointestinal issues in this specific population.
Our findings suggest a noteworthy connection: as dietary calcium intake increases, the risk of constipation decreases among those with metabolic syndrome. This suggests that calcium could play a beneficial role in gastrointestinal health.
By analyzing dietary recalls and bowel movement frequency, we provided valuable insights into how making dietary changes can potentially improve symptoms for those affected by metabolic syndrome. This emphasizes the importance of dietary calcium as a simple yet impactful strategy for managing gastrointestinal issues in this specific population.
8.8
Improved experience
Most Useful Review
This vitamin is fantastic. My husband and I are pleased we purchased it; it has helped us tremendously. It’s wonderful to enhance energy levels without side effects, other than occasional constipation...
