5/4/2025
Last update
5/4/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
Top Medical Research Studies
8
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Read More
7
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Read More
7
Vitamin D's uncertain impact on allergies
We looked into whether vitamin D supplementation during pregnancy could lower the risk of asthma and allergies in children. Our study, the Vitamin D Antenatal Asthma Reduction Trial (VDAART), involved pregnant women receiving either vitamin D or a placebo. The trial was carefully designed, randomizing participants to ensure reliable results.
While the interest in vitamin D’s effect on allergies is strong, the outcomes of our study will take time to reveal any significant benefits for preventing these conditions in children.
While the interest in vitamin D’s effect on allergies is strong, the outcomes of our study will take time to reveal any significant benefits for preventing these conditions in children.
Read More
Most Useful Reviews
9
Alleviates allergies
202 people found this helpful
Calcium citrate is excellent value. It absorbs well without side effects, unlike other forms like carbonate. It’s particularly beneficial for allergies and urolithiasis, as it can break down kidney stones. I’ve noticed improvements in my mood and sleep since starting it. For adults, a dose of 800-1200 mg is recommended, which I believe protects against conditions like osteoporosis while also relieving irritability.
Read More
9
Effective for allergies
3 people found this helpful
I prefer calcium in citrate form as it’s better absorbed compared to carbonate. Since taking two tablets daily in the evening, I’ve seen substantial improvement in my nails and overall health, including my allergy symptoms. It’s easy to digest and has no side effects.
Read More
9
Helps with seasonal allergies
Calcium citrate significantly alleviated my seasonal allergies to pollen and grass.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
- All Researches
8
We investigated the effects of combining vitamin D3 with fluticasone propionate inhalation aerosol in children with bronchial asthma. Our study involved 110 patients who were divided into two groups: one receiving only the inhalation treatment and the other receiving both the inhalation treatment and vitamin D3. By comparing these groups, we aimed to understand how vitamin D3 could potentially enhance immune function and improve symptoms related to asthma.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
Read More
8
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Read More
7
Vitamin D's uncertain impact on allergies
We looked into whether vitamin D supplementation during pregnancy could lower the risk of asthma and allergies in children. Our study, the Vitamin D Antenatal Asthma Reduction Trial (VDAART), involved pregnant women receiving either vitamin D or a placebo. The trial was carefully designed, randomizing participants to ensure reliable results.
While the interest in vitamin D’s effect on allergies is strong, the outcomes of our study will take time to reveal any significant benefits for preventing these conditions in children.
While the interest in vitamin D’s effect on allergies is strong, the outcomes of our study will take time to reveal any significant benefits for preventing these conditions in children.
Read More
7
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Read More
7
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Alleviates allergies
202 people found this helpful
Calcium citrate is excellent value. It absorbs well without side effects, unlike other forms like carbonate. It’s particularly beneficial for allergies and urolithiasis, as it can break down kidney stones. I’ve noticed improvements in my mood and sleep since starting it. For adults, a dose of 800-1200 mg is recommended, which I believe protects against conditions like osteoporosis while also relieving irritability.
Read More
9
Effective for allergies
3 people found this helpful
I prefer calcium in citrate form as it’s better absorbed compared to carbonate. Since taking two tablets daily in the evening, I’ve seen substantial improvement in my nails and overall health, including my allergy symptoms. It’s easy to digest and has no side effects.
Read More
9
Helps with seasonal allergies
Calcium citrate significantly alleviated my seasonal allergies to pollen and grass.
Read More
9
Reduces allergy symptoms
This supplement has normalised my sleep and reduced my migraine frequency, which is helpful for managing my allergies with regular magnesium intake. I don’t experience the previous intensity or duration of symptoms, leading to a more manageable condition.
Read More
9
Boosts overall health
I began taking this supplement recently and have noticed increased energy, improved skin and hair. However, individual results may vary, and consulting a doctor is advisable, particularly for allergies or chronic conditions. I’m very pleased with the supplement so far.
Read More
Frequently Asked Questions
9
Helps with seasonal allergies
Calcium citrate significantly alleviated my seasonal allergies to pollen and grass.
7.5
Helps with allergies
333 people found this helpful
Calcium citrate has been beneficial for my allergies. Though I enjoy milk, I wasn't sure how much calcium I needed. I discovered that a balanced diet sometimes lacks nutrients for proper absorption. Testing showed my calcium was at the lower limit, and I started taking it to alleviate symptoms. It does help to alkalise the body, and it’s essential to combine it with magnesium and vitamins for better absorption. Overall, it has helped me manage my allergic reactions effectively.
9
Boosts overall health
I began taking this supplement recently and have noticed increased energy, improved skin and hair. However, individual results may vary, and consulting a doctor is advisable, particularly for allergies or chronic conditions. I’m very pleased with the supplement so far.
9
Effective for allergies
3 people found this helpful
I prefer calcium in citrate form as it’s better absorbed compared to carbonate. Since taking two tablets daily in the evening, I’ve seen substantial improvement in my nails and overall health, including my allergy symptoms. It’s easy to digest and has no side effects.
9
Reduces allergy symptoms
This supplement has normalised my sleep and reduced my migraine frequency, which is helpful for managing my allergies with regular magnesium intake. I don’t experience the previous intensity or duration of symptoms, leading to a more manageable condition.
9
Alleviates allergies
202 people found this helpful
Calcium citrate is excellent value. It absorbs well without side effects, unlike other forms like carbonate. It’s particularly beneficial for allergies and urolithiasis, as it can break down kidney stones. I’ve noticed improvements in my mood and sleep since starting it. For adults, a dose of 800-1200 mg is recommended, which I believe protects against conditions like osteoporosis while also relieving irritability.
7.5
Aids skin allergies
Despite the large tablets, I’ve found calcium helpful for my skin allergies alongside antihistamines, improving my condition significantly since starting it.
7.5
Aids allergy relief
3 people found this helpful
I bought calcium primarily for its benefits, including alleviating allergies. Despite my fondness for milk, I realised the need for supplements due to poor dietary absorption. Calcium helps manage allergies and works best when taken with magnesium and vitamins. This particular citrate form is fantastic for reducing my allergic reactions effectively.
7
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
8
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
8
We investigated the effects of combining vitamin D3 with fluticasone propionate inhalation aerosol in children with bronchial asthma. Our study involved 110 patients who were divided into two groups: one receiving only the inhalation treatment and the other receiving both the inhalation treatment and vitamin D3. By comparing these groups, we aimed to understand how vitamin D3 could potentially enhance immune function and improve symptoms related to asthma.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
References
- Litonjua AA, Lange NE, Carey VJ, Brown S, Laranjo N, et al. The Vitamin D Antenatal Asthma Reduction Trial (VDAART): rationale, design, and methods of a randomized, controlled trial of vitamin D supplementation in pregnancy for the primary prevention of asthma and allergies in children. Contemp Clin Trials. 2014;38:37. 10.1016/j.cct.2014.02.006
- Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
- Biswas B, Chattopadhyay S, Hazra S, Goswami R. Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis. J Immunol. 2024;213:831. 10.4049/jimmunol.2400078
- Zeng R, Lodge CJ, Koplin JJ, Lopez DJ, Erbas B, et al. Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age. Nutrients. 2024;16. 10.3390/nu16091303
- Al-Allaff RGM, Bakr Al-Sawaf TM. Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis. Pak J Biol Sci. 2024;27:27. 10.3923/pjbs.2024.27.34
- Bagheri P, Nouri M, Eskandarzadeh H, Darvishi M. Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study. Recent Adv Inflamm Allergy Drug Discov. 2024;18:108. 10.2174/0127722708281623240116100806
