Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
Top Medical Research Studies
8
Vitamin D improves heart health
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Read More
8
We examined how vitamin D3 could play a role in protecting the heart from damage caused by cisplatin, a chemotherapy drug. In our research, we worked with male Balb-c mice, dividing them into several groups to evaluate different treatment approaches. Some groups received vitamin D3 before or after cisplatin injection, while others acted as controls.
Our findings revealed that cisplatin significantly raised markers indicating heart damage and increased oxidative stress levels. In contrast, when we administered vitamin D3, whether as a preventive measure or treatment after cisplatin exposure, it showed promising results. It was able to improve heart tissue structure and biochemical indicators associated with heart injury, suggesting that vitamin D3 may mitigate some of the cardiac risks linked with chemotherapy.
However, while vitamin D3 showed a protective effect in the groups that received it before cisplatin treatment, the benefits were only partial when given afterward. This highlights the potential of vitamin D3 in supporting heart health during cancer treatment, although more research is necessary to understand its full capabilities and best applications.
Our findings revealed that cisplatin significantly raised markers indicating heart damage and increased oxidative stress levels. In contrast, when we administered vitamin D3, whether as a preventive measure or treatment after cisplatin exposure, it showed promising results. It was able to improve heart tissue structure and biochemical indicators associated with heart injury, suggesting that vitamin D3 may mitigate some of the cardiac risks linked with chemotherapy.
However, while vitamin D3 showed a protective effect in the groups that received it before cisplatin treatment, the benefits were only partial when given afterward. This highlights the potential of vitamin D3 in supporting heart health during cancer treatment, although more research is necessary to understand its full capabilities and best applications.
Read More
4
We investigated how vitamin D3 treatment affects heart disease, particularly focusing on the connection between aortic calcification and cardiac dysfunction. In our study, C57BL/6 mice received daily doses of vitamin D for two weeks, allowing us to observe various factors such as arterial elasticity and cardiac health over an extended period.
As we analyzed the results, we found that vitamin D treatment led to significant aortic calcification and increased pulse propagation velocity. Unfortunately, rather than improving heart function, this treatment correlated with worsened cardiac performance and increased apoptosis, or programmed cell death, among heart cells.
By examining rat heart cells exposed to media from calcified vascular smooth muscle cells, we noticed a similar trend—these conditions caused apoptosis and altered the expression of genes crucial for heart function. Overall, our findings suggest that while vitamin D is often associated with health benefits, in this context, it accelerates cardiac dysfunction through mechanisms like inducing cell death in heart tissues.
These results offer critical insights into the potential dangers of elevated vitamin D levels, particularly in relation to heart health. They highlight the need for further research to better understand these effects and guide treatment strategies for those at risk of heart disease.
As we analyzed the results, we found that vitamin D treatment led to significant aortic calcification and increased pulse propagation velocity. Unfortunately, rather than improving heart function, this treatment correlated with worsened cardiac performance and increased apoptosis, or programmed cell death, among heart cells.
By examining rat heart cells exposed to media from calcified vascular smooth muscle cells, we noticed a similar trend—these conditions caused apoptosis and altered the expression of genes crucial for heart function. Overall, our findings suggest that while vitamin D is often associated with health benefits, in this context, it accelerates cardiac dysfunction through mechanisms like inducing cell death in heart tissues.
These results offer critical insights into the potential dangers of elevated vitamin D levels, particularly in relation to heart health. They highlight the need for further research to better understand these effects and guide treatment strategies for those at risk of heart disease.
Read More
Most Useful Reviews
9
Valuable for health
1 people found this helpful
Calcium is vital for developing healthy bones and teeth, regulating the heartbeat, and preventing heart disease. A deficiency leads to fragility of bones and teeth. Having vitamin D is necessary for calcium absorption, making it crucial for overall bodily functions.
Read More
7.5
Effective treatment
103 people found this helpful
Just something important 💚 Calcium in citrate form is well absorbed by our bodies, unlike the carbonate form. I have noticed improvement in my teeth's condition after a week of taking these tablets. My sensitivity and roughness of the enamel have disappeared, and my teeth feel smooth. This calcium is effective, with good dosage and volume, so I don't see the need for more expensive options.
Read More
7.5
Heart health support
1 people found this helpful
The tablets are large but effective. I take them for a month twice a year, as calcium is essential for heart health and muscle function. It helps regulate the heartbeat, and getting adequate calcium is crucial to avoid complications related to heart disease. I find it beneficial for my overall health.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
- All Researches
9
Mitochondrial calcium uptake and heart
We explored how enhancing mitochondrial calcium uptake can influence heart disease, particularly in the context of heart hypertrophy, a condition that can lead to heart failure. The study focused on the mitochondrial calcium uniporter (MCU), a protein responsible for transporting calcium into mitochondria.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
Read More
8
Vitamin D improves heart health
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Read More
8
Vitamin D3 shows potential heart protection
We explored the effects of vitamin D3 and paricalcitol on heart health, particularly in the context of doxorubicin-induced cardiotoxicity. In our study, we worked with male Wistar rats divided into various groups, some receiving doxorubicin, a drug known for its heart-damaging potential. Others were treated with vitamin D3 or paricalcitol, both thought to have protective qualities against heart injury.
After administering doxorubicin, we observed significant changes in a range of biochemical markers and physiological indicators, including ECG readings and scintigraphy results. The findings suggested that both vitamin D3 and paricalcitol demonstrate potential cardioprotective effects by reducing inflammation and oxidative stress linked to heart damage.
This study shines a light on the possible benefits of vitamin D3 in protecting the heart during chemotherapy treatments. However, readers should note that while our findings are promising, they stem from an animal model, and further research is needed to confirm these effects in humans.
After administering doxorubicin, we observed significant changes in a range of biochemical markers and physiological indicators, including ECG readings and scintigraphy results. The findings suggested that both vitamin D3 and paricalcitol demonstrate potential cardioprotective effects by reducing inflammation and oxidative stress linked to heart damage.
This study shines a light on the possible benefits of vitamin D3 in protecting the heart during chemotherapy treatments. However, readers should note that while our findings are promising, they stem from an animal model, and further research is needed to confirm these effects in humans.
Read More
8
We examined how vitamin D3 could play a role in protecting the heart from damage caused by cisplatin, a chemotherapy drug. In our research, we worked with male Balb-c mice, dividing them into several groups to evaluate different treatment approaches. Some groups received vitamin D3 before or after cisplatin injection, while others acted as controls.
Our findings revealed that cisplatin significantly raised markers indicating heart damage and increased oxidative stress levels. In contrast, when we administered vitamin D3, whether as a preventive measure or treatment after cisplatin exposure, it showed promising results. It was able to improve heart tissue structure and biochemical indicators associated with heart injury, suggesting that vitamin D3 may mitigate some of the cardiac risks linked with chemotherapy.
However, while vitamin D3 showed a protective effect in the groups that received it before cisplatin treatment, the benefits were only partial when given afterward. This highlights the potential of vitamin D3 in supporting heart health during cancer treatment, although more research is necessary to understand its full capabilities and best applications.
Our findings revealed that cisplatin significantly raised markers indicating heart damage and increased oxidative stress levels. In contrast, when we administered vitamin D3, whether as a preventive measure or treatment after cisplatin exposure, it showed promising results. It was able to improve heart tissue structure and biochemical indicators associated with heart injury, suggesting that vitamin D3 may mitigate some of the cardiac risks linked with chemotherapy.
However, while vitamin D3 showed a protective effect in the groups that received it before cisplatin treatment, the benefits were only partial when given afterward. This highlights the potential of vitamin D3 in supporting heart health during cancer treatment, although more research is necessary to understand its full capabilities and best applications.
Read More
8
We conducted a randomized trial to see how combining coronary artery calcium (CAC) scoring with a prevention strategy could limit plaque progression in patients who have a family history of heart disease. The study involved participants aged 40 to 70 who were asymptomatic but had relatives with early-onset coronary artery disease (CAD).
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Valuable for health
1 people found this helpful
Calcium is vital for developing healthy bones and teeth, regulating the heartbeat, and preventing heart disease. A deficiency leads to fragility of bones and teeth. Having vitamin D is necessary for calcium absorption, making it crucial for overall bodily functions.
Read More
7.5
Effective treatment
103 people found this helpful
Just something important 💚 Calcium in citrate form is well absorbed by our bodies, unlike the carbonate form. I have noticed improvement in my teeth's condition after a week of taking these tablets. My sensitivity and roughness of the enamel have disappeared, and my teeth feel smooth. This calcium is effective, with good dosage and volume, so I don't see the need for more expensive options.
Read More
7.5
Heart health support
1 people found this helpful
The tablets are large but effective. I take them for a month twice a year, as calcium is essential for heart health and muscle function. It helps regulate the heartbeat, and getting adequate calcium is crucial to avoid complications related to heart disease. I find it beneficial for my overall health.
Read More
7.5
Vital mineral
1 people found this helpful
I purchased calcium citrate with vitamin D3 and noticed improvements that I did not experience with calcium carbonate. This form is absorbed better and does not depend on stomach acidity. I recommend it, as calcium is essential for preventing heart disease, amongst other bodily functions.
Read More
7.5
Health improvement
10 people found this helpful
Calcium in citrate form, combined with vitamin D3, is an excellent choice and affordable. I buy a large jar for my family, as elderly people benefit greatly from this supplement due to the development of heart disease and osteoporosis. Regular use leads to noticeable improvements in well-being and physical health, and I see positive changes within two weeks.
Read More
Frequently Asked Questions
7.5
Effective treatment
103 people found this helpful
Just something important 💚 Calcium in citrate form is well absorbed by our bodies, unlike the carbonate form. I have noticed improvement in my teeth's condition after a week of taking these tablets. My sensitivity and roughness of the enamel have disappeared, and my teeth feel smooth. This calcium is effective, with good dosage and volume, so I don't see the need for more expensive options.
7.5
Health improvement
10 people found this helpful
Calcium in citrate form, combined with vitamin D3, is an excellent choice and affordable. I buy a large jar for my family, as elderly people benefit greatly from this supplement due to the development of heart disease and osteoporosis. Regular use leads to noticeable improvements in well-being and physical health, and I see positive changes within two weeks.
7.5
Heart health support
1 people found this helpful
The tablets are large but effective. I take them for a month twice a year, as calcium is essential for heart health and muscle function. It helps regulate the heartbeat, and getting adequate calcium is crucial to avoid complications related to heart disease. I find it beneficial for my overall health.
7
Pain relief
8 people found this helpful
I experienced joint pain, but calcium with vitamin D helped alleviate it. It's been effective and affordable, leading to improvements in my hair health as well. I appreciate the reasonable price and quantity, making it a suitable choice for my needs. 🥰
7.5
Vital mineral
1 people found this helpful
I purchased calcium citrate with vitamin D3 and noticed improvements that I did not experience with calcium carbonate. This form is absorbed better and does not depend on stomach acidity. I recommend it, as calcium is essential for preventing heart disease, amongst other bodily functions.
8
Vitamin D improves heart health
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
7
We explored the effects of vitamin D3, a vital nutrient, on heart health, particularly in relation to a common risk factor known as angiotensin II. Our study focused on H9c2 cardiomyoblasts, a type of heart cell, to understand how vitamin D3 interacts with this condition.
By exposing these cells to angiotensin II along with vitamin D3, we aimed to see if the vitamin could shield the cells from damage. Interestingly, we found that vitamin D3 showed significant potential for preventing cell damage when SIRT1, a protein involved in cell survival, was present. However, when we blocked SIRT1, vitamin D3 wasn’t able to protect the heart cells effectively against the harmful effects induced by angiotensin II.
While vitamin D3 did help mitigate some effects of hypertrophy, or heart cell enlargement, it was clear that SIRT1 was crucial for the vitamin's protective benefits. This finding suggests that enhancing SIRT1 activity could be an exciting path forward for developing treatments to combat heart disease linked to hypertrophy and other conditions related to angiotensin II.
By exposing these cells to angiotensin II along with vitamin D3, we aimed to see if the vitamin could shield the cells from damage. Interestingly, we found that vitamin D3 showed significant potential for preventing cell damage when SIRT1, a protein involved in cell survival, was present. However, when we blocked SIRT1, vitamin D3 wasn’t able to protect the heart cells effectively against the harmful effects induced by angiotensin II.
While vitamin D3 did help mitigate some effects of hypertrophy, or heart cell enlargement, it was clear that SIRT1 was crucial for the vitamin's protective benefits. This finding suggests that enhancing SIRT1 activity could be an exciting path forward for developing treatments to combat heart disease linked to hypertrophy and other conditions related to angiotensin II.
4
We explored the effects of vitamin D3 in conjunction with marine n-3 fatty acids on heart disease, specifically looking at a large-scale study known as the VITAL trial. This secondary analysis involved over 25,000 healthy older adults who were given either a daily supplement of 1 gram of marine n-3 fatty acids and vitamin D3 or a placebo.
The primary focus was to see if these supplements could lower the risk of cardiovascular disease events. We examined various heart-related outcomes, including fatal coronary heart disease, other fatal cardiovascular issues like strokes, and non-fatal events such as heart attacks.
Our findings revealed that there was no significant overall benefit from vitamin D3 on heart disease risk when combined with n-3 fatty acids. Specifically, while we did see a reduction in heart attacks among those who consumed less fish, the data suggested that the benefits were not substantial enough to make a definitive claim about the efficacy of vitamin D3 alone.
Ultimately, although we observed some protective effects for certain individuals, the overall results indicated that vitamin D3 may not significantly impact heart disease risk when evaluated alongside n-3 fatty acids.
The primary focus was to see if these supplements could lower the risk of cardiovascular disease events. We examined various heart-related outcomes, including fatal coronary heart disease, other fatal cardiovascular issues like strokes, and non-fatal events such as heart attacks.
Our findings revealed that there was no significant overall benefit from vitamin D3 on heart disease risk when combined with n-3 fatty acids. Specifically, while we did see a reduction in heart attacks among those who consumed less fish, the data suggested that the benefits were not substantial enough to make a definitive claim about the efficacy of vitamin D3 alone.
Ultimately, although we observed some protective effects for certain individuals, the overall results indicated that vitamin D3 may not significantly impact heart disease risk when evaluated alongside n-3 fatty acids.
References
- Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. 10.1007/s11033-024-10168-6
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
- Sato AY, Cregor M, McAndrews K, Schurman CA, Schaible E, et al. Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease. JCI Insight. 2024;9. 10.1172/jci.insight.182664
- Stankiewicz B, Mieszkowski J, Kochanowicz A, Brzezińska P, Niespodziński B, et al. Effect of Single High-Dose Vitamin D Supplementation on Post-Ultra Mountain Running Heart Damage and Iron Metabolism Changes: A Double-Blind Randomized Controlled Trial. Nutrients. 2024;16. 10.3390/nu16152479
- Koroglu R, Koroglu M, Aygun H. Electrocardiographic, biochemical, and scintigraphic evidence for the cardioprotective effect of paricalcitol and vitamin D3 on doxorubicin-induced acute cardiotoxicity in rats. Bratisl Lek Listy. 2024;125:281. 10.4149/BLL_2024_42
- Hao N, Yong H, Zhang F, Liu C, Qiu Y, et al. Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes. Int J Med Sci. 2024;21:306. 10.7150/ijms.90324
- Samavati I, Ranjbar A, Haddadi R. Cardioprotective effect of vitamin D3 on cisplatin-induced cardiotoxicity in male mice: role of oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:4761. 10.1007/s00210-023-02848-0
- Ogata S, Manson JE, Kang JH, Buring JE, Lee IM, et al. Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease: A Novel Analysis of the VITAL Trial Using Win Ratio and Hierarchical Composite Outcomes. Nutrients. 2023;15. 10.3390/nu15194235
- Arroyo E, Leber CA, Burney HN, Li Y, Li X, et al. Epimeric vitamin D and cardiovascular structure and function in advanced CKD and after kidney transplantation. Nephrol Dial Transplant. 2024;39:264. 10.1093/ndt/gfad168
- Hasific S, Øvrehus KA, Hosbond S, Lambrechtsen J, Kumarathurai P, et al. Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial. BMJ Open. 2023;13:e073233. 10.1136/bmjopen-2023-073233
- Thompson B, Waterhouse M, English DR, McLeod DS, Armstrong BK, et al. Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial. BMJ. 2023;381:e075230. 10.1136/bmj-2023-075230
- Sato T, Matsumura M, Yamamoto K, Sugizaki Y, Shlofmitz E, et al. A Revised Optical Coherence Tomography-Derived Calcium Score to Predict Stent Underexpansion in Severely Calcified Lesions. JACC Cardiovasc Interv. 2025;18:622. 10.1016/j.jcin.2024.12.001
- Zaglia T, Campo A, Moro N, Di Mauro V, Borile G, et al. Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt. Proc Natl Acad Sci U S A. 2025;122:e2402639122. 10.1073/pnas.2402639122
- Nerlekar N, Vasanthakumar SA, Whitmore K, Soh CH, Chan J, et al. Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial. JAMA. 2025. 10.1001/jama.2025.0584
