21st Century Calcium 600 Plus D Plus Minerals

We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.

Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.

Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.

Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.

9.5

Nighttime cramps gone

Most Useful Review

After reading a review, I began taking calcium tablets, and my feet no longer experience leg cramps at night. I bought some for my mother, and after a month, she has also stopped having cramps at night, which is wonderful! However, I find the pills a bit large and hard for the elderly to swallow; I plan on trying liquid calcium instead.

Osteoporosis details

SCIENTIFIC SCORE

Possibly Effective

Based on 6 Researches

Calcium complex enhances bone health

A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health.

Most Relevant Research

Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.

We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.

Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.

9.5

Bone mass enhancement

Most Useful Review

Good way to translate calcium into bone mass! 21st Century Calcium 600 Plus D Plus Minerals is part of my comprehensive programme to maintain and increase my bone mass. For many years, my bone scans indicated I had osteopenia, a precursor to osteoporosis. I researched how calcium enters the bones and discovered that large doses of powdered marble or oyster shell don’t necessarily increase bone mass. That process requires minerals to help absorb calcium properly. I take 600mg at bedtime, which also aids my sleep. Most doctors advise a maximum of 1200mg daily. Dietary calcium is best, supplemented by exercise, though I don't do as much as I should. By the way, I am pleased to say my osteopenia diagnosis has vanished! My bone scan reveals a 4% increase in bone mass, and my doctor is astonished. Last year, I saw an additional 1% increase.

Autoimmune Disorder details

SCIENTIFIC SCORE

Likely Very Effective

Calcium's role in RA treatment

Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.

Most Relevant Research

We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.

Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.

We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.

Helps with IBS

Most Useful Review

Great value and prompt delivery! I sought a Calcium product with minimal Magnesium as I suffer from an autoimmune disorder, IBS-D. I understand that Calcium can generally slow digestion but not when combined with high levels of Magnesium. Finding pure Calcium in the UK proved challenging, so I looked online and discovered this product. I believe it has positively impacted my IBS while also enhancing my Calcium and Vitamin D levels. The delivery was swift, and the price was reasonable, prompting me to order again.

Pelvic Pain details

I bought this supplement after experiencing hip and knee pain possibly from apple cider vinegar. After a couple of days, my joint pain improved, and it was gone after two weeks. My bones feel much stronger now.

Bone Pain details

Calcium's role in bone pain unclear

In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.

Most Relevant Research

We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.

After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.

Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.

8.3

Joint relief

Most Useful Review

This complex works wonders for bone and joint health. After just a week, I noticed a reduction in the unpleasant clicks and creaks in my knees that I'd suffered from for an extended period.