' 
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Thiamin (as Thiamin Mononitrate, Vitamin B-1)
100 mg
8,333%
Riboflavin (Vitamin B-2)
100 mg
7,692%
Niacin (as Niacinamide)
100 mg
625%
Vitamin B-6 (as Pyridoxine HCl)
100 mg
5,882%
Folate
667 mcg DFE(400 mcg Folic Acid
167%
Vitamin B-12 (as Cyanocobalamin)
100 mcg
4,167%
Biotin
100 mcg
333%
Pantothenic Acid (as d-Calcium Pantothenate)
100 mg
2,000%
Calcium (as Calcium Carbonate & Dicalcium Phosphate)
124 mg
10%
Top Medical Research Studies
8
Pyridoxine promotes glioblastoma cell death
Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line.
Relevant vitamin therapy insights
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Read More
7
Nicotinamide induces reversible senescence
Nicotinamide metabolism reprogramming drives reversible senescence of glioblastoma cells.
Moderate relevance to brain tumor research
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
Read More
Most Useful Reviews
9.5
Life restoration
Life-changing! I have tried every type of B12 vitamin available, including injectable, designer prescription, and compounded forms, but this is the only one that works for me. The quality and ingredients are excellent. Although I’m not one to pen reviews, this supplement has transformed my life. I went from struggling to get through the day due to relentless fatigue to actively engaging in life again with full energy. The brain fog has disappeared, and so have the pins and needles. Not to sound clichéd, but I finally feel like I have my life back.
Read More
8
Sleep improvement
The B-100 Vitamin is an excellent supplement for relaxing my brain and improving my sleep. I have ordered it multiple times already. Thank you, iHerb!🙂
Read More
7.3
Health support
A necessary supplement, vitamin B plays a crucial role in maintaining good health and well-being. As the building blocks of a healthy body, B vitamins directly impact energy levels, brain function, and cell metabolism. This provides the essential support needed for health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Pyridoxine promotes glioblastoma cell death
Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line.
Relevant vitamin therapy insights
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Read More
7
Nicotinamide induces reversible senescence
Nicotinamide metabolism reprogramming drives reversible senescence of glioblastoma cells.
Moderate relevance to brain tumor research
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Life restoration
Life-changing! I have tried every type of B12 vitamin available, including injectable, designer prescription, and compounded forms, but this is the only one that works for me. The quality and ingredients are excellent. Although I’m not one to pen reviews, this supplement has transformed my life. I went from struggling to get through the day due to relentless fatigue to actively engaging in life again with full energy. The brain fog has disappeared, and so have the pins and needles. Not to sound clichéd, but I finally feel like I have my life back.
Read More
8
Sleep improvement
The B-100 Vitamin is an excellent supplement for relaxing my brain and improving my sleep. I have ordered it multiple times already. Thank you, iHerb!🙂
7.3
Health support
A necessary supplement, vitamin B plays a crucial role in maintaining good health and well-being. As the building blocks of a healthy body, B vitamins directly impact energy levels, brain function, and cell metabolism. This provides the essential support needed for health.
0
Negative effects
Unfortunately, this gave me migraines and a fuzzy brain.
