Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
The product is found useful for the following medical conditions
Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.7
8
We explored how 25-hydroxyvitamin D3 (25OHD), a form of vitamin D, influences upper respiratory tract infections (URTIs), commonly known as colds. In a carefully designed clinical study, we followed 428 participants aged 45 to 74 over a 16-week period. They were randomly assigned to receive either 10 μg of 25OHD daily or a placebo, all while maintaining a double-blind setup to ensure accurate results.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
10
Cold prevention success
Most Useful Review
135 people found this helpful
Vitamins D3 effectively boost the immune system. Throughout my life, I have suffered from herpes and tried many things to raise my immunity, but nothing worked. I decided to try these vitamins, and now, in autumn, all my colleagues except me got a cold; even those who were sceptical now take them.
Updated: Apr 2025
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.7
9
Pain relief
Most Useful Review
19 people found this helpful
I ordered this due to its price, not expecting much. I had pain in my shoulder joints and was pleasantly surprised when, after two weeks, I realised the pelvic pain had disappeared. I highly recommend it; it truly works!
Updated: Apr 2025
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.6
8
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
9
Effective for allergies
Most Useful Review
3 people found this helpful
I prefer calcium in citrate form as it’s better absorbed compared to carbonate. Since taking two tablets daily in the evening, I’ve seen substantial improvement in my nails and overall health, including my allergy symptoms. It’s easy to digest and has no side effects.
Updated: Mar 2026
Bacterial Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
Prevents bacterial infection
Most Useful Review
103 people found this helpful
Calcium citrate is an excellent choice for those needing supplemental calcium. It's eco-friendly and has been shown to be 22-27% more effective in absorption compared to carbonate. It's advisable to consider the source of calcium, as those from animal origins can pose the risk of lead contamination, affecting health adversely. Calcium citrate not only aids in calcium absorption but also assists in preventing kidney stones and suppressing infection in the bladder due to its alkalising effect on urine. I wholeheartedly recommend it to anyone.
Updated: Mar 2026
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
9
Calcium normalised
Most Useful Review
7 people found this helpful
My mum has taken calcium as prescribed by her doctor for over ten years, but it was never absorbed properly and her levels often dropped to a dangerous low, causing seizures. After trying this product, her calcium is now normal, which hasn't happened for a long time! I highly recommend this supplement, especially as it costs half the price of previous ones.
Updated: Mar 2026
Premenstrual Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Migraine relief
Most Useful Review
GREAT It normalises sleep with a regular intake of 2 capsules. It improves the course of my migraines; special effects begin, I take pills as usual, add magnesium, and the migraine dissipates easily within a few hours. Previously, I was out for half a day. The frequency has also decreased, though I also have medicinal support. Regular intake of magnesium makes both premenstrual syndrome and menstruation easier to endure. I don't become irritable nor need painkillers on the first day. Chronic nasopharyngeal pain rarely worsens. I think magnesium, alongside omega-3 and new supplements, has been beneficial. Collagen has shown great effects as well. No allergies or rashes. Quality ingredients and easy to use.
Updated: Mar 2026
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
9
Helps with osteoarthritis
Most Useful Review
Excellent! This citrate formula genuinely aids with osteoarthritis. I buy it regularly; however, it's disappointing that the 1kg cans have been discontinued, leaving only smaller sizes available.
Updated: Mar 2026
Blood Clot details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
We explored the connection between vitamin D levels and coronary thrombus load in patients who experienced ST-elevation myocardial infarction (STEMI). The study included 77 patients where we measured serum vitamin D levels, thrombus degree, and other relevant factors.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
9
Maintained blood clotting
Most Useful Review
1 people found this helpful
My husband has been on this calcium for nearly two years after his thyroid surgery. It is essential for him due to his affected parathyroid glands. With this supplement, his calcium levels remain nearly normal, unlike with other pharmacy options. The price for such quality is excellent, especially in bulk.
Updated: Mar 2026
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Vitamin D3 improves cold symptoms
We conducted a thorough investigation into how 25-hydroxyvitamin D3, commonly referred to as vitamin D3, impacts upper respiratory tract infections (URTIs), particularly the common cold. This study was carried out as a randomized, double-blind, placebo-controlled trial, engaging 428 participants, all aged between 45 and 74, across three clinics in Japan.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
9
Boosted immunity
Most Useful Review
135 people found this helpful
Vitamins D3 have significantly improved my immune system. I used to struggle with herpes and tried many things for my immunity. After taking these vitamins, I noticed that all my colleagues fell ill with the common cold, but I remained fine. Now, even the sceptics around me take these vitamins.
Updated: Apr 2025
Diarrhea details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.5
2
We conducted a thorough investigation into how vitamin D3 supplementation affects diarrhea in young children. The study involved 3,046 infants aged 1 to 11 months living in high-risk areas of Kabul, Afghanistan. They were randomly assigned to receive either six doses of vitamin D3 or a placebo over 18 months.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
9
No discomfort noted
Most Useful Review
1 people found this helpful
This calcium has been taken for some time without any discomfort or diarrhoea. It is calcium citrate, which is easy to absorb. Taking 2 tablets a day provides 630mg of calcium. Additionally, it contains D3 to assist with calcium absorption. The price is reasonable. It is my preferred choice for calcium supplements. Recommended! (However, the particles are somewhat large, so those with swallowing difficulties should choose carefully.)
Updated: Apr 2025
Leg Cramps details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
5.9
USERS' SCORE
Good
Based on 30 Reviews
8.5
9
Calcium dobesilate reduces leg cramps
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
9
Healed broken leg
Most Useful Review
174 people found this helpful
After breaking my leg, I used calcium in chelate form for three months, which significantly aided my recovery. Now I’ve switched to citrate form and ordered a larger pack. It seems effective in strengthening my bones, easing my ability to walk, reducing leg cramps, and expediting my healing process.
Updated: Mar 2026
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Seeking competent doctor
Most Useful Review
1 people found this helpful
I needed these vitamins urgently. Twice a year, in spring and autumn, my foot joints worsen, making it painful to walk and causing my shoes to feel too tight due to swelling. I have consulted doctors, but the only advice I've received is that it's due to my age, which I believe is not that advanced yet. I'm currently in search of a knowledgeable doctor, and I have foot X-rays available. Meanwhile, I've been taking these vitamins at my own risk, but they seem to help!
Updated: Apr 2025
Bloating details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 6 Reviews
8.4
9
We explored the effectiveness of OsteoCalVitFort, a supplement combining 500 mg of calcium and 400 IU of vitamin D3, focusing specifically on its impact on bloating. The study involved 186 participants aged 18 to 65 years, who took two tablets daily—one after breakfast and one after dinner.
Through follow-up phone calls, we gathered information about any side effects and the overall satisfaction with the supplement. Notably, we observed a significant reduction in bloating, with the rate decreasing from 12.5% before taking the supplement to just 0.6% after. This impressive drop highlights the potential benefits of vitamin D3 in alleviating bloating discomfort.
Overall, the findings suggest that OsteoCalVitFort is not only effective but also well-received by users, with 94% reporting satisfaction with their experience. Importantly, we noted that no significant adverse effects were reported, setting OsteoCalVitFort apart from other supplements often linked with gastrointestinal issues.
Through follow-up phone calls, we gathered information about any side effects and the overall satisfaction with the supplement. Notably, we observed a significant reduction in bloating, with the rate decreasing from 12.5% before taking the supplement to just 0.6% after. This impressive drop highlights the potential benefits of vitamin D3 in alleviating bloating discomfort.
Overall, the findings suggest that OsteoCalVitFort is not only effective but also well-received by users, with 94% reporting satisfaction with their experience. Importantly, we noted that no significant adverse effects were reported, setting OsteoCalVitFort apart from other supplements often linked with gastrointestinal issues.
9
Improved mood
Most Useful Review
83 people found this helpful
After taking this product for two weeks, I've noticed an improvement in my mood and energy, as well as my overall health. I no longer experience bloating when consuming this food!
Updated: Mar 2026
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
Vitamin D3 improves depressive symptoms
We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
7.5
Positive self-change
Most Useful Review
102 people found this helpful
I used to suffer from depression and insomnia. As I listened to the products, I noticed they were creating a positive change in me.
Updated: Mar 2026
Hypothyroidism details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.4
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
9
Reduced muscle cramps
Most Useful Review
Calcium citrate has become an essential part of my routine and began working in just ten days. I take 6 tablets daily, along with alfacalcidol to enhance calcium absorption. The quality is excellent for a reasonable price. Following surgery for hypothyroidism and hypoparathyroidism, I noticed improved nerve conduction, and muscle twitching and cramps have ceased. This formulation has been suitable for me.
Updated: Mar 2026
Knee Pain details
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
USERS' SCORE
Good
Based on 13 Reviews
8.4
1
We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
9
Knee pain reduced
Most Useful Review
7 people found this helpful
After surgery, I realised I had a calcium deficiency. I combined this calcium citrate with other supplements. After a week, my knees stopped crunching. My flattened nails improved significantly as well.
Updated: Mar 2026
Menopause details
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.1
USERS' SCORE
Good
Based on 8 Reviews
8.4
1
We set out to explore the impact of calcium and vitamin D supplements on menopause-related symptoms among postmenopausal women. In the Women's Health Initiative Calcium/Vitamin D Trial, over 34,000 women participated, receiving either the supplements or a placebo over an average of 5.7 years.
Our results revealed that women taking the calcium and vitamin D supplements experienced no significant differences in menopause symptoms, including sleep disturbances and emotional well-being, compared to those on the placebo. This suggests that the combination does not have the expected benefits for managing menopause symptoms.
Our results revealed that women taking the calcium and vitamin D supplements experienced no significant differences in menopause symptoms, including sleep disturbances and emotional well-being, compared to those on the placebo. This suggests that the combination does not have the expected benefits for managing menopause symptoms.
9
Bone health support
Most Useful Review
1 people found this helpful
I give this calcium citrate to my parents to prevent osteoporosis during menopause, and it's far superior to other products. I would appreciate a positive click on my review. Stay healthy!
Updated: Mar 2026
Rheumatoid Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
We investigated the role of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, in managing rheumatoid arthritis (RA). Our study focused on how this vitamin influences macrophage activation, especially in patients with RA.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.
We found that vitamin D3 has a unique ability to suppress M1 macrophage polarization, a process that intensifies inflammation and is linked to RA symptoms. The treatment reduced levels of various inflammatory markers in macrophages, which are crucial players in our immune response.
In controlled experiments using THP-1 cells (a type of human immune cell), vitamin D3 enhanced the expression of fructose-1,6-bisphosphatase 1 (FBP1). This interaction was significant because FBP1 helps manage the degradation of another protein called PKR, which is involved in the inflammatory response.
By interacting with FBP1 and PKR, vitamin D3 diminishes the inflammatory activity of macrophages, suggesting a pathway for reducing arthritis symptoms. We also observed promising effects in TNF-transgenic mice, where vitamin D3 treatment alleviated arthritic manifestations and promoted a healthier macrophage profile in cells taken from swollen joints.
Overall, our findings affirm the potential of vitamin D3 as a beneficial treatment option for individuals struggling with rheumatoid arthritis.
9
Significant symptom relief
Most Useful Review
Ordered for my father, who has rheumatoid arthritis, he experienced very painful and swollen joints during flare-ups. After taking it for two months, the symptoms virtually disappeared, but they returned, so I bought it again. I hope the results from this calcium continue to be positive. The complex is low in vitamin D3, so my dad takes an additional vitamin supplement.
Updated: Apr 2025
Chest Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.7
USERS' SCORE
Good
Based on 3 Reviews
8.3
9.5
We looked at the case of a 69-year-old woman experiencing intermittent shortness of breath and chest pain. Interestingly, she also described a peculiar symptom—a phantom odor sensation that preceded her episodes. During an exercise stress echocardiography, she demonstrated abnormal smell perception alongside transient changes in her heart's electrical activity, which indicated possible cardiac issues.
After conducting invasive coronary angiography, no significant blockages were found in her coronary arteries. This led to a diagnosis of vasospastic angina, a condition that can cause chest pain due to spasms in the coronary arteries rather than physical blockages. To alleviate her symptoms, she was started on calcium channel blocker therapy. Thankfully, this treatment helped in resolving her discomfort.
While the study highlights the role of calcium treatment in managing her symptoms effectively, it's essential to note that this isn't a guaranteed solution for everyone with chest pain. Phantom odors as an indicative symptom of cardiovascular issues are quite rare, suggesting a need for healthcare providers to remain vigilant when patients present with atypical symptoms.
After conducting invasive coronary angiography, no significant blockages were found in her coronary arteries. This led to a diagnosis of vasospastic angina, a condition that can cause chest pain due to spasms in the coronary arteries rather than physical blockages. To alleviate her symptoms, she was started on calcium channel blocker therapy. Thankfully, this treatment helped in resolving her discomfort.
While the study highlights the role of calcium treatment in managing her symptoms effectively, it's essential to note that this isn't a guaranteed solution for everyone with chest pain. Phantom odors as an indicative symptom of cardiovascular issues are quite rare, suggesting a need for healthcare providers to remain vigilant when patients present with atypical symptoms.
9
Reduced chest pain
Most Useful Review
2 people found this helpful
An excellent preparation of calcium that has been beneficial for my stomach. After experiencing early menopause with severe bone pain and muscle weakness, I switched from a pharmacy calcium with no results and stomach issues. The pharmacist suggested this easily absorbed form. After one can of 240 tablets, my cramps lessened, and my chest pain decreased. I now take it regularly and have no pain. I highly recommend it.
Updated: Apr 2025
Ear Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
7.5
Pain relief noted
Most Useful Review
2 people found this helpful
This is an excellent calcium preparation that is gentle on the stomach. After struggling with severe bone pain due to early menopause, my doctor recommended switching to a more digestible form of calcium. Since taking this product, not only have my cramps ceased, but I've also seen a significant decrease in bone pain. I’m continuing with this supplement regularly and highly recommend it to others in need of calcium.
Updated: Mar 2026
Heart Disease details
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
Vitamin D improves heart health
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
7.5
Effective treatment
Most Useful Review
103 people found this helpful
Just something important 💚 Calcium in citrate form is well absorbed by our bodies, unlike the carbonate form. I have noticed improvement in my teeth's condition after a week of taking these tablets. My sensitivity and roughness of the enamel have disappeared, and my teeth feel smooth. This calcium is effective, with good dosage and volume, so I don't see the need for more expensive options.
Updated: Mar 2026
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
Vitamin D3 improves adolescent insomnia
We studied how high-dose vitamin D3 supplementation might affect insomnia in adolescent girls. Over nine weeks, 940 participants received a weekly dose of 50,000 IU of vitamin D3 while we tracked changes in their sleep patterns.
Interestingly, we observed a notable reduction in insomnia rates after the treatment. The number of girls reporting insomnia dropped from 15.0% to 11.3%, indicating that this vitamin can potentially improve sleep quality.
We also noticed a slight decrease in daytime sleepiness, with cases falling from 15.6% to 14.7%. Furthermore, those experiencing both insomnia and sleepiness saw a decline from 8.0% to 6.1%.
These findings suggest that high-dose vitamin D can play a significant role in alleviating sleep issues among adolescent girls. However, further studies are needed to see if these effects are consistent across diverse age and gender groups.
Interestingly, we observed a notable reduction in insomnia rates after the treatment. The number of girls reporting insomnia dropped from 15.0% to 11.3%, indicating that this vitamin can potentially improve sleep quality.
We also noticed a slight decrease in daytime sleepiness, with cases falling from 15.6% to 14.7%. Furthermore, those experiencing both insomnia and sleepiness saw a decline from 8.0% to 6.1%.
These findings suggest that high-dose vitamin D can play a significant role in alleviating sleep issues among adolescent girls. However, further studies are needed to see if these effects are consistent across diverse age and gender groups.
9
Decreased insomnia
Most Useful Review
Budget calcium that I buy for my mother. She notices the effects, and her insomnia has diminished.
Updated: Apr 2025
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 16 Reviews
8.3
7
We explored the effects of oral calcium and vitamin D on patients suffering from dengue fever. In our study involving five cases, we observed significant improvement in the overall clinical condition of the patients. Additionally, there was a noticeable reduction in the duration of symptoms, including nausea. Despite these improvements, it is vital to note that the study's small size limits the generalizability of these findings. More extensive research is necessary to confirm these effects.
9
Best for nausea
Most Useful Review
100 people found this helpful
I wish I had discovered this vitamin sooner, having tried numerous others without success. This one is by far the most effective for arthritis and is gentle on the stomach. If you're seeking something to combat nausea, I highly recommend giving this a try.
Updated: Mar 2026
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.
By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.
Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.
Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
7.5
Improved sleep quality
Most Useful Review
1 people found this helpful
Calcium plus D3 Sugar, salt (sodium chloride) and excess protein hinder calcium absorption, increasing calcium excretion in urine. If dietary calcium is insufficient, it is drawn from bones. Sugary drinks, including non-carbonated juices and colas, significantly elevate fracture risks. Soft drinks worsen the situation due to sugar and acid phosphates, leading to greater calcium loss. I find calcium absorbs well with D3. I take it at night, and it has improved my sleep.
Updated: Mar 2026
Autoimmune Disorder details
SCIENTIFIC SCORE
Questionable
Based on 30 Researches
6.6
USERS' SCORE
Good
Based on 6 Reviews
8.2
9
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
9
Beauty maintenance
Most Useful Review
4 people found this helpful
I bought this for my sister, a young nursing mother. Her doctor recommended a regimen including calcium citrate, vitamin D, EPA-DHA balance, and Lecithin for maintaining beauty and health. She's pleased with how it's positively affected her skin, hair, nails, and overall resilience during sleepless nights.
Updated: Mar 2026
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.1
USERS' SCORE
Good
Based on 5 Reviews
8.2
9
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
9
Improved calcium levels
Most Useful Review
1 people found this helpful
This calcium is one of the best I take for my mother with severe osteoporosis. Calcium citrate's absorption is superior, particularly for the elderly. Despite needing extra vitamin D3, this affordable option has shown good results in her calcium levels and overall health!
Updated: Mar 2026
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 62 Reviews
8.2
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
9
Morning pain relief
Most Useful Review
162 people found this helpful
I recommend this product for anyone with a calcium deficiency. It offers a good price-to-quality ratio, has no unpleasant aftertaste, and I experienced no side effects. My bone pain and lower back issues have decreased, making mornings much better.
Updated: Mar 2026
Flu details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.5
USERS' SCORE
Good
Based on 6 Reviews
8.2
8
We carried out a study to investigate whether vitamin D3 supplements could help prevent seasonal influenza A in schoolchildren. Our approach involved a randomized, double-blind, placebo-controlled trial conducted from December 2008 to March 2009.
This ensured that neither the participants nor the researchers knew who was receiving the vitamin D3 or the placebo, making our findings more reliable. During the trial, we provided 1200 IU of vitamin D3 daily to one group while the other received a placebo.
The results were promising; we found that only 10.8% of the children taking vitamin D3 contracted influenza A, compared to 18.6% in the placebo group. This reduced incidence led us to a relative risk of 0.58, suggesting that vitamin D3 supplementation may lower the chances of getting the flu.
Interestingly, we noticed the most significant benefits among children who hadn’t been taking any other vitamin D supplements and those who began nursery school after age three. Additionally, in children with a past asthma diagnosis, vitamin D3 seemed to dramatically reduce asthma attacks.
Overall, our findings indicate that taking vitamin D3 in the winter could be beneficial for schoolchildren, especially for certain groups. We believe this study adds valuable insights into preventive health measures against influenza A.
This ensured that neither the participants nor the researchers knew who was receiving the vitamin D3 or the placebo, making our findings more reliable. During the trial, we provided 1200 IU of vitamin D3 daily to one group while the other received a placebo.
The results were promising; we found that only 10.8% of the children taking vitamin D3 contracted influenza A, compared to 18.6% in the placebo group. This reduced incidence led us to a relative risk of 0.58, suggesting that vitamin D3 supplementation may lower the chances of getting the flu.
Interestingly, we noticed the most significant benefits among children who hadn’t been taking any other vitamin D supplements and those who began nursery school after age three. Additionally, in children with a past asthma diagnosis, vitamin D3 seemed to dramatically reduce asthma attacks.
Overall, our findings indicate that taking vitamin D3 in the winter could be beneficial for schoolchildren, especially for certain groups. We believe this study adds valuable insights into preventive health measures against influenza A.
7.5
Joint improvement noted
Most Useful Review
3 people found this helpful
Good calcium at a great price. This is not the first time I've taken it for myself and my parents. They noticed the positive effect on their joints and health overall. Calcium is essential for those recovering from fractures, as coffee flushes out calcium from the body. The only drawback is the large size of the tablets, which aren’t easy for everyone to swallow.
Updated: Mar 2026
Hair Loss details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
USERS' SCORE
Good
Based on 17 Reviews
8.1
9
This study dives into how 1,25-(OH)D, a potent form of vitamin D, influences hair growth. Through a combination of experiments in live mice, hair follicle organ culture, and detailed cellular investigations, we uncovered that this vitamin enhances hair regeneration.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
9
Stronger, thicker hair
Most Useful Review
10 people found this helpful
After giving birth, hair loss became my most pressing concern. The endocrinologist suggested taking calcium citrate with D3 for two months. Following this treatment, I noticed a significant improvement; my hair has grown much stronger and thicker. I hope my review helps others.
Updated: Mar 2026
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8
8
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
7.5
Positive results noted
Most Useful Review
This calcium supplement has proven effective with a good combination of vitamin D3. I purchased it for a friend's parents dealing with cancer, relying on positive reviews from cancer patients' forums. The packaging is great and priced reasonably. There has already been noticeable improvement after taking it, so I highly recommend it!
Updated: Apr 2025
Diabetes details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 3 Reviews
8
2
Vitamin D3 shows no diabetes benefit
We conducted a thorough investigation to understand how vitamin D3 supplementation influences the risk of developing type 2 diabetes in healthy older adults. Over the course of five years, we carried out a randomized, placebo-controlled trial involving 2,271 participants aged 60 and over. This diverse group of adults was free from cardiovascular disease and cancer, ensuring a focus on individuals not at high risk for diabetes.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
8
Pain relief noted
Most Useful Review
Great for diabetics. The complications linked to a deficiency of calcium manifest significantly in individuals with diabetes mellitus. Therefore, it's essential to ensure a regular intake of calcium. The citrate form, along with vitamin D, enhances absorption. Moreover, coffee can deplete calcium from the body. I take two tablets each evening, and after just two weeks, the persistent ache in my hand has vanished. It's reasonably priced and well-balanced. I recommend it.
Updated: Mar 2026
Adenoiditis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.9
7.5
Effective alternative found
Most Useful Review
The thought of taking four chewables a day literally turned my stomach, as I found their taste quite vile. My doctor recommended these as an alternative and they've worked remarkably well for me; I've already purchased a year's supply. Although the pills are large, I take them one at a time and they go down easily with no discomfort. There’s no smell or taste, making it a perfect solution for me. I’ve been using them almost a month, four times a day, and have yet to encounter any issues.
Updated: Apr 2025
Kidney Stones details
SCIENTIFIC SCORE
Likely Ineffective
Based on 7 Researches
4.4
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.9
7
We examined the effects of calcium, with or without calcitriol, on kidney stone risk in postmenopausal Thai women. The study involved 53 women who took either calcium alone or calcium plus calcitriol for three months.
We found that while calcium levels in urine increased, there was no significant rise in the risk of kidney stones. Overall, most subjects did not experience significant changes in factors that would predispose them to kidney stones.
Our results suggest that calcium and vitamin D supplementation does not contribute to an increased risk of kidney stones, making it a safer option for bone health in this population.
We found that while calcium levels in urine increased, there was no significant rise in the risk of kidney stones. Overall, most subjects did not experience significant changes in factors that would predispose them to kidney stones.
Our results suggest that calcium and vitamin D supplementation does not contribute to an increased risk of kidney stones, making it a safer option for bone health in this population.
9
Inhibits kidney stones
Most Useful Review
3 people found this helpful
This calcium citrate with vitamin D3 is efficiently absorbed by the body and effective at inhibiting kidney stones. I recommend it for the whole family.
Updated: Mar 2026
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.8
USERS' SCORE
Moderately Good
Based on 142 Reviews
7.9
9
We examined a collection of randomized controlled trials to determine the impact of calcium plus vitamin D supplementation on fracture prevention.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
The results revealed a promising 15% reduction in total fractures and a remarkable 30% drop in hip fractures among those taking these supplements.
This convincing evidence supports the recommendation of calcium and vitamin D for reducing fracture risk, especially in older adults, whether living at home or in care facilities.
10
Essential for women
Most Useful Review
34 people found this helpful
Calcium citrate with vitamin D3 is a true find. It absorbs completely and is vital for women to prevent osteoporosis while improving hair, nails, and teeth health.
Updated: Mar 2026
Heartburn details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.7
8
We explored the effectiveness of calcium in alleviating heartburn, especially in pregnant women. Our findings highlighted that many expectant mothers experience heartburn due to hormonal changes and the physical pressure of a growing fetus on the stomach.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
9
No heartburn relief
Most Useful Review
I loved it; very beautiful, and it does not cause heartburn like other formulations. Calcium is beneficial for bone and dental health, as well as maintaining electrolyte balance in the body. The package is large and sufficient, and the quality is among the best. I recommend it.
Updated: Mar 2026
Attention Deficit Hyperactivity Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 12 Reviews
7
9
Effective calcium supplement
Most Useful Review
We take this calcium regularly. After a course of treatment, my blood calcium levels normalised, indicating that it works. The price is very reasonable! It contains vitamin D, enhancing calcium absorption, and adding K2 would create an excellent combination!
Updated: Mar 2026
Data last updated:
