We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
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7
Vitamin D3 and low back pain
Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study.
We conducted a study to explore the connection between vitamin D3 levels and the impact of low back pain (LBP) on function and pain levels among a group of middle-aged Azeri individuals in North West Iran. Our case-control approach included 63 patients suffering from LBP and 55 healthy participants.
By analyzing blood samples, we found that the average serum concentration of 25-hydroxyvitamin D3 was notably lower in the LBP group compared to the healthy controls. This suggests that those with lower vitamin D levels are more likely to experience LBP.
Moreover, our analysis revealed a significant relationship between vitamin D3 levels and both pain intensity and disability. Specifically, we noted that lower vitamin D levels correlated with higher pain intensity as measured by a Visual Analogue Scale and greater functional disability assessed with the Modified Oswestry Questionnaire.
Overall, our findings highlight the potential role of vitamin D3 in managing back pain and suggest that addressing vitamin D deficiency could help improve outcomes for individuals suffering from LBP.
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7
Vitamin D3 may reduce back pain
Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults.
We explored the potential benefits of vitamin D3 supplementation for alleviating back pain in overweight or obese adults who were also vitamin D deficient. In a controlled study, 65 participants with a body mass index (BMI) of 25 or higher and low vitamin D levels received either a high dose of vitamin D3 or a placebo for 16 weeks.
After the treatment, we found that while vitamin D levels significantly increased in those taking the supplement, there were no overall significant differences in back pain intensity or disability scores between the vitamin D group and the placebo group.
However, it was noteworthy that among participants whose vitamin D levels were particularly low—under 30 nmol/L—those taking vitamin D did experience a meaningful reduction in back pain disability compared to those receiving placebo. This indicates that addressing severe vitamin D deficiency might not only support bone health but also improve the quality of life for those suffering from back pain—especially in overweight individuals.
These insights invite consideration for regular vitamin D testing in this demographic, offering a potential pathway to managing back pain more effectively.
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Most Useful Reviews
9
Reduced back pain
162 people found this helpful
I recommend this to anyone lacking calcium. The price-to-quality ratio is good, and I did not experience any aftertaste or side effects. My back pain has significantly decreased in the morning, especially with my osteochondrosis.
Read More
9
Back pain relief
19 people found this helpful
I ordered this calcium supplement on a whim due to the price. To my surprise, after two weeks, my shoulder pain, from which I suffered greatly, disappeared, even with arthrosis. I highly recommend it; it truly works!
Read More
9
Reduced back pain
6 people found this helpful
I purchased this for my husband to relieve his back pain from osteochondrosis. He experienced no side effects and found it good value for money, significantly reducing his pain.
We observed a rare condition known as pregnancy-associated osteoporosis, which affected a 38-year-old woman after she gave birth. Just a month postpartum, she experienced sudden back pain due to four vertebral fractures, and her bone density was notably low, especially in the spine.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
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9.5
PLO treatment and vitamin D3
Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature.
We explored the impact of various treatments, including vitamin D3, on severe back pain caused by pregnancy-related osteoporosis (PLO). In a significant case study, a 23-year-old woman experiencing debilitating back pain was treated after her first childbirth. By monitoring her bone mineral density, we noted low T- and Z-scores in her lumbar spine.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
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9
Teriparatide reduces back pain effectively
Relationship between duration of teriparatide therapy and clinical outcomes in postmenopausal women with osteoporosis.
We looked into the impact of teriparatide therapy on back pain in postmenopausal women with osteoporosis. Participants receiving either teriparatide or placebo took part in a randomized study where the duration of treatment was carefully monitored.
The results showed that each additional month on teriparatide significantly decreased the risk of back pain. In fact, the relative hazard of back pain dropped by 8.3% for those on 20 microg and 8.7% for those on 40 microg of teriparatide. This suggests that longer treatment not only helps with fractures but also effectively alleviates back pain.
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9
Alfacalcidol outperforms plain vitamin D
Alfacalcidol versus plain vitamin D in the treatment of glucocorticoid/inflammation-induced osteoporosis.
We explored the effectiveness of alfacalcidol, a hormonal therapy, versus plain vitamin D in treating osteoporosis caused by glucocorticoid use. In a study with patients on long-term glucocorticoid therapy, those taking alfacalcidol experienced significant improvements in bone density and fewer vertebral fractures compared to those receiving plain vitamin D.
Notably, the alfacalcidol group reported a greater reduction in back pain, highlighting its therapeutic advantage. We believe the results indicate that alfacalcidol plus calcium should replace plain vitamin D as a primary treatment, given its superior efficacy without major side effects.
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9
Denosumab improves back pain outcomes
Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures.
We explored the effectiveness of denosumab on alleviating back pain and enhancing quality of life in post-menopausal women suffering from vertebral fractures. This study, involving 140 women aged around 70, assessed participants who received denosumab alongside calcium and vitamin D3 for a year.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
I recommend this to anyone lacking calcium. The price-to-quality ratio is good, and I did not experience any aftertaste or side effects. My back pain has significantly decreased in the morning, especially with my osteochondrosis.
Read More
9
Back pain relief
19 people found this helpful
I ordered this calcium supplement on a whim due to the price. To my surprise, after two weeks, my shoulder pain, from which I suffered greatly, disappeared, even with arthrosis. I highly recommend it; it truly works!
Read More
9
Reduced back pain
6 people found this helpful
I purchased this for my husband to relieve his back pain from osteochondrosis. He experienced no side effects and found it good value for money, significantly reducing his pain.
Read More
9
Back pain relief
3 people found this helpful
This has helped my 67-year-old mother with her osteochondrosis. After three months, her back pain improved significantly. We are very pleased and will continue taking this supplement.
Read More
9
Joint pain relief
2 people found this helpful
After completing a course of this calcium, my joint pains vanished, and my teeth have become stronger. I'm thrilled with the results, as the calcium citrate absorbed well without causing any discomfort.
Back pain is a common ailment that affects millions of people worldwide and can vary significantly in intensity and duration. It can be classified into two main categories: acute and chronic. Acute back pain often arises suddenly due to a specific injury or strain, while chronic back pain persists for a longer duration, typically defined as lasting for 12 weeks or more. The pain can occur in various regions of the back, including the lower, middle, or upper sections, and may be accompanied by additional symptoms such as stiffness, muscle spasms, or reduced mobility.
Causes of back pain can range from poor posture, overexertion, or lifting heavy objects incorrectly to more serious conditions such as herniated discs, arthritis, or spinal abnormalities. Treatment options usually depend on the underlying cause and may include rest, physical therapy, medications, or, in some cases, surgical interventions. Maintaining a healthy lifestyle through regular exercise, proper ergonomics, and strength training can help prevent back pain and improve overall spinal health.
Calcium Plus Vitamin D is a dietary supplement that combines calcium, an essential mineral vital for maintaining strong bones and teeth, with Vitamin D, a nutrient that enhances calcium absorption in the body. This combination is particularly beneficial for individuals looking to support their bone health, especially those at risk for osteoporosis or conditions that lead to decreased bone density. Calcium plays a key role in various bodily functions, including muscle contraction and nerve signaling, while Vitamin D aids in the regulation of calcium levels within the blood and helps promote overall immune function.
Many formulations of Calcium Plus Vitamin D are available in various forms, including tablets, capsules, and chewables, catering to different preferences and dietary needs. When considering adding a calcium and vitamin D supplement to your daily routine, it's essential to consult with a healthcare professional to ensure it's appropriate for your specific health requirements and to determine the right dosage. A balanced diet combined with regular sunlight exposure can also help maintain adequate calcium and vitamin D levels without the need for supplementation. However, for individuals who have limited sun exposure or have dietary restrictions, such supplements can provide a convenient and effective way to support bone health.
Calcium and vitamin D are essential nutrients for bone health, and while they play a significant role in maintaining strong bones, their direct impact on back pain can be more nuanced. Calcium helps in building and maintaining bone density, which is crucial for preventing conditions such as osteoporosis that can lead to fractures and chronic back pain. Vitamin D, on the other hand, aids in the absorption of calcium and supports muscle function. Adequate levels of vitamin D are particularly important because deficiencies can lead to muscle weakness and pain, particularly in the back.
However, taking calcium and vitamin D alone may not directly alleviate back pain if it is due to muscle strain, injury, or structural problems. They can be part of a comprehensive approach that includes physical therapy, exercise, and possibly medication depending on the underlying causes of the pain. For those experiencing chronic back pain, it’s advisable to consult a healthcare professional who can provide personalized recommendations based on individual health needs.
Based on user reviews, the timeline for experiencing relief from back pain after starting this calcium supplement varies significantly among individuals. Some users report positive effects within a week, such as a mother who noted a significant decrease in her mother's severe leg pain due to osteoporosis Read Review. Others have experienced noticeable improvements after two to three weeks, such as a user who stated their back pain eased after a similar time frame Read Review.
In contrast, some users have mentioned longer periods before experiencing relief. For instance, one user indicated a gradual improvement over three months Read Review. Therefore, while many users have felt relief within two to three weeks, others might require more time to notice significant changes. It may be beneficial to be patient and consistent with the supplement for the best outcomes.
Based on the available research, several supplements show promise in alleviating back pain, particularly when addressing conditions related to osteoporosis and vitamin D deficiency. For instance, a study found that neridronate significantly improved bone mineral density and reduced back pain in individuals with osteoporosis after just three months of treatment [1]. Additionally, vitamin D3 supplementation was associated with improved pain relief in various contexts, including chronic low back pain and conditions like lumbar spinal stenosis [6] and after spinal surgery [10].
While many studies highlight the benefits of these supplements for back pain, it is essential to note that their effectiveness may vary based on individual health conditions and the presence of other treatments. For example, vitamin D3's direct impact on back pain relief was challenging to isolate when combined with other therapies like teriparatide or NSAIDs [8][17], indicating a need for further research to understand the nuances of these treatments. Overall, incorporating certain supplements, especially vitamin D3 and neridronate, appears to provide significant benefits for managing back pain, particularly in populations with deficiency or osteoporosis.
Based on user reviews, many individuals have reported noticeable improvements in their symptoms after using this calcium supplement. For instance, a user noted that their back pain significantly decreased in the morning, particularly with their osteochondrosis condition Read Review. Another reviewer mentioned that their shoulder pain vanished after just two weeks of use, providing relief from arthrosis Read Review. The feedback suggests that the supplement may offer quick results, particularly for those experiencing chronic pain conditions.
Several users reported prolonged periods of improvement after longer use. For example, one user shared that their back pain resolved after two months Read Review. Another mentioned their mother saw significant reductions in her osteochondrosis-related pain after three months, highlighting the potential for cumulative benefits over time Read Review. Additionally, users appreciated the absence of side effects and the gentle nature of the supplement on the stomach, further enhancing their overall experience with it Read Review. However, it’s essential to note that individual results can vary, so some may not experience the same benefits.
Users have reported mixed experiences when combining this supplement with other supplements for managing back pain. Some individuals indicated that they took it alongside collagen, but they were unsure which specific supplement contributed more to their improvement in back pain and knee issues Read Review. Others noted the effectiveness of pairing this calcium supplement with vitamin D3, as one user mentioned that this combination had significantly helped reduce their mother's pain from osteoporosis Read Review. Another user also highlighted the enhanced absorption of calcium citrate, particularly when combined with vitamin D3, leading to noticeable reductions in joint and back pain Read Review.
However, it's essential to approach these combinations with caution, as one user reported a drop in hemoglobin levels after prolonged use of calcium alone, implying the necessity for careful monitoring when using multiple supplements Read Review. Overall, while users generally found positive results when combining this calcium supplement with others like vitamin D3 and collagen, individual outcomes varied significantly, and consulting with a healthcare professional is advisable for anyone considering these combinations.
Users report a variety of experiences regarding the effectiveness of the Calcium Plus Vitamin D supplement for alleviating back pain. Many noted substantial improvements in their conditions following consistent use. For instance, one user highlighted a significant decrease in morning back pain and attributed it to the supplement, particularly in the context of osteochondrosis (Read Review). Similarly, another mentioned that after two to three weeks of consistent use, they observed a marked reduction in their back pain (Read Review).
Several reviews emphasized the importance of dosage and consistency, with users suggesting that long-term use contributed to noticeable improvements. One user indicated success after two months of taking the supplement, confidently stating that they really needed it for their back pain (Read Review). Another user shared that their mother, who previously suffered from severe pain, experienced significant relief after consistent consumption of the calcium supplement (Read Review). Overall, users commonly felt that regular intake of Calcium Plus Vitamin D, particularly when paired with adequate vitamin D, was key in managing their back pain effectively.
9
Pain reduction
2 people found this helpful
My mother suffered from severe leg pain due to osteoporosis. After giving her these tablets, her pain significantly decreased within a week. I am very satisfied with this product's effectiveness.
7.5
Improved back pain
This calcium is well absorbed and helped alleviate my back pain after 2-3 weeks of use. However, I must be cautious as my haemoglobin dropped sharply after prolonged use.
9
Back pain relief
3 people found this helpful
This has helped my 67-year-old mother with her osteochondrosis. After three months, her back pain improved significantly. We are very pleased and will continue taking this supplement.
9
Reduced back pain
162 people found this helpful
I recommend this to anyone lacking calcium. The price-to-quality ratio is good, and I did not experience any aftertaste or side effects. My back pain has significantly decreased in the morning, especially with my osteochondrosis.
9
Back pain relief
19 people found this helpful
I ordered this calcium supplement on a whim due to the price. To my surprise, after two weeks, my shoulder pain, from which I suffered greatly, disappeared, even with arthrosis. I highly recommend it; it truly works!
9
Back pain improvement
1 people found this helpful
I love this calcium for its value and composition. After two months, my back pain finally resolved. It turns out I really needed to take calcium!
7.5
Bone pain relief
2 people found this helpful
This calcium preparation is excellent and gentle on the stomach. It has greatly reduced my bone pain associated with early menopause, especially compared to other brands.
9
Back and knee relief
I completed a box and felt noticeable improvement in my back pain and knees. I took it alongside collagen, but I’m unsure which contributed more to the improvement.
9
Decreased leg pain
1 people found this helpful
My mother has osteoporosis, and her doctor recommended calcium with vitamin D3. This combination has significantly reduced her leg pain.
9
Joint pain relief
1 people found this helpful
This supplement is excellent for preventing chondrosis. Calcium citrate facilitates the best absorption, especially with vitamin D3. My family noticed reduced joint and back pain after three weeks. For the family, buying this large volume is a great deal. I recommend it!
7
Neridronate reduces back pain effectively
Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis: results from a phase 2, randomized, parallel-arm, open-label study.
In our study involving adults with β-thalassaemia and osteoporosis, we compared two treatment options: calcium and vitamin D alone or with neridronate. We found that neridronate not only improved bone mineral density at the lumbar spine and hip but also significantly reduced back pain after just three months of treatment.
Patients enjoyed a better quality of life, and the treatment was well-tolerated. Overall, our results suggest that neridronate may be a promising option for addressing back pain related to osteoporosis in this population.
8
Vitamin D3 helps alleviate back pain
The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study.
We investigated whether vitamin D3 supplementation could help alleviate back pain in patients with lumbar spinal stenosis who are not undergoing surgery. This study involved patients with low vitamin D levels and split them into two groups: one received vitamin D3 supplements and the other did not.
Over several weeks, we measured changes in back pain, spinal function, and quality of life. Those in the supplementation group reported improvements in their lower back pain, demonstrating that high-dose vitamin D3 can play a significant role in managing symptoms associated with spinal stenosis.
The results suggest that for patients struggling with vitamin D deficiency and spinal stenosis, receiving vitamin D3 injections could significantly enhance both their pain levels and overall well-being.
8
Vitamin D alleviates post-surgery pain
The Preoperative Supplementation With Vitamin D Attenuated Pain Intensity and Reduced the Level of Pro-inflammatory Markers in Patients After Posterior Lumbar Interbody Fusion.
We conducted a study to see how vitamin D3 affects pain levels in patients undergoing a specific type of spinal surgery called posterior lumbar interbody fusion (PLIF), while also undergoing rehabilitation. In this experimental setup, 42 participants were split into two groups: one receiving vitamin D supplementation and another receiving a placebo. The vitamin D group took a daily dose of 3200 IU for five weeks leading up to their surgery.
After surgery, we tracked pain levels and inflammation markers in both groups over a period of ten weeks. We found that patients taking vitamin D experienced a significant increase in vitamin D levels compared to the placebo group. Notably, those in the vitamin D group reported lower pain intensity four weeks after the surgery, which coincided with a decrease in certain inflammatory markers in their blood.
These findings suggest that vitamin D3 might help reduce systemic inflammation and lower pain levels in those undergoing spinal surgery. It seems beneficial for patients with lower back pain to consider vitamin D supplements around the time of their surgery and recovery.
7
Vitamin D3's impact on pain unclear
Effects of teriparatide versus percutaneous vertebroplasty on pain relief, quality of life and cost-effectiveness in postmenopausal females with acute osteoporotic vertebral compression fracture: A prospective cohort study.
We explored the effectiveness of vitamin D3 as part of a treatment regimen for postmenopausal women suffering from acute osteoporotic vertebral compression fractures (OVCFs). In this study, the participants were divided between two treatment options: Teriparatide (TPTD) and percutaneous vertebroplasty (PVP) paired with alendronate. Vitamin D3 was administered alongside these treatments to help support overall bone health.
While vitamin D3 plays a vital role in bone maintenance and is included in the treatment plan, the specific impact it has on back pain relief remains unclear. This uncertainty arises because vitamin D3 was used in combination with other effective medications, making it challenging to isolate its benefits directly related to pain alleviation.
Our findings indicated that TPTD, which includes vitamin D3, yielded similar pain relief effects compared to PVP but at a lower cost. However, without clear, isolated evidence of vitamin D3's effect on back pain, we cannot definitively conclude its individual impact. Therefore, while vitamin D3 is important for bone health, we cannot assert its direct benefit on back pain from the data provided.
7
Elcatonin outperforms NSAID+Vitamin D3
Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures.
In a recent study, we aimed to understand how vitamin D3, when combined with a nonsteroidal anti-inflammatory drug (NSAID), affects back pain in elderly patients suffering from vertebral fractures. Our research was structured as an open-label, multicenter, randomized trial that included 107 women aged 55 and older. They were randomly assigned to receive either elcatonin injections or the NSAID combined with vitamin D3 for a period of six months.
Though participants in both groups received treatment, we found that the group taking elcatonin experienced significantly greater improvements in quality of life and pain relief compared to those on the NSAID and vitamin D3 regimen. While vitamin D3 is acknowledged for its role in bone health, the combination with the NSAID made it difficult to isolate its specific effects on back pain.
Ultimately, our findings suggest that while vitamin D3 did not independently demonstrate a significant impact in alleviating pain when combined with an NSAID, the elcatonin treatment provided better overall outcomes for pain management and quality of life improvement. This highlights the importance of specific therapeutic approaches in managing pain related to osteoporotic fractures.
References
Forni GL, Perrotta S, Giusti A, Quarta G, Pitrolo L, et al. Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis: results from a phase 2, randomized, parallel-arm, open-label study. Br J Haematol. 2012;158:274. 10.1111/j.1365-2141.2012.09152.x
Lindsay R, Miller P, Pohl G, Glass EV, Chen P, et al. Relationship between duration of teriparatide therapy and clinical outcomes in postmenopausal women with osteoporosis. Osteoporos Int. 2009;20:943. 10.1007/s00198-008-0766-0
Ringe JD, Farahmand P, Faber H, Dorst A. Sustained efficacy of risedronate in men with primary and secondary osteoporosis: results of a 2-year study. Rheumatol Int. 2009;29:311. 10.1007/s00296-008-0689-2
Ringe JD, Faber H, Fahramand P, Schacht E. Alfacalcidol versus plain vitamin D in the treatment of glucocorticoid/inflammation-induced osteoporosis. J Rheumatol Suppl. 2005;76:33.
Scaturro D, Vitagliani F, Tomasello S, Sconza C, Respizzi S, et al. Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial. Medicina (Kaunas). 2023;59. 10.3390/medicina59122197
Ko S, Kim HC, Kwon J. The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study. Medicine (Baltimore). 2023;102:e32672. 10.1097/MD.0000000000032672
Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. 10.1097/BRS.0000000000004309
Ma Y, Wu X, Xiao X, Ma Y, Feng L, et al. Effects of teriparatide versus percutaneous vertebroplasty on pain relief, quality of life and cost-effectiveness in postmenopausal females with acute osteoporotic vertebral compression fracture: A prospective cohort study. Bone. 2020;131:115154. 10.1016/j.bone.2019.115154
Pishgahi A, Dolatkhah N, Shakouri SK, Hashemian M, Amiri A, et al. Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study. BMC Res Notes. 2019;12:738. 10.1186/s13104-019-4768-0
Krasowska K, Skrobot W, Liedtke E, Sawicki P, Flis DJ, et al. The Preoperative Supplementation With Vitamin D Attenuated Pain Intensity and Reduced the Level of Pro-inflammatory Markers in Patients After Posterior Lumbar Interbody Fusion. Front Pharmacol. 2019;10:527. 10.3389/fphar.2019.00527
Moretti A, de Sire A, Curci C, Toro G, Gimigliano F, et al. Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures. Curr Med Res Opin. 2019;35:151. 10.1080/03007995.2018.1545636
Brady SRE, Naderpoor N, de Courten MPJ, Scragg R, Cicuttini F, et al. Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults. J Steroid Biochem Mol Biol. 2019;185:212. 10.1016/j.jsbmb.2018.09.005
Dzik K, Skrobot W, Flis DJ, Karnia M, Libionka W, et al. Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain. Eur J Appl Physiol. 2018;118:143. 10.1007/s00421-017-3755-1
Englund M, Persson J, Bergström I. Lower pain and higher muscular strength in immigrant women with vitamin D deficiency following vitamin D treatment. Int J Circumpolar Health. 2017;76:1340547. 10.1080/22423982.2017.1340547
Gaudio A, Fiore CE. Successful neridronate therapy in pregnancy-associated osteoporosis. Clin Cases Miner Bone Metab. 2016;13:241. 10.11138/ccmbm/2016.13.3.241
Ghai B, Bansal D, Kanukula R, Gudala K, Sachdeva N, et al. Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial. Pain Physician. 2017;20:E99.
Tanaka S, Yoshida A, Kono S, Oguma T, Hasegawa K, et al. Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures. J Bone Miner Metab. 2017;35:544. 10.1007/s00774-016-0791-6
Polat SB, Evranos B, Aydin C, Cuhaci N, Ersoy R, et al. Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature. Gynecol Endocrinol. 2015;31:522. 10.3109/09513590.2015.1014787
Gendelman O, Itzhaki D, Makarov S, Bennun M, Amital H. A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. Lupus. 2015;24:483. 10.1177/0961203314558676
Shin MY, Kang YE, Kong SE, Ju SH, Back MK, et al. A case of low bone mineral density with vitamin d deficiency due to prolonged lactation and severe malnutrition. J Bone Metab. 2015;22:39. 10.11005/jbm.2015.22.1.39
Liu J, Xu D, Liu L, Huang C, Guo Z, et al. Regular sling core stabilization training improves bone density based on calcium and vitamin D supplementation. BMC Musculoskelet Disord. 2023;24:815. 10.1186/s12891-023-06896-8