Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
5.9
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
20 mcg(800 IU)
100%
Calcium (as Calcium Carbonate)
600 mg
46%
Magnesium (as Magnesium Oxide)
50 mg
12%
Zinc (as Zinc Oxide)
7.5 mg
68%
Copper (as Copper Oxide)
1 mg
111%
Manganese (as Manganese Sulfate)
1.8 mg
78%
Boron (as Sodium Borate)
250 mcg
**
Top Medical Research Studies
9
Calcium dobesilate reduces leg cramps
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Read More
8
Calcium reduces leg cramps effectively
We assessed the effectiveness of calcium in alleviating leg cramps, a common issue faced by many women in the later stages of pregnancy. Through a review of three randomized trials involving 217 women, we found promising results regarding calcium's impact on leg cramps.
The trials were of moderate quality and specifically measured the frequency of cramps compared to a placebo. Our findings showed that calcium significantly reduced leg cramps, with an odds ratio of 0.29, suggesting a much lower likelihood of cramps occurring among those taking calcium.
It's important to note that there was also substantial variability in the results from different studies. Additionally, a trial that compared sodium chloride with placebo indicated even more drastic reductions in cramps, presenting an odds ratio of 0.08.
However, the comparison between calcium and sodium chloride did not reveal a notable difference. While both treatments appear beneficial, the relevance of the sodium chloride results may be diminished due to changes in dietary patterns over time. Thus, calcium stands out as a practical option for those looking to manage leg cramps during pregnancy.
The trials were of moderate quality and specifically measured the frequency of cramps compared to a placebo. Our findings showed that calcium significantly reduced leg cramps, with an odds ratio of 0.29, suggesting a much lower likelihood of cramps occurring among those taking calcium.
It's important to note that there was also substantial variability in the results from different studies. Additionally, a trial that compared sodium chloride with placebo indicated even more drastic reductions in cramps, presenting an odds ratio of 0.08.
However, the comparison between calcium and sodium chloride did not reveal a notable difference. While both treatments appear beneficial, the relevance of the sodium chloride results may be diminished due to changes in dietary patterns over time. Thus, calcium stands out as a practical option for those looking to manage leg cramps during pregnancy.
Read More
7
We explored the effects of calcium supplements on leg cramps experienced during pregnancy by analyzing studies that compared calcium treatment to no treatment. The research included one trial with 43 women, evaluating how well calcium helped alleviate leg cramps.
The findings suggested that women taking calcium were more likely to experience fewer leg cramps after treatment compared to those who didn't receive any treatment. Specifically, a higher proportion of women reported having no leg cramps at all after taking calcium. However, the evidence was classified as very low quality, making it difficult to draw strong conclusions.
Overall, while calcium appeared to offer some benefit in reducing leg cramps, the lack of rigorous studies and clear outcomes means we should approach these findings with caution. Further research is needed to confirm these effects and establish a clearer understanding of how calcium works for pregnant women dealing with leg cramps.
The findings suggested that women taking calcium were more likely to experience fewer leg cramps after treatment compared to those who didn't receive any treatment. Specifically, a higher proportion of women reported having no leg cramps at all after taking calcium. However, the evidence was classified as very low quality, making it difficult to draw strong conclusions.
Overall, while calcium appeared to offer some benefit in reducing leg cramps, the lack of rigorous studies and clear outcomes means we should approach these findings with caution. Further research is needed to confirm these effects and establish a clearer understanding of how calcium works for pregnant women dealing with leg cramps.
Read More
Most Useful Reviews
9
Nighttime cramps gone
After reading a review, I began taking calcium tablets, and my feet no longer experience leg cramps at night. I bought some for my mother, and after a month, she has also stopped having cramps at night, which is wonderful! However, I find the pills a bit large and hard for the elderly to swallow; I plan on trying liquid calcium instead.
Read More
9
Cramps ceased
An excellent vitamin that my children enjoy. The condition of our muscles and bones has improved, and my leg cramps have stopped. I highly recommend it.
Read More
9
Cramps no more
Excellent! This complex offers a well-crafted blend of essential minerals that enhance one another’s effects. It strengthens bone tissue, teeth, and nails while also regulating muscle function. Plus, it improves skin and hair condition—stopping nocturnal leg cramps.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
5.9
- All Researches
9.5
We observed an interesting case regarding the effects of calcium treatment on leg cramps related to a chemotherapy drug called oxaliplatin. In this case, a 62-year-old woman undergoing palliative treatment for stage IV colon cancer experienced acute neurotoxicity symptoms. Notably, thirty minutes after her first infusion of oxaliplatin, which she received in her left arm, she developed cramps and paresthesia in her right leg.
As part of her treatment for these symptoms, intravenous calcium gluconate was administered alongside magnesium sulfate. This combination helped alleviate her leg cramping and associated symptoms within three hours. However, while calcium was part of the treatment regimen, it is important to note that its isolated effectiveness on leg cramps is unclear due to its concurrent administration with magnesium.
Consequently, while we saw improvement in the patient's symptoms, it is difficult to attribute these results solely to calcium. Instead, it suggests that magnesium might be playing a significant role as well. Future investigations could help clarify the specific contributions of calcium in treating leg cramps related to neurotoxicity and other conditions.
As part of her treatment for these symptoms, intravenous calcium gluconate was administered alongside magnesium sulfate. This combination helped alleviate her leg cramping and associated symptoms within three hours. However, while calcium was part of the treatment regimen, it is important to note that its isolated effectiveness on leg cramps is unclear due to its concurrent administration with magnesium.
Consequently, while we saw improvement in the patient's symptoms, it is difficult to attribute these results solely to calcium. Instead, it suggests that magnesium might be playing a significant role as well. Future investigations could help clarify the specific contributions of calcium in treating leg cramps related to neurotoxicity and other conditions.
Read More
9
Calcium dobesilate reduces leg cramps
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Read More
8
We explored the impact of calcium treatment on leg cramps in an adolescent diagnosed with pseudohypoparathyroidism type 1B. The patient experienced symptoms such as muscle cramps and leg pain during activities, with laboratory tests revealing hypocalcemia and an elevated parathyroid hormone level.
While calcium treatment was part of a combined therapy that included other medications, we observed that the muscle cramps and hypocalcemia resolved after administering calcium carbonate, ergocalciferol, and calcitriol. However, due to the combination of treatments, it is challenging to determine the isolated effect of calcium on the leg cramps specifically.
Ultimately, while calcium contributed to symptom relief, our study does not provide conclusive evidence on its effectiveness alone for alleviating leg cramps. This highlights the need for further investigation into how calcium might individually influence leg cramp symptoms in such patients.
While calcium treatment was part of a combined therapy that included other medications, we observed that the muscle cramps and hypocalcemia resolved after administering calcium carbonate, ergocalciferol, and calcitriol. However, due to the combination of treatments, it is challenging to determine the isolated effect of calcium on the leg cramps specifically.
Ultimately, while calcium contributed to symptom relief, our study does not provide conclusive evidence on its effectiveness alone for alleviating leg cramps. This highlights the need for further investigation into how calcium might individually influence leg cramp symptoms in such patients.
Read More
8
Calcium reduces leg cramps effectively
We assessed the effectiveness of calcium in alleviating leg cramps, a common issue faced by many women in the later stages of pregnancy. Through a review of three randomized trials involving 217 women, we found promising results regarding calcium's impact on leg cramps.
The trials were of moderate quality and specifically measured the frequency of cramps compared to a placebo. Our findings showed that calcium significantly reduced leg cramps, with an odds ratio of 0.29, suggesting a much lower likelihood of cramps occurring among those taking calcium.
It's important to note that there was also substantial variability in the results from different studies. Additionally, a trial that compared sodium chloride with placebo indicated even more drastic reductions in cramps, presenting an odds ratio of 0.08.
However, the comparison between calcium and sodium chloride did not reveal a notable difference. While both treatments appear beneficial, the relevance of the sodium chloride results may be diminished due to changes in dietary patterns over time. Thus, calcium stands out as a practical option for those looking to manage leg cramps during pregnancy.
The trials were of moderate quality and specifically measured the frequency of cramps compared to a placebo. Our findings showed that calcium significantly reduced leg cramps, with an odds ratio of 0.29, suggesting a much lower likelihood of cramps occurring among those taking calcium.
It's important to note that there was also substantial variability in the results from different studies. Additionally, a trial that compared sodium chloride with placebo indicated even more drastic reductions in cramps, presenting an odds ratio of 0.08.
However, the comparison between calcium and sodium chloride did not reveal a notable difference. While both treatments appear beneficial, the relevance of the sodium chloride results may be diminished due to changes in dietary patterns over time. Thus, calcium stands out as a practical option for those looking to manage leg cramps during pregnancy.
Read More
7
We explored the effects of calcium supplements on leg cramps experienced during pregnancy by analyzing studies that compared calcium treatment to no treatment. The research included one trial with 43 women, evaluating how well calcium helped alleviate leg cramps.
The findings suggested that women taking calcium were more likely to experience fewer leg cramps after treatment compared to those who didn't receive any treatment. Specifically, a higher proportion of women reported having no leg cramps at all after taking calcium. However, the evidence was classified as very low quality, making it difficult to draw strong conclusions.
Overall, while calcium appeared to offer some benefit in reducing leg cramps, the lack of rigorous studies and clear outcomes means we should approach these findings with caution. Further research is needed to confirm these effects and establish a clearer understanding of how calcium works for pregnant women dealing with leg cramps.
The findings suggested that women taking calcium were more likely to experience fewer leg cramps after treatment compared to those who didn't receive any treatment. Specifically, a higher proportion of women reported having no leg cramps at all after taking calcium. However, the evidence was classified as very low quality, making it difficult to draw strong conclusions.
Overall, while calcium appeared to offer some benefit in reducing leg cramps, the lack of rigorous studies and clear outcomes means we should approach these findings with caution. Further research is needed to confirm these effects and establish a clearer understanding of how calcium works for pregnant women dealing with leg cramps.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Nighttime cramps gone
After reading a review, I began taking calcium tablets, and my feet no longer experience leg cramps at night. I bought some for my mother, and after a month, she has also stopped having cramps at night, which is wonderful! However, I find the pills a bit large and hard for the elderly to swallow; I plan on trying liquid calcium instead.
Read More
9
Cramps ceased
An excellent vitamin that my children enjoy. The condition of our muscles and bones has improved, and my leg cramps have stopped. I highly recommend it.
Read More
9
Cramps no more
Excellent! This complex offers a well-crafted blend of essential minerals that enhance one another’s effects. It strengthens bone tissue, teeth, and nails while also regulating muscle function. Plus, it improves skin and hair condition—stopping nocturnal leg cramps.
Read More
9
Leg cramps resolved
My wife has not experienced any leg cramps since using this product.
Read More
7.5
Leg pain relief
This product aids with leg pain. The ingredients are of good quality, and the packaging arrived intact. I took it as advised before bed and addressed my calcium deficiency; my knees and legs no longer ache, and my fatigue has lessened. I also combined it with vitamin D3 (2000 units) and magnesium.
Read More
Frequently Asked Questions
7.5
Noticeable results
I purchased this for my elderly parents, who suffer from nightly leg cramps. After a month of use, my mother has shown significant improvement.
9
Nighttime cramps gone
After reading a review, I began taking calcium tablets, and my feet no longer experience leg cramps at night. I bought some for my mother, and after a month, she has also stopped having cramps at night, which is wonderful! However, I find the pills a bit large and hard for the elderly to swallow; I plan on trying liquid calcium instead.
7.5
Leg pain relief
This product aids with leg pain. The ingredients are of good quality, and the packaging arrived intact. I took it as advised before bed and addressed my calcium deficiency; my knees and legs no longer ache, and my fatigue has lessened. I also combined it with vitamin D3 (2000 units) and magnesium.
9
Leg cramps resolved
My wife has not experienced any leg cramps since using this product.
9
Cramps ceased
An excellent vitamin that my children enjoy. The condition of our muscles and bones has improved, and my leg cramps have stopped. I highly recommend it.
9
Cramps no more
Excellent! This complex offers a well-crafted blend of essential minerals that enhance one another’s effects. It strengthens bone tissue, teeth, and nails while also regulating muscle function. Plus, it improves skin and hair condition—stopping nocturnal leg cramps.
7.5
Magnesium effective
Best value! The magnesium level in these capsules is excellent for those suffering from leg cramps, and the added vitamin D3 is a fantastic bonus.
8
Calcium reduces leg cramps effectively
We assessed the effectiveness of calcium in alleviating leg cramps, a common issue faced by many women in the later stages of pregnancy. Through a review of three randomized trials involving 217 women, we found promising results regarding calcium's impact on leg cramps.
The trials were of moderate quality and specifically measured the frequency of cramps compared to a placebo. Our findings showed that calcium significantly reduced leg cramps, with an odds ratio of 0.29, suggesting a much lower likelihood of cramps occurring among those taking calcium.
It's important to note that there was also substantial variability in the results from different studies. Additionally, a trial that compared sodium chloride with placebo indicated even more drastic reductions in cramps, presenting an odds ratio of 0.08.
However, the comparison between calcium and sodium chloride did not reveal a notable difference. While both treatments appear beneficial, the relevance of the sodium chloride results may be diminished due to changes in dietary patterns over time. Thus, calcium stands out as a practical option for those looking to manage leg cramps during pregnancy.
The trials were of moderate quality and specifically measured the frequency of cramps compared to a placebo. Our findings showed that calcium significantly reduced leg cramps, with an odds ratio of 0.29, suggesting a much lower likelihood of cramps occurring among those taking calcium.
It's important to note that there was also substantial variability in the results from different studies. Additionally, a trial that compared sodium chloride with placebo indicated even more drastic reductions in cramps, presenting an odds ratio of 0.08.
However, the comparison between calcium and sodium chloride did not reveal a notable difference. While both treatments appear beneficial, the relevance of the sodium chloride results may be diminished due to changes in dietary patterns over time. Thus, calcium stands out as a practical option for those looking to manage leg cramps during pregnancy.
2
Calcium ineffective for leg cramps
We evaluated the effectiveness of calcium treatment for leg cramps experienced during pregnancy. In our exploration, we focused on five clinical trials involving 352 women, which were considered to be of moderate quality.
The results showed that calcium did not provide any significant benefit in reducing leg cramps. In fact, the only placebo-controlled trial specifically testing calcium revealed no evidence that it alleviated this common discomfort. This suggests that any perceived benefits might primarily stem from placebo effects rather than the calcium itself.
Additionally, when comparing calcium to sodium chloride, or even looking at multivitamins and magnesium treatment, the evidence remained inconclusive. While some trials hinted at potential benefits from other supplements, particularly magnesium, our results emphasize that calcium alone is unlikely to be a solution for managing leg cramps in pregnant women.
If cramping is bothersome, options like magnesium lactate or citrate are better supported by the evidence.
The results showed that calcium did not provide any significant benefit in reducing leg cramps. In fact, the only placebo-controlled trial specifically testing calcium revealed no evidence that it alleviated this common discomfort. This suggests that any perceived benefits might primarily stem from placebo effects rather than the calcium itself.
Additionally, when comparing calcium to sodium chloride, or even looking at multivitamins and magnesium treatment, the evidence remained inconclusive. While some trials hinted at potential benefits from other supplements, particularly magnesium, our results emphasize that calcium alone is unlikely to be a solution for managing leg cramps in pregnant women.
If cramping is bothersome, options like magnesium lactate or citrate are better supported by the evidence.
9
Calcium dobesilate reduces leg cramps
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
References
- Sasidharan Pillai S, Reyes M, Jüppner H, Topor LS. Growth Hormone Deficiency in an Adolescent With Pseudohypoparathyroidism Type 1B. JCEM Case Rep. 2024;2:luae152. 10.1210/jcemcr/luae152
- Luo L, Zhou K, Zhang J, Xu L, Yin W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2020;12:CD010655. 10.1002/14651858.CD010655.pub3
- Mansouri A, Mirghafourvand M, Charandabi SMA, Najafi M. The effect of Vitamin D and calcium plus Vitamin D on leg cramps in pregnant women: A randomized controlled trial. J Res Med Sci. 2017;22:24. 10.4103/1735-1995.200271
- Zhou K, West HM, Zhang J, Xu L, Li W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2015. 10.1002/14651858.CD010655.pub2
- Uña E. Atypical presentation of acute neurotoxicity secondary to oxaliplatin. J Oncol Pharm Pract. 2010;16:280. 10.1177/1078155209355849
- Ciapponi A, Laffaire E, Roqué M. Calcium dobesilate for chronic venous insufficiency: a systematic review. Angiology. 2004;55:147.
- Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2002.
- Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2000;2002:CD000121.
