Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.1
USERS' SCORE
Good
Based on 26 Reviews
8.4
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%

Top Medical Research Studies

9
Vitamin D3 improves back pain
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.

Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.

The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.

Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
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We conducted a study to explore the connection between vitamin D3 levels and the impact of low back pain (LBP) on function and pain levels among a group of middle-aged Azeri individuals in North West Iran. Our case-control approach included 63 patients suffering from LBP and 55 healthy participants.

By analyzing blood samples, we found that the average serum concentration of 25-hydroxyvitamin D3 was notably lower in the LBP group compared to the healthy controls. This suggests that those with lower vitamin D levels are more likely to experience LBP.

Moreover, our analysis revealed a significant relationship between vitamin D3 levels and both pain intensity and disability. Specifically, we noted that lower vitamin D levels correlated with higher pain intensity as measured by a Visual Analogue Scale and greater functional disability assessed with the Modified Oswestry Questionnaire.

Overall, our findings highlight the potential role of vitamin D3 in managing back pain and suggest that addressing vitamin D deficiency could help improve outcomes for individuals suffering from LBP.
Read More
We explored the potential benefits of vitamin D3 supplementation for alleviating back pain in overweight or obese adults who were also vitamin D deficient. In a controlled study, 65 participants with a body mass index (BMI) of 25 or higher and low vitamin D levels received either a high dose of vitamin D3 or a placebo for 16 weeks.

After the treatment, we found that while vitamin D levels significantly increased in those taking the supplement, there were no overall significant differences in back pain intensity or disability scores between the vitamin D group and the placebo group.

However, it was noteworthy that among participants whose vitamin D levels were particularly low—under 30 nmol/L—those taking vitamin D did experience a meaningful reduction in back pain disability compared to those receiving placebo. This indicates that addressing severe vitamin D deficiency might not only support bone health but also improve the quality of life for those suffering from back pain—especially in overweight individuals.

These insights invite consideration for regular vitamin D testing in this demographic, offering a potential pathway to managing back pain more effectively.
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Most Useful Reviews

9
Reduced back pain
162 people found this helpful
I recommend this to anyone lacking calcium. The price-to-quality ratio is good, and I did not experience any aftertaste or side effects. My back pain has significantly decreased in the morning, especially with my osteochondrosis.
Read More
9
Back pain relief
19 people found this helpful
I ordered this calcium supplement on a whim due to the price. To my surprise, after two weeks, my shoulder pain, from which I suffered greatly, disappeared, even with arthrosis. I highly recommend it; it truly works!
Read More
9
Reduced back pain
6 people found this helpful
I purchased this for my husband to relieve his back pain from osteochondrosis. He experienced no side effects and found it good value for money, significantly reducing his pain.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.1
  • All Researches
9.5
Pregnancy osteoporosis therapy outcomes
We observed a rare condition known as pregnancy-associated osteoporosis, which affected a 38-year-old woman after she gave birth. Just a month postpartum, she experienced sudden back pain due to four vertebral fractures, and her bone density was notably low, especially in the spine.

While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.

Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
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We explored the impact of various treatments, including vitamin D3, on severe back pain caused by pregnancy-related osteoporosis (PLO). In a significant case study, a 23-year-old woman experiencing debilitating back pain was treated after her first childbirth. By monitoring her bone mineral density, we noted low T- and Z-scores in her lumbar spine.

The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.

Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
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9
Teriparatide reduces back pain effectively
We looked into the impact of teriparatide therapy on back pain in postmenopausal women with osteoporosis. Participants receiving either teriparatide or placebo took part in a randomized study where the duration of treatment was carefully monitored.

The results showed that each additional month on teriparatide significantly decreased the risk of back pain. In fact, the relative hazard of back pain dropped by 8.3% for those on 20 microg and 8.7% for those on 40 microg of teriparatide. This suggests that longer treatment not only helps with fractures but also effectively alleviates back pain.
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9
Alfacalcidol outperforms plain vitamin D
We explored the effectiveness of alfacalcidol, a hormonal therapy, versus plain vitamin D in treating osteoporosis caused by glucocorticoid use. In a study with patients on long-term glucocorticoid therapy, those taking alfacalcidol experienced significant improvements in bone density and fewer vertebral fractures compared to those receiving plain vitamin D.

Notably, the alfacalcidol group reported a greater reduction in back pain, highlighting its therapeutic advantage. We believe the results indicate that alfacalcidol plus calcium should replace plain vitamin D as a primary treatment, given its superior efficacy without major side effects.
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We explored the effectiveness of denosumab on alleviating back pain and enhancing quality of life in post-menopausal women suffering from vertebral fractures. This study, involving 140 women aged around 70, assessed participants who received denosumab alongside calcium and vitamin D3 for a year.

While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.

The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
Read More

User Reviews

USERS' SCORE
Good
Based on 26 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduced back pain
162 people found this helpful
I recommend this to anyone lacking calcium. The price-to-quality ratio is good, and I did not experience any aftertaste or side effects. My back pain has significantly decreased in the morning, especially with my osteochondrosis.
Read More
9
Back pain relief
19 people found this helpful
I ordered this calcium supplement on a whim due to the price. To my surprise, after two weeks, my shoulder pain, from which I suffered greatly, disappeared, even with arthrosis. I highly recommend it; it truly works!
Read More
9
Reduced back pain
6 people found this helpful
I purchased this for my husband to relieve his back pain from osteochondrosis. He experienced no side effects and found it good value for money, significantly reducing his pain.
Read More
9
Back pain relief
3 people found this helpful
This has helped my 67-year-old mother with her osteochondrosis. After three months, her back pain improved significantly. We are very pleased and will continue taking this supplement.
Read More
9
Joint pain relief
2 people found this helpful
After completing a course of this calcium, my joint pains vanished, and my teeth have become stronger. I'm thrilled with the results, as the calcium citrate absorbed well without causing any discomfort.
Read More

Frequently Asked Questions

9
Pain reduction
2 people found this helpful
My mother suffered from severe leg pain due to osteoporosis. After giving her these tablets, her pain significantly decreased within a week. I am very satisfied with this product's effectiveness.
7.5
Improved back pain
This calcium is well absorbed and helped alleviate my back pain after 2-3 weeks of use. However, I must be cautious as my haemoglobin dropped sharply after prolonged use.
9
Back pain relief
3 people found this helpful
This has helped my 67-year-old mother with her osteochondrosis. After three months, her back pain improved significantly. We are very pleased and will continue taking this supplement.
9
Reduced back pain
162 people found this helpful
I recommend this to anyone lacking calcium. The price-to-quality ratio is good, and I did not experience any aftertaste or side effects. My back pain has significantly decreased in the morning, especially with my osteochondrosis.
9
Back pain relief
19 people found this helpful
I ordered this calcium supplement on a whim due to the price. To my surprise, after two weeks, my shoulder pain, from which I suffered greatly, disappeared, even with arthrosis. I highly recommend it; it truly works!
9
Back pain improvement
1 people found this helpful
I love this calcium for its value and composition. After two months, my back pain finally resolved. It turns out I really needed to take calcium!
7.5
Bone pain relief
2 people found this helpful
This calcium preparation is excellent and gentle on the stomach. It has greatly reduced my bone pain associated with early menopause, especially compared to other brands.
9
Back and knee relief
I completed a box and felt noticeable improvement in my back pain and knees. I took it alongside collagen, but I’m unsure which contributed more to the improvement.
9
Decreased leg pain
1 people found this helpful
My mother has osteoporosis, and her doctor recommended calcium with vitamin D3. This combination has significantly reduced her leg pain.
9
Joint pain relief
1 people found this helpful
This supplement is excellent for preventing chondrosis. Calcium citrate facilitates the best absorption, especially with vitamin D3. My family noticed reduced joint and back pain after three weeks. For the family, buying this large volume is a great deal. I recommend it!
7
Neridronate reduces back pain effectively
In our study involving adults with β-thalassaemia and osteoporosis, we compared two treatment options: calcium and vitamin D alone or with neridronate. We found that neridronate not only improved bone mineral density at the lumbar spine and hip but also significantly reduced back pain after just three months of treatment.

Patients enjoyed a better quality of life, and the treatment was well-tolerated. Overall, our results suggest that neridronate may be a promising option for addressing back pain related to osteoporosis in this population.
8
Vitamin D3 helps alleviate back pain
We investigated whether vitamin D3 supplementation could help alleviate back pain in patients with lumbar spinal stenosis who are not undergoing surgery. This study involved patients with low vitamin D levels and split them into two groups: one received vitamin D3 supplements and the other did not.

Over several weeks, we measured changes in back pain, spinal function, and quality of life. Those in the supplementation group reported improvements in their lower back pain, demonstrating that high-dose vitamin D3 can play a significant role in managing symptoms associated with spinal stenosis.

The results suggest that for patients struggling with vitamin D deficiency and spinal stenosis, receiving vitamin D3 injections could significantly enhance both their pain levels and overall well-being.
8
Vitamin D alleviates post-surgery pain
We conducted a study to see how vitamin D3 affects pain levels in patients undergoing a specific type of spinal surgery called posterior lumbar interbody fusion (PLIF), while also undergoing rehabilitation. In this experimental setup, 42 participants were split into two groups: one receiving vitamin D supplementation and another receiving a placebo. The vitamin D group took a daily dose of 3200 IU for five weeks leading up to their surgery.

After surgery, we tracked pain levels and inflammation markers in both groups over a period of ten weeks. We found that patients taking vitamin D experienced a significant increase in vitamin D levels compared to the placebo group. Notably, those in the vitamin D group reported lower pain intensity four weeks after the surgery, which coincided with a decrease in certain inflammatory markers in their blood.

These findings suggest that vitamin D3 might help reduce systemic inflammation and lower pain levels in those undergoing spinal surgery. It seems beneficial for patients with lower back pain to consider vitamin D supplements around the time of their surgery and recovery.
7
Vitamin D3's impact on pain unclear
We explored the effectiveness of vitamin D3 as part of a treatment regimen for postmenopausal women suffering from acute osteoporotic vertebral compression fractures (OVCFs). In this study, the participants were divided between two treatment options: Teriparatide (TPTD) and percutaneous vertebroplasty (PVP) paired with alendronate. Vitamin D3 was administered alongside these treatments to help support overall bone health.

While vitamin D3 plays a vital role in bone maintenance and is included in the treatment plan, the specific impact it has on back pain relief remains unclear. This uncertainty arises because vitamin D3 was used in combination with other effective medications, making it challenging to isolate its benefits directly related to pain alleviation.

Our findings indicated that TPTD, which includes vitamin D3, yielded similar pain relief effects compared to PVP but at a lower cost. However, without clear, isolated evidence of vitamin D3's effect on back pain, we cannot definitively conclude its individual impact. Therefore, while vitamin D3 is important for bone health, we cannot assert its direct benefit on back pain from the data provided.
7
Elcatonin outperforms NSAID+Vitamin D3
In a recent study, we aimed to understand how vitamin D3, when combined with a nonsteroidal anti-inflammatory drug (NSAID), affects back pain in elderly patients suffering from vertebral fractures. Our research was structured as an open-label, multicenter, randomized trial that included 107 women aged 55 and older. They were randomly assigned to receive either elcatonin injections or the NSAID combined with vitamin D3 for a period of six months.

Though participants in both groups received treatment, we found that the group taking elcatonin experienced significantly greater improvements in quality of life and pain relief compared to those on the NSAID and vitamin D3 regimen. While vitamin D3 is acknowledged for its role in bone health, the combination with the NSAID made it difficult to isolate its specific effects on back pain.

Ultimately, our findings suggest that while vitamin D3 did not independently demonstrate a significant impact in alleviating pain when combined with an NSAID, the elcatonin treatment provided better overall outcomes for pain management and quality of life improvement. This highlights the importance of specific therapeutic approaches in managing pain related to osteoporotic fractures.

References

  1. Forni GL, Perrotta S, Giusti A, Quarta G, Pitrolo L, et al. Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis: results from a phase 2, randomized, parallel-arm, open-label study. Br J Haematol. 2012;158:274. 10.1111/j.1365-2141.2012.09152.x
  2. Lindsay R, Miller P, Pohl G, Glass EV, Chen P, et al. Relationship between duration of teriparatide therapy and clinical outcomes in postmenopausal women with osteoporosis. Osteoporos Int. 2009;20:943. 10.1007/s00198-008-0766-0
  3. Ringe JD, Farahmand P, Faber H, Dorst A. Sustained efficacy of risedronate in men with primary and secondary osteoporosis: results of a 2-year study. Rheumatol Int. 2009;29:311. 10.1007/s00296-008-0689-2
  4. Ringe JD, Faber H, Fahramand P, Schacht E. Alfacalcidol versus plain vitamin D in the treatment of glucocorticoid/inflammation-induced osteoporosis. J Rheumatol Suppl. 2005;76:33.
  5. Scaturro D, Vitagliani F, Tomasello S, Sconza C, Respizzi S, et al. Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial. Medicina (Kaunas). 2023;59. 10.3390/medicina59122197
  6. Ko S, Kim HC, Kwon J. The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study. Medicine (Baltimore). 2023;102:e32672. 10.1097/MD.0000000000032672
  7. Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. 10.1097/BRS.0000000000004309
  8. Ma Y, Wu X, Xiao X, Ma Y, Feng L, et al. Effects of teriparatide versus percutaneous vertebroplasty on pain relief, quality of life and cost-effectiveness in postmenopausal females with acute osteoporotic vertebral compression fracture: A prospective cohort study. Bone. 2020;131:115154. 10.1016/j.bone.2019.115154
  9. Pishgahi A, Dolatkhah N, Shakouri SK, Hashemian M, Amiri A, et al. Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study. BMC Res Notes. 2019;12:738. 10.1186/s13104-019-4768-0
  10. Krasowska K, Skrobot W, Liedtke E, Sawicki P, Flis DJ, et al. The Preoperative Supplementation With Vitamin D Attenuated Pain Intensity and Reduced the Level of Pro-inflammatory Markers in Patients After Posterior Lumbar Interbody Fusion. Front Pharmacol. 2019;10:527. 10.3389/fphar.2019.00527
  11. Moretti A, de Sire A, Curci C, Toro G, Gimigliano F, et al. Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures. Curr Med Res Opin. 2019;35:151. 10.1080/03007995.2018.1545636
  12. Brady SRE, Naderpoor N, de Courten MPJ, Scragg R, Cicuttini F, et al. Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults. J Steroid Biochem Mol Biol. 2019;185:212. 10.1016/j.jsbmb.2018.09.005
  13. Dzik K, Skrobot W, Flis DJ, Karnia M, Libionka W, et al. Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain. Eur J Appl Physiol. 2018;118:143. 10.1007/s00421-017-3755-1
  14. Englund M, Persson J, Bergström I. Lower pain and higher muscular strength in immigrant women with vitamin D deficiency following vitamin D treatment. Int J Circumpolar Health. 2017;76:1340547. 10.1080/22423982.2017.1340547
  15. Gaudio A, Fiore CE. Successful neridronate therapy in pregnancy-associated osteoporosis. Clin Cases Miner Bone Metab. 2016;13:241. 10.11138/ccmbm/2016.13.3.241
  16. Ghai B, Bansal D, Kanukula R, Gudala K, Sachdeva N, et al. Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial. Pain Physician. 2017;20:E99.
  17. Tanaka S, Yoshida A, Kono S, Oguma T, Hasegawa K, et al. Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures. J Bone Miner Metab. 2017;35:544. 10.1007/s00774-016-0791-6
  18. Polat SB, Evranos B, Aydin C, Cuhaci N, Ersoy R, et al. Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature. Gynecol Endocrinol. 2015;31:522. 10.3109/09513590.2015.1014787
  19. Gendelman O, Itzhaki D, Makarov S, Bennun M, Amital H. A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. Lupus. 2015;24:483. 10.1177/0961203314558676
  20. Shin MY, Kang YE, Kong SE, Ju SH, Back MK, et al. A case of low bone mineral density with vitamin d deficiency due to prolonged lactation and severe malnutrition. J Bone Metab. 2015;22:39. 10.11005/jbm.2015.22.1.39
  21. Liu J, Xu D, Liu L, Huang C, Guo Z, et al. Regular sling core stabilization training improves bone density based on calcium and vitamin D supplementation. BMC Musculoskelet Disord. 2023;24:815. 10.1186/s12891-023-06896-8
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