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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Calcium (as Calcium Carbonate)
600 mg
46%
The product is found useful for the following medical conditions
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 32 Reviews
8.9
8
Calcium's role in bone pain unclear
In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.
Most Relevant Research
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
9.5
Joint pain relief
Most Useful Review
Thanks to this supplement, I've forgotten about bone pain and my bones no longer crunch.
Autoimmune Disorder details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Calcium's role in RA treatment
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.
Most Relevant Research
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
8.3
Knee pain relief
Most Useful Review
Thank you, iHerb! This is my second time taking this fantastic calcium supplement. My knee pain, which I had suffered from for five years, has nearly disappeared. I had tried everything else without success, but this calcium has worked wonders! I've ordered another jar just in case. I hope it helps someone else, too!
Back Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 11 Reviews
8.6
9
Calcium aids in back pain relief
Regular sling core stabilization training improves bone density based on calcium and vitamin D supplementation.
Most Relevant Research
We explored the impact of calcium and vitamin D supplementation combined with sling core stabilization training on back pain in a 70-year-old female patient suffering from osteoporosis. The patient engaged in this form of exercise three times a week, focusing on strengthening the deep muscles of her spine.
After a year of dedicated training, not only did her back pain significantly improve, but a follow-up examination also indicated an increase in her bone mineral density. This suggests that the combined approach of exercise and supplementation might promote better bone health and potentially reduce pain.
However, it’s important to note that while we saw positive changes in this case, the specific contributions of calcium alone cannot be clearly identified due to the concurrent treatments involved. Therefore, we recognize that further studies are needed to isolate calcium's effects to conclusively determine its role in managing back pain effectively.
After a year of dedicated training, not only did her back pain significantly improve, but a follow-up examination also indicated an increase in her bone mineral density. This suggests that the combined approach of exercise and supplementation might promote better bone health and potentially reduce pain.
However, it’s important to note that while we saw positive changes in this case, the specific contributions of calcium alone cannot be clearly identified due to the concurrent treatments involved. Therefore, we recognize that further studies are needed to isolate calcium's effects to conclusively determine its role in managing back pain effectively.
8.3
Knee pain alleviated
Most Useful Review
Thank you, iHerb! This is the second time I've ordered this excellent calcium. My knee pain has almost disappeared after five years of suffering. I hope my positive experience encourages others, though I did feel slightly nauseous, which I managed by taking it at night.
High Cholesterol details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Embelin influences cholesterol metabolism
Embelin Elevates Endoplasmic Reticulum Calcium Levels and Blocks the Sterol Regulatory Element-Binding Protein 2 Mediated Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Improves the Low-Density Lipoprotein Receptor Mediated Lipid Clearance on Hepatocytes.
Most Relevant Research
We examined the effects of embelin, a compound derived from the dried berries of Embelia ribes, on cholesterol levels by focusing on its relationship with calcium in liver cells. Our analysis showed that embelin treatment aids in regulating cholesterol metabolism by influencing key proteins associated with cholesterol clearance.
The study highlighted how embelin can elevate calcium levels within the endoplasmic reticulum (ER), which is essential for proper cellular function. By increasing calcium, we observed a decrease in the activity of a protein known as PCSK9, which typically hinders the liver's ability to remove low-density lipoprotein (LDL) cholesterol from circulation.
By regulating the levels of SREBP2, another protein linked to cholesterol control, embelin ultimately enhances the liver's capacity to clear LDL from the bloodstream. This mechanism reveals that calcium plays an important role, particularly in how embelin mediates cholesterol levels through its effects on proteins involved in cholesterol metabolism.
Overall, the findings suggest that embelin may offer a natural avenue for improving cholesterol management, particularly in the context of cardiovascular health.
The study highlighted how embelin can elevate calcium levels within the endoplasmic reticulum (ER), which is essential for proper cellular function. By increasing calcium, we observed a decrease in the activity of a protein known as PCSK9, which typically hinders the liver's ability to remove low-density lipoprotein (LDL) cholesterol from circulation.
By regulating the levels of SREBP2, another protein linked to cholesterol control, embelin ultimately enhances the liver's capacity to clear LDL from the bloodstream. This mechanism reveals that calcium plays an important role, particularly in how embelin mediates cholesterol levels through its effects on proteins involved in cholesterol metabolism.
Overall, the findings suggest that embelin may offer a natural avenue for improving cholesterol management, particularly in the context of cardiovascular health.
9.5
Joint pain relief
Most Useful Review
I was suffering from joint pain and brittle nails due to vitamin D and calcium deficiency. After taking this vitamin with vitamin D daily, I noticed a significant difference. It has eased my joint pain, and although I was not initially focused on high cholesterol, I feel overall healthier. I recommend taking it at night to aid sleep.
Leg Cramps details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
5.9
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Calcium dobesilate reduces leg cramps
Calcium dobesilate for chronic venous insufficiency: a systematic review.
Most Relevant Research
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
8.3
Stable joints observed
Most Useful Review
I have been using 21st Century Calcium Supplement 600 for several weeks and I'm pleased with the results. Each tablet contains 600mg of calcium, essential for maintaining strong bones and teeth. I've found them easy to swallow without any stomach upset. Since starting this supplement, I’ve noticed my joints feel more stable and I’ve had no issues with muscle cramps, which are often linked to a lack of calcium.
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7
USERS' SCORE
Good
Based on 12 Reviews
8.6
9
Calcium complex enhances bone health
A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health.
Most Relevant Research
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
9.5
Value for osteoporosis
Most Useful Review
21st Century Calcium Supplement 600 offers excellent value. As a sufferer of osteoporosis, taking calcium daily is essential, and buying a 400-tablet bottle at an affordable price is fantastic. It’s not in a gel cap, which suits me as a vegetarian.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.6
9.5
Joint pain relief
Most Useful Review
Save me from joint pain and brittle nails, which I suffered from due to vitamin D and calcium deficiency. I don't get enough sunlight and dislike dairy. After taking this vitamin with vitamin D daily, I've noticed significant improvement. It's best to take it at night as it helps with sleep. Please show appreciation if you find this helpful.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.3
8.3
Pain relief achieved
Most Useful Review
Thank you, Ayherb! This is my second purchase of this excellent calcium. After suffering from knee pain for five years, I've experienced remarkable relief. I even tried gelatin before with no success. This product has been transformative; however, I do feel slightly nauseous after taking it, so I’ve adapted by taking it at night.
Blood Clot details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 3 Reviews
8.1
8
Calcium type affects clot risk
Thrombotic Complications Associated With Right Atrial Lines in Neonates and Infants Undergoing Cardiac Surgery. Is Calcium Chloride a Culprit?
Most Relevant Research
We explored the impact of different calcium infusions on clotting risks in neonates undergoing cardiac surgery. Our study involved analyzing data from 135 babies who received either calcium chloride or calcium gluconate during their treatment.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
8
Awaiting blood clot results
Most Useful Review
The packaging is substantial and the price is low, with large pills that I can cut in half. I have a severe calcium deficiency due to health issues. I will have blood tests in a month to see if these pills improve my condition regarding the blood clot.
Knee Pain details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.8
9
Calcium injection aids knee function
Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee.
Most Relevant Research
We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
8.3
Miraculous calcium
Most Useful Review
Thank you, Ayherb! This is my second purchase. Excellent calcium; my knee pain has almost stopped! After suffering for five years, this product has worked wonders. I’ve ordered a second jar just in case. I’ve felt slightly nauseous after taking it, but I manage by taking it at night.
